{"id":"https://openalex.org/W2017492367","doi":"https://doi.org/10.1038/sj.bjp.0706040","title":"Effects of piperine, the pungent component of black pepper, at the human vanilloid receptor (TRPV1)","display_name":"Effects of piperine, the pungent component of black pepper, at the human vanilloid receptor (TRPV1)","publication_year":2005,"publication_date":"2005-02-01","ids":{"openalex":"https://openalex.org/W2017492367","doi":"https://doi.org/10.1038/sj.bjp.0706040","mag":"2017492367","pmid":"https://pubmed.ncbi.nlm.nih.gov/15685214","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1576058"},"language":"en","primary_location":{"id":"doi:10.1038/sj.bjp.0706040","doi":"https://doi.org/10.1038/sj.bjp.0706040","is_oa":false,"landing_page_url":"https://doi.org/10.1038/sj.bjp.0706040","pdf_url":null,"source":{"id":"https://openalex.org/S55107261","display_name":"British Journal of Pharmacology","issn_l":"0007-1188","issn":["0007-1188","1476-5381"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1576058/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085427926","display_name":"Fergal N McNamara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I188950975","display_name":"GlaxoSmithKline (United Kingdom)","ror":"https://ror.org/01xsqw823","country_code":"GB","type":"company","lineage":["https://openalex.org/I188950975"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Fergal N McNamara","raw_affiliation_strings":["Neurology & GI-CEDD, GlaxoSmithKline, New Fronteirs Science Park, Third Avenue, Harlow, Essex CM19 5AW"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurology & GI-CEDD, GlaxoSmithKline, New Fronteirs Science Park, Third Avenue, Harlow, Essex CM19 5AW","institution_ids":["https://openalex.org/I188950975"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018828484","display_name":"Andrew D. Randall","orcid":"https://orcid.org/0000-0001-8852-3671","observed_orcids":["https://orcid.org/0000-0001-8852-3671"]},"institutions":[{"id":"https://openalex.org/I188950975","display_name":"GlaxoSmithKline (United Kingdom)","ror":"https://ror.org/01xsqw823","country_code":"GB","type":"company","lineage":["https://openalex.org/I188950975"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Andrew Randall","raw_affiliation_strings":["Neurology & GI-CEDD, GlaxoSmithKline, New Fronteirs Science Park, Third Avenue, Harlow, Essex CM19 5AW"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurology & GI-CEDD, GlaxoSmithKline, New Fronteirs Science Park, Third Avenue, Harlow, Essex CM19 5AW","institution_ids":["https://openalex.org/I188950975"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037876897","display_name":"Martin J. Gunthorpe","orcid":"https://orcid.org/0000-0002-0216-1735","observed_orcids":["https://orcid.org/0000-0002-0216-1735"]},"institutions":[{"id":"https://openalex.org/I188950975","display_name":"GlaxoSmithKline (United Kingdom)","ror":"https://ror.org/01xsqw823","country_code":"GB","type":"company","lineage":["https://openalex.org/I188950975"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Martin J Gunthorpe","raw_affiliation_strings":["Neurology & GI-CEDD, GlaxoSmithKline, New Fronteirs Science Park, Third Avenue, Harlow, Essex CM19 5AW"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurology & GI-CEDD, GlaxoSmithKline, New Fronteirs Science Park, Third Avenue, Harlow, Essex CM19 5AW","institution_ids":["https://openalex.org/I188950975"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5037876897"],"corresponding_institution_ids":["https://openalex.org/I188950975"],"apc_list":{"value":4780,"currency":"USD","value_usd":4780},"apc_paid":null,"fwci":5.0746,"has_fulltext":false,"cited_by_count":317,"citation_normalized_percentile":{"value":0.96129613,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"144","issue":"6","first_page":"781","last_page":"790"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13037","display_name":"Piperaceae Chemical and Biological Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11584","display_name":"Biochemical Analysis and Sensing Techniques","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/piperine","display_name":"piperine","score":1.0},{"id":"https://openalex.org/keywords/trpv1","display_name":"TRPV1","score":0.9369999766349792},{"id":"https://openalex.org/keywords/vanilloid-receptor","display_name":"vanilloid receptor","score":0.9319999814033508},{"id":"https://openalex.org/keywords/black-pepper","display_name":"black pepper","score":0.7799999713897705},{"id":"https://openalex.org/keywords/capsaicin","display_name":"capsaicin","score":0.9580000042915344},{"id":"https://openalex.org/keywords/receptor-desensitization","display_name":"receptor desensitization","score":0.8939999938011169},{"id":"https://openalex.org/keywords/tachyphylaxis","display_name":"tachyphylaxis","score":0.9710000157356262},{"id":"https://openalex.org/keywords/receptor-efficacy","display_name":"receptor efficacy","score":0.7279999852180481},{"id":"https://openalex.org/keywords/capsazepine","display_name":"capsazepine","score":0.7070000171661377},{"id":"https://openalex.org/keywords/ruthenium-red","display_name":"ruthenium red","score":0.9959999918937683},{"id":"https://openalex.org/keywords/gastrointestinal-function","display_name":"gastrointestinal function","score":0.6700000166893005}],"concepts":[{"id":"https://openalex.org/C2780133158","wikidata":"https://www.wikidata.org/wiki/Q414501","display_name":"Piperine","level":2,"score":0.9608646631240845},{"id":"https://openalex.org/C2780071552","wikidata":"https://www.wikidata.org/wiki/Q5036336","display_name":"Capsazepine","level":5,"score":0.9036426544189453},{"id":"https://openalex.org/C160145004","wikidata":"https://www.wikidata.org/wiki/Q413209","display_name":"TRPV1","level":4,"score":0.8719354867935181},{"id":"https://openalex.org/C2780051329","wikidata":"https://www.wikidata.org/wiki/Q273169","display_name":"Capsaicin","level":3,"score":0.867084801197052},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7542940378189087},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.698739767074585},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6445633769035339},{"id":"https://openalex.org/C168481208","wikidata":"https://www.wikidata.org/wiki/Q2464757","display_name":"Tachyphylaxis","level":2,"score":0.550506591796875},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.36083167791366577},{"id":"https://openalex.org/C155164980","wikidata":"https://www.wikidata.org/wiki/Q304043","display_name":"Transient receptor potential channel","level":3,"score":0.3292139768600464},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.22579485177993774},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.16649678349494934}],"mesh":[{"descriptor_ui":"D000470","descriptor_name":"Alkaloids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002211","descriptor_name":"Capsaicin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D002211","descriptor_name":"Capsaicin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002211","descriptor_name":"Capsaicin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010880","descriptor_name":"Piperidines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011955","descriptor_name":"Receptors, Drug","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D011955","descriptor_name":"Receptors, Drug","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":true},{"descriptor_ui":"D012430","descriptor_name":"Ruthenium Red","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018408","descriptor_name":"Patch-Clamp Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029222","descriptor_name":"Piper nigrum","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D052117","descriptor_name":"Benzodioxoles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053284","descriptor_name":"Polyunsaturated Alkamides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1038/sj.bjp.0706040","doi":"https://doi.org/10.1038/sj.bjp.0706040","is_oa":false,"landing_page_url":"https://doi.org/10.1038/sj.bjp.0706040","pdf_url":null,"source":{"id":"https://openalex.org/S55107261","display_name":"British Journal of Pharmacology","issn_l":"0007-1188","issn":["0007-1188","1476-5381"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Pharmacology","raw_type":"journal-article"},{"id":"pmid:15685214","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15685214","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British journal of pharmacology","raw_type":"Comparative Study"},{"id":"pmh:oai:pubmedcentral.nih.gov:1576058","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1576058/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Br J Pharmacol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1576058","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1576058/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Br J Pharmacol","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.504800021648407,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":53,"referenced_works":["https://openalex.org/W111973194","https://openalex.org/W1487719749","https://openalex.org/W1488329806","https://openalex.org/W1511198581","https://openalex.org/W1583251247","https://openalex.org/W1832560920","https://openalex.org/W1919664406","https://openalex.org/W1952328179","https://openalex.org/W1964624214","https://openalex.org/W1965407094","https://openalex.org/W1968366571","https://openalex.org/W1975348529","https://openalex.org/W1976531685","https://openalex.org/W1978097698","https://openalex.org/W1980209044","https://openalex.org/W1988985577","https://openalex.org/W1998698456","https://openalex.org/W2008522439","https://openalex.org/W2014458126","https://openalex.org/W2021247550","https://openalex.org/W2021876302","https://openalex.org/W2022819833","https://openalex.org/W2023971821","https://openalex.org/W2028621748","https://openalex.org/W2033223894","https://openalex.org/W2033576768","https://openalex.org/W2035936202","https://openalex.org/W2043271992","https://openalex.org/W2045959196","https://openalex.org/W2059742450","https://openalex.org/W2060101272","https://openalex.org/W2061146673","https://openalex.org/W2067200668","https://openalex.org/W2068382277","https://openalex.org/W2082708562","https://openalex.org/W2083463797","https://openalex.org/W2085802434","https://openalex.org/W2088764206","https://openalex.org/W2093617388","https://openalex.org/W2100713606","https://openalex.org/W2107705149","https://openalex.org/W2123057791","https://openalex.org/W2129030082","https://openalex.org/W2129900856","https://openalex.org/W2130600650","https://openalex.org/W2131809780","https://openalex.org/W2136684513","https://openalex.org/W2168686026","https://openalex.org/W2171717653","https://openalex.org/W2179500285","https://openalex.org/W2417748670","https://openalex.org/W2950165494","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2096419853","https://openalex.org/W2010893335","https://openalex.org/W1540519711","https://openalex.org/W2949330739","https://openalex.org/W1969061731","https://openalex.org/W2079143176","https://openalex.org/W2035009697","https://openalex.org/W1832560920","https://openalex.org/W2158848973","https://openalex.org/W2034655176"],"abstract_inverted_index":{"1.":[0],"We":[1],"have":[2],"characterised":[3],"the":[4,16,33,46,52,88,129,133,205,243],"effects":[5,161,206,245],"of":[6,62,79,87,132,139,162,207,216,246],"piperine,":[7],"a":[8,28,76,97,109,136,231],"pungent":[9],"alkaloid":[10],"found":[11],"in":[12,120,177,193],"black":[13],"pepper,":[14],"on":[15,248],"human":[17,34,210],"vanilloid":[18],"receptor":[19,36,134,165,225],"TRPV1":[20,35,48,54,90,211],"using":[21],"whole-cell":[22,40],"patch-clamp":[23],"electrophysiology.":[24],"2.":[25],"Piperine":[26],"produced":[27],"clear":[29],"agonist":[30,91,100,197],"activity":[31],"at":[32,115,209],"yielding":[37],"rapidly":[38],"activating":[39],"currents":[41,64],"that":[42,86,204],"were":[43,167],"antagonised":[44],"by":[45,146],"competitive":[47],"antagonist":[49],"capsazepine":[50],"and":[51,72,75,188],"non-competitive":[53],"blocker":[55],"ruthenium":[56],"red.":[57],"3.":[58],"The":[59,160],"current-voltage":[60],"relationship":[61],"piperine-activated":[63],"showed":[65],"pronounced":[66,179],"outward":[67],"rectification":[68],"(25+/-4-fold":[69],"between":[70],"-70":[71],"+70":[73],"mV)":[74],"reversal":[77],"potential":[78],"0.0+/-0.4":[80],"mV,":[81],"which":[82],"was":[83,96,141],"indistinguishable":[84],"from":[85],"prototypical":[89],"capsaicin.":[92],"4.":[93],"Although":[94],"piperine":[95,147,163,175,208,247],"less":[98],"potent":[99],"(EC50=37.9+/-1.9":[101],"microM)":[102],"than":[103,184,234],"capsaicin":[104,151,185,217,235],"(EC50=0.29+/-0.05":[105],"microM),":[106],"it":[107],"demonstrated":[108],"much":[110],"greater":[111,191,224,232],"efficacy":[112,121,233],"(approximately":[113],"two-fold)":[114],"TRPV1.":[116],"5.":[117],"This":[118],"difference":[119],"did":[122],"not":[123],"appear":[124],"to":[125,128,156,170,195,214,222],"be":[126],"related":[127],"proton-mediated":[130],"regulation":[131],"since":[135,174],"similar":[137,213],"degree":[138],"potentiation":[140],"observed":[142],"for":[143,219],"responses":[144],"evoked":[145],"(230+/-20%,":[148],"n=11)":[149],"or":[150],"(284+/-32%,":[152],"n=8)":[153],"upon":[154,164],"acidification":[155],"pH":[157],"6.5.":[158],"6.":[159],"desensitisation":[166,181,226],"also":[168,189],"unable":[169],"explain":[171],"this":[172],"effect":[173],"resulted":[176],"more":[178],"macroscopic":[180],"(t(1/2)=9.9+/-0.7":[182],"s)":[183,187],"(t(1/2)>20":[186],"caused":[190],"tachyphylaxis":[192],"response":[194],"repetitive":[196],"applications.":[198],"7.":[199],"Overall,":[200],"our":[201],"data":[202],"suggest":[203],"are":[212],"those":[215],"except":[218],"its":[220],"propensity":[221],"induce":[223],"and,":[227],"rather":[228],"remarkably,":[229],"exhibit":[230],"itself.":[236],"These":[237],"results":[238],"may":[239],"provide":[240],"insight":[241],"into":[242],"TRPV1-mediated":[244],"gastrointestinal":[249],"function.":[250]},"counts_by_year":[{"year":2026,"cited_by_count":12},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":16},{"year":2023,"cited_by_count":15},{"year":2022,"cited_by_count":17},{"year":2021,"cited_by_count":14},{"year":2020,"cited_by_count":21},{"year":2019,"cited_by_count":14},{"year":2018,"cited_by_count":13},{"year":2017,"cited_by_count":19},{"year":2016,"cited_by_count":15},{"year":2015,"cited_by_count":20},{"year":2014,"cited_by_count":26},{"year":2013,"cited_by_count":13},{"year":2012,"cited_by_count":9}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
