{"id":"https://openalex.org/W2017479662","doi":"https://doi.org/10.1111/j.1755-9294.2008.00005.x","title":"Inducible nitric oxide mediates systemic microvascular leak following acid aspiration and mechanical ventilation","display_name":"Inducible nitric oxide mediates systemic microvascular leak following acid aspiration and mechanical ventilation","publication_year":2008,"publication_date":"2008-03-01","ids":{"openalex":"https://openalex.org/W2017479662","doi":"https://doi.org/10.1111/j.1755-9294.2008.00005.x","mag":"2017479662"},"language":"en","primary_location":{"id":"doi:10.1111/j.1755-9294.2008.00005.x","doi":"https://doi.org/10.1111/j.1755-9294.2008.00005.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1755-9294.2008.00005.x","pdf_url":null,"source":{"id":"https://openalex.org/S14707475","display_name":"Basic and Applied Pathology","issn_l":"1755-9294","issn":["1755-9294"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Basic and Applied Pathology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://kumel.medlib.dsmc.or.kr/handle/2015.oak/35143","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042335321","display_name":"Jae Hwa Cho","orcid":"https://orcid.org/0000-0002-3432-3997","observed_orcids":["https://orcid.org/0000-0002-3432-3997"]},"institutions":[{"id":"https://openalex.org/I4405261187","display_name":"Keimyung University Dongsan Hospital","ror":"https://ror.org/04xxe0935","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210128080","https://openalex.org/I4405261187"]},{"id":"https://openalex.org/I52010207","display_name":"Keimyung University","ror":"https://ror.org/00tjv0s33","country_code":"KR","type":"education","lineage":["https://openalex.org/I52010207"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Won\u2010Il Choi","raw_affiliation_strings":["Pulmonary Unit, Department of Medicine, Dongsan Hospital, Keimyung University School of Medicine, Daegu, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pulmonary Unit, Department of Medicine, Dongsan Hospital, Keimyung University School of Medicine, Daegu, Korea","institution_ids":["https://openalex.org/I4405261187","https://openalex.org/I52010207"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103443607","display_name":"Deborah A. Quinn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Deborah A Quinn","raw_affiliation_strings":["Pulmonary-Critical Care Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pulmonary-Critical Care Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036741190","display_name":"Kun Young Kwon","orcid":"https://orcid.org/0000-0002-1711-8553","observed_orcids":["https://orcid.org/0000-0002-1711-8553"]},"institutions":[{"id":"https://openalex.org/I4405261187","display_name":"Keimyung University Dongsan Hospital","ror":"https://ror.org/04xxe0935","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210128080","https://openalex.org/I4405261187"]},{"id":"https://openalex.org/I52010207","display_name":"Keimyung University","ror":"https://ror.org/00tjv0s33","country_code":"KR","type":"education","lineage":["https://openalex.org/I52010207"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Kun Young Kwon","raw_affiliation_strings":["Department of Pathology, Dongsan Hospital, Keimyung University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Dongsan Hospital, Keimyung University School of Medicine","institution_ids":["https://openalex.org/I4405261187","https://openalex.org/I52010207"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086651935","display_name":"Kwon Moo Park","orcid":"https://orcid.org/0000-0002-1617-5919","observed_orcids":["https://orcid.org/0000-0002-1617-5919"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kwon Moo Park","raw_affiliation_strings":["Department of Anatomy, Kyungpook University College of Medicine, Daegu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, Kyungpook University College of Medicine, Daegu","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001916792","display_name":"Jeong\u2010Wook Seo","orcid":"https://orcid.org/0000-0003-0242-1805","observed_orcids":["https://orcid.org/0000-0003-0242-1805"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I2802835388","display_name":"Seoul National University Hospital","ror":"https://ror.org/01z4nnt86","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I139264467","https://openalex.org/I2802835388"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jeong Wook Seo","raw_affiliation_strings":["Department of Pathology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea","institution_ids":["https://openalex.org/I139264467","https://openalex.org/I2802835388"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049457557","display_name":"Olga L. Syrkina","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Olga Syrkina","raw_affiliation_strings":["Pulmonary-Critical Care Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pulmonary-Critical Care Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084394132","display_name":"Cristhiaan D. Ochoa","orcid":"https://orcid.org/0000-0001-9113-2137","observed_orcids":["https://orcid.org/0000-0001-9113-2137"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cristhiaan D Ochoa","raw_affiliation_strings":["Pulmonary-Critical Care Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pulmonary-Critical Care Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089781525","display_name":"Joseph Vincent Bonventre","orcid":"https://orcid.org/0000-0001-7144-386X","observed_orcids":["https://orcid.org/0000-0001-7144-386X"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph V Bonventre","raw_affiliation_strings":["Renal Unit, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Renal Unit, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011409227","display_name":"Charles A. Hales","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles A Hales","raw_affiliation_strings":["Pulmonary-Critical Care Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pulmonary-Critical Care Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5042335321"],"corresponding_institution_ids":["https://openalex.org/I4405261187","https://openalex.org/I52010207"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.21438186,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"1","issue":"1","first_page":"23","last_page":"29"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acid-aspiration","display_name":"acid aspiration","score":0.7839999794960022},{"id":"https://openalex.org/keywords/hydrochloric-acid","display_name":"hydrochloric acid","score":0.8820000290870667},{"id":"https://openalex.org/keywords/mechanical-ventilation","display_name":"mechanical ventilation","score":0.9660000205039978},{"id":"https://openalex.org/keywords/high-tidal-volume","display_name":"high tidal volume","score":0.6850000023841858},{"id":"https://openalex.org/keywords/inducible-nitric-oxide-synthase","display_name":"inducible nitric oxide synthase","score":0.9319999814033508},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.9490000009536743},{"id":"https://openalex.org/keywords/kidney-injury","display_name":"kidney injury","score":0.5879999995231628},{"id":"https://openalex.org/keywords/lung-injury","display_name":"lung injury","score":0.9570000171661377},{"id":"https://openalex.org/keywords/proteinuria","display_name":"proteinuria","score":0.9020000100135803},{"id":"https://openalex.org/keywords/l-nil","display_name":"L-NIL","score":0.7540000081062317}],"concepts":[{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.5876635313034058},{"id":"https://openalex.org/C2780378346","wikidata":"https://www.wikidata.org/wiki/Q1349983","display_name":"Leak","level":2,"score":0.5755463242530823},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5390230417251587},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.5274781584739685},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.5244536399841309},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.46897658705711365},{"id":"https://openalex.org/C2777080012","wikidata":"https://www.wikidata.org/wiki/Q3766250","display_name":"Mechanical ventilation","level":2,"score":0.45368021726608276},{"id":"https://openalex.org/C2777649898","wikidata":"https://www.wikidata.org/wiki/Q5415983","display_name":"Evans Blue","level":2,"score":0.44045916199684143},{"id":"https://openalex.org/C2777257755","wikidata":"https://www.wikidata.org/wiki/Q3493813","display_name":"Tidal volume","level":3,"score":0.435874342918396},{"id":"https://openalex.org/C200457457","wikidata":"https://www.wikidata.org/wiki/Q584049","display_name":"Ventilation (architecture)","level":2,"score":0.432608038187027},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.41358378529548645},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3989485204219818},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.33678102493286133},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3279229998588562},{"id":"https://openalex.org/C534529494","wikidata":"https://www.wikidata.org/wiki/Q7891","display_name":"Respiratory system","level":2,"score":0.23576965928077698},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C87717796","wikidata":"https://www.wikidata.org/wiki/Q146326","display_name":"Environmental engineering","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1111/j.1755-9294.2008.00005.x","doi":"https://doi.org/10.1111/j.1755-9294.2008.00005.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1755-9294.2008.00005.x","pdf_url":null,"source":{"id":"https://openalex.org/S14707475","display_name":"Basic and Applied Pathology","issn_l":"1755-9294","issn":["1755-9294"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Basic and Applied Pathology","raw_type":"journal-article"},{"id":"pmh:oai:kumel.medlib.dsmc.or.kr:2015.oak/35143","doi":null,"is_oa":true,"landing_page_url":"http://kumel.medlib.dsmc.or.kr/handle/2015.oak/35143","pdf_url":null,"source":{"id":"https://openalex.org/S4377196386","display_name":"KUMeL Repository (Keimyung University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I52010207","host_organization_name":"Keimyung University","host_organization_lineage":["https://openalex.org/I52010207"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:s-space.snu.ac.kr:10371/3695","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/10371/3695","pdf_url":null,"source":{"id":"https://openalex.org/S4306401345","display_name":"Seoul National University Open Repository (Seoul National University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I139264467","host_organization_name":"Seoul National University","host_organization_lineage":["https://openalex.org/I139264467"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"}],"best_oa_location":{"id":"pmh:oai:kumel.medlib.dsmc.or.kr:2015.oak/35143","doi":null,"is_oa":true,"landing_page_url":"http://kumel.medlib.dsmc.or.kr/handle/2015.oak/35143","pdf_url":null,"source":{"id":"https://openalex.org/S4377196386","display_name":"KUMeL Repository (Keimyung University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I52010207","host_organization_name":"Keimyung University","host_organization_lineage":["https://openalex.org/I52010207"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W79099120","https://openalex.org/W90386804","https://openalex.org/W1601219197","https://openalex.org/W1892829132","https://openalex.org/W1923690398","https://openalex.org/W1956073601","https://openalex.org/W1967245379","https://openalex.org/W1971065785","https://openalex.org/W1982584027","https://openalex.org/W1984689210","https://openalex.org/W1990347899","https://openalex.org/W1992035469","https://openalex.org/W1995784096","https://openalex.org/W2001093269","https://openalex.org/W2018882468","https://openalex.org/W2024330176","https://openalex.org/W2045873616","https://openalex.org/W2068114941","https://openalex.org/W2070506007","https://openalex.org/W2077568216","https://openalex.org/W2077808518","https://openalex.org/W2080572230","https://openalex.org/W2083376892","https://openalex.org/W2087599939","https://openalex.org/W2087957246","https://openalex.org/W2093772735","https://openalex.org/W2094673336","https://openalex.org/W2114365046","https://openalex.org/W2121390660","https://openalex.org/W2127525287","https://openalex.org/W2134812427","https://openalex.org/W2155807245","https://openalex.org/W2160035006","https://openalex.org/W2179702494","https://openalex.org/W2406656179","https://openalex.org/W2411090169","https://openalex.org/W2429421878","https://openalex.org/W2597070792","https://openalex.org/W4240587962"],"related_works":["https://openalex.org/W2083376892","https://openalex.org/W2913238560","https://openalex.org/W2020564957","https://openalex.org/W2041750190","https://openalex.org/W2290183151","https://openalex.org/W1981126790","https://openalex.org/W2122508908","https://openalex.org/W2030935015","https://openalex.org/W2009951439","https://openalex.org/W7100995696"],"abstract_inverted_index":{"ABSTRACT":[0],"Background":[1],"and":[2,32,50,109,127,152,181,204,206],"aims:":[3],"The":[4,190],"systemic":[5,140,222],"effects":[6],"associated":[7],"with":[8,84,96,157,166,187,212],"mechanical":[9,78],"ventilation":[10],"of":[11,43,63,73,101,139],"lungs":[12],"injured":[13],"by":[14,120,128],"hydrochloric":[15],"acid":[16,26,53,188,213],"(HCl)":[17],"aspiration":[18,27,214],"are":[19],"unexplored.":[20],"We":[21],"hypothesize":[22],"that":[23],"low":[24],"dose":[25],"will":[28],"predispose":[29],"the":[30,33,71,169,179,182,198,207,210,221,226],"lung":[31,151,180,203],"kidney":[34,153,183,205],"to":[35,77,155,160,163],"damage":[36],"from":[37],"large":[38],"tidal":[39,98],"volumes":[40],"through":[41],"activation":[42],"inducible":[44],"nitric":[45],"oxide":[46],"synthase":[47],"(iNOS).":[48],"Materials":[49],"methods:":[51],"Hydrochloric":[52],"(HCl;":[54],"pH":[55],"1.25,":[56],"1":[57],"mL/kg),":[58],"or":[59,104,168],"an":[60,137],"equal":[61],"amount":[62],"0.9%":[64],"sodium":[65],"chloride":[66],"(NaCl),":[67],"were":[68,81],"inserted":[69],"into":[70],"trachea":[72],"rats":[74],"immediately":[75],"prior":[76],"ventilation.":[79],"Rats":[80],"then":[82],"ventilated":[83],"room":[85],"air":[86],"at":[87],"85":[88],"breaths":[89],"per":[90],"minute":[91],"for":[92],"2":[93],"hours,":[94],"either":[95,164],"a":[97],"volume":[99],"(VT)":[100],"7":[102],"mL/kg":[103,106],"14":[105],"(VT7,":[107],"VT14)":[108],"zero":[110],"end":[111],"expiratory":[112],"pressure.":[113],"Kidney":[114],"microvascular":[115,141,146,200,223],"leak,":[116],"which":[117],"was":[118,134,175],"assessed":[119],"measuring":[121],"urine":[122],"protein":[123],"over":[124],"24":[125],"hours":[126],"Evans":[129],"blue":[130],"dye":[131],"(EBD)":[132],"technique,":[133],"used":[135],"as":[136],"indicator":[138],"leak.":[142],"Results:":[143],"A":[144],"significant":[145],"leak":[147,201,224],"occurred":[148],"in":[149,178,185,202,209,225],"both":[150],"exposed":[154,162],"VT14":[156,186,211],"HCl":[158,167],"compared":[159],"those":[161],"VT7":[165],"NaCl":[170],"control":[171],"group.":[172,215],"iNOS":[173,193,217],"activity":[174],"significantly":[176],"increased":[177],"tissue":[184],"aspiration.":[189],"relatively":[191],"selective":[192],"inhibitor,":[194],"l\u2010N6\u2010(1\u2010iminoethyl)lysine":[195],"(l\u2010NIL),":[196],"attenuated":[197],"EBD":[199],"proteinuria":[208],"Conclusion:":[216],"may":[218],"have":[219],"mediated":[220],"present":[227],"model.":[228]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
