{"id":"https://openalex.org/W2017506148","doi":"https://doi.org/10.1136/jmg.26.3.172","title":"Distribution of haptoglobin phenotypes in oesophageal and gastric cancer.","display_name":"Distribution of haptoglobin phenotypes in oesophageal and gastric cancer.","publication_year":1989,"publication_date":"1989-03-01","ids":{"openalex":"https://openalex.org/W2017506148","doi":"https://doi.org/10.1136/jmg.26.3.172","mag":"2017506148","pmid":"https://pubmed.ncbi.nlm.nih.gov/2709394","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1015578"},"language":"en","primary_location":{"id":"doi:10.1136/jmg.26.3.172","doi":"https://doi.org/10.1136/jmg.26.3.172","is_oa":true,"landing_page_url":"https://doi.org/10.1136/jmg.26.3.172","pdf_url":"https://jmg.bmj.com/content/jmedgenet/26/3/172.full.pdf","source":{"id":"https://openalex.org/S112540174","display_name":"Journal of Medical Genetics","issn_l":"0022-2593","issn":["0022-2593","1468-6244"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medical Genetics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://jmg.bmj.com/content/jmedgenet/26/3/172.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"M Jayanthi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802348842","display_name":"Osmania General Hospital","ror":"https://ror.org/053cd8j25","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I2802348842"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"M Jayanthi","raw_affiliation_strings":["Department of Gastroenterology, Osmania General Hospital, Hyderabad, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Osmania General Hospital, Hyderabad, India","institution_ids":["https://openalex.org/I2802348842"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109437156","display_name":"Chittor M. Habibullah","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802348842","display_name":"Osmania General Hospital","ror":"https://ror.org/053cd8j25","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I2802348842"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"C M Habibullah","raw_affiliation_strings":["Department of Gastroenterology, Osmania General Hospital, Hyderabad, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Osmania General Hospital, Hyderabad, India","institution_ids":["https://openalex.org/I2802348842"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108456273","display_name":"M Ishaq","orcid":"https://orcid.org/0009-0007-4322-5663","observed_orcids":["https://orcid.org/0009-0007-4322-5663"]},"institutions":[{"id":"https://openalex.org/I2802348842","display_name":"Osmania General Hospital","ror":"https://ror.org/053cd8j25","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I2802348842"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"M Ishaq","raw_affiliation_strings":["Department of Gastroenterology, Osmania General Hospital, Hyderabad, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Osmania General Hospital, Hyderabad, India","institution_ids":["https://openalex.org/I2802348842"]}]},{"author_position":"middle","author":{"id":null,"display_name":"H Ali","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802348842","display_name":"Osmania General Hospital","ror":"https://ror.org/053cd8j25","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I2802348842"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"H Ali","raw_affiliation_strings":["Department of Gastroenterology, Osmania General Hospital, Hyderabad, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Osmania General Hospital, Hyderabad, India","institution_ids":["https://openalex.org/I2802348842"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110028763","display_name":"P. Babu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802348842","display_name":"Osmania General Hospital","ror":"https://ror.org/053cd8j25","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I2802348842"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"P S Babu","raw_affiliation_strings":["Department of Gastroenterology, Osmania General Hospital, Hyderabad, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Osmania General Hospital, Hyderabad, India","institution_ids":["https://openalex.org/I2802348842"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113575646","display_name":"Mutaz Mohamed Ali","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802348842","display_name":"Osmania General Hospital","ror":"https://ror.org/053cd8j25","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I2802348842"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"M M Ali","raw_affiliation_strings":["Department of Gastroenterology, Osmania General Hospital, Hyderabad, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Osmania General Hospital, Hyderabad, India","institution_ids":["https://openalex.org/I2802348842"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I2802348842"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":15,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"26","issue":"3","first_page":"172","last_page":"173"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12094","display_name":"Hemoglobin structure and function","score":0.6098999977111816,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12094","display_name":"Hemoglobin structure and function","score":0.6098999977111816,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10619","display_name":"Esophageal Cancer Research and Treatment","score":0.12290000170469284,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.04729999974370003,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/haptoglobin","display_name":"haptoglobin","score":0.9380000233650208},{"id":"https://openalex.org/keywords/haptoglobin-phenotypes","display_name":"haptoglobin phenotypes","score":0.9150000214576721},{"id":"https://openalex.org/keywords/esophageal-cancer","display_name":"esophageal cancer","score":0.9670000076293945},{"id":"https://openalex.org/keywords/gastric-cancer","display_name":"gastric cancer","score":1.0},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.8330000042915344},{"id":"https://openalex.org/keywords/cancer-etiology","display_name":"cancer etiology","score":0.8679999709129333}],"concepts":[{"id":"https://openalex.org/C206396517","wikidata":"https://www.wikidata.org/wiki/Q422025","display_name":"Haptoglobin","level":2,"score":0.9297288656234741},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.7495728731155396},{"id":"https://openalex.org/C2779399171","wikidata":"https://www.wikidata.org/wiki/Q1483951","display_name":"Malignancy","level":2,"score":0.7378532886505127},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.6715063452720642},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.6496949195861816},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.6156076788902283},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5722529292106628},{"id":"https://openalex.org/C137627325","wikidata":"https://www.wikidata.org/wiki/Q156318","display_name":"Etiology","level":2,"score":0.484365314245224},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4588170647621155},{"id":"https://openalex.org/C2780512811","wikidata":"https://www.wikidata.org/wiki/Q11829360","display_name":"Gastrointestinal tract","level":2,"score":0.448678195476532},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3669598698616028},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.17916926741600037},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09669098258018494}],"mesh":[{"descriptor_ui":"D004938","descriptor_name":"Esophageal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005787","descriptor_name":"Gene Frequency","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006242","descriptor_name":"Haptoglobins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013274","descriptor_name":"Stomach Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1136/jmg.26.3.172","doi":"https://doi.org/10.1136/jmg.26.3.172","is_oa":true,"landing_page_url":"https://doi.org/10.1136/jmg.26.3.172","pdf_url":"https://jmg.bmj.com/content/jmedgenet/26/3/172.full.pdf","source":{"id":"https://openalex.org/S112540174","display_name":"Journal of Medical Genetics","issn_l":"0022-2593","issn":["0022-2593","1468-6244"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medical Genetics","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1015578","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1015578","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1015578/pdf/jmedgene00053-0028.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Med Genet","raw_type":"Text"},{"id":"pmid:2709394","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2709394","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of medical genetics","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1136/jmg.26.3.172","doi":"https://doi.org/10.1136/jmg.26.3.172","is_oa":true,"landing_page_url":"https://doi.org/10.1136/jmg.26.3.172","pdf_url":"https://jmg.bmj.com/content/jmedgenet/26/3/172.full.pdf","source":{"id":"https://openalex.org/S112540174","display_name":"Journal of Medical Genetics","issn_l":"0022-2593","issn":["0022-2593","1468-6244"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medical Genetics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2017506148.pdf","grobid_xml":"https://content.openalex.org/works/W2017506148.grobid-xml"},"referenced_works_count":15,"referenced_works":["https://openalex.org/W609251364","https://openalex.org/W1974830882","https://openalex.org/W1975439405","https://openalex.org/W1981286144","https://openalex.org/W1986008486","https://openalex.org/W2023346038","https://openalex.org/W2256201166","https://openalex.org/W2338109959","https://openalex.org/W2338576041","https://openalex.org/W2357099407","https://openalex.org/W2408763223","https://openalex.org/W2410790258","https://openalex.org/W2413559345","https://openalex.org/W2413971824","https://openalex.org/W2430564466"],"related_works":["https://openalex.org/W2354179404","https://openalex.org/W609251364","https://openalex.org/W2409794442","https://openalex.org/W7095621576","https://openalex.org/W2738950558","https://openalex.org/W2268164569","https://openalex.org/W2064843636","https://openalex.org/W2430564466","https://openalex.org/W2774113989","https://openalex.org/W1976002975"],"abstract_inverted_index":{"Haptoglobin":[0],"(Hp)":[1],"phenotypes":[2],"were":[3],"studied":[4],"in":[5,48,63],"72":[6],"oesophageal":[7,27,49],"and":[8,13,28,31,44,50,66],"104":[9],"gastric":[10,29,51],"cancer":[11,30,52],"patients":[12],"compared":[14],"with":[15],"100":[16],"healthy":[17],"controls":[18],"to":[19],"see":[20],"if":[21],"there":[22],"is":[23],"any":[24],"association":[25],"between":[26],"haptoglobin":[32],"type.":[33],"There":[34],"was":[35],"a":[36,61],"significantly":[37],"increased":[38],"frequency":[39],"of":[40,68],"Hp":[41,45],"2-1":[42],"(59.7%)":[43],"2-2":[46],"(91.3%)":[47],"patients.":[53],"Our":[54],"results":[55],"suggest":[56],"that":[57],"genetic":[58],"factors":[59],"play":[60],"role":[62],"the":[64],"aetiology":[65],"pathogenesis":[67],"gastrointestinal":[69],"tract":[70],"malignancy.":[71]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2016-06-24T00:00:00"}