{"id":"https://openalex.org/W2017484494","doi":"https://doi.org/10.3791/51581","title":"Method for Obtaining Primary Ovarian Cancer Cells From Solid Specimens","display_name":"Method for Obtaining Primary Ovarian Cancer Cells From Solid Specimens","publication_year":2014,"publication_date":"2014-02-04","ids":{"openalex":"https://openalex.org/W2017484494","doi":"https://doi.org/10.3791/51581","mag":"2017484494","pmid":"https://pubmed.ncbi.nlm.nih.gov/24562185","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4116823"},"language":"en","primary_location":{"id":"doi:10.3791/51581","doi":"https://doi.org/10.3791/51581","is_oa":false,"landing_page_url":"https://doi.org/10.3791/51581","pdf_url":null,"source":{"id":"https://openalex.org/S199738284","display_name":"Journal of Visualized Experiments","issn_l":"1940-087X","issn":["1940-087X","2834-8400"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320416","host_organization_name":"MyJOVE","host_organization_lineage":["https://openalex.org/P4310320416"],"host_organization_lineage_names":["MyJOVE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Visualized Experiments","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4116823","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083654656","display_name":"Lee J. Pribyl","orcid":"https://orcid.org/0000-0003-0209-7814","observed_orcids":["https://orcid.org/0000-0003-0209-7814"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lee J. Pribyl","raw_affiliation_strings":["Department of Obstetrics, Gynecology, and Women's Heath, University of Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics, Gynecology, and Women's Heath, University of Minnesota","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053872135","display_name":"Kathleen A. Coughlin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kathleen A. Coughlin","raw_affiliation_strings":["Department of Obstetrics, Gynecology, and Women's Heath, University of Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics, Gynecology, and Women's Heath, University of Minnesota","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113102184","display_name":"Thanasak Sueblinvong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thanasak Sueblinvong","raw_affiliation_strings":["Department of Obstetrics, Gynecology, and Women's Heath, University of Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics, Gynecology, and Women's Heath, University of Minnesota","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043165760","display_name":"Kristin M. Shields","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210125289","display_name":"Maricopa Medical Center","ror":"https://ror.org/03bbhv598","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210125289","https://openalex.org/I4210152461"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kristin Shields","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Maricopa Medical Center and St Josephs Hospital and Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Maricopa Medical Center and St Josephs Hospital and Medical Center","institution_ids":["https://openalex.org/I4210125289"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108833844","display_name":"Yoshie Iizuka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I4390039358","display_name":"Masonic Cancer Center","ror":"https://ror.org/05x083d20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I130238516","https://openalex.org/I4390039358"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yoshie Iizuka","raw_affiliation_strings":["Department of Obstetrics, Gynecology, and Women's Heath, University of Minnesota; Masonic Cancer Center, University of Minnesota","Department of Obstetrics, Gynecology, and Women's Heath, University of Minnesota","Masonic Cancer Center, University of Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics, Gynecology, and Women's Heath, University of Minnesota; Masonic Cancer Center, University of Minnesota","institution_ids":["https://openalex.org/I130238516","https://openalex.org/I4390039358"]},{"raw_affiliation_string":"Department of Obstetrics, Gynecology, and Women's Heath, University of Minnesota","institution_ids":["https://openalex.org/I130238516"]},{"raw_affiliation_string":"Masonic Cancer Center, University of Minnesota","institution_ids":["https://openalex.org/I130238516","https://openalex.org/I4390039358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110114528","display_name":"Levi S. Downs","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I4390039358","display_name":"Masonic Cancer Center","ror":"https://ror.org/05x083d20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I130238516","https://openalex.org/I4390039358"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Levi S. Downs","raw_affiliation_strings":["Department of Obstetrics, Gynecology, and Women's Heath, University of Minnesota; Masonic Cancer Center, University of Minnesota","Department of Obstetrics, Gynecology, and Women's Heath, University of Minnesota","Masonic Cancer Center, University of Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics, Gynecology, and Women's Heath, University of Minnesota; Masonic Cancer Center, University of Minnesota","institution_ids":["https://openalex.org/I130238516","https://openalex.org/I4390039358"]},{"raw_affiliation_string":"Department of Obstetrics, Gynecology, and Women's Heath, University of Minnesota","institution_ids":["https://openalex.org/I130238516"]},{"raw_affiliation_string":"Masonic Cancer Center, University of Minnesota","institution_ids":["https://openalex.org/I130238516","https://openalex.org/I4390039358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044115888","display_name":"Rahel G. Ghebre","orcid":"https://orcid.org/0000-0001-7049-290X","observed_orcids":["https://orcid.org/0000-0001-7049-290X"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I4390039358","display_name":"Masonic Cancer Center","ror":"https://ror.org/05x083d20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I130238516","https://openalex.org/I4390039358"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rahel G. Ghebre","raw_affiliation_strings":["Department of Obstetrics, Gynecology, and Women's Heath, University of Minnesota; Masonic Cancer Center, University of Minnesota","Department of Obstetrics, Gynecology, and Women's Heath, University of Minnesota","Masonic Cancer Center, University of Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics, Gynecology, and Women's Heath, University of Minnesota; Masonic Cancer Center, University of Minnesota","institution_ids":["https://openalex.org/I130238516","https://openalex.org/I4390039358"]},{"raw_affiliation_string":"Department of Obstetrics, Gynecology, and Women's Heath, University of Minnesota","institution_ids":["https://openalex.org/I130238516"]},{"raw_affiliation_string":"Masonic Cancer Center, University of Minnesota","institution_ids":["https://openalex.org/I130238516","https://openalex.org/I4390039358"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019481339","display_name":"Martina Bazzaro","orcid":"https://orcid.org/0000-0002-9426-9515","observed_orcids":["https://orcid.org/0000-0002-9426-9515"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I4390039358","display_name":"Masonic Cancer Center","ror":"https://ror.org/05x083d20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I130238516","https://openalex.org/I4390039358"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Martina Bazzaro","raw_affiliation_strings":["Department of Obstetrics, Gynecology, and Women's Heath, University of Minnesota; Masonic Cancer Center, University of Minnesota; mbazzaro@umn.edu","Department of Obstetrics, Gynecology, and Women's Heath, University of Minnesota","Masonic Cancer Center, University of Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics, Gynecology, and Women's Heath, University of Minnesota; Masonic Cancer Center, University of Minnesota; mbazzaro@umn.edu","institution_ids":["https://openalex.org/I130238516","https://openalex.org/I4390039358"]},{"raw_affiliation_string":"Department of Obstetrics, Gynecology, and Women's Heath, University of Minnesota","institution_ids":["https://openalex.org/I130238516"]},{"raw_affiliation_string":"Masonic Cancer Center, University of Minnesota","institution_ids":["https://openalex.org/I130238516","https://openalex.org/I4390039358"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.7451,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.74582805,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":null,"issue":"84","first_page":"e51581","last_page":"e51581"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ovarian-cancer","display_name":"ovarian cancer","score":0.6499999761581421},{"id":"https://openalex.org/keywords/enzymatic-digestion","display_name":"enzymatic digestion","score":0.8960000276565552},{"id":"https://openalex.org/keywords/primary-cell-lines","display_name":"primary cell lines","score":0.7400000095367432},{"id":"https://openalex.org/keywords/metastatic-ovarian-cancer","display_name":"metastatic ovarian cancer","score":0.7400000095367432},{"id":"https://openalex.org/keywords/drug-screening","display_name":"drug screening","score":0.7929999828338623},{"id":"https://openalex.org/keywords/tumor-heterogeneity","display_name":"tumor heterogeneity","score":0.5889999866485596}],"concepts":[{"id":"https://openalex.org/C2780427987","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian cancer","level":3,"score":0.935677170753479},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5920869708061218},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5103244185447693},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.47088417410850525},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4237910211086273},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.40398654341697693},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.38658568263053894},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3675054609775543},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.29402053356170654}],"mesh":[{"descriptor_ui":"D000077216","descriptor_name":"Carcinoma, Ovarian Epithelial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003584","descriptor_name":"Cytological Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009375","descriptor_name":"Neoplasms, Glandular and Epithelial","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.3791/51581","doi":"https://doi.org/10.3791/51581","is_oa":false,"landing_page_url":"https://doi.org/10.3791/51581","pdf_url":null,"source":{"id":"https://openalex.org/S199738284","display_name":"Journal of Visualized Experiments","issn_l":"1940-087X","issn":["1940-087X","2834-8400"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320416","host_organization_name":"MyJOVE","host_organization_lineage":["https://openalex.org/P4310320416"],"host_organization_lineage_names":["MyJOVE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Visualized Experiments","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3690154","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4116823","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4116823","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4116823","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Vis Exp","raw_type":"Text"},{"id":"pmid:24562185","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24562185","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of visualized experiments : JoVE","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:3690154","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4116823","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306078","display_name":"U.S. Department of Defense","ror":"https://ror.org/0447fe631"},{"id":"https://openalex.org/F4320307349","display_name":"Minnesota Ovarian Cancer Alliance","ror":"https://ror.org/0205s4214"},{"id":"https://openalex.org/F4320309636","display_name":"University of Minnesota","ror":"https://ror.org/03grvy078"},{"id":"https://openalex.org/F4320314098","display_name":"Randy Shaver Cancer Research and Community Fund","ror":"https://ror.org/02cjqz178"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W1555767072","https://openalex.org/W1973422778","https://openalex.org/W1980260368","https://openalex.org/W1985280742","https://openalex.org/W2023414851","https://openalex.org/W2044822742","https://openalex.org/W2046448644","https://openalex.org/W2065036320","https://openalex.org/W2103580364","https://openalex.org/W2408972802"],"related_works":["https://openalex.org/W4412801161","https://openalex.org/W2103580364","https://openalex.org/W2205836737","https://openalex.org/W2007097356","https://openalex.org/W27844308","https://openalex.org/W2746894177","https://openalex.org/W2044822742","https://openalex.org/W7095887036","https://openalex.org/W2002852712","https://openalex.org/W2062541312"],"abstract_inverted_index":{"Reliable":[0],"tools":[1],"for":[2,24,58,86,101],"investigating":[3],"ovarian":[4,16,26,63,111,117,147],"cancer":[5,17,64,112,118],"initiation":[6],"and":[7,39,97,136],"progression":[8],"are":[9,124,133],"urgently":[10],"needed.":[11],"While":[12],"the":[13,35,40,72,127],"use":[14,29],"of":[15,37,42,61,74,79,109,126],"cell":[18,91,113,119],"lines":[19,114,120],"remains":[20],"a":[21,54],"valuable":[22],"tool":[23],"understanding":[25],"cancer,":[27],"their":[28],"has":[30],"many":[31],"limitations.":[32],"These":[33],"include":[34],"lack":[36],"heterogeneity":[38],"plethora":[41],"genetic":[43],"alterations":[44],"associated":[45],"with":[46],"extended":[47],"in":[48],"vitro":[49],"passaging.":[50],"Here":[51],"we":[52],"describe":[53],"method":[55,77],"that":[56,122],"allows":[57],"rapid":[59],"establishment":[60],"primary":[62,110,144],"cells":[65],"form":[66],"solid":[67],"clinical":[68,81,130],"specimens":[69,82,131],"collected":[70],"at":[71],"time":[73],"surgery.":[75],"The":[76,89,107],"consists":[78],"subjecting":[80],"to":[83,95],"enzymatic":[84],"digestion":[85],"30":[87],"min.":[88],"isolated":[90],"suspension":[92],"is":[93,121],"allowed":[94],"grow":[96],"can":[98,137],"be":[99,138],"used":[100],"downstream":[102],"application":[103],"including":[104],"drug":[105],"screening.":[106],"advantage":[108],"over":[115],"established":[116],"they":[123,132],"representative":[125],"original":[128],"specific":[129],"derived":[134,139],"from":[135,140],"different":[141],"sites":[142],"whether":[143],"or":[145],"metastatic":[146],"cancer.":[148]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}