{"id":"https://openalex.org/W2017504202","doi":"https://doi.org/10.1073/pnas.78.5.3005","title":"Interaction of alpha-actinin and vinculin with actin: opposite effects on filament network formation.","display_name":"Interaction of alpha-actinin and vinculin with actin: opposite effects on filament network formation.","publication_year":1981,"publication_date":"1981-05-01","ids":{"openalex":"https://openalex.org/W2017504202","doi":"https://doi.org/10.1073/pnas.78.5.3005","mag":"2017504202","pmid":"https://pubmed.ncbi.nlm.nih.gov/6789327","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/319488"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.78.5.3005","doi":"https://doi.org/10.1073/pnas.78.5.3005","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.78.5.3005","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2017504202"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC319488","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112131651","display_name":"B. M. Jockusch","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B M Jockusch","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5072813012","display_name":"G. Isenberg","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Isenberg","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":5.4091,"has_fulltext":false,"cited_by_count":233,"citation_normalized_percentile":{"value":0.96943383,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"78","issue":"5","first_page":"3005","last_page":"3009"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11650","display_name":"Skin and Cellular Biology Research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alpha-actinin","display_name":"alpha-actinin","score":1.0},{"id":"https://openalex.org/keywords/vinculin","display_name":"vinculin","score":1.0},{"id":"https://openalex.org/keywords/actin-filaments","display_name":"F-actin","score":0.7570000290870667},{"id":"https://openalex.org/keywords/f-actin-binding","display_name":"F-actin binding","score":0.8610000014305115},{"id":"https://openalex.org/keywords/actin-bundling","display_name":"actin bundling","score":0.6179999709129333},{"id":"https://openalex.org/keywords/actin-associated-proteins","display_name":"actin-associated proteins","score":0.753000020980835}],"concepts":[{"id":"https://openalex.org/C2777979848","wikidata":"https://www.wikidata.org/wiki/Q424042","display_name":"Vinculin","level":4,"score":0.904771625995636},{"id":"https://openalex.org/C133702464","wikidata":"https://www.wikidata.org/wiki/Q3487083","display_name":"Actinin","level":4,"score":0.7185739874839783},{"id":"https://openalex.org/C125705527","wikidata":"https://www.wikidata.org/wiki/Q185269","display_name":"Actin","level":2,"score":0.6849462389945984},{"id":"https://openalex.org/C130861313","wikidata":"https://www.wikidata.org/wiki/Q3775363","display_name":"Actin-binding protein","level":5,"score":0.5964703559875488},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5141151547431946},{"id":"https://openalex.org/C14228908","wikidata":"https://www.wikidata.org/wiki/Q2920483","display_name":"Protein filament","level":2,"score":0.4877975285053253},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4858064651489258},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.48073506355285645},{"id":"https://openalex.org/C3620293","wikidata":"https://www.wikidata.org/wiki/Q14908027","display_name":"Actin remodeling","level":5,"score":0.4675660729408264},{"id":"https://openalex.org/C2776190535","wikidata":"https://www.wikidata.org/wiki/Q4676836","display_name":"Actina","level":4,"score":0.4325253963470459},{"id":"https://openalex.org/C142669718","wikidata":"https://www.wikidata.org/wiki/Q154626","display_name":"Cytoskeleton","level":3,"score":0.35849452018737793},{"id":"https://openalex.org/C2993400109","wikidata":"https://www.wikidata.org/wiki/Q329638","display_name":"Actin cytoskeleton","level":4,"score":0.28553828597068787},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2758745551109314},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.27340275049209595},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.16027462482452393}],"mesh":[{"descriptor_ui":"D000185","descriptor_name":"Actinin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000199","descriptor_name":"Actins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008854","descriptor_name":"Microscopy, Electron","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008970","descriptor_name":"Molecular Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009124","descriptor_name":"Muscle Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009132","descriptor_name":"Muscles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014783","descriptor_name":"Viscosity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016596","descriptor_name":"Vinculin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046911","descriptor_name":"Macromolecular Substances","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1073/pnas.78.5.3005","doi":"https://doi.org/10.1073/pnas.78.5.3005","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.78.5.3005","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:56325","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC319488","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:6789327","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6789327","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:319488","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC319488/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:56325","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC319488","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W150939891","https://openalex.org/W1521392208","https://openalex.org/W1538692246","https://openalex.org/W1544245820","https://openalex.org/W1579521718","https://openalex.org/W1966120793","https://openalex.org/W1982014176","https://openalex.org/W1984353845","https://openalex.org/W1984911200","https://openalex.org/W1992056692","https://openalex.org/W2000186902","https://openalex.org/W2003468593","https://openalex.org/W2008495158","https://openalex.org/W2037294635","https://openalex.org/W2037943750","https://openalex.org/W2039723960","https://openalex.org/W2039855901","https://openalex.org/W2056666479","https://openalex.org/W2062099855","https://openalex.org/W2071948587","https://openalex.org/W2091400786","https://openalex.org/W2155291985","https://openalex.org/W2198608779"],"related_works":["https://openalex.org/W2081132980","https://openalex.org/W2784195799","https://openalex.org/W2027949267","https://openalex.org/W1973225594","https://openalex.org/W2574729116","https://openalex.org/W2147001859","https://openalex.org/W2019499517","https://openalex.org/W3112172086","https://openalex.org/W2014194778","https://openalex.org/W1997555622"],"abstract_inverted_index":{"The":[0],"interaction":[1],"of":[2,45,81,97,103],"actin":[3,67,82],"filaments":[4,51],"with":[5,19],"two":[6,34],"actin-associated":[7],"proteins,":[8],"alpha-actinin":[9,48,77],"and":[10,21,23,32,59],"vinculin":[11,65,86],"(Mr":[12],"130,000":[13],"protein),":[14],"was":[15],"studied":[16],"in":[17,52,100],"vitro":[18],"viscometry":[20],"light":[22],"electron":[24],"microscopy.":[25],"Vinculin,":[26],"like":[27],"alpha-actinin,":[28],"binds":[29],"to":[30,38],"F-actin,":[31],"the":[33,43,79,101],"proteins":[35,99],"were":[36],"found":[37],"have":[39],"different":[40],"effects":[41],"on":[42,57],"formation":[44],"filament":[46],"networks:":[47],"crosslinks":[49],"individual":[50],"a":[53,62,71,89],"manner":[54],"strongly":[55],"dependent":[56],"temperature":[58],"acts":[60,87],"as":[61,88],"spacer,":[63],"whereas":[64,85],"forms":[66],"bundles":[68],"that":[69],"display":[70],"paracrystalline":[72],"substructure.":[73],"In":[74],"viscometric":[75],"assays,":[76],"mimics":[78],"effect":[80],"gelation":[83,90],"factors,":[84],"inhibitor.":[91],"These":[92],"findings":[93],"imply":[94],"complementary":[95],"functions":[96],"these":[98],"regulation":[102],"cellular":[104],"mobility.":[105]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":4},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}