{"id":"https://openalex.org/W2017519243","doi":"https://doi.org/10.1074/jbc.271.45.27991","title":"ASCT-1 Is a Neutral Amino Acid Exchanger with Chloride Channel Activity","display_name":"ASCT-1 Is a Neutral Amino Acid Exchanger with Chloride Channel Activity","publication_year":1996,"publication_date":"1996-11-01","ids":{"openalex":"https://openalex.org/W2017519243","doi":"https://doi.org/10.1074/jbc.271.45.27991","mag":"2017519243","pmid":"https://pubmed.ncbi.nlm.nih.gov/8910405"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.271.45.27991","doi":"https://doi.org/10.1074/jbc.271.45.27991","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.271.45.27991","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1074/jbc.271.45.27991","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111663051","display_name":"Noa Zerangue","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]},{"id":"https://openalex.org/I2802707198","display_name":"Vollum Institute","ror":"https://ror.org/054hm6j14","country_code":"US","type":"facility","lineage":["https://openalex.org/I2802707198"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Noa Zerangue","raw_affiliation_strings":["Vollum Institute, Oregon Health Sciences University, Portland, Oregon 97201, USA. kavanaug@ohsu.edu","Vollum Institute Oregon Health Sciences University Portland, Oregon 97201, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vollum Institute, Oregon Health Sciences University, Portland, Oregon 97201, USA. kavanaug@ohsu.edu","institution_ids":["https://openalex.org/I165690674","https://openalex.org/I2802707198"]},{"raw_affiliation_string":"Vollum Institute Oregon Health Sciences University Portland, Oregon 97201, USA","institution_ids":["https://openalex.org/I165690674","https://openalex.org/I2802707198"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112780072","display_name":"Michael P. Kavanaugh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]},{"id":"https://openalex.org/I2802707198","display_name":"Vollum Institute","ror":"https://ror.org/054hm6j14","country_code":"US","type":"facility","lineage":["https://openalex.org/I2802707198"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Michael P. Kavanaugh","raw_affiliation_strings":["Vollum Institute, Oregon Health Sciences University, Portland, Oregon 97201","From the Vollum Institute, Oregon Health Sciences University, Portland Oregon 97201"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vollum Institute, Oregon Health Sciences University, Portland, Oregon 97201","institution_ids":["https://openalex.org/I165690674","https://openalex.org/I2802707198"]},{"raw_affiliation_string":"From the Vollum Institute, Oregon Health Sciences University, Portland Oregon 97201","institution_ids":["https://openalex.org/I165690674","https://openalex.org/I2802707198"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5112780072"],"corresponding_institution_ids":["https://openalex.org/I165690674","https://openalex.org/I2802707198"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":2.2941,"has_fulltext":false,"cited_by_count":186,"citation_normalized_percentile":{"value":0.88345613,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"271","issue":"45","first_page":"27991","last_page":"27994"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11247","display_name":"Plant nutrient uptake and metabolism","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/system-asc","display_name":"system ASC","score":0.8379999995231628},{"id":"https://openalex.org/keywords/neutral-amino-acid-transport","display_name":"neutral amino acid transport","score":0.7839999794960022},{"id":"https://openalex.org/keywords/chloride-channel-activity","display_name":"chloride channel activity","score":0.7229999899864197},{"id":"https://openalex.org/keywords/electroneutral-exchange","display_name":"electroneutral exchange","score":0.8610000014305115},{"id":"https://openalex.org/keywords/sodium-dependence","display_name":"sodium dependence","score":0.7509999871253967},{"id":"https://openalex.org/keywords/alanine","display_name":"alanine","score":0.6209999918937683},{"id":"https://openalex.org/keywords/serine","display_name":"serine","score":0.9769999980926514},{"id":"https://openalex.org/keywords/cysteine","display_name":"cysteine","score":1.0}],"concepts":[{"id":"https://openalex.org/C2778695967","wikidata":"https://www.wikidata.org/wiki/Q44791900","display_name":"Chloride","level":2,"score":0.5402372479438782},{"id":"https://openalex.org/C117760992","wikidata":"https://www.wikidata.org/wiki/Q389137","display_name":"Ion exchange","level":3,"score":0.4995098114013672},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.48022276163101196},{"id":"https://openalex.org/C145822097","wikidata":"https://www.wikidata.org/wiki/Q106916978","display_name":"Chloride channel","level":2,"score":0.46441835165023804},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.24567446112632751},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.1390036940574646},{"id":"https://openalex.org/C145148216","wikidata":"https://www.wikidata.org/wiki/Q36496","display_name":"Ion","level":2,"score":0.13200035691261292}],"mesh":[{"descriptor_ui":"D000409","descriptor_name":"Alanine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011188","descriptor_name":"Potassium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012964","descriptor_name":"Sodium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014982","descriptor_name":"Xenopus laevis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018118","descriptor_name":"Chloride Channels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D026905","descriptor_name":"Amino Acid Transport Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1074/jbc.271.45.27991","doi":"https://doi.org/10.1074/jbc.271.45.27991","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.271.45.27991","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:8910405","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8910405","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:scholarworks.umt.edu:biopharm_pubs-1056","doi":null,"is_oa":false,"landing_page_url":"https://scholarworks.umt.edu/biopharm_pubs/54","pdf_url":null,"source":{"id":"https://openalex.org/S190740074","display_name":"The Mathematics Enthusiast","issn_l":"1551-3440","issn":["1551-3440"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","norway-1","poland-20","russia-white-list-3"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biomedical and Pharmaceutical Sciences Faculty Publications","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1074/jbc.271.45.27991","doi":"https://doi.org/10.1074/jbc.271.45.27991","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.271.45.27991","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G5447155094","display_name":"BASIC AMINO ACID TRANSPORTERS","funder_award_id":"R01GM048709","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W225011772","https://openalex.org/W1483519009","https://openalex.org/W1485152408","https://openalex.org/W1489911254","https://openalex.org/W1512720139","https://openalex.org/W1538569506","https://openalex.org/W1582272079","https://openalex.org/W1604834760","https://openalex.org/W1607476467","https://openalex.org/W1975715220","https://openalex.org/W1982557947","https://openalex.org/W1995122601","https://openalex.org/W2003723227","https://openalex.org/W2016342626","https://openalex.org/W2018149549","https://openalex.org/W2020854995","https://openalex.org/W2028002685","https://openalex.org/W2028697308","https://openalex.org/W2031130299","https://openalex.org/W2032299952","https://openalex.org/W2038189991","https://openalex.org/W2045037622","https://openalex.org/W2045619782","https://openalex.org/W2052099900","https://openalex.org/W2078310394","https://openalex.org/W2086529934","https://openalex.org/W2087438458","https://openalex.org/W2094673798","https://openalex.org/W2151350796","https://openalex.org/W2163057250","https://openalex.org/W2174879004"],"related_works":["https://openalex.org/W2027606247","https://openalex.org/W2040293424","https://openalex.org/W7002250310","https://openalex.org/W2130377197","https://openalex.org/W4206274146","https://openalex.org/W1982557947","https://openalex.org/W258350697","https://openalex.org/W2023318397","https://openalex.org/W1512720139","https://openalex.org/W1996577648"],"abstract_inverted_index":{"The":[0,66,137],"ubiquitous":[1],"transport":[2,76,117],"activity":[3,102],"known":[4],"as":[5,55],"system":[6,30],"ASC":[7],"is":[8,133],"characterized":[9],"by":[10,119],"a":[11,36,44,81,116,156],"preference":[12],"for":[13,93],"small":[14],"neutral":[15,151],"amino":[16,38,63,130,152,160],"acids":[17,131,153],"including":[18],"alanine,":[19],"serine,":[20],"and":[21,24,114,127,132,154],"cysteine.":[22],"ASCT-1":[23,123,140],"ASCT-2,":[25],"recently":[26],"cloned":[27],"transporters":[28],"exhibiting":[29],"ASC-like":[31],"selectivity,":[32],"are":[33],"members":[34],"of":[35,46,80,121,129,139,150],"major":[37],"acid":[39,64,161],"transporter":[40,96],"family":[41],"that":[42,52,59,142],"includes":[43],"number":[45],"glutamate":[47,95,99,108],"transporters.":[48],"Here":[49],"we":[50],"show":[51],"ASCT1":[53,101],"functions":[54],"an":[56],"electroneutral":[57],"exchanger":[58],"mediates":[60,124],"negligible":[61],"net":[62,112],"flux.":[65],"electrical":[67],"currents":[68],"previously":[69],"shown":[70],"to":[71,90,135,146,158],"be":[72],"associated":[73],"with":[74,86],"ASCT1-mediated":[75],"result":[77],"from":[78],"activation":[79],"thermodynamically":[82],"uncoupled":[83],"chloride":[84],"conductance":[85],"permeation":[87],"properties":[88,138],"similar":[89],"those":[91],"described":[92],"the":[94],"subfamily.":[97],"Like":[98],"transporters,":[100,109],"requires":[103],"extracellular":[104],"Na+.":[105],"However,":[106],"unlike":[107],"which":[110],"mediate":[111],"flux":[113],"complete":[115],"cycle":[118],"countertransport":[120],"K+,":[122],"only":[125],"homo-":[126],"heteroexchange":[128],"insensitive":[134],"K+.":[136],"suggest":[141],"it":[143],"may":[144],"function":[145],"equilibrate":[147],"different":[148],"pools":[149],"provide":[155],"mechanism":[157],"link":[159],"concentration":[162],"gradients.":[163]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}