{"id":"https://openalex.org/W2017500718","doi":"https://doi.org/10.1210/endo-78-4-791","title":"Adrenocortical Response to Stress and ACTH in Pacific Salmon (Oncorhynchus tshawytscha) and Steelhead Trout (Salmo gairdnerii) at Successive Stages in the Sexual Cycle","display_name":"Adrenocortical Response to Stress and ACTH in Pacific Salmon (Oncorhynchus tshawytscha) and Steelhead Trout (Salmo gairdnerii) at Successive Stages in the Sexual Cycle","publication_year":1966,"publication_date":"1966-04-01","ids":{"openalex":"https://openalex.org/W2017500718","doi":"https://doi.org/10.1210/endo-78-4-791","mag":"2017500718","pmid":"https://pubmed.ncbi.nlm.nih.gov/4285824"},"language":"en","primary_location":{"id":"doi:10.1210/endo-78-4-791","doi":"https://doi.org/10.1210/endo-78-4-791","is_oa":false,"landing_page_url":"https://doi.org/10.1210/endo-78-4-791","pdf_url":null,"source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026915178","display_name":"Satoshi Hane","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4210110664","display_name":"University of California San Francisco Medical Center","ror":"https://ror.org/01t8svj65","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210110664"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"SATOSHI HANE","raw_affiliation_strings":["Metabolic Research Unit, University of California School of Medicine, San Francisco; Department of Biology, Stanford University; May Institute for Medical Research, Cincinnati, Ohio; Palo Alto Medical Research Foundation Palo Alto, California","Department of Biology, Stanford University","May Institute for Medical Research, Cincinnati, Ohio","Metabolic Research Unit, University of California School of Medicine, San Francisco","Palo Alto Medical Research Foundation Palo Alto, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Metabolic Research Unit, University of California School of Medicine, San Francisco; Department of Biology, Stanford University; May Institute for Medical Research, Cincinnati, Ohio; Palo Alto Medical Research Foundation Palo Alto, California","institution_ids":["https://openalex.org/I180670191","https://openalex.org/I4210110664","https://openalex.org/I97018004"]},{"raw_affiliation_string":"Department of Biology, Stanford University","institution_ids":["https://openalex.org/I97018004"]},{"raw_affiliation_string":"May Institute for Medical Research, Cincinnati, Ohio","institution_ids":[]},{"raw_affiliation_string":"Metabolic Research Unit, University of California School of Medicine, San Francisco","institution_ids":["https://openalex.org/I180670191","https://openalex.org/I4210110664"]},{"raw_affiliation_string":"Palo Alto Medical Research Foundation Palo Alto, California","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111375442","display_name":"OSWALD H. ROBERTSON","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4210110664","display_name":"University of California San Francisco Medical Center","ror":"https://ror.org/01t8svj65","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210110664"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"O. H. ROBERTSON","raw_affiliation_strings":["Metabolic Research Unit, University of California School of Medicine, San Francisco; Department of Biology, Stanford University; May Institute for Medical Research, Cincinnati, Ohio; Palo Alto Medical Research Foundation Palo Alto, California","Department of Biology, Stanford University","May Institute for Medical Research, Cincinnati, Ohio","Metabolic Research Unit, University of California School of Medicine, San Francisco","Palo Alto Medical Research Foundation Palo Alto, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Metabolic Research Unit, University of California School of Medicine, San Francisco; Department of Biology, Stanford University; May Institute for Medical Research, Cincinnati, Ohio; Palo Alto Medical Research Foundation Palo Alto, California","institution_ids":["https://openalex.org/I180670191","https://openalex.org/I4210110664","https://openalex.org/I97018004"]},{"raw_affiliation_string":"Department of Biology, Stanford University","institution_ids":["https://openalex.org/I97018004"]},{"raw_affiliation_string":"May Institute for Medical Research, Cincinnati, Ohio","institution_ids":[]},{"raw_affiliation_string":"Metabolic Research Unit, University of California School of Medicine, San Francisco","institution_ids":["https://openalex.org/I180670191","https://openalex.org/I4210110664"]},{"raw_affiliation_string":"Palo Alto Medical Research Foundation Palo Alto, California","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086356690","display_name":"Bernard C. Wexler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4210110664","display_name":"University of California San Francisco Medical Center","ror":"https://ror.org/01t8svj65","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210110664"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"BERNARD C. WEXLER","raw_affiliation_strings":["Metabolic Research Unit, University of California School of Medicine, San Francisco; Department of Biology, Stanford University; May Institute for Medical Research, Cincinnati, Ohio; Palo Alto Medical Research Foundation Palo Alto, California","Department of Biology, Stanford University","May Institute for Medical Research, Cincinnati, Ohio","Metabolic Research Unit, University of California School of Medicine, San Francisco","Palo Alto Medical Research Foundation Palo Alto, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Metabolic Research Unit, University of California School of Medicine, San Francisco; Department of Biology, Stanford University; May Institute for Medical Research, Cincinnati, Ohio; Palo Alto Medical Research Foundation Palo Alto, California","institution_ids":["https://openalex.org/I180670191","https://openalex.org/I4210110664","https://openalex.org/I97018004"]},{"raw_affiliation_string":"Department of Biology, Stanford University","institution_ids":["https://openalex.org/I97018004"]},{"raw_affiliation_string":"May Institute for Medical Research, Cincinnati, Ohio","institution_ids":[]},{"raw_affiliation_string":"Metabolic Research Unit, University of California School of Medicine, San Francisco","institution_ids":["https://openalex.org/I180670191","https://openalex.org/I4210110664"]},{"raw_affiliation_string":"Palo Alto Medical Research Foundation Palo Alto, California","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036271820","display_name":"Marcus A. Krupp","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4210110664","display_name":"University of California San Francisco Medical Center","ror":"https://ror.org/01t8svj65","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210110664"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"MARCUS A. KRUPP","raw_affiliation_strings":["Metabolic Research Unit, University of California School of Medicine, San Francisco; Department of Biology, Stanford University; May Institute for Medical Research, Cincinnati, Ohio; Palo Alto Medical Research Foundation Palo Alto, California","Department of Biology, Stanford University","May Institute for Medical Research, Cincinnati, Ohio","Metabolic Research Unit, University of California School of Medicine, San Francisco","Palo Alto Medical Research Foundation Palo Alto, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Metabolic Research Unit, University of California School of Medicine, San Francisco; Department of Biology, Stanford University; May Institute for Medical Research, Cincinnati, Ohio; Palo Alto Medical Research Foundation Palo Alto, California","institution_ids":["https://openalex.org/I180670191","https://openalex.org/I4210110664","https://openalex.org/I97018004"]},{"raw_affiliation_string":"Department of Biology, Stanford University","institution_ids":["https://openalex.org/I97018004"]},{"raw_affiliation_string":"May Institute for Medical Research, Cincinnati, Ohio","institution_ids":[]},{"raw_affiliation_string":"Metabolic Research Unit, University of California School of Medicine, San Francisco","institution_ids":["https://openalex.org/I180670191","https://openalex.org/I4210110664"]},{"raw_affiliation_string":"Palo Alto Medical Research Foundation Palo Alto, California","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":4.5024,"has_fulltext":false,"cited_by_count":65,"citation_normalized_percentile":{"value":0.92765957,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"78","issue":"4","first_page":"791","last_page":"800"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11505","display_name":"Reproductive biology and impacts on aquatic species","score":0.9688000082969666,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11505","display_name":"Reproductive biology and impacts on aquatic species","score":0.9688000082969666,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.007600000128149986,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11056","display_name":"Physiological and biochemical adaptations","score":0.0044999998062849045,"subfield":{"id":"https://openalex.org/subfields/2303","display_name":"Ecology"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acth","display_name":"ACTH","score":0.9589999914169312},{"id":"https://openalex.org/keywords/pacific-salmon","display_name":"Pacific salmon","score":0.8659999966621399},{"id":"https://openalex.org/keywords/chinook-salmon","display_name":"Oncorhynchus tshawytscha","score":0.9940000176429749},{"id":"https://openalex.org/keywords/steelhead","display_name":"steelhead","score":0.9980000257492065},{"id":"https://openalex.org/keywords/rainbow-trout","display_name":"rainbow trout","score":0.9909999966621399},{"id":"https://openalex.org/keywords/17-hydroxycorticosteroids","display_name":"17-hydroxycorticosteroids","score":0.9670000076293945},{"id":"https://openalex.org/keywords/plasma-corticosteroids","display_name":"plasma corticosteroids","score":0.9440000057220459},{"id":"https://openalex.org/keywords/adrenocortical-hyperplasia","display_name":"adrenocortical hyperplasia","score":0.8740000128746033},{"id":"https://openalex.org/keywords/river-channel-migration","display_name":"river channel migration","score":0.6600000262260437},{"id":"https://openalex.org/keywords/gonad-maturation","display_name":"gonadal maturation","score":0.8370000123977661},{"id":"https://openalex.org/keywords/spawning","display_name":"spawning","score":0.5960000157356262},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.8539999723434448},{"id":"https://openalex.org/keywords/fish-stress-response","display_name":"fish stress","score":0.3499999940395355}],"concepts":[{"id":"https://openalex.org/C2777940460","wikidata":"https://www.wikidata.org/wiki/Q310436","display_name":"Salmo","level":3,"score":0.9119014739990234},{"id":"https://openalex.org/C2779140988","wikidata":"https://www.wikidata.org/wiki/Q133325","display_name":"Oncorhynchus","level":3,"score":0.7905492782592773},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7097469568252563},{"id":"https://openalex.org/C2778427672","wikidata":"https://www.wikidata.org/wiki/Q3487056","display_name":"Smoltification","level":5,"score":0.6942996382713318},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6563576459884644},{"id":"https://openalex.org/C2779363728","wikidata":"https://www.wikidata.org/wiki/Q2258881","display_name":"Trout","level":3,"score":0.6544378399848938},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5713562965393066},{"id":"https://openalex.org/C192536144","wikidata":"https://www.wikidata.org/wiki/Q609370","display_name":"Sexual maturity","level":2,"score":0.5094152092933655},{"id":"https://openalex.org/C2994167347","wikidata":"https://www.wikidata.org/wiki/Q187986","display_name":"Rainbow trout","level":3,"score":0.4121294617652893},{"id":"https://openalex.org/C505870484","wikidata":"https://www.wikidata.org/wiki/Q180538","display_name":"Fishery","level":1,"score":0.3956749737262726},{"id":"https://openalex.org/C2779911052","wikidata":"https://www.wikidata.org/wiki/Q184238","display_name":"Salmonidae","level":4,"score":0.3701602518558502},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.16160079836845398},{"id":"https://openalex.org/C2909208804","wikidata":"https://www.wikidata.org/wiki/Q127282","display_name":"Fish <Actinopterygii>","level":2,"score":0.1437961459159851}],"mesh":[{"descriptor_ui":"D000311","descriptor_name":"Adrenal Glands","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D000324","descriptor_name":"Adrenocorticotropic Hormone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005399","descriptor_name":"Fishes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006965","descriptor_name":"Hyperplasia","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012723","descriptor_name":"Sex","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013312","descriptor_name":"Stress, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015065","descriptor_name":"17-Hydroxycorticosteroids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1210/endo-78-4-791","doi":"https://doi.org/10.1210/endo-78-4-791","is_oa":false,"landing_page_url":"https://doi.org/10.1210/endo-78-4-791","pdf_url":null,"source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},{"id":"pmid:4285824","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4285824","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2070322382","https://openalex.org/W1997452698","https://openalex.org/W1989127585","https://openalex.org/W2022770890","https://openalex.org/W2026883496","https://openalex.org/W2065127351","https://openalex.org/W1967192490","https://openalex.org/W2063126220","https://openalex.org/W1974563319","https://openalex.org/W2057842633"],"abstract_inverted_index":{"With":[0],"the":[1,7,11,15,27,30,35,50,53,59,67,104,116,120,123,154,158,166,175,193,197,202,208],"purpose":[2],"of":[3,10,14,23,37,52,62,72,106,115,122,165,177,199,210,223],"acquiring":[4],"information":[5],"concerning":[6],"functional":[8],"activity":[9],"adrenocortical":[12,54,117,169],"tissue":[13,55],"Pacific":[16],"salmon":[17,75,151,159,244],"(O.":[18],"tshawytscha)":[19],"during":[20],"various":[21],"stages":[22],"its":[24],"migration":[25,162],"from":[26],"sea":[28,74],"to":[29,48,96,181],"spawning":[31,243],"grounds,":[32],"ACTH":[33,133,182,246],"administration,":[34],"stress":[36,71,184],"holding":[38,73,128],"in":[39,58,66,76,89,93,139,153,192,201,237],"a":[40,77,90,100,136,234],"confined":[41],"space":[42],"and":[43,132,163,217],"repeated":[44],"bleeding":[45,131],"were":[46],"employed":[47],"determine":[49],"response":[51,180],"as":[56,97,99,145,147,157],"reflected":[57],"changing":[60],"concentration":[61],"17-hydroxycorticosteroids":[63],"(17-":[64],"OHCS)":[65],"blood":[68],"plasma.":[69],"The":[70],"tank":[78],"on":[79],"board":[80],"ship,":[81],"without":[82],"other":[83],"disturbance,":[84],"resulted":[85],"after":[86],"1":[87],"hr":[88],"progressive":[91],"rise":[92,236],"plasma":[94,140,203,221,238],"17-OHCS":[95,200],"much":[98],"4-fold":[101],"increase":[102,138],"by":[103,113,150,174],"end":[105],"24\u201348":[107],"hr.":[108],"This":[109],"change":[110],"was":[111],"accompanied":[112],"hyperplasia":[114],"tissue.":[118],"At":[119,188],"beginning":[121,209],"salmon's":[124,194],"river":[125],"migration,":[126,213],"both":[127,215],"alone":[129],"plus":[130],"injection":[134],"produced":[135],"marked":[137],"17-OHCS,":[141],"but":[142],"not":[143],"quite":[144],"great":[146],"that":[148],"shown":[149],"taken":[152],"sea.":[155],"Thereafter,":[156],"continued":[160],"their":[161,168,211],"maturation":[164],"gonads,":[167],"reactivity":[170],"diminished":[171],"progressively":[172],"until,":[173],"time":[176],"spawning,":[178,218],"little":[179],"or":[183],"could":[185],"be":[186],"elicited.":[187],"this":[189],"terminal":[190],"period":[191],"life":[195],"cycle":[196],"levels":[198,240],"remained":[204],"high.":[205],"Except":[206],"at":[207],"fluvial":[212],"females,":[214],"maturing":[216],"exhibited":[219],"higher":[220,235],"concentrations":[222],"17-":[224],"OHCS":[225],"than":[226,241],"did":[227,242],"male":[228],"salmon.":[229],"Spawning":[230],"steelhead":[231],"trout":[232],"showed":[233],"corticosteroid":[239],"following":[245],"injection.":[247],"(Endocrinology78:":[248],"791,":[249],"1966)":[250]},"counts_by_year":[{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}