{"id":"https://openalex.org/W2017477656","doi":"https://doi.org/10.1002/ana.410060616","title":"Acute intoxication with sodium valproate","display_name":"Acute intoxication with sodium valproate","publication_year":1979,"publication_date":"1979-12-01","ids":{"openalex":"https://openalex.org/W2017477656","doi":"https://doi.org/10.1002/ana.410060616","mag":"2017477656","pmid":"https://pubmed.ncbi.nlm.nih.gov/119482"},"language":"en","primary_location":{"id":"doi:10.1002/ana.410060616","doi":"https://doi.org/10.1002/ana.410060616","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ana.410060616","pdf_url":null,"source":{"id":"https://openalex.org/S114530997","display_name":"Annals of Neurology","issn_l":"0364-5134","issn":["0364-5134","1531-8249"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Neurology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048642442","display_name":"David William Chadwick","orcid":"https://orcid.org/0000-0003-3145-055X","observed_orcids":["https://orcid.org/0000-0003-3145-055X"]},"institutions":[{"id":"https://openalex.org/I2800516725","display_name":"Royal Victoria Infirmary","ror":"https://ror.org/01p19k166","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800516725","https://openalex.org/I2801663869"]},{"id":"https://openalex.org/I4210124950","display_name":"Newcastle upon Tyne Hospital","ror":"https://ror.org/02w91w637","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210109172","https://openalex.org/I4210124950"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"D. W. Chadwick","raw_affiliation_strings":["Department of Neurology, Royal Victoria Infirmary, and the Regional Neurological Centre, Newcastle General Hospital, Newcastle upon Tyne, England"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Royal Victoria Infirmary, and the Regional Neurological Centre, Newcastle General Hospital, Newcastle upon Tyne, England","institution_ids":["https://openalex.org/I2800516725","https://openalex.org/I4210124950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113575607","display_name":"W. J. K. Cumming","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800516725","display_name":"Royal Victoria Infirmary","ror":"https://ror.org/01p19k166","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800516725","https://openalex.org/I2801663869"]},{"id":"https://openalex.org/I4210124950","display_name":"Newcastle upon Tyne Hospital","ror":"https://ror.org/02w91w637","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210109172","https://openalex.org/I4210124950"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"W. J. K. Cumming","raw_affiliation_strings":["Department of Neurology, Royal Victoria Infirmary, and the Regional Neurological Centre, Newcastle General Hospital, Newcastle upon Tyne, England"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Royal Victoria Infirmary, and the Regional Neurological Centre, Newcastle General Hospital, Newcastle upon Tyne, England","institution_ids":["https://openalex.org/I2800516725","https://openalex.org/I4210124950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012352123","display_name":"I. Livingstone","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800516725","display_name":"Royal Victoria Infirmary","ror":"https://ror.org/01p19k166","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800516725","https://openalex.org/I2801663869"]},{"id":"https://openalex.org/I4210124950","display_name":"Newcastle upon Tyne Hospital","ror":"https://ror.org/02w91w637","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210109172","https://openalex.org/I4210124950"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"I. Livingstone","raw_affiliation_strings":["Department of Neurology, Royal Victoria Infirmary, and the Regional Neurological Centre, Newcastle General Hospital, Newcastle upon Tyne, England"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Royal Victoria Infirmary, and the Regional Neurological Centre, Newcastle General Hospital, Newcastle upon Tyne, England","institution_ids":["https://openalex.org/I2800516725","https://openalex.org/I4210124950"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111965713","display_name":"N.E.F. Cartlidge","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800516725","display_name":"Royal Victoria Infirmary","ror":"https://ror.org/01p19k166","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800516725","https://openalex.org/I2801663869"]},{"id":"https://openalex.org/I4210124950","display_name":"Newcastle upon Tyne Hospital","ror":"https://ror.org/02w91w637","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210109172","https://openalex.org/I4210124950"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"N. E. F. Cartlidge","raw_affiliation_strings":["Department of Neurology, Royal Victoria Infirmary, and the Regional Neurological Centre, Newcastle General Hospital, Newcastle upon Tyne, England"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Royal Victoria Infirmary, and the Regional Neurological Centre, Newcastle General Hospital, Newcastle upon Tyne, England","institution_ids":["https://openalex.org/I2800516725","https://openalex.org/I4210124950"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5048642442"],"corresponding_institution_ids":["https://openalex.org/I2800516725","https://openalex.org/I4210124950"],"apc_list":{"value":4700,"currency":"USD","value_usd":4700},"apc_paid":null,"fwci":5.9356,"has_fulltext":false,"cited_by_count":72,"citation_normalized_percentile":{"value":0.96014493,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"6","issue":"6","first_page":"552","last_page":"553"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.448199987411499,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.448199987411499,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12229","display_name":"Pharmacological Effects and Toxicity Studies","score":0.3190999925136566,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11635","display_name":"Poisoning and overdose treatments","score":0.2152000069618225,"subfield":{"id":"https://openalex.org/subfields/2711","display_name":"Emergency Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/valproic-acid","display_name":"valproic acid","score":0.9850000143051147},{"id":"https://openalex.org/keywords/drug-toxicity","display_name":"drug toxicity","score":0.7350000143051147},{"id":"https://openalex.org/keywords/epilepsy","display_name":"epilepsy","score":0.6899999976158142},{"id":"https://openalex.org/keywords/dose-reduction","display_name":"dose reduction","score":0.671999990940094},{"id":"https://openalex.org/keywords/seizure-control","display_name":"seizure control","score":0.7089999914169312},{"id":"https://openalex.org/keywords/altered-behavior","display_name":"altered behavior","score":0.6420000195503235},{"id":"https://openalex.org/keywords/confusion","display_name":"confusion","score":0.9100000262260437}],"concepts":[{"id":"https://openalex.org/C2781140086","wikidata":"https://www.wikidata.org/wiki/Q557945","display_name":"Confusion","level":2,"score":0.7704098224639893},{"id":"https://openalex.org/C2777172819","wikidata":"https://www.wikidata.org/wiki/Q240642","display_name":"Valproic Acid","level":3,"score":0.6857634782791138},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5947077870368958},{"id":"https://openalex.org/C537181965","wikidata":"https://www.wikidata.org/wiki/Q658","display_name":"Sodium","level":2,"score":0.554986834526062},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.5325103402137756},{"id":"https://openalex.org/C2778621155","wikidata":"https://www.wikidata.org/wiki/Q576349","display_name":"Encephalopathy","level":2,"score":0.5314233303070068},{"id":"https://openalex.org/C2777257487","wikidata":"https://www.wikidata.org/wiki/Q7830379","display_name":"Toxic encephalopathy","level":3,"score":0.4820905029773712},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.46959272027015686},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.4508303999900818},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.413576602935791},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3366957902908325},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.20842772722244263},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.1267491579055786},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0986860990524292},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C11171543","wikidata":"https://www.wikidata.org/wiki/Q41630","display_name":"Psychoanalysis","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000208","descriptor_name":"Acute Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001927","descriptor_name":"Brain Diseases","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D001927","descriptor_name":"Brain Diseases","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D004827","descriptor_name":"Epilepsy","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014635","descriptor_name":"Valproic Acid","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D014635","descriptor_name":"Valproic Acid","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D014635","descriptor_name":"Valproic Acid","qualifier_ui":"Q000506","qualifier_name":"poisoning","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1002/ana.410060616","doi":"https://doi.org/10.1002/ana.410060616","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ana.410060616","pdf_url":null,"source":{"id":"https://openalex.org/S114530997","display_name":"Annals of Neurology","issn_l":"0364-5134","issn":["0364-5134","1531-8249"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Neurology","raw_type":"journal-article"},{"id":"pmid:119482","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/119482","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of neurology","raw_type":"Case Reports"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":6,"referenced_works":["https://openalex.org/W1964683260","https://openalex.org/W1978173138","https://openalex.org/W1982489437","https://openalex.org/W2015659398","https://openalex.org/W2054779080","https://openalex.org/W2095405908"],"related_works":["https://openalex.org/W2396073119","https://openalex.org/W2096133773","https://openalex.org/W1541512996","https://openalex.org/W2921653165","https://openalex.org/W2078410418","https://openalex.org/W2094527839","https://openalex.org/W4307070338","https://openalex.org/W2412698283","https://openalex.org/W2006739512","https://openalex.org/W2737837257"],"abstract_inverted_index":{"Two":[0],"epileptic":[1],"patients":[2],"developed":[3],"an":[4],"acute":[5],"toxic":[6],"encephalopathy":[7],"consisting":[8],"of":[9,38,49],"altered":[10],"behavior,":[11],"deteriorating":[12],"seizure":[13],"control,":[14],"and":[15],"confusion":[16],"while":[17],"taking":[18],"sodium":[19],"valproate":[20,23,39],"alone.":[21],"Serum":[22],"levels":[24],"were":[25],"greater":[26],"than":[27],"100":[28],"microgram/ml":[29],"in":[30,46],"both.":[31],"Toxic":[32],"symptoms":[33],"resolved":[34],"when":[35],"the":[36,50],"dose":[37],"was":[40],"reduced,":[41],"with":[42],"a":[43],"consequent":[44],"fall":[45],"serum":[47],"concentration":[48],"drug.":[51]},"counts_by_year":[{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
