{"id":"https://openalex.org/W2017497448","doi":"https://doi.org/10.1016/s0304-3940(03)00540-8","title":"Neuroprotection of naloxone against ischemic injury in rats: role of mu receptor antagonism","display_name":"Neuroprotection of naloxone against ischemic injury in rats: role of mu receptor antagonism","publication_year":2003,"publication_date":"2003-06-21","ids":{"openalex":"https://openalex.org/W2017497448","doi":"https://doi.org/10.1016/s0304-3940(03)00540-8","mag":"2017497448","pmid":"https://pubmed.ncbi.nlm.nih.gov/12842283"},"language":"en","primary_location":{"id":"doi:10.1016/s0304-3940(03)00540-8","doi":"https://doi.org/10.1016/s0304-3940(03)00540-8","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0304-3940(03)00540-8","pdf_url":null,"source":{"id":"https://openalex.org/S203050076","display_name":"Neuroscience Letters","issn_l":"0304-3940","issn":["0304-3940","1872-7972"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","medline","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuroscience Letters","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5104145212","display_name":"Su\u2010Lan Liao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210091773","display_name":"Taichung Veterans General Hospital","ror":"https://ror.org/00e87hq62","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210091773"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Su-Lan Liao","raw_affiliation_strings":["Department of Education and Research, Taichung Veterans General Hospital, Taichung, Taiwan, ROC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Education and Research, Taichung Veterans General Hospital, Taichung, Taiwan, ROC","institution_ids":["https://openalex.org/I4210091773"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091150759","display_name":"Wen\u2010Yin Chen","orcid":"https://orcid.org/0000-0001-8626-6472","observed_orcids":["https://orcid.org/0000-0001-8626-6472"]},"institutions":[{"id":"https://openalex.org/I4210091773","display_name":"Taichung Veterans General Hospital","ror":"https://ror.org/00e87hq62","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210091773"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Wen-Yin Chen","raw_affiliation_strings":["Department of Education and Research, Taichung Veterans General Hospital, Taichung, Taiwan, ROC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Education and Research, Taichung Veterans General Hospital, Taichung, Taiwan, ROC","institution_ids":["https://openalex.org/I4210091773"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113601770","display_name":"Shue\u2010Ling Raung","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210091773","display_name":"Taichung Veterans General Hospital","ror":"https://ror.org/00e87hq62","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210091773"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Shue-Ling Raung","raw_affiliation_strings":["Department of Education and Research, Taichung Veterans General Hospital, Taichung, Taiwan, ROC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Education and Research, Taichung Veterans General Hospital, Taichung, Taiwan, ROC","institution_ids":["https://openalex.org/I4210091773"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043997420","display_name":"Chun\u2010Jung Chen","orcid":"https://orcid.org/0000-0002-5157-4288","observed_orcids":["https://orcid.org/0000-0002-5157-4288"]},"institutions":[{"id":"https://openalex.org/I4210091773","display_name":"Taichung Veterans General Hospital","ror":"https://ror.org/00e87hq62","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210091773"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Chun-Jung Chen","raw_affiliation_strings":["Department of Education and Research, Taichung Veterans General Hospital, Taichung, Taiwan, ROC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Education and Research, Taichung Veterans General Hospital, Taichung, Taiwan, ROC","institution_ids":["https://openalex.org/I4210091773"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5043997420"],"corresponding_institution_ids":["https://openalex.org/I4210091773"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":null,"fwci":0.7015,"has_fulltext":false,"cited_by_count":52,"citation_normalized_percentile":{"value":0.58584974,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"345","issue":"3","first_page":"169","last_page":"172"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.3540000021457672,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.3540000021457672,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13796","display_name":"Neuroprotection in Cerebral Ischemia","score":0.30640000104904175,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.19189999997615814,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/naloxone","display_name":"naloxone","score":1.0},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.9520000219345093},{"id":"https://openalex.org/keywords/cerebral-ischemia-reperfusion-injury","display_name":"cerebral ischemia-reperfusion injury","score":0.8840000033378601},{"id":"https://openalex.org/keywords/mu-opioid-receptor-antagonism","display_name":"mu-opioid receptor antagonism","score":0.9309999942779541},{"id":"https://openalex.org/keywords/beta-funaltrexamine","display_name":"beta-funaltrexamine","score":0.925000011920929},{"id":"https://openalex.org/keywords/cortical-infarction","display_name":"cortical infarction","score":0.718999981880188},{"id":"https://openalex.org/keywords/neutrophil-infiltration","display_name":"neutrophil infiltration","score":0.7580000162124634},{"id":"https://openalex.org/keywords/myeloperoxidase","display_name":"myeloperoxidase","score":0.9879999756813049},{"id":"https://openalex.org/keywords/chemokines","display_name":"chemokines","score":0.7910000085830688},{"id":"https://openalex.org/keywords/macrophage-inflammatory-protein-1-alpha","display_name":"macrophage inflammatory protein-1alpha","score":0.8849999904632568},{"id":"https://openalex.org/keywords/mip-2","display_name":"CXCL2","score":0.9330000281333923},{"id":"https://openalex.org/keywords/cerebral-edema","display_name":"cerebral edema","score":0.9700000286102295},{"id":"https://openalex.org/keywords/opioid-receptors","display_name":"opioid receptors","score":0.5580000281333923}],"concepts":[{"id":"https://openalex.org/C2778750930","wikidata":"https://www.wikidata.org/wiki/Q4540629","display_name":"(+)-Naloxone","level":4,"score":0.844762921333313},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.688586413860321},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.682248592376709},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5438684821128845},{"id":"https://openalex.org/C2779886867","wikidata":"https://www.wikidata.org/wiki/Q421797","display_name":"Opioid receptor","level":4,"score":0.5291783213615417},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.48865869641304016},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.4825805723667145},{"id":"https://openalex.org/C2777953665","wikidata":"https://www.wikidata.org/wiki/Q3743642","display_name":"Naltrindole","level":5,"score":0.44334858655929565},{"id":"https://openalex.org/C2781063702","wikidata":"https://www.wikidata.org/wiki/Q427523","display_name":"Opioid","level":3,"score":0.4243966341018677},{"id":"https://openalex.org/C14397066","wikidata":"https://www.wikidata.org/wiki/Q14911924","display_name":"\u03bc-opioid receptor","level":4,"score":0.4194607734680176},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3615080714225769},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.35548073053359985},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3299906849861145}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002544","descriptor_name":"Cerebral Infarction","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D002544","descriptor_name":"Cerebral Infarction","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D003327","descriptor_name":"Coronary Disease","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D007839","descriptor_name":"Functional Laterality","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009270","descriptor_name":"Naloxone","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D009271","descriptor_name":"Naltrexone","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D009271","descriptor_name":"Naltrexone","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D009292","descriptor_name":"Narcotic Antagonists","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017450","descriptor_name":"Receptors, Opioid, mu","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D017450","descriptor_name":"Receptors, Opioid, mu","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017536","descriptor_name":"Carotid Artery, Common","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020244","descriptor_name":"Infarction, Middle Cerebral Artery","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D020925","descriptor_name":"Hypoxia-Ischemia, Brain","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D020925","descriptor_name":"Hypoxia-Ischemia, Brain","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0304-3940(03)00540-8","doi":"https://doi.org/10.1016/s0304-3940(03)00540-8","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0304-3940(03)00540-8","pdf_url":null,"source":{"id":"https://openalex.org/S203050076","display_name":"Neuroscience Letters","issn_l":"0304-3940","issn":["0304-3940","1872-7972"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","medline","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuroscience Letters","raw_type":"journal-article"},{"id":"pmid:12842283","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12842283","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuroscience letters","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320326232","display_name":"Taichung Veterans General Hospital","ror":"https://ror.org/00e87hq62"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W1891696008","https://openalex.org/W1913750811","https://openalex.org/W1971317435","https://openalex.org/W1985624231","https://openalex.org/W1987351333","https://openalex.org/W2008443071","https://openalex.org/W2012865789","https://openalex.org/W2019607920","https://openalex.org/W2027298607","https://openalex.org/W2038854479","https://openalex.org/W2039470219","https://openalex.org/W2052517638","https://openalex.org/W2071778946","https://openalex.org/W2071998745","https://openalex.org/W2097293665","https://openalex.org/W2101355906","https://openalex.org/W2126707631","https://openalex.org/W2127233792","https://openalex.org/W2140894985","https://openalex.org/W2417243857"],"related_works":["https://openalex.org/W2012865789","https://openalex.org/W2808500918","https://openalex.org/W3029496387","https://openalex.org/W2378438887","https://openalex.org/W1966356640","https://openalex.org/W2366662162","https://openalex.org/W2112201374","https://openalex.org/W2348888875","https://openalex.org/W2373064865","https://openalex.org/W2386181186"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}