{"id":"https://openalex.org/W2017482453","doi":null,"title":"Clinical safety of flurazepam and midazolam during 14-day use in chronic insomniacs.","display_name":"Clinical safety of flurazepam and midazolam during 14-day use in chronic insomniacs.","publication_year":1990,"publication_date":"1990-08-01","ids":{"openalex":"https://openalex.org/W2017482453","mag":"2017482453","pmid":"https://pubmed.ncbi.nlm.nih.gov/2229460"},"language":"en","primary_location":{"id":"pmid:2229460","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2229460","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of clinical psychopharmacology","raw_type":"Case Reports"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009634757","display_name":"Michael J. Sateia","orcid":"https://orcid.org/0009-0009-7131-0560","observed_orcids":["https://orcid.org/0009-0009-7131-0560"]},"institutions":[{"id":"https://openalex.org/I1289422878","display_name":"Dartmouth\u2013Hitchcock Medical Center","ror":"https://ror.org/00d1dhh09","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I107672454","https://openalex.org/I1289422878","https://openalex.org/I4390039337"]},{"id":"https://openalex.org/I4390039337","display_name":"Dartmouth Health","ror":"https://ror.org/01pa9ed26","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I107672454","https://openalex.org/I4390039337"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M J Sateia","raw_affiliation_strings":["Sleep Disorders Center, Dartmouth-Hitchcock Medical Center, Hanover, New Hampshire 03756"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sleep Disorders Center, Dartmouth-Hitchcock Medical Center, Hanover, New Hampshire 03756","institution_ids":["https://openalex.org/I1289422878","https://openalex.org/I4390039337"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013860053","display_name":"Peter Hauri","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Hauri","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012766008","display_name":"Daniel F. Kripke","orcid":"https://orcid.org/0000-0002-2318-8179","observed_orcids":["https://orcid.org/0000-0002-2318-8179"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D Kripke","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5041608204","display_name":"Timothy Roehrs","orcid":"https://orcid.org/0000-0001-9237-0153","observed_orcids":["https://orcid.org/0000-0001-9237-0153"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Roehrs","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.21356579,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"10","issue":"4 Suppl","first_page":"28S","last_page":"31S"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10316","display_name":"Sleep and related disorders","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T10316","display_name":"Sleep and related disorders","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10496","display_name":"Pharmaceutical Practices and Patient Outcomes","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10234","display_name":"Obstructive Sleep Apnea Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/flurazepam","display_name":"flurazepam","score":0.9990000128746033},{"id":"https://openalex.org/keywords/midazolam","display_name":"midazolam","score":1.0},{"id":"https://openalex.org/keywords/benzodiazepine-hypnotics","display_name":"benzodiazepine hypnotics","score":0.9129999876022339},{"id":"https://openalex.org/keywords/chronic-insomnia","display_name":"chronic insomnia","score":0.9309999942779541},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.9480000138282776},{"id":"https://openalex.org/keywords/adverse-effects","display_name":"adverse effects","score":0.7059999704360962},{"id":"https://openalex.org/keywords/sleep-apnea","display_name":"sleep apnea","score":0.828000009059906},{"id":"https://openalex.org/keywords/placebo-controlled-comparison","display_name":"placebo comparison","score":0.3919999897480011}],"concepts":[{"id":"https://openalex.org/C2776156762","wikidata":"https://www.wikidata.org/wiki/Q418998","display_name":"Flurazepam","level":4,"score":0.8705112934112549},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.793632984161377},{"id":"https://openalex.org/C2778000748","wikidata":"https://www.wikidata.org/wiki/Q423071","display_name":"Midazolam","level":3,"score":0.7561968564987183},{"id":"https://openalex.org/C2776476923","wikidata":"https://www.wikidata.org/wiki/Q7725","display_name":"Evening","level":2,"score":0.7478829026222229},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.707416296005249},{"id":"https://openalex.org/C2780930544","wikidata":"https://www.wikidata.org/wiki/Q62962","display_name":"Hypnotic","level":2,"score":0.6917849183082581},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.6616993546485901},{"id":"https://openalex.org/C2778173252","wikidata":"https://www.wikidata.org/wiki/Q83871","display_name":"Benzodiazepine","level":3,"score":0.6308172941207886},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.4742264449596405},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.22227272391319275},{"id":"https://openalex.org/C2776814716","wikidata":"https://www.wikidata.org/wiki/Q574801","display_name":"Sedation","level":2,"score":0.1286126971244812},{"id":"https://openalex.org/C1276947","wikidata":"https://www.wikidata.org/wiki/Q333","display_name":"Astronomy","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005479","descriptor_name":"Flurazepam","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D005479","descriptor_name":"Flurazepam","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007319","descriptor_name":"Sleep Initiation and Maintenance Disorders","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008874","descriptor_name":"Midazolam","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D008874","descriptor_name":"Midazolam","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012891","descriptor_name":"Sleep Apnea Syndromes","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:2229460","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2229460","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of clinical psychopharmacology","raw_type":"Case Reports"},{"id":"mag:2017482453","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2229460","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4296275642","https://openalex.org/W2418023049","https://openalex.org/W2138710945","https://openalex.org/W2040819022","https://openalex.org/W2419281617","https://openalex.org/W2063288139","https://openalex.org/W2076966772","https://openalex.org/W2132492995","https://openalex.org/W2076151299","https://openalex.org/W97449018"],"abstract_inverted_index":{"Data":[0],"from":[1],"evening":[2],"questionnaires,":[3],"reports":[4],"of":[5,37,80,118,124,127],"side":[6],"effects,":[7],"laboratory":[8],"findings,":[9],"and":[10,35,58],"all-night":[11],"respiratory":[12],"measurements":[13],"were":[14,28,63,70,95],"collected":[15],"on":[16],"the":[17,32,83,89,111,125],"99":[18,87],"chronic":[19],"insomniacs":[20],"examined":[21],"in":[22,97,107],"this":[23,119],"multicenter":[24],"study.":[25,90],"These":[26],"data":[27],"used":[29],"to":[30],"compare":[31],"clinical":[33],"safety":[34,126],"desirability":[36],"a":[38,42,50,53,66],"benzodiazepine":[39,128],"hypnotic":[40,51],"with":[41,49,52,65],"very":[43],"short":[44],"half-life,":[45,55],"midazolam":[46],"15":[47,57],"mg,":[48],"longer":[54],"flurazepam":[56],"30":[59],"mg;":[60],"both":[61],"compounds":[62],"compared":[64],"placebo":[67,73],"control.":[68],"There":[69,103],"2":[71],"prestudy":[72],"nights":[74,79],"followed":[75],"by":[76],"14":[77],"consecutive":[78],"treatment.":[81],"Of":[82],"107":[84],"patients":[85],"accepted,":[86],"completed":[88],"No":[91],"marked":[92],"adverse":[93],"reactions":[94],"found":[96],"any":[98,101,115],"area":[99],"for":[100,114],"group.":[102,116],"was":[104],"no":[105],"increase":[106],"sleep":[108],"apneas":[109],"during":[110],"treatment":[112],"period":[113],"Results":[117],"study":[120],"provide":[121],"additional":[122],"evidence":[123],"hypnotics.":[129]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
