{"id":"https://openalex.org/W2017519608","doi":"https://doi.org/10.1097/yco.0000000000000132","title":"An update on pharmacotherapy for autism spectrum disorder in children and adolescents","display_name":"An update on pharmacotherapy for autism spectrum disorder in children and adolescents","publication_year":2015,"publication_date":"2015-01-17","ids":{"openalex":"https://openalex.org/W2017519608","doi":"https://doi.org/10.1097/yco.0000000000000132","mag":"2017519608","pmid":"https://pubmed.ncbi.nlm.nih.gov/25602248"},"language":"en","primary_location":{"id":"doi:10.1097/yco.0000000000000132","doi":"https://doi.org/10.1097/yco.0000000000000132","is_oa":false,"landing_page_url":"https://doi.org/10.1097/yco.0000000000000132","pdf_url":null,"source":{"id":"https://openalex.org/S15258550","display_name":"Current Opinion in Psychiatry","issn_l":"0951-7367","issn":["0951-7367","1473-6578"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Psychiatry","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025379529","display_name":"Na Young Ji","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1298154867","display_name":"Kennedy Krieger Institute","ror":"https://ror.org/05q6tgt32","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1298154867"]},{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Na Young Ji","raw_affiliation_strings":["aKennedy Krieger Institute bDepartment of Psychiatry and Behavioral Sciences, Division of Child and Adolescent Psychiatry, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA","Department of Psychiatry and Behavioral Sciences, Division of Child and Adolescent Psychiatry, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA","Kennedy Krieger Institute","e-mail: [email\u00a0protected]","fax: +1 443 923 7788","to Dr Na Young Ji, Kennedy Krieger School Programs, 3825 Greenspring Ave, Baltimore, MD 21231, USA. Tel: +1 443 923 7793"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"aKennedy Krieger Institute bDepartment of Psychiatry and Behavioral Sciences, Division of Child and Adolescent Psychiatry, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA","institution_ids":["https://openalex.org/I1298154867","https://openalex.org/I145311948","https://openalex.org/I2799853436"]},{"raw_affiliation_string":"Department of Psychiatry and Behavioral Sciences, Division of Child and Adolescent Psychiatry, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]},{"raw_affiliation_string":"Kennedy Krieger Institute","institution_ids":["https://openalex.org/I1298154867"]},{"raw_affiliation_string":"e-mail: [email\u00a0protected]","institution_ids":[]},{"raw_affiliation_string":"fax: +1 443 923 7788","institution_ids":[]},{"raw_affiliation_string":"to Dr Na Young Ji, Kennedy Krieger School Programs, 3825 Greenspring Ave, Baltimore, MD 21231, USA. Tel: +1 443 923 7793","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042787535","display_name":"Robert L. Findling","orcid":"https://orcid.org/0000-0002-7654-5782","observed_orcids":["https://orcid.org/0000-0002-7654-5782"]},"institutions":[{"id":"https://openalex.org/I1298154867","display_name":"Kennedy Krieger Institute","ror":"https://ror.org/05q6tgt32","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1298154867"]},{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert L. Findling","raw_affiliation_strings":["Department of Psychiatry and Behavioral Sciences, Division of Child and Adolescent Psychiatry, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA","Kennedy Krieger Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry and Behavioral Sciences, Division of Child and Adolescent Psychiatry, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]},{"raw_affiliation_string":"Kennedy Krieger Institute","institution_ids":["https://openalex.org/I1298154867"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5025379529"],"corresponding_institution_ids":["https://openalex.org/I1298154867","https://openalex.org/I145311948","https://openalex.org/I2799853436"],"apc_list":null,"apc_paid":null,"fwci":2.7677,"has_fulltext":false,"cited_by_count":271,"citation_normalized_percentile":{"value":0.93488024,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"28","issue":"2","first_page":"91","last_page":"101"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10106","display_name":"Autism Spectrum Disorder Research","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10106","display_name":"Autism Spectrum Disorder Research","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10537","display_name":"Attention Deficit Hyperactivity Disorder","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13393","display_name":"Child Nutrition and Feeding Issues","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/autism-spectrum-disorder","display_name":"autism spectrum disorder","score":0.9980000257492065},{"id":"https://openalex.org/keywords/drug-therapy","display_name":"pharmacotherapy","score":0.9200000166893005},{"id":"https://openalex.org/keywords/atypical-antipsychotics","display_name":"atypical antipsychotics","score":0.8709999918937683},{"id":"https://openalex.org/keywords/risperidone","display_name":"risperidone","score":1.0},{"id":"https://openalex.org/keywords/aripiprazole","display_name":"aripiprazole","score":0.9990000128746033},{"id":"https://openalex.org/keywords/irritability","display_name":"irritability","score":0.781000018119812},{"id":"https://openalex.org/keywords/stereotyped-behavior","display_name":"stereotypy","score":0.8640000224113464},{"id":"https://openalex.org/keywords/hyperactivity","display_name":"hyperactivity","score":0.8059999942779541},{"id":"https://openalex.org/keywords/methylphenidate","display_name":"methylphenidate","score":0.9789999723434448},{"id":"https://openalex.org/keywords/atomoxetine","display_name":"atomoxetine","score":0.847000002861023},{"id":"https://openalex.org/keywords/alpha-2-adrenergic-agonists","display_name":"alpha-2 adrenergic agonists","score":0.9660000205039978},{"id":"https://openalex.org/keywords/attention-deficit-hyperactivity-disorder","display_name":"attention deficit hyperactivity disorder","score":0.8600000143051147},{"id":"https://openalex.org/keywords/selective-serotonin-reuptake-inhibitors","display_name":"selective serotonin reuptake inhibitors","score":0.9890000224113464},{"id":"https://openalex.org/keywords/repetitive-behavior","display_name":"repetitive behavior","score":0.7120000123977661},{"id":"https://openalex.org/keywords/antiepileptic-drugs","display_name":"antiepileptic drugs","score":0.9779999852180481},{"id":"https://openalex.org/keywords/glutamatergic-agents","display_name":"glutamatergic agents","score":0.9419999718666077},{"id":"https://openalex.org/keywords/oxytocin","display_name":"oxytocin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/metabolic-side-effects","display_name":"metabolic side effects","score":0.8040000200271606},{"id":"https://openalex.org/keywords/children-and-adolescents","display_name":"children and adolescents","score":0.7580000162124634}],"concepts":[{"id":"https://openalex.org/C2778538070","wikidata":"https://www.wikidata.org/wiki/Q1436063","display_name":"Autism spectrum disorder","level":3,"score":0.8237998485565186},{"id":"https://openalex.org/C500440147","wikidata":"https://www.wikidata.org/wiki/Q701216","display_name":"Pharmacotherapy","level":2,"score":0.7938779592514038},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.4319833517074585},{"id":"https://openalex.org/C205778803","wikidata":"https://www.wikidata.org/wiki/Q38404","display_name":"Autism","level":2,"score":0.4166221022605896},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.38518744707107544},{"id":"https://openalex.org/C70410870","wikidata":"https://www.wikidata.org/wiki/Q199906","display_name":"Clinical psychology","level":1,"score":0.35067781805992126},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.31383222341537476}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002659","descriptor_name":"Child Development Disorders, Pervasive","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002659","descriptor_name":"Child Development Disorders, Pervasive","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014150","descriptor_name":"Antipsychotic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1097/yco.0000000000000132","doi":"https://doi.org/10.1097/yco.0000000000000132","is_oa":false,"landing_page_url":"https://doi.org/10.1097/yco.0000000000000132","pdf_url":null,"source":{"id":"https://openalex.org/S15258550","display_name":"Current Opinion in Psychiatry","issn_l":"0951-7367","issn":["0951-7367","1473-6578"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Psychiatry","raw_type":"journal-article"},{"id":"pmid:25602248","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25602248","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current opinion in psychiatry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":129,"referenced_works":["https://openalex.org/W40940716","https://openalex.org/W46703679","https://openalex.org/W48331108","https://openalex.org/W95956550","https://openalex.org/W106578406","https://openalex.org/W749806508","https://openalex.org/W1503862109","https://openalex.org/W1508227306","https://openalex.org/W1597533526","https://openalex.org/W1624939785","https://openalex.org/W1645273149","https://openalex.org/W1669076017","https://openalex.org/W1823169087","https://openalex.org/W1931362782","https://openalex.org/W1933613998","https://openalex.org/W1965294510","https://openalex.org/W1966317054","https://openalex.org/W1967530458","https://openalex.org/W1968228654","https://openalex.org/W1968430210","https://openalex.org/W1969516074","https://openalex.org/W1969581400","https://openalex.org/W1972045074","https://openalex.org/W1972563006","https://openalex.org/W1973471819","https://openalex.org/W1973561392","https://openalex.org/W1976230665","https://openalex.org/W1976498610","https://openalex.org/W1976684277","https://openalex.org/W1979628056","https://openalex.org/W1980825934","https://openalex.org/W1981466770","https://openalex.org/W1988747626","https://openalex.org/W1990859497","https://openalex.org/W1993459964","https://openalex.org/W2000565519","https://openalex.org/W2004511233","https://openalex.org/W2007445647","https://openalex.org/W2007655600","https://openalex.org/W2009214635","https://openalex.org/W2018998808","https://openalex.org/W2019499554","https://openalex.org/W2020374060","https://openalex.org/W2020586498","https://openalex.org/W2025036806","https://openalex.org/W2025450822","https://openalex.org/W2029331443","https://openalex.org/W2029818273","https://openalex.org/W2033990638","https://openalex.org/W2034220807","https://openalex.org/W2035017299","https://openalex.org/W2035688952","https://openalex.org/W2043475191","https://openalex.org/W2046005693","https://openalex.org/W2051273046","https://openalex.org/W2051587828","https://openalex.org/W2058684270","https://openalex.org/W2059496726","https://openalex.org/W2060413296","https://openalex.org/W2061205980","https://openalex.org/W2061313353","https://openalex.org/W2061864344","https://openalex.org/W2064529484","https://openalex.org/W2064562795","https://openalex.org/W2066810529","https://openalex.org/W2066817339","https://openalex.org/W2072009719","https://openalex.org/W2078913169","https://openalex.org/W2079773266","https://openalex.org/W2081758073","https://openalex.org/W2081857076","https://openalex.org/W2082404293","https://openalex.org/W2084609003","https://openalex.org/W2085180470","https://openalex.org/W2087357295","https://openalex.org/W2087683767","https://openalex.org/W2088932057","https://openalex.org/W2090450562","https://openalex.org/W2092691320","https://openalex.org/W2094107633","https://openalex.org/W2094366931","https://openalex.org/W2100398017","https://openalex.org/W2101716121","https://openalex.org/W2104193444","https://openalex.org/W2107605715","https://openalex.org/W2112163143","https://openalex.org/W2113512187","https://openalex.org/W2115061863","https://openalex.org/W2116795013","https://openalex.org/W2119098759","https://openalex.org/W2120426123","https://openalex.org/W2122550040","https://openalex.org/W2123247267","https://openalex.org/W2131522463","https://openalex.org/W2131568512","https://openalex.org/W2131922391","https://openalex.org/W2134810756","https://openalex.org/W2136581101","https://openalex.org/W2137328236","https://openalex.org/W2141395995","https://openalex.org/W2143188771","https://openalex.org/W2144696231","https://openalex.org/W2147802796","https://openalex.org/W2152449622","https://openalex.org/W2156015873","https://openalex.org/W2158210077","https://openalex.org/W2160438215","https://openalex.org/W2193951151","https://openalex.org/W2213143536","https://openalex.org/W2234492752","https://openalex.org/W2267011174","https://openalex.org/W2281435534","https://openalex.org/W2301348266","https://openalex.org/W2336678555","https://openalex.org/W2339010716","https://openalex.org/W2406587744","https://openalex.org/W2437871075","https://openalex.org/W2479069490","https://openalex.org/W2514055214","https://openalex.org/W2514199772","https://openalex.org/W2536129703","https://openalex.org/W2536387587","https://openalex.org/W2555743000","https://openalex.org/W2565405058","https://openalex.org/W2576165191","https://openalex.org/W2602801922","https://openalex.org/W2606925384","https://openalex.org/W2735278545","https://openalex.org/W2756112142"],"related_works":["https://openalex.org/W2802198909","https://openalex.org/W2005281014","https://openalex.org/W4381251656","https://openalex.org/W2799421848","https://openalex.org/W3154003670","https://openalex.org/W2004096395","https://openalex.org/W4214953333","https://openalex.org/W4255902512","https://openalex.org/W2510525601","https://openalex.org/W2156712014"],"abstract_inverted_index":{"PURPOSE":[0],"OF":[1],"REVIEW:":[2],"Although":[3],"there":[4],"is":[5,68,112],"no":[6],"known":[7],"efficacious":[8],"pharmacotherapy":[9,33,119,153,171,185],"for":[10,23,187],"core":[11,188],"symptoms":[12,25,189,194],"of":[13,109,118,175,195],"autism":[14],"spectrum":[15],"disorder":[16,74],"(ASD),":[17],"psychotropic":[18],"medications":[19],"are":[20,49,65,91,124,159,197],"commonly":[21],"prescribed":[22],"behavioral/emotional":[24],"associated":[26],"with":[27,100,122,134,147,157],"ASD.":[28],"We":[29],"reviewed":[30],"current":[31],"evidence-based":[32,152],"options":[34,154,186],"and":[35,47,55,63,78,102,116,142,162,178,182],"updates":[36],"from":[37],"recent":[38],"noteworthy":[39],"studies.":[40],"RECENT":[41],"FINDINGS:":[42],"Atypical":[43],"antipsychotics,":[44],"particularly":[45],"risperidone":[46],"aripiprazole,":[48],"effective":[50,69,82,93],"in":[51,70,83,94,98,120,130,155,198],"reducing":[52,71,84],"irritability,":[53],"stereotypy":[54],"hyperactivity.":[56],"Metabolic":[57],"adverse":[58,106,166],"events,":[59],"including":[60,139],"weight":[61],"gain":[62],"dyslipidemia,":[64],"common.":[66],"Methylphenidate":[67],"attention-deficit":[72],"hyperactivity":[73],"(ADHD)":[75],"symptoms.":[76,86,136],"Atomoxetine":[77],"alpha-2":[79],"agonists":[80],"appear":[81,144],"ADHD":[85],"Selective":[87],"serotonin":[88],"reuptake":[89],"inhibitors":[90],"not":[92],"improving":[95],"repetitive":[96],"behaviors":[97],"children":[99,121,133,156],"ASD,":[101],"frequently":[103],"cause":[104],"activating":[105],"events.":[107,167],"Efficacy":[108],"antiepileptic":[110],"drugs":[111],"inconclusive.":[113],"Overall,":[114],"efficacy":[115],"tolerability":[117],"ASD":[123,158,196],"less":[125],"favorable":[126],"than":[127],"data":[128],"seen":[129],"typically":[131],"developing":[132],"similar":[135],"Newer":[137],"agents,":[138],"glutamatergic":[140],"agents":[141],"oxytocin,":[143],"promising":[145],"albeit":[146],"mixed":[148],"results.":[149],"SUMMARY:":[150],"Current":[151],"very":[160],"limited,":[161],"many":[163],"have":[164],"substantial":[165],"Clinicians":[168],"should":[169],"use":[170],"as":[172,190,192],"a":[173],"part":[174],"comprehensive":[176],"treatment,":[177],"judiciously":[179],"weigh":[180],"risks":[181],"benefits.":[183],"New":[184],"well":[191],"co-occurring":[193],"urgent":[199],"need.":[200]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":20},{"year":2021,"cited_by_count":27},{"year":2020,"cited_by_count":35},{"year":2019,"cited_by_count":71},{"year":2018,"cited_by_count":21},{"year":2017,"cited_by_count":26},{"year":2016,"cited_by_count":36},{"year":2015,"cited_by_count":9},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
