{"id":"https://openalex.org/W2017515817","doi":"https://doi.org/10.1115/nemb2010-13372","title":"Development of Nanofiber Scaffolds for Engineering an Artificial Salivary Gland","display_name":"Development of Nanofiber Scaffolds for Engineering an Artificial Salivary Gland","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W2017515817","doi":"https://doi.org/10.1115/nemb2010-13372","mag":"2017515817"},"language":"en","primary_location":{"id":"doi:10.1115/nemb2010-13372","doi":"https://doi.org/10.1115/nemb2010-13372","is_oa":false,"landing_page_url":"https://doi.org/10.1115/nemb2010-13372","pdf_url":null,"source":{"id":"https://openalex.org/S7407086725","display_name":"ASME Global Congress on NanoEngineering for Medicine and Biology (NEMB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ASME 2010 First Global Congress on NanoEngineering for Medicine and Biology","raw_type":"proceedings-article"},"volume":null,"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087618896","display_name":"Melinda Larsen","orcid":"https://orcid.org/0000-0002-5026-2012","observed_orcids":["https://orcid.org/0000-0002-5026-2012"]},"institutions":[{"id":"https://openalex.org/I392282","display_name":"University at Albany, State University of New York","ror":"https://ror.org/012zs8222","country_code":"US","type":"education","lineage":["https://openalex.org/I392282"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Melinda Larsen","raw_affiliation_strings":["University at Albany, SUNY, Albany, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University at Albany, SUNY, Albany, NY","institution_ids":["https://openalex.org/I392282"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086005009","display_name":"Riffard Jean-Gilles","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I392282","display_name":"University at Albany, State University of New York","ror":"https://ror.org/012zs8222","country_code":"US","type":"education","lineage":["https://openalex.org/I392282"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Riffard Jean-Gilles","raw_affiliation_strings":["University at Albany, SUNY, Albany, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University at Albany, SUNY, Albany, NY","institution_ids":["https://openalex.org/I392282"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054382953","display_name":"David A. Soscia","orcid":"https://orcid.org/0000-0003-3489-4463","observed_orcids":["https://orcid.org/0000-0003-3489-4463"]},"institutions":[{"id":"https://openalex.org/I392282","display_name":"University at Albany, State University of New York","ror":"https://ror.org/012zs8222","country_code":"US","type":"education","lineage":["https://openalex.org/I392282"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Soscia","raw_affiliation_strings":["University at Albany, SUNY, Albany, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University at Albany, SUNY, Albany, NY","institution_ids":["https://openalex.org/I392282"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045343474","display_name":"Sharon J. Sequeira","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I392282","display_name":"University at Albany, State University of New York","ror":"https://ror.org/012zs8222","country_code":"US","type":"education","lineage":["https://openalex.org/I392282"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sharon Sequeira","raw_affiliation_strings":["University at Albany, SUNY, Albany, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University at Albany, SUNY, Albany, NY","institution_ids":["https://openalex.org/I392282"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037520621","display_name":"Michael D. Melfi","orcid":"https://orcid.org/0000-0001-8613-8526","observed_orcids":["https://orcid.org/0000-0001-8613-8526"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Melfi","raw_affiliation_strings":["Cornell University, Ithaca, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cornell University, Ithaca, NY","institution_ids":["https://openalex.org/I205783295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110486044","display_name":"Anand P. Gadre","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I392282","display_name":"University at Albany, State University of New York","ror":"https://ror.org/012zs8222","country_code":"US","type":"education","lineage":["https://openalex.org/I392282"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anand Gadre","raw_affiliation_strings":["University at Albany, SUNY, Albany, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University at Albany, SUNY, Albany, NY","institution_ids":["https://openalex.org/I392282"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055059104","display_name":"James Castracane","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I392282","display_name":"University at Albany, State University of New York","ror":"https://ror.org/012zs8222","country_code":"US","type":"education","lineage":["https://openalex.org/I392282"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James Castracane","raw_affiliation_strings":["University at Albany, SUNY, Albany, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University at Albany, SUNY, Albany, NY","institution_ids":["https://openalex.org/I392282"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.0177,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.859375,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":96},"biblio":{"volume":null,"issue":null,"first_page":"185","last_page":"186"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10729","display_name":"Electrospun Nanofibers in Biomedical Applications","score":0.9775000214576721,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10729","display_name":"Electrospun Nanofibers in Biomedical Applications","score":0.9775000214576721,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.005100000184029341,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11521","display_name":"Salivary Gland Disorders and Functions","score":0.00430000014603138,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nanofibrous-scaffolds","display_name":"nanofibrous scaffolds","score":0.8859999775886536},{"id":"https://openalex.org/keywords/xerostomia","display_name":"xerostomia","score":0.9679999947547913},{"id":"https://openalex.org/keywords/epithelial-cell-polarity","display_name":"epithelial polarity","score":0.7110000252723694},{"id":"https://openalex.org/keywords/apicobasal-polarity","display_name":"apical-basal polarity","score":0.9559999704360962},{"id":"https://openalex.org/keywords/acinar-cells","display_name":"acinar cells","score":0.7670000195503235},{"id":"https://openalex.org/keywords/plga","display_name":"PLGA","score":0.9399999976158142},{"id":"https://openalex.org/keywords/tight-junction-proteins","display_name":"tight junction proteins","score":0.7829999923706055},{"id":"https://openalex.org/keywords/zo-1","display_name":"ZO-1","score":0.9929999709129333},{"id":"https://openalex.org/keywords/claudins","display_name":"claudins","score":0.9829999804496765},{"id":"https://openalex.org/keywords/integrin-alpha6","display_name":"CD49f","score":0.8529999852180481},{"id":"https://openalex.org/keywords/fibronectin","display_name":"fibronectin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cell-self-organization","display_name":"cell self-organization","score":0.6520000100135803},{"id":"https://openalex.org/keywords/salivary-secretion","display_name":"salivary secretion","score":0.6779999732971191}],"concepts":[{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6760238409042358},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.6479585766792297},{"id":"https://openalex.org/C39587587","wikidata":"https://www.wikidata.org/wiki/Q5383698","display_name":"Epithelial polarity","level":3,"score":0.6125693321228027},{"id":"https://openalex.org/C49353375","wikidata":"https://www.wikidata.org/wiki/Q189100","display_name":"Cell polarity","level":3,"score":0.6112020611763},{"id":"https://openalex.org/C2778937882","wikidata":"https://www.wikidata.org/wiki/Q134938","display_name":"Salivary gland","level":2,"score":0.5543653964996338},{"id":"https://openalex.org/C49892992","wikidata":"https://www.wikidata.org/wiki/Q1540285","display_name":"Tissue engineering","level":2,"score":0.5043998956680298},{"id":"https://openalex.org/C89429830","wikidata":"https://www.wikidata.org/wiki/Q735710","display_name":"Scaffold","level":2,"score":0.46883243322372437},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4375922977924347},{"id":"https://openalex.org/C91129048","wikidata":"https://www.wikidata.org/wiki/Q594196","display_name":"Nanofiber","level":2,"score":0.4368998110294342},{"id":"https://openalex.org/C2780165375","wikidata":"https://www.wikidata.org/wiki/Q2102907","display_name":"PLGA","level":3,"score":0.4306797385215759},{"id":"https://openalex.org/C504460877","wikidata":"https://www.wikidata.org/wiki/Q155925","display_name":"Saliva","level":2,"score":0.4268595576286316},{"id":"https://openalex.org/C2777361361","wikidata":"https://www.wikidata.org/wiki/Q1112585","display_name":"Polarity (international relations)","level":3,"score":0.4144696891307831},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.34738144278526306},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.33812111616134644},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.31254252791404724},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2915512025356293},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.2781285047531128},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.2449597716331482},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.21545809507369995},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.10946634411811829}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1115/nemb2010-13372","doi":"https://doi.org/10.1115/nemb2010-13372","is_oa":false,"landing_page_url":"https://doi.org/10.1115/nemb2010-13372","pdf_url":null,"source":{"id":"https://openalex.org/S7407086725","display_name":"ASME Global Congress on NanoEngineering for Medicine and Biology (NEMB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ASME 2010 First Global Congress on NanoEngineering for Medicine and Biology","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.428600013256073,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2064944078","https://openalex.org/W2031462648","https://openalex.org/W4410805166","https://openalex.org/W2794675746","https://openalex.org/W2052180293","https://openalex.org/W2162617666","https://openalex.org/W144360007","https://openalex.org/W2744473680","https://openalex.org/W4411326163","https://openalex.org/W4406792347"],"abstract_inverted_index":{"There":[0],"is":[1,68],"currently":[2],"a":[3,12],"significant":[4],"clinical":[5],"need":[6],"for":[7,15,192],"artificial":[8],"salivary":[9,75,199],"glands":[10],"as":[11,161],"therapeutic":[13],"option":[14],"patients":[16],"suffering":[17],"from":[18],"xerostomia.":[19],"To":[20],"achieve":[21,47,63,94],"unidirectional":[22,48],"fluid":[23,49],"secretion,":[24],"the":[25,36,80,103,116,125,139,165,172],"epithelial":[26,55,84,131],"acinar":[27,56],"cells":[28,85],"must":[29],"establish":[30],"and":[31,42,52,66,93,112,114,135,147,155,157,164],"maintain":[32],"polarity":[33,58,137],"by":[34],"partitioning":[35],"plasma":[37],"membrane":[38,44],"into":[39],"distinct":[40],"apical":[41,150],"basolateral":[43],"surfaces":[45],"to":[46,62,83,91,144,180],"secretion.":[50],"Establishment":[51],"maintenance":[53],"of":[54,79,118,127,149,171],"cell":[57,132],"has":[59],"been":[60],"difficult":[61],"in":[64,72,195],"vitro,":[65],"yet":[67],"critical":[69],"saliva":[70],"secretion":[71],"an":[73,189,196],"engineered":[74,99,197],"gland.":[76],"Physical":[77],"properties":[78],"scaffold":[81,191],"provided":[82],"will":[86,187],"likely":[87],"influence":[88],"their":[89],"ability":[90],"differentiate":[92],"apical-basal":[95,183],"polarity.":[96,184],"We":[97,123],"have":[98],"nanofiber":[100,173],"matrices":[101],"using":[102,121,141],"biocompatible":[104],"polymer,":[105],"PLGA":[106],"(poly-L-lactic-co-glycolic":[107],"acid)":[108],"having":[109],"differing":[110],"topology":[111],"organization":[113,148],"documented":[115],"structure":[117],"these":[119],"scaffolds":[120,140],"SEM.":[122],"evaluated":[124],"effects":[126],"several":[128],"factors":[129],"on":[130,138],"attachment,":[133],"self-organization,":[134],"apico-basal":[136],"confocal":[142],"microscopy":[143],"examine":[145],"expression":[146],"tight":[151],"junction":[152],"proteins,":[153],"ZO-1":[154],"claudins,":[156],"basal":[158],"markers,":[159],"such":[160],"integrin":[162],"\u03b16":[163],"ECM":[166],"protein":[167],"fibronectin.":[168],"The":[169],"surface":[170],"matrix":[174],"was":[175],"functionalized":[176],"with":[177],"chemically-linked":[178],"ligands":[179],"further":[181],"optimize":[182],"These":[185],"studies":[186],"identify":[188],"optimal":[190],"future":[193],"use":[194],"functional":[198],"gland":[200],"construct.":[201]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2017,"cited_by_count":2}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}
