{"id":"https://openalex.org/W2017477136","doi":"https://doi.org/10.1111/j.1600-051x.2004.00485.x","title":"Association of gingival crevicular fluid and serum intracytoplasmic enzyme levels in periodontally healthy homozygous (major) \u03b2\u2010thalassemia patients","display_name":"Association of gingival crevicular fluid and serum intracytoplasmic enzyme levels in periodontally healthy homozygous (major) \u03b2\u2010thalassemia patients","publication_year":2004,"publication_date":"2004-03-25","ids":{"openalex":"https://openalex.org/W2017477136","doi":"https://doi.org/10.1111/j.1600-051x.2004.00485.x","mag":"2017477136","pmid":"https://pubmed.ncbi.nlm.nih.gov/15086617"},"language":"en","primary_location":{"id":"doi:10.1111/j.1600-051x.2004.00485.x","doi":"https://doi.org/10.1111/j.1600-051x.2004.00485.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1600-051x.2004.00485.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1600-051X.2004.00485.x","source":{"id":"https://openalex.org/S61859066","display_name":"Journal Of Clinical Periodontology","issn_l":"0303-6979","issn":["0303-6979","1600-051X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Periodontology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1600-051X.2004.00485.x","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047287643","display_name":"Lazaros Tsalikis","orcid":"https://orcid.org/0000-0002-2916-3511","observed_orcids":["https://orcid.org/0000-0002-2916-3511"]},"institutions":[{"id":"https://openalex.org/I21370196","display_name":"Aristotle University of Thessaloniki","ror":"https://ror.org/02j61yw88","country_code":"GR","type":"education","lineage":["https://openalex.org/I21370196"]}],"countries":["GR"],"is_corresponding":true,"raw_author_name":"Lazaros E. Tsalikis","raw_affiliation_strings":["Department of Preventive Dentistry, Periodontology and Implant Biology, Dental School, Aristotle University of Thessaloniki, Greece. tsalikis@dent.auth.gr","Department of Preventive Dentistry, Periodontology and Implant Biology Dental School, Aristotle University of Thessaloniki, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Preventive Dentistry, Periodontology and Implant Biology, Dental School, Aristotle University of Thessaloniki, Greece. tsalikis@dent.auth.gr","institution_ids":["https://openalex.org/I21370196"]},{"raw_affiliation_string":"Department of Preventive Dentistry, Periodontology and Implant Biology Dental School, Aristotle University of Thessaloniki, Greece","institution_ids":["https://openalex.org/I21370196"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041029570","display_name":"Eleftherios G. Kaklamanos","orcid":"https://orcid.org/0000-0002-0513-5110","observed_orcids":["https://orcid.org/0000-0002-0513-5110"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eleftherios G. Kaklamanos","raw_affiliation_strings":["Private Practice, Thessaloniki, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Private Practice, Thessaloniki, Greece","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002392011","display_name":"Smaragda Kavadia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I21370196","display_name":"Aristotle University of Thessaloniki","ror":"https://ror.org/02j61yw88","country_code":"GR","type":"education","lineage":["https://openalex.org/I21370196"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Smaragda Kavadia\u2010Tsatala","raw_affiliation_strings":["Department of Orthodontics, Dental School, Aristotle University of Thessaloniki, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthodontics, Dental School, Aristotle University of Thessaloniki, Greece","institution_ids":["https://openalex.org/I21370196"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059876153","display_name":"Eleni Chasapopoulou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I21370196","display_name":"Aristotle University of Thessaloniki","ror":"https://ror.org/02j61yw88","country_code":"GR","type":"education","lineage":["https://openalex.org/I21370196"]},{"id":"https://openalex.org/I2800980381","display_name":"AHEPA University Hospital","ror":"https://ror.org/01q1jaw52","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I2800980381"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Eleni Chasapopoulou","raw_affiliation_strings":["Thalassemia and Sickle-cell Anemia Unit, AHEPA University Hospital, Medical School, Aristotle University of Thessaloniki, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Thalassemia and Sickle-cell Anemia Unit, AHEPA University Hospital, Medical School, Aristotle University of Thessaloniki, Greece","institution_ids":["https://openalex.org/I21370196","https://openalex.org/I2800980381"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083888987","display_name":"Ifigenia Pidonia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I21370196","display_name":"Aristotle University of Thessaloniki","ror":"https://ror.org/02j61yw88","country_code":"GR","type":"education","lineage":["https://openalex.org/I21370196"]},{"id":"https://openalex.org/I2800980381","display_name":"AHEPA University Hospital","ror":"https://ror.org/01q1jaw52","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I2800980381"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Ifigenia Pidonia\u2010Manika","raw_affiliation_strings":["Biochemical Laboratory, AHEPA University Hospital, Medical School, Aristotle University of Thessaloniki, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemical Laboratory, AHEPA University Hospital, Medical School, Aristotle University of Thessaloniki, Greece","institution_ids":["https://openalex.org/I21370196","https://openalex.org/I2800980381"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5047287643"],"corresponding_institution_ids":["https://openalex.org/I21370196"],"apc_list":{"value":5510,"currency":"USD","value_usd":5510},"apc_paid":null,"fwci":0.287,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.5898318,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"31","issue":"5","first_page":"356","last_page":"363"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":0.9789999723434448,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":0.9789999723434448,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.00839999970048666,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13768","display_name":"Oral and gingival health research","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/beta-thalassemia-major","display_name":"beta-thalassemia major","score":0.9470000267028809},{"id":"https://openalex.org/keywords/gingival-crevicular-fluid","display_name":"gingival crevicular fluid","score":0.9829999804496765},{"id":"https://openalex.org/keywords/serum-enzymes","display_name":"serum enzymes","score":0.8270000219345093},{"id":"https://openalex.org/keywords/lactate-dehydrogenase","display_name":"lactate dehydrogenase","score":0.984000027179718},{"id":"https://openalex.org/keywords/aspartate-aminotransferase","display_name":"aspartate aminotransferase","score":0.9990000128746033},{"id":"https://openalex.org/keywords/alanine-aminotransferase","display_name":"alanine aminotransferase","score":1.0},{"id":"https://openalex.org/keywords/periodontal-assessment","display_name":"periodontal assessment","score":0.7990000247955322}],"concepts":[{"id":"https://openalex.org/C2777318727","wikidata":"https://www.wikidata.org/wiki/Q409464","display_name":"Lactate dehydrogenase","level":3,"score":0.7481057643890381},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6976612210273743},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6103584170341492},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5674151182174683},{"id":"https://openalex.org/C2992872382","wikidata":"https://www.wikidata.org/wiki/Q305481","display_name":"Alanine aminotransferase","level":2,"score":0.5575665235519409},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3342565894126892},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.24310719966888428},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.1437031626701355},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08433994650840759}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000410","descriptor_name":"Alanine Transaminase","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D000410","descriptor_name":"Alanine Transaminase","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D001219","descriptor_name":"Aspartate Aminotransferases","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D001219","descriptor_name":"Aspartate Aminotransferases","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005883","descriptor_name":"Gingival Crevicular Fluid","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D006720","descriptor_name":"Homozygote","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007770","descriptor_name":"L-Lactate Dehydrogenase","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D007770","descriptor_name":"L-Lactate Dehydrogenase","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009910","descriptor_name":"Oral Hygiene","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010512","descriptor_name":"Periodontal Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010519","descriptor_name":"Periodontium","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D017086","descriptor_name":"beta-Thalassemia","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D017086","descriptor_name":"beta-Thalassemia","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D017086","descriptor_name":"beta-Thalassemia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018709","descriptor_name":"Statistics, Nonparametric","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1600-051x.2004.00485.x","doi":"https://doi.org/10.1111/j.1600-051x.2004.00485.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1600-051x.2004.00485.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1600-051X.2004.00485.x","source":{"id":"https://openalex.org/S61859066","display_name":"Journal Of Clinical Periodontology","issn_l":"0303-6979","issn":["0303-6979","1600-051X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Periodontology","raw_type":"journal-article"},{"id":"pmid:15086617","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15086617","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of clinical periodontology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1111/j.1600-051x.2004.00485.x","doi":"https://doi.org/10.1111/j.1600-051x.2004.00485.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1600-051x.2004.00485.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1600-051X.2004.00485.x","source":{"id":"https://openalex.org/S61859066","display_name":"Journal Of Clinical Periodontology","issn_l":"0303-6979","issn":["0303-6979","1600-051X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Periodontology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320321917","display_name":"General Secretariat for Research and Technology","ror":"https://ror.org/04yeh8h63"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2017477136.pdf","grobid_xml":"https://content.openalex.org/works/W2017477136.grobid-xml"},"referenced_works_count":59,"referenced_works":["https://openalex.org/W42200071","https://openalex.org/W66152339","https://openalex.org/W1491376074","https://openalex.org/W1503045649","https://openalex.org/W1523677790","https://openalex.org/W1604593335","https://openalex.org/W1696812454","https://openalex.org/W1954422640","https://openalex.org/W1966347979","https://openalex.org/W1968679820","https://openalex.org/W1973303736","https://openalex.org/W1979592990","https://openalex.org/W1979917018","https://openalex.org/W1987360020","https://openalex.org/W1988979439","https://openalex.org/W1992199164","https://openalex.org/W1992871923","https://openalex.org/W2003862510","https://openalex.org/W2010839008","https://openalex.org/W2011424590","https://openalex.org/W2025903772","https://openalex.org/W2027842050","https://openalex.org/W2031292404","https://openalex.org/W2047000481","https://openalex.org/W2048706307","https://openalex.org/W2050921294","https://openalex.org/W2051193475","https://openalex.org/W2054244053","https://openalex.org/W2055777815","https://openalex.org/W2055869583","https://openalex.org/W2059671545","https://openalex.org/W2062964324","https://openalex.org/W2063653505","https://openalex.org/W2067115654","https://openalex.org/W2071859791","https://openalex.org/W2075223615","https://openalex.org/W2080563242","https://openalex.org/W2083242731","https://openalex.org/W2086330855","https://openalex.org/W2094665456","https://openalex.org/W2114102308","https://openalex.org/W2116523495","https://openalex.org/W2117346415","https://openalex.org/W2123657693","https://openalex.org/W2135226017","https://openalex.org/W2139974197","https://openalex.org/W2142115064","https://openalex.org/W2163332711","https://openalex.org/W2163929070","https://openalex.org/W2170455328","https://openalex.org/W2198168714","https://openalex.org/W2316668640","https://openalex.org/W2330217293","https://openalex.org/W2331162460","https://openalex.org/W2408045718","https://openalex.org/W2410468329","https://openalex.org/W2467707462","https://openalex.org/W4206464515","https://openalex.org/W4212971731"],"related_works":["https://openalex.org/W1973348805","https://openalex.org/W2117364493","https://openalex.org/W2355365064","https://openalex.org/W1992199164","https://openalex.org/W1968679820","https://openalex.org/W2050921294","https://openalex.org/W2316668640","https://openalex.org/W2186301831","https://openalex.org/W2023454156","https://openalex.org/W2036871076"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"assess":[2],"tissue":[3,32,67],"necrosis":[4],"in":[5,10,38,44,75,82,101,124,183,191],"beta-thalassemia":[6,97],"major":[7],"patients,":[8],"as":[9],"other":[11],"areas":[12],"of":[13,31,52,66,85,113,133,138,178,194],"medicine,":[14],"lactate":[15],"dehydrogenase":[16],"(LDH),":[17],"aspartate":[18],"aminotransferase":[19,23],"(AST)":[20],"and":[21,105,110,116,142,150,155,166,181],"alanine":[22],"(ALT)":[24],"have":[25,34],"been":[26,36],"widely":[27],"used.":[28],"These":[29],"markers":[30,65],"degradation":[33,68],"also":[35],"studied":[37],"the":[39,72,83,86,102,111,120,131,163,195],"gingival":[40],"crevicular":[41],"fluid":[42],"(GCF)":[43],"relation":[45],"to":[46,56,170],"periodontal":[47,59,88],"disease":[48],"status.":[49,89],"The":[50],"purpose":[51],"this":[53],"study":[54],"was":[55,146],"investigate":[57],"whether":[58],"diagnostic":[60],"tests":[61],"based":[62],"on":[63],"these":[64],"are":[69,158],"influenced":[70],"from":[71],"enzymes'":[73],"levels":[74,112,145],"serum":[76,106,141,151,153,156,184],"and,":[77],"therefore,":[78],"could":[79],"be":[80,171],"used":[81],"assessment":[84],"patient's":[87],"MATERIAL":[90],"AND":[91],"METHODS:":[92],"Forty-four":[93],"periodontally":[94],"healthy,":[95],"homozygous":[96],"patients":[98],"were":[99,108,118,168],"enrolled":[100],"study.":[103],"GCF":[104,143,192],"samples":[107],"obtained":[109],"AST,":[114,152],"ALT":[115,157,167,180],"LDH":[117,149],"determined;":[119],"measurements":[121,193],"took":[122],"place":[123],"an":[125],"automated":[126],"analyzer":[127],"(Hitachi":[128],"777)":[129],"using":[130],"kits":[132],"Roche":[134],"Company.":[135],"RESULTS:":[136],"Lack":[137],"correlations":[139],"between":[140],"enzyme":[144],"demonstrated.":[147],"Serum":[148],"AST":[154,165,182],"significantly":[159,172],"positively":[160,173],"correlated.":[161,174],"Concerning":[162],"GCF,":[164],"proved":[169],"CONCLUSIONS:":[175],"Elevated":[176],"values":[177],"LDH,":[179],"do":[185],"not":[186],"constitute":[187],"a":[188],"confounding":[189],"factor":[190],"respective":[196],"enzymes.":[197]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}