{"id":"https://openalex.org/W2017500086","doi":"https://doi.org/10.1158/0008-5472.can-11-2194","title":"Genetic Deficiency in Plasma Protein HRG Enhances Tumor Growth and Metastasis by Exacerbating Immune Escape and Vessel Abnormalization","display_name":"Genetic Deficiency in Plasma Protein HRG Enhances Tumor Growth and Metastasis by Exacerbating Immune Escape and Vessel Abnormalization","publication_year":2012,"publication_date":"2012-02-28","ids":{"openalex":"https://openalex.org/W2017500086","doi":"https://doi.org/10.1158/0008-5472.can-11-2194","mag":"2017500086","pmid":"https://pubmed.ncbi.nlm.nih.gov/22374984"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.can-11-2194","doi":"https://doi.org/10.1158/0008-5472.can-11-2194","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.can-11-2194","pdf_url":"https://aacrjournals.org/cancerres/article-pdf/72/8/1953/2680572/1953.pdf","source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://aacrjournals.org/cancerres/article-pdf/72/8/1953/2680572/1953.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026271741","display_name":"S\u00f2nia Tugues","orcid":"https://orcid.org/0000-0003-1206-3386","observed_orcids":["https://orcid.org/0000-0003-1206-3386"]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]},{"id":"https://openalex.org/I887968799","display_name":"RWTH Aachen University","ror":"https://ror.org/04xfq0f34","country_code":"DE","type":"education","lineage":["https://openalex.org/I887968799"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE","DE","SE"],"is_corresponding":false,"raw_author_name":"S\u00f2nia Tugues","raw_affiliation_strings":["Authors' Affiliations:\u20081Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden; 2Vesalius Research Center, VIB; 3Vesalius Research Center, K.U. Leuven, Leuven, Belgium; and 4Department of Biomedical Engineering, RWTH Aachen University, Aachen, Germany","Department of Biomedical Engineering, RWTH Aachen University, Aachen, Germany","Vesalius Research Center, VIB"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden; 2Vesalius Research Center, VIB; 3Vesalius Research Center, K.U. Leuven, Leuven, Belgium; and 4Department of Biomedical Engineering, RWTH Aachen University, Aachen, Germany","institution_ids":["https://openalex.org/I123387679","https://openalex.org/I887968799","https://openalex.org/I99464096"]},{"raw_affiliation_string":"Department of Biomedical Engineering, RWTH Aachen University, Aachen, Germany","institution_ids":["https://openalex.org/I887968799"]},{"raw_affiliation_string":"Vesalius Research Center, VIB","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Satoshi Honjo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]},{"id":"https://openalex.org/I887968799","display_name":"RWTH Aachen University","ror":"https://ror.org/04xfq0f34","country_code":"DE","type":"education","lineage":["https://openalex.org/I887968799"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE","DE","SE"],"is_corresponding":false,"raw_author_name":"Satoshi Honjo","raw_affiliation_strings":["Authors' Affiliations:\u20081Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden; 2Vesalius Research Center, VIB; 3Vesalius Research Center, K.U. Leuven, Leuven, Belgium; and 4Department of Biomedical Engineering, RWTH Aachen University, Aachen, Germany","Department of Biomedical Engineering, RWTH Aachen University, Aachen, Germany","Vesalius Research Center, VIB"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden; 2Vesalius Research Center, VIB; 3Vesalius Research Center, K.U. Leuven, Leuven, Belgium; and 4Department of Biomedical Engineering, RWTH Aachen University, Aachen, Germany","institution_ids":["https://openalex.org/I123387679","https://openalex.org/I887968799","https://openalex.org/I99464096"]},{"raw_affiliation_string":"Department of Biomedical Engineering, RWTH Aachen University, Aachen, Germany","institution_ids":["https://openalex.org/I887968799"]},{"raw_affiliation_string":"Vesalius Research Center, VIB","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016283293","display_name":"Christian M. K\u00f6nig","orcid":"https://orcid.org/0000-0001-7671-231X","observed_orcids":["https://orcid.org/0000-0001-7671-231X"]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]},{"id":"https://openalex.org/I887968799","display_name":"RWTH Aachen University","ror":"https://ror.org/04xfq0f34","country_code":"DE","type":"education","lineage":["https://openalex.org/I887968799"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE","DE","SE"],"is_corresponding":false,"raw_author_name":"Christian K\u00f6nig","raw_affiliation_strings":["Authors' Affiliations:\u20081Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden; 2Vesalius Research Center, VIB; 3Vesalius Research Center, K.U. Leuven, Leuven, Belgium; and 4Department of Biomedical Engineering, RWTH Aachen University, Aachen, Germany","Department of Biomedical Engineering, RWTH Aachen University, Aachen, Germany","Vesalius Research Center, VIB"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden; 2Vesalius Research Center, VIB; 3Vesalius Research Center, K.U. Leuven, Leuven, Belgium; and 4Department of Biomedical Engineering, RWTH Aachen University, Aachen, Germany","institution_ids":["https://openalex.org/I123387679","https://openalex.org/I887968799","https://openalex.org/I99464096"]},{"raw_affiliation_string":"Department of Biomedical Engineering, RWTH Aachen University, Aachen, Germany","institution_ids":["https://openalex.org/I887968799"]},{"raw_affiliation_string":"Vesalius Research Center, VIB","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003755248","display_name":"Oriol Noguer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]},{"id":"https://openalex.org/I887968799","display_name":"RWTH Aachen University","ror":"https://ror.org/04xfq0f34","country_code":"DE","type":"education","lineage":["https://openalex.org/I887968799"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE","DE","SE"],"is_corresponding":false,"raw_author_name":"Oriol Noguer","raw_affiliation_strings":["Authors' Affiliations:\u20081Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden; 2Vesalius Research Center, VIB; 3Vesalius Research Center, K.U. Leuven, Leuven, Belgium; and 4Department of Biomedical Engineering, RWTH Aachen University, Aachen, Germany","Department of Biomedical Engineering, RWTH Aachen University, Aachen, Germany","Vesalius Research Center, VIB"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden; 2Vesalius Research Center, VIB; 3Vesalius Research Center, K.U. Leuven, Leuven, Belgium; and 4Department of Biomedical Engineering, RWTH Aachen University, Aachen, Germany","institution_ids":["https://openalex.org/I123387679","https://openalex.org/I887968799","https://openalex.org/I99464096"]},{"raw_affiliation_string":"Department of Biomedical Engineering, RWTH Aachen University, Aachen, Germany","institution_ids":["https://openalex.org/I887968799"]},{"raw_affiliation_string":"Vesalius Research Center, VIB","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113902232","display_name":"Marie Hedlund","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]},{"id":"https://openalex.org/I887968799","display_name":"RWTH Aachen University","ror":"https://ror.org/04xfq0f34","country_code":"DE","type":"education","lineage":["https://openalex.org/I887968799"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE","DE","SE"],"is_corresponding":false,"raw_author_name":"Marie Hedlund","raw_affiliation_strings":["Authors' Affiliations:\u20081Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden; 2Vesalius Research Center, VIB; 3Vesalius Research Center, K.U. Leuven, Leuven, Belgium; and 4Department of Biomedical Engineering, RWTH Aachen University, Aachen, Germany","Department of Biomedical Engineering, RWTH Aachen University, Aachen, Germany","Vesalius Research Center, VIB"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden; 2Vesalius Research Center, VIB; 3Vesalius Research Center, K.U. Leuven, Leuven, Belgium; and 4Department of Biomedical Engineering, RWTH Aachen University, Aachen, Germany","institution_ids":["https://openalex.org/I123387679","https://openalex.org/I887968799","https://openalex.org/I99464096"]},{"raw_affiliation_string":"Department of Biomedical Engineering, RWTH Aachen University, Aachen, Germany","institution_ids":["https://openalex.org/I887968799"]},{"raw_affiliation_string":"Vesalius Research Center, VIB","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091504498","display_name":"Johan Botling","orcid":"https://orcid.org/0000-0003-2226-3517","observed_orcids":["https://orcid.org/0000-0003-2226-3517"]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]},{"id":"https://openalex.org/I887968799","display_name":"RWTH Aachen University","ror":"https://ror.org/04xfq0f34","country_code":"DE","type":"education","lineage":["https://openalex.org/I887968799"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE","DE","SE"],"is_corresponding":false,"raw_author_name":"Johan Botling","raw_affiliation_strings":["Authors' Affiliations:\u20081Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden; 2Vesalius Research Center, VIB; 3Vesalius Research Center, K.U. Leuven, Leuven, Belgium; and 4Department of Biomedical Engineering, RWTH Aachen University, Aachen, Germany","Department of Biomedical Engineering, RWTH Aachen University, Aachen, Germany","Vesalius Research Center, VIB"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden; 2Vesalius Research Center, VIB; 3Vesalius Research Center, K.U. Leuven, Leuven, Belgium; and 4Department of Biomedical Engineering, RWTH Aachen University, Aachen, Germany","institution_ids":["https://openalex.org/I123387679","https://openalex.org/I887968799","https://openalex.org/I99464096"]},{"raw_affiliation_string":"Department of Biomedical Engineering, RWTH Aachen University, Aachen, Germany","institution_ids":["https://openalex.org/I887968799"]},{"raw_affiliation_string":"Vesalius Research Center, VIB","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045148243","display_name":"Sofie Deschoemaeker","orcid":"https://orcid.org/0000-0001-5449-282X","observed_orcids":["https://orcid.org/0000-0001-5449-282X"]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]},{"id":"https://openalex.org/I887968799","display_name":"RWTH Aachen University","ror":"https://ror.org/04xfq0f34","country_code":"DE","type":"education","lineage":["https://openalex.org/I887968799"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE","DE","SE"],"is_corresponding":false,"raw_author_name":"Sofie Deschoemaeker","raw_affiliation_strings":["Authors' Affiliations:\u20081Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden; 2Vesalius Research Center, VIB; 3Vesalius Research Center, K.U. Leuven, Leuven, Belgium; and 4Department of Biomedical Engineering, RWTH Aachen University, Aachen, Germany","Vesalius Research Center, VIB"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden; 2Vesalius Research Center, VIB; 3Vesalius Research Center, K.U. Leuven, Leuven, Belgium; and 4Department of Biomedical Engineering, RWTH Aachen University, Aachen, Germany","institution_ids":["https://openalex.org/I123387679","https://openalex.org/I887968799","https://openalex.org/I99464096"]},{"raw_affiliation_string":"Vesalius Research Center, VIB","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053744258","display_name":"Mathias Wenes","orcid":"https://orcid.org/0000-0001-8478-8592","observed_orcids":["https://orcid.org/0000-0001-8478-8592"]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]},{"id":"https://openalex.org/I887968799","display_name":"RWTH Aachen University","ror":"https://ror.org/04xfq0f34","country_code":"DE","type":"education","lineage":["https://openalex.org/I887968799"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE","DE","SE"],"is_corresponding":false,"raw_author_name":"Mathias Wenes","raw_affiliation_strings":["Authors' Affiliations:\u20081Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden; 2Vesalius Research Center, VIB; 3Vesalius Research Center, K.U. Leuven, Leuven, Belgium; and 4Department of Biomedical Engineering, RWTH Aachen University, Aachen, Germany","Vesalius Research Center, VIB"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden; 2Vesalius Research Center, VIB; 3Vesalius Research Center, K.U. Leuven, Leuven, Belgium; and 4Department of Biomedical Engineering, RWTH Aachen University, Aachen, Germany","institution_ids":["https://openalex.org/I123387679","https://openalex.org/I887968799","https://openalex.org/I99464096"]},{"raw_affiliation_string":"Vesalius Research Center, VIB","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050667858","display_name":"Charlotte Rolny","orcid":"https://orcid.org/0000-0003-4979-9266","observed_orcids":["https://orcid.org/0000-0003-4979-9266"]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]},{"id":"https://openalex.org/I887968799","display_name":"RWTH Aachen University","ror":"https://ror.org/04xfq0f34","country_code":"DE","type":"education","lineage":["https://openalex.org/I887968799"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE","DE","SE"],"is_corresponding":false,"raw_author_name":"Charlotte Rolny","raw_affiliation_strings":["Authors' Affiliations:\u20081Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden; 2Vesalius Research Center, VIB; 3Vesalius Research Center, K.U. Leuven, Leuven, Belgium; and 4Department of Biomedical Engineering, RWTH Aachen University, Aachen, Germany","Department of Biomedical Engineering, RWTH Aachen University, Aachen, Germany","Vesalius Research Center, VIB"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden; 2Vesalius Research Center, VIB; 3Vesalius Research Center, K.U. Leuven, Leuven, Belgium; and 4Department of Biomedical Engineering, RWTH Aachen University, Aachen, Germany","institution_ids":["https://openalex.org/I123387679","https://openalex.org/I887968799","https://openalex.org/I99464096"]},{"raw_affiliation_string":"Department of Biomedical Engineering, RWTH Aachen University, Aachen, Germany","institution_ids":["https://openalex.org/I887968799"]},{"raw_affiliation_string":"Vesalius Research Center, VIB","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020084081","display_name":"Willi Jahnen\u2010Dechent","orcid":"https://orcid.org/0000-0003-1315-4407","observed_orcids":["https://orcid.org/0000-0003-1315-4407"]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]},{"id":"https://openalex.org/I887968799","display_name":"RWTH Aachen University","ror":"https://ror.org/04xfq0f34","country_code":"DE","type":"education","lineage":["https://openalex.org/I887968799"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE","DE","SE"],"is_corresponding":false,"raw_author_name":"Wilhelm Jahnen-Dechent","raw_affiliation_strings":["Authors' Affiliations:\u20081Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden; 2Vesalius Research Center, VIB; 3Vesalius Research Center, K.U. Leuven, Leuven, Belgium; and 4Department of Biomedical Engineering, RWTH Aachen University, Aachen, Germany","Department of Biomedical Engineering, RWTH Aachen University, Aachen, Germany","Vesalius Research Center, VIB"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden; 2Vesalius Research Center, VIB; 3Vesalius Research Center, K.U. Leuven, Leuven, Belgium; and 4Department of Biomedical Engineering, RWTH Aachen University, Aachen, Germany","institution_ids":["https://openalex.org/I123387679","https://openalex.org/I887968799","https://openalex.org/I99464096"]},{"raw_affiliation_string":"Department of Biomedical Engineering, RWTH Aachen University, Aachen, Germany","institution_ids":["https://openalex.org/I887968799"]},{"raw_affiliation_string":"Vesalius Research Center, VIB","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005112202","display_name":"Massimiliano Mazzone","orcid":"https://orcid.org/0000-0001-8824-4015","observed_orcids":["https://orcid.org/0000-0001-8824-4015"]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]},{"id":"https://openalex.org/I887968799","display_name":"RWTH Aachen University","ror":"https://ror.org/04xfq0f34","country_code":"DE","type":"education","lineage":["https://openalex.org/I887968799"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE","DE","SE"],"is_corresponding":false,"raw_author_name":"Massimiliano Mazzone","raw_affiliation_strings":["Authors' Affiliations:\u20081Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden; 2Vesalius Research Center, VIB; 3Vesalius Research Center, K.U. Leuven, Leuven, Belgium; and 4Department of Biomedical Engineering, RWTH Aachen University, Aachen, Germany","Vesalius Research Center, VIB"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden; 2Vesalius Research Center, VIB; 3Vesalius Research Center, K.U. Leuven, Leuven, Belgium; and 4Department of Biomedical Engineering, RWTH Aachen University, Aachen, Germany","institution_ids":["https://openalex.org/I123387679","https://openalex.org/I887968799","https://openalex.org/I99464096"]},{"raw_affiliation_string":"Vesalius Research Center, VIB","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082204429","display_name":"Lena Claesson","orcid":"https://orcid.org/0000-0003-4275-2000","observed_orcids":["https://orcid.org/0000-0003-4275-2000"]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]},{"id":"https://openalex.org/I887968799","display_name":"RWTH Aachen University","ror":"https://ror.org/04xfq0f34","country_code":"DE","type":"education","lineage":["https://openalex.org/I887968799"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE","DE","SE"],"is_corresponding":true,"raw_author_name":"Lena Claesson-Welsh","raw_affiliation_strings":["Authors' Affiliations:\u20081Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden; 2Vesalius Research Center, VIB; 3Vesalius Research Center, K.U. Leuven, Leuven, Belgium; and 4Department of Biomedical Engineering, RWTH Aachen University, Aachen, Germany","Department of Biomedical Engineering, RWTH Aachen University, Aachen, Germany","Vesalius Research Center, VIB"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden; 2Vesalius Research Center, VIB; 3Vesalius Research Center, K.U. Leuven, Leuven, Belgium; and 4Department of Biomedical Engineering, RWTH Aachen University, Aachen, Germany","institution_ids":["https://openalex.org/I123387679","https://openalex.org/I887968799","https://openalex.org/I99464096"]},{"raw_affiliation_string":"Department of Biomedical Engineering, RWTH Aachen University, Aachen, Germany","institution_ids":["https://openalex.org/I887968799"]},{"raw_affiliation_string":"Vesalius Research Center, VIB","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5082204429"],"corresponding_institution_ids":["https://openalex.org/I123387679","https://openalex.org/I887968799","https://openalex.org/I99464096"],"apc_list":null,"apc_paid":null,"fwci":2.4688,"has_fulltext":true,"cited_by_count":43,"citation_normalized_percentile":{"value":0.88628173,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"72","issue":"8","first_page":"1953","last_page":"1963"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.9639000296592712,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.9639000296592712,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.03280000016093254,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/histidine-rich-glycoprotein","display_name":"histidine-rich glycoprotein","score":0.9990000128746033},{"id":"https://openalex.org/keywords/tumor-growth","display_name":"tumor growth","score":0.9079999923706055},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.9549999833106995},{"id":"https://openalex.org/keywords/tumor-immune-evasion","display_name":"tumor immune evasion","score":0.9210000038146973},{"id":"https://openalex.org/keywords/tumor-associated-macrophages","display_name":"tumor-associated macrophages","score":0.8309999704360962},{"id":"https://openalex.org/keywords/m2-macrophages","display_name":"M2 macrophages","score":0.9399999976158142},{"id":"https://openalex.org/keywords/dendritic-cells","display_name":"dendritic cells","score":0.7929999828338623},{"id":"https://openalex.org/keywords/cytotoxic-t-lymphocytes","display_name":"cytotoxic T lymphocytes","score":0.9850000143051147},{"id":"https://openalex.org/keywords/tumor-angiogenesis","display_name":"tumor angiogenesis","score":0.8539999723434448},{"id":"https://openalex.org/keywords/tumor-hypoxia","display_name":"tumor hypoxia","score":0.8859999775886536},{"id":"https://openalex.org/keywords/tumor-necrosis","display_name":"tumor necrosis","score":0.6909999847412109},{"id":"https://openalex.org/keywords/plasma-proteins","display_name":"plasma proteins","score":0.6299999952316284},{"id":"https://openalex.org/keywords/peritoneal-macrophages","display_name":"peritoneal macrophages","score":0.7490000128746033},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":0.6470000147819519},{"id":"https://openalex.org/keywords/pancreatic-cancer","display_name":"pancreatic cancer","score":0.6039999723434448},{"id":"https://openalex.org/keywords/fibrosarcoma","display_name":"fibrosarcoma","score":1.0}],"concepts":[{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.7619564533233643},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.7002159953117371},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.59674072265625},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5498124361038208},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.5168572068214417},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5008430480957031},{"id":"https://openalex.org/C2778536324","wikidata":"https://www.wikidata.org/wiki/Q1030169","display_name":"Peritoneal cavity","level":2,"score":0.4677942395210266},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.46648767590522766},{"id":"https://openalex.org/C2778753947","wikidata":"https://www.wikidata.org/wiki/Q18027691","display_name":"CYR61","level":5,"score":0.4608544707298279},{"id":"https://openalex.org/C153400128","wikidata":"https://www.wikidata.org/wiki/Q3150731","display_name":"Infiltration (HVAC)","level":2,"score":0.4457913041114807},{"id":"https://openalex.org/C2776495794","wikidata":"https://www.wikidata.org/wiki/Q1362453","display_name":"Fibrosarcoma","level":2,"score":0.4442238211631775},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3392292559146881},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2974793314933777},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.24476191401481628},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.18699055910110474},{"id":"https://openalex.org/C2780631158","wikidata":"https://www.wikidata.org/wiki/Q14907752","display_name":"CTGF","level":4,"score":0.12618762254714966},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.0},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000099053","descriptor_name":"Histidine-Rich Glycoprotein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009374","descriptor_name":"Neoplasms, Experimental","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009374","descriptor_name":"Neoplasms, Experimental","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D009374","descriptor_name":"Neoplasms, Experimental","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019139","descriptor_name":"Tumor Escape","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1158/0008-5472.can-11-2194","doi":"https://doi.org/10.1158/0008-5472.can-11-2194","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.can-11-2194","pdf_url":"https://aacrjournals.org/cancerres/article-pdf/72/8/1953/2680572/1953.pdf","source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},{"id":"pmid:22374984","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22374984","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"pmh:oai:lirias2repo.kuleuven.be:123456789/668052","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22374984","pdf_url":null,"source":{"id":"https://openalex.org/S7407055369","display_name":"Lirias","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cancer Research, vol. 72 (8), (1953-1963)","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:publications.rwth-aachen.de:134029","doi":null,"is_oa":false,"landing_page_url":"https://publications.rwth-aachen.de/search?p=id:%22RWTH-CONV-015065%22","pdf_url":null,"source":{"id":"https://openalex.org/S4306401362","display_name":"RWTH Publications (RWTH Aachen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I887968799","host_organization_name":"RWTH Aachen University","host_organization_lineage":["https://openalex.org/I887968799"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cancer research 72(8), 1953-1963 (2012). doi:10.1158/0008-5472.CAN-11-2194","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1158/0008-5472.can-11-2194","doi":"https://doi.org/10.1158/0008-5472.can-11-2194","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.can-11-2194","pdf_url":"https://aacrjournals.org/cancerres/article-pdf/72/8/1953/2680572/1953.pdf","source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2017500086.pdf","grobid_xml":"https://content.openalex.org/works/W2017500086.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W180825365","https://openalex.org/W1970689220","https://openalex.org/W1976588449","https://openalex.org/W1981073043","https://openalex.org/W1984803858","https://openalex.org/W1992702243","https://openalex.org/W1993324234","https://openalex.org/W1994298287","https://openalex.org/W1994528447","https://openalex.org/W2000837955","https://openalex.org/W2013994536","https://openalex.org/W2021955841","https://openalex.org/W2027607692","https://openalex.org/W2037281949","https://openalex.org/W2038717735","https://openalex.org/W2038781914","https://openalex.org/W2039863327","https://openalex.org/W2051736585","https://openalex.org/W2058648826","https://openalex.org/W2061177902","https://openalex.org/W2061519258","https://openalex.org/W2066409110","https://openalex.org/W2075435162","https://openalex.org/W2076113561","https://openalex.org/W2076409617","https://openalex.org/W2081810806","https://openalex.org/W2087843002","https://openalex.org/W2094736478","https://openalex.org/W2100861708","https://openalex.org/W2101796936","https://openalex.org/W2103457670","https://openalex.org/W2117692326","https://openalex.org/W2118278569","https://openalex.org/W2119897005","https://openalex.org/W2128255644","https://openalex.org/W2133764756","https://openalex.org/W2138430027","https://openalex.org/W2145002468","https://openalex.org/W2154589460","https://openalex.org/W2154655593","https://openalex.org/W2155318909","https://openalex.org/W2158642531","https://openalex.org/W2163194111"],"related_works":["https://openalex.org/W2158642531","https://openalex.org/W2025732287","https://openalex.org/W7098415812","https://openalex.org/W2080443489","https://openalex.org/W2027726289","https://openalex.org/W2112922523","https://openalex.org/W425844021","https://openalex.org/W7098444881","https://openalex.org/W2087843002","https://openalex.org/W325525663"],"abstract_inverted_index":{"Histidine-rich":[0],"glycoprotein":[1],"(HRG)":[2],"is":[3],"a":[4,63,108,142],"75-kDa":[5],"heparin-binding":[6],"plasma":[7],"protein":[8],"implicated":[9],"in":[10,44,90,127],"the":[11],"regulation":[12],"of":[13,72,79,87,104,124,145,157,161],"tumor":[14,158,162,167],"growth":[15,168],"and":[16,51,76,82,110,131,165,169],"vascularization.":[17],"In":[18,113,134],"this":[19],"study,":[20],"we":[21],"show":[22,138],"that":[23,139],"hrg(-/-)":[24,45,98],"mice":[25,46,99],"challenged":[26],"with":[27,35,40,62,68,107],"fibrosarcoma":[28],"or":[29],"pancreatic":[30],"carcinoma":[31],"grow":[32],"larger":[33],"tumors":[34],"increased":[36,70,102,166],"metastatic":[37,170],"properties.":[38],"Compared":[39],"wild-type":[41],"mice,":[42],"fibrosarcomas":[43],"were":[47],"more":[48],"hypoxic,":[49],"necrotic,":[50],"less":[52],"perfused,":[53],"indicating":[54],"enhanced":[55],"vessel":[56],"abnormalization.":[57],"HRG":[58,147],"deficiency":[59],"was":[60],"associated":[61,106],"suppressed":[64],"antitumor":[65],"immune":[66,132,163],"response,":[67,164],"both":[69],"infiltration":[71,78],"M2":[73],"marker-expressing":[74],"macrophages":[75,96,121,140],"decreased":[77],"dendritic":[80],"cells":[81],"cytotoxic":[83],"T":[84],"cells.":[85],"Analysis":[86],"transcript":[88],"expression":[89,103,115],"tumor-associated":[91],"as":[92,94],"well":[93],"peritoneal":[95,120],"from":[97],"revealed":[100],"an":[101],"genes":[105,125],"proangiogenic":[109],"immunoinhibitory":[111],"phenotype.":[112],"accordance,":[114],"arrays":[116],"conducted":[117],"on":[118],"HRG-treated":[119],"showed":[122],"induction":[123],"involved":[126],"extracellular":[128],"matrix":[129],"biology":[130],"responsiveness.":[133],"conclusion,":[135],"our":[136],"findings":[137],"are":[141],"direct":[143],"target":[144],"HRG.":[146],"loss":[148],"influences":[149],"macrophage":[150],"gene":[151],"regulation,":[152],"leading":[153],"to":[154],"excessive":[155],"stimulation":[156],"angiogenesis,":[159],"suppression":[160],"spread.":[171]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":4},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
