{"id":"https://openalex.org/W2017505808","doi":"https://doi.org/10.1097/00004647-200109000-00001","title":"Metabotropic Glutamate Receptor Subtypes as Targets for Neuroprotective Drugs","display_name":"Metabotropic Glutamate Receptor Subtypes as Targets for Neuroprotective Drugs","publication_year":2001,"publication_date":"2001-09-01","ids":{"openalex":"https://openalex.org/W2017505808","doi":"https://doi.org/10.1097/00004647-200109000-00001","mag":"2017505808","pmid":"https://pubmed.ncbi.nlm.nih.gov/11524608"},"language":"en","primary_location":{"id":"doi:10.1097/00004647-200109000-00001","doi":"https://doi.org/10.1097/00004647-200109000-00001","is_oa":true,"landing_page_url":"https://doi.org/10.1097/00004647-200109000-00001","pdf_url":"https://journals.sagepub.com/doi/pdf/10.1097/00004647-200109000-00001","source":{"id":"https://openalex.org/S89339265","display_name":"Journal of Cerebral Blood Flow & Metabolism","issn_l":"0271-678X","issn":["0271-678X","1559-7016"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cerebral Blood Flow &amp; Metabolism","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://journals.sagepub.com/doi/pdf/10.1097/00004647-200109000-00001","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033485888","display_name":"Valeria Bruno","orcid":"https://orcid.org/0000-0003-4231-0739","observed_orcids":["https://orcid.org/0000-0003-4231-0739"]},"institutions":[{"id":"https://openalex.org/I3018288129","display_name":"Istituto Neurologico Mediterraneo","ror":"https://ror.org/00cpb6264","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I3018288129","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Valeria Bruno","raw_affiliation_strings":["I.N.M. Neuromed, Pozzilli, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"I.N.M. Neuromed, Pozzilli, Italy","institution_ids":["https://openalex.org/I3018288129"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083505605","display_name":"Giuseppe Battaglia","orcid":"https://orcid.org/0000-0001-7571-3417","observed_orcids":["https://orcid.org/0000-0001-7571-3417"]},"institutions":[{"id":"https://openalex.org/I3018288129","display_name":"Istituto Neurologico Mediterraneo","ror":"https://ror.org/00cpb6264","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I3018288129","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giuseppe Battaglia","raw_affiliation_strings":["I.N.M. Neuromed, Pozzilli, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"I.N.M. Neuromed, Pozzilli, Italy","institution_ids":["https://openalex.org/I3018288129"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056468131","display_name":"Agata Copani","orcid":"https://orcid.org/0000-0003-3730-2590","observed_orcids":["https://orcid.org/0000-0003-3730-2590"]},"institutions":[{"id":"https://openalex.org/I39063666","display_name":"University of Catania","ror":"https://ror.org/03a64bh57","country_code":"IT","type":"education","lineage":["https://openalex.org/I39063666"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Agata Copani","raw_affiliation_strings":["Department of Pharmaceutical Sciences, University of Catania, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, University of Catania, Italy","institution_ids":["https://openalex.org/I39063666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102749629","display_name":"Mara D\u2019Onofrio","orcid":"https://orcid.org/0000-0002-5199-7918","observed_orcids":["https://orcid.org/0000-0002-5199-7918"]},"institutions":[{"id":"https://openalex.org/I3018288129","display_name":"Istituto Neurologico Mediterraneo","ror":"https://ror.org/00cpb6264","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I3018288129","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Mara D'Onofrio","raw_affiliation_strings":["I.N.M. Neuromed, Pozzilli, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"I.N.M. Neuromed, Pozzilli, Italy","institution_ids":["https://openalex.org/I3018288129"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043450015","display_name":"Patrizia Di Iorio","orcid":"https://orcid.org/0000-0002-0804-7925","observed_orcids":["https://orcid.org/0000-0002-0804-7925"]},"institutions":[{"id":"https://openalex.org/I39387349","display_name":"University of Chieti-Pescara","ror":"https://ror.org/00qjgza05","country_code":"IT","type":"education","lineage":["https://openalex.org/I39387349"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"P. Di Iorio","raw_affiliation_strings":["Department of Biomedical Sciences, University of Chieti, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, University of Chieti, Italy","institution_ids":["https://openalex.org/I39387349"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044214963","display_name":"Antonio De Blasi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3018288129","display_name":"Istituto Neurologico Mediterraneo","ror":"https://ror.org/00cpb6264","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I3018288129","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Antonio De Blasi","raw_affiliation_strings":["I.N.M. Neuromed, Pozzilli, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"I.N.M. Neuromed, Pozzilli, Italy","institution_ids":["https://openalex.org/I3018288129"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054049827","display_name":"Daniela Melchiorri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Daniela Melchiorri","raw_affiliation_strings":["Department of Human Physiology and Pharmacology, University of Rome \u201cLa Sapienza\u201d, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Physiology and Pharmacology, University of Rome \u201cLa Sapienza\u201d, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108703414","display_name":"Peter Josef Flor","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283582996","display_name":"Novartis (Switzerland)","ror":"https://ror.org/02f9zrr09","country_code":"CH","type":"company","lineage":["https://openalex.org/I1283582996"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Peter J. Flor","raw_affiliation_strings":["Novartis Pharma AG, Nervous System Research, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis Pharma AG, Nervous System Research, Basel, Switzerland","institution_ids":["https://openalex.org/I1283582996"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062403608","display_name":"Ferdinando Nicoletti","orcid":"https://orcid.org/0000-0003-0917-443X","observed_orcids":["https://orcid.org/0000-0003-0917-443X","https://orcid.org/0000-0003-3366-7269","https://orcid.org/0000-0002-4570-8462"]},"institutions":[{"id":"https://openalex.org/I3018288129","display_name":"Istituto Neurologico Mediterraneo","ror":"https://ror.org/00cpb6264","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I3018288129","https://openalex.org/I4210153126"]},{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Ferdinando Nicoletti","raw_affiliation_strings":["Department of Human Physiology and Pharmacology, University of Rome \u201cLa Sapienza\u201d, Italy","I.N.M. Neuromed, Pozzilli, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Physiology and Pharmacology, University of Rome \u201cLa Sapienza\u201d, Italy","institution_ids":["https://openalex.org/I861853513"]},{"raw_affiliation_string":"I.N.M. Neuromed, Pozzilli, Italy","institution_ids":["https://openalex.org/I3018288129"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5062403608"],"corresponding_institution_ids":["https://openalex.org/I3018288129","https://openalex.org/I861853513"],"apc_list":{"value":4200,"currency":"USD","value_usd":4200},"apc_paid":null,"fwci":1.7823,"has_fulltext":true,"cited_by_count":312,"citation_normalized_percentile":{"value":0.86086957,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"21","issue":"9","first_page":"1013","last_page":"1033"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metabotropic-glutamate-receptors","display_name":"metabotropic glutamate receptors","score":0.9950000047683716},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.8349999785423279},{"id":"https://openalex.org/keywords/mglu5-receptor-antagonists","display_name":"mGlu5 receptor antagonists","score":0.9779999852180481},{"id":"https://openalex.org/keywords/mglu2-3-receptor-agonists","display_name":"mGlu2/3 receptor agonists","score":0.9940000176429749},{"id":"https://openalex.org/keywords/cpccoet","display_name":"CPCCOEt","score":0.7749999761581421},{"id":"https://openalex.org/keywords/ly354740","display_name":"LY354740","score":0.843999981880188},{"id":"https://openalex.org/keywords/ly379268","display_name":"LY379268","score":0.9490000009536743},{"id":"https://openalex.org/keywords/nmda-receptor","display_name":"NMDA receptor","score":0.6779999732971191},{"id":"https://openalex.org/keywords/cerebral-ischemia","display_name":"cerebral ischemia","score":0.8149999976158142},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.7149999737739563},{"id":"https://openalex.org/keywords/amyotrophic-lateral-sclerosis","display_name":"amyotrophic lateral sclerosis","score":0.9670000076293945},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9990000128746033},{"id":"https://openalex.org/keywords/glutamate-release","display_name":"glutamate release","score":0.8880000114440918},{"id":"https://openalex.org/keywords/neurotrophic-factors","display_name":"neurotrophic factors","score":0.9110000133514404},{"id":"https://openalex.org/keywords/epilepsy","display_name":"epilepsy","score":0.746999979019165},{"id":"https://openalex.org/keywords/excitatory-synaptic-transmission","display_name":"excitatory synaptic transmission","score":0.878000020980835},{"id":"https://openalex.org/keywords/central-nervous-system-diseases","display_name":"central nervous system disorders","score":0.7179999947547913},{"id":"https://openalex.org/keywords/drug-development","display_name":"drug development","score":0.5830000042915344},{"id":"https://openalex.org/keywords/subtype-selective-ligands","display_name":"subtype-selective ligands","score":0.7749999761581421},{"id":"https://openalex.org/keywords/astrocytes","display_name":"astrocytes","score":0.5680000185966492}],"concepts":[{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.8855741024017334},{"id":"https://openalex.org/C26702167","wikidata":"https://www.wikidata.org/wiki/Q901988","display_name":"Metabotropic receptor","level":4,"score":0.7956883311271667},{"id":"https://openalex.org/C49051014","wikidata":"https://www.wikidata.org/wiki/Q2033959","display_name":"Metabotropic glutamate receptor","level":4,"score":0.7032129764556885},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5999013185501099},{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.599247395992279},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5324163436889648},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5193489789962769},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.4620167016983032},{"id":"https://openalex.org/C41653306","wikidata":"https://www.wikidata.org/wiki/Q6589190","display_name":"Metabotropic glutamate receptor 5","level":5,"score":0.4619467854499817},{"id":"https://openalex.org/C67018056","wikidata":"https://www.wikidata.org/wiki/Q414896","display_name":"NMDA receptor","level":3,"score":0.4592260420322418},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4059428870677948},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.22604000568389893},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.12610206007957458},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09742063283920288},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.06947499513626099}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001927","descriptor_name":"Brain Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018094","descriptor_name":"Receptors, Metabotropic Glutamate","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D018094","descriptor_name":"Receptors, Metabotropic Glutamate","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":true},{"descriptor_ui":"D018696","descriptor_name":"Neuroprotective Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1097/00004647-200109000-00001","doi":"https://doi.org/10.1097/00004647-200109000-00001","is_oa":true,"landing_page_url":"https://doi.org/10.1097/00004647-200109000-00001","pdf_url":"https://journals.sagepub.com/doi/pdf/10.1097/00004647-200109000-00001","source":{"id":"https://openalex.org/S89339265","display_name":"Journal of Cerebral Blood Flow & Metabolism","issn_l":"0271-678X","issn":["0271-678X","1559-7016"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cerebral Blood Flow &amp; Metabolism","raw_type":"journal-article"},{"id":"pmid:11524608","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11524608","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism","raw_type":"Journal Article"},{"id":"pmh:oai:iris.uniroma1.it:11573/250578","doi":null,"is_oa":false,"landing_page_url":"http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=000170839000001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=0c7ff228ccbaaa74236f48834a34396a","pdf_url":null,"source":{"id":"https://openalex.org/S4377196107","display_name":"IRIS Research product catalog (Sapienza University of Rome)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1097/00004647-200109000-00001","doi":"https://doi.org/10.1097/00004647-200109000-00001","is_oa":true,"landing_page_url":"https://doi.org/10.1097/00004647-200109000-00001","pdf_url":"https://journals.sagepub.com/doi/pdf/10.1097/00004647-200109000-00001","source":{"id":"https://openalex.org/S89339265","display_name":"Journal of Cerebral Blood Flow & Metabolism","issn_l":"0271-678X","issn":["0271-678X","1559-7016"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cerebral Blood Flow &amp; Metabolism","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2017505808.pdf","grobid_xml":"https://content.openalex.org/works/W2017505808.grobid-xml"},"referenced_works_count":205,"referenced_works":["https://openalex.org/W111663151","https://openalex.org/W1195334433","https://openalex.org/W1487123995","https://openalex.org/W1493473330","https://openalex.org/W1503789839","https://openalex.org/W1548706173","https://openalex.org/W1563427807","https://openalex.org/W1577728810","https://openalex.org/W1595843790","https://openalex.org/W1600525795","https://openalex.org/W1637170049","https://openalex.org/W1653383134","https://openalex.org/W1716703308","https://openalex.org/W1777733877","https://openalex.org/W1818767073","https://openalex.org/W1823231128","https://openalex.org/W1824128596","https://openalex.org/W1835964184","https://openalex.org/W1891815016","https://openalex.org/W1913636106","https://openalex.org/W1923206427","https://openalex.org/W1935475606","https://openalex.org/W1939092506","https://openalex.org/W1945680072","https://openalex.org/W1946755838","https://openalex.org/W1950417202","https://openalex.org/W1964535391","https://openalex.org/W1965312515","https://openalex.org/W1966755346","https://openalex.org/W1966761076","https://openalex.org/W1967627800","https://openalex.org/W1970022157","https://openalex.org/W1970625707","https://openalex.org/W1971602384","https://openalex.org/W1972704887","https://openalex.org/W1972763842","https://openalex.org/W1972884505","https://openalex.org/W1973047647","https://openalex.org/W1973733505","https://openalex.org/W1974121861","https://openalex.org/W1974240711","https://openalex.org/W1974502513","https://openalex.org/W1975424623","https://openalex.org/W1976585164","https://openalex.org/W1977887400","https://openalex.org/W1977987248","https://openalex.org/W1978161256","https://openalex.org/W1978407600","https://openalex.org/W1979610285","https://openalex.org/W1980011256","https://openalex.org/W1980587895","https://openalex.org/W1980803132","https://openalex.org/W1981760433","https://openalex.org/W1981993146","https://openalex.org/W1986077377","https://openalex.org/W1988345610","https://openalex.org/W1989877978","https://openalex.org/W1990625157","https://openalex.org/W1991444172","https://openalex.org/W1991500856","https://openalex.org/W1991542726","https://openalex.org/W1994166466","https://openalex.org/W1994470095","https://openalex.org/W1995830387","https://openalex.org/W1996888805","https://openalex.org/W1998822019","https://openalex.org/W2002360249","https://openalex.org/W2002613500","https://openalex.org/W2003750373","https://openalex.org/W2005127919","https://openalex.org/W2005678155","https://openalex.org/W2005913521","https://openalex.org/W2007081573","https://openalex.org/W2007239691","https://openalex.org/W2007984180","https://openalex.org/W2008176410","https://openalex.org/W2009311043","https://openalex.org/W2010472439","https://openalex.org/W2011212122","https://openalex.org/W2012824611","https://openalex.org/W2013413008","https://openalex.org/W2016413308","https://openalex.org/W2018421841","https://openalex.org/W2021029707","https://openalex.org/W2023247734","https://openalex.org/W2023732918","https://openalex.org/W2025824385","https://openalex.org/W2027526383","https://openalex.org/W2027989984","https://openalex.org/W2029533997","https://openalex.org/W2030787020","https://openalex.org/W2031010234","https://openalex.org/W2031125523","https://openalex.org/W2031315226","https://openalex.org/W2033159055","https://openalex.org/W2034509535","https://openalex.org/W2035135723","https://openalex.org/W2035550082","https://openalex.org/W2039267613","https://openalex.org/W2039937066","https://openalex.org/W2040456704","https://openalex.org/W2041098374","https://openalex.org/W2042651745","https://openalex.org/W2043166209","https://openalex.org/W2043473753","https://openalex.org/W2047082179","https://openalex.org/W2047702346","https://openalex.org/W2047884170","https://openalex.org/W2048661219","https://openalex.org/W2050419480","https://openalex.org/W2051030364","https://openalex.org/W2053114980","https://openalex.org/W2053429985","https://openalex.org/W2053755737","https://openalex.org/W2054466896","https://openalex.org/W2054488262","https://openalex.org/W2055134750","https://openalex.org/W2055137643","https://openalex.org/W2058027773","https://openalex.org/W2058308506","https://openalex.org/W2060588252","https://openalex.org/W2060663941","https://openalex.org/W2060714812","https://openalex.org/W2063205768","https://openalex.org/W2063375748","https://openalex.org/W2063675915","https://openalex.org/W2067874558","https://openalex.org/W2068230856","https://openalex.org/W2068273333","https://openalex.org/W2069434795","https://openalex.org/W2070503276","https://openalex.org/W2071203240","https://openalex.org/W2071452249","https://openalex.org/W2072926617","https://openalex.org/W2073732519","https://openalex.org/W2074350658","https://openalex.org/W2074742153","https://openalex.org/W2074873783","https://openalex.org/W2077288868","https://openalex.org/W2077326004","https://openalex.org/W2079473624","https://openalex.org/W2083152713","https://openalex.org/W2085673544","https://openalex.org/W2086947453","https://openalex.org/W2089919714","https://openalex.org/W2090938600","https://openalex.org/W2091281983","https://openalex.org/W2091555205","https://openalex.org/W2091730749","https://openalex.org/W2091884483","https://openalex.org/W2092777123","https://openalex.org/W2093704321","https://openalex.org/W2094074715","https://openalex.org/W2094820080","https://openalex.org/W2095311852","https://openalex.org/W2095472033","https://openalex.org/W2097293665","https://openalex.org/W2100503686","https://openalex.org/W2101347364","https://openalex.org/W2102527735","https://openalex.org/W2103292884","https://openalex.org/W2103990201","https://openalex.org/W2112952507","https://openalex.org/W2115826405","https://openalex.org/W2117465944","https://openalex.org/W2135349758","https://openalex.org/W2135652742","https://openalex.org/W2140120675","https://openalex.org/W2140653571","https://openalex.org/W2144069692","https://openalex.org/W2148142238","https://openalex.org/W2149247762","https://openalex.org/W2152667872","https://openalex.org/W2153290897","https://openalex.org/W2153450997","https://openalex.org/W2154193664","https://openalex.org/W2154745271","https://openalex.org/W2157101044","https://openalex.org/W2157324068","https://openalex.org/W2157496987","https://openalex.org/W2159484326","https://openalex.org/W2163029180","https://openalex.org/W2163431685","https://openalex.org/W2167891371","https://openalex.org/W2170106326","https://openalex.org/W2170453612","https://openalex.org/W2181611325","https://openalex.org/W2222594107","https://openalex.org/W2227521591","https://openalex.org/W2246678623","https://openalex.org/W2311816167","https://openalex.org/W2325257956","https://openalex.org/W2325494665","https://openalex.org/W2339425442","https://openalex.org/W2394663403","https://openalex.org/W2408990270","https://openalex.org/W2410004099","https://openalex.org/W2413148011","https://openalex.org/W2415755816","https://openalex.org/W2418489533","https://openalex.org/W2418492450","https://openalex.org/W2426656559","https://openalex.org/W2734291336","https://openalex.org/W4253415771","https://openalex.org/W4322703206"],"related_works":["https://openalex.org/W79930021","https://openalex.org/W1967286178","https://openalex.org/W1501657654","https://openalex.org/W1993849253","https://openalex.org/W2149247762","https://openalex.org/W4403004718","https://openalex.org/W1991542726","https://openalex.org/W2898331726","https://openalex.org/W2002994569","https://openalex.org/W2053755737"],"abstract_inverted_index":{"Metabotropic":[0],"glutamate":[1,207,244],"(mGlu)":[2],"receptors":[3,107,115,170,274],"have":[4,225,247],"been":[5],"considered":[6],"as":[7,196,229,308],"potential":[8,185,249],"targets":[9],"for":[10,134,141],"neuroprotective":[11,24,230],"drugs,":[12],"but":[13,209,278],"the":[14,21,57,66,75,83,93,135,142,212,270,296,301],"lack":[15],"of":[16,23,29,40,56,59,71,103,111,121,137,144,162,181,187,216,235,256,295,303,313],"specific":[17],"drugs":[18,73,133,222,259],"has":[19,47],"limited":[20],"development":[22],"strategies":[25],"in":[26,63,118,122,125,176,191,219,232,251],"experimental":[27],"models":[28],"acute":[30],"or":[31,105,108,113,124,140,264,310],"chronic":[32,192],"central":[33],"nervous":[34],"system":[35],"(CNS)":[36],"disorders.":[37,237,253],"The":[38,254],"advent":[39],"potent":[41,94],"and":[42,81,90,92,99,168,173,200,214,246,315],"centrally":[43],"available":[44],"subtype-selective":[45],"ligands":[46,292],"overcome":[48],"this":[49],"limitation,":[50],"leading":[51],"to":[52,262],"an":[53,311],"extensive":[54],"investigation":[55],"role":[58],"mGlu":[60,273,290],"receptor":[61,78,86,96,129,152,189,204,240,266,291],"subtypes":[62],"neurodegeneration":[64],"during":[65],"last":[67],"2":[68],"years.":[69],"Examples":[70],"these":[72,258],"are":[74,131,171,293],"noncompetitive":[76,84],"mGlu1":[77,104],"antagonists,":[79,87],"CPCCOEt":[80],"BAY-36-7620;":[82],"mGlu5":[85,106,167,188],"2-methyl-6-(phenylethynyl)pyridine,":[88],"SIB-1893,":[89],"SIB-1757;":[91],"mGlu2/3":[95,112],"agonists,":[97],"LY354740":[98],"LY379268.":[100],"Pharmacologic":[101],"blockade":[102],"pharmacologic":[109],"activation":[110],"mGlu4/7/8":[114,239],"produces":[116],"neuroprotection":[117],"a":[119,160,184,226,233,248],"variety":[120,234],"vitro":[123],"vivo":[126],"models.":[127],"MGlu1":[128],"antagonists":[130,153,190],"promising":[132],"treatment":[136],"brain":[138],"ischemia":[139],"prophylaxis":[143],"neuronal":[145,156,177],"damage":[146,157],"induced":[147,158],"by":[148,159],"synaptic":[149,282,305],"hyperactivity.":[150],"MGlu5":[151],"may":[154,223],"limit":[155],"hyperactivity":[161],"N-methyl-d-aspartate":[163],"(NMDA)":[164],"receptors,":[165],"because":[166],"NMDA":[169,263],"physically":[172],"functionally":[174],"connected":[175],"membranes.":[178],"A":[179],"series":[180],"observations":[182],"suggest":[183],"application":[186,228,250],"neurodegenerative":[193],"disorders,":[194],"such":[195,307],"amyotrophic":[197],"lateral":[198],"sclerosis":[199],"Alzheimer":[201],"disease.":[202],"MGlu2/3":[203],"agonists":[205,241,267],"inhibit":[206,243],"release,":[208],"also":[210],"promote":[211],"synthesis":[213],"release":[215,245],"neurotrophic":[217],"factors":[218],"astrocytes.":[220],"These":[221],"therefore":[224],"broad":[227],"agents":[231],"CNS":[236],"Finally,":[238],"potently":[242],"seizure":[252],"advantage":[255],"all":[257],"with":[260],"respect":[261],"AMPA":[265],"derives":[268],"from":[269,300],"evidence":[271],"that":[272,289],"do":[275],"not":[276],"\"mediate,\"":[277],"rather":[279],"\"modulate\"":[280],"excitatory":[281,304],"transmission.":[283],"Therefore,":[284],"it":[285],"can":[286],"be":[287],"expected":[288],"devoid":[294],"undesirable":[297],"effects":[298],"resulting":[299],"inhibition":[302],"transmission,":[306],"sedation":[309],"impairment":[312],"learning":[314],"memory.":[316]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":14},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":14},{"year":2012,"cited_by_count":12}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
