{"id":"https://openalex.org/W2017467476","doi":"https://doi.org/10.1021/bi00747a033","title":"Biosynthesis of chloramphenicol. V. Origin and degradation of the aromatic ring","display_name":"Biosynthesis of chloramphenicol. V. Origin and degradation of the aromatic ring","publication_year":1973,"publication_date":"1973-11-01","ids":{"openalex":"https://openalex.org/W2017467476","doi":"https://doi.org/10.1021/bi00747a033","mag":"2017467476","pmid":"https://pubmed.ncbi.nlm.nih.gov/4773855"},"language":"en","primary_location":{"id":"doi:10.1021/bi00747a033","doi":"https://doi.org/10.1021/bi00747a033","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi00747a033","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027242979","display_name":"William Patrick O'neill","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"William P. O'Neill","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114019161","display_name":"Robert F. Nystrom","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert F. Nystrom","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109209715","display_name":"KENNETH L. Jr. RINEHART","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kenneth L. Rinehart","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"David Gottlieb","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David Gottlieb","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":2.391,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.8691358,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"12","issue":"23","first_page":"4775","last_page":"4784"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13859","display_name":"Organic Chemistry Synthesis Methods","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13736","display_name":"Steroid Chemistry and Biochemistry","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chloramphenicol-biosynthesis","display_name":"chloramphenicol biosynthesis","score":0.984000027179718},{"id":"https://openalex.org/keywords/aromatic-ring-degradation","display_name":"aromatic ring degradation","score":0.9850000143051147},{"id":"https://openalex.org/keywords/antibiotic-biosynthesis","display_name":"antibiotic biosynthesis","score":0.5860000252723694},{"id":"https://openalex.org/keywords/streptomyces","display_name":"Streptomyces","score":0.6140000224113464}],"concepts":[{"id":"https://openalex.org/C2778473333","wikidata":"https://www.wikidata.org/wiki/Q274515","display_name":"Chloramphenicol","level":3,"score":0.8573472499847412},{"id":"https://openalex.org/C2780378348","wikidata":"https://www.wikidata.org/wiki/Q25351438","display_name":"Ring (chemistry)","level":2,"score":0.7367823123931885},{"id":"https://openalex.org/C2779679103","wikidata":"https://www.wikidata.org/wiki/Q5251805","display_name":"Degradation (telecommunications)","level":2,"score":0.6945028305053711},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6078484654426575},{"id":"https://openalex.org/C553450214","wikidata":"https://www.wikidata.org/wiki/Q851162","display_name":"Biosynthesis","level":3,"score":0.6045833826065063},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.4412342309951782},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3557366728782654},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.21096372604370117},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.20722708106040955},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.13126525282859802},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.08367288112640381},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000085","descriptor_name":"Acetates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001407","descriptor_name":"Bacillus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001681","descriptor_name":"Biological Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002250","descriptor_name":"Carbon Radioisotopes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002701","descriptor_name":"Chloramphenicol","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D002701","descriptor_name":"Chloramphenicol","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D002849","descriptor_name":"Chromatography, Gas","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002854","descriptor_name":"Chromatography, Paper","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002855","descriptor_name":"Chromatography, Thin Layer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003470","descriptor_name":"Culture Media","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005990","descriptor_name":"Glycerol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012765","descriptor_name":"Shikimic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013302","descriptor_name":"Streptomyces","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D013302","descriptor_name":"Streptomyces","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/bi00747a033","doi":"https://doi.org/10.1021/bi00747a033","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi00747a033","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},{"id":"pmid:4773855","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4773855","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W89079014","https://openalex.org/W1557393593","https://openalex.org/W1996705755","https://openalex.org/W1998202653","https://openalex.org/W2002528196","https://openalex.org/W2023821219","https://openalex.org/W2032412064","https://openalex.org/W2054372071","https://openalex.org/W2072073207","https://openalex.org/W2080564863","https://openalex.org/W2103865147","https://openalex.org/W2329868771","https://openalex.org/W2330862007","https://openalex.org/W2334613894","https://openalex.org/W2891542075"],"related_works":["https://openalex.org/W2289982380","https://openalex.org/W2515920635","https://openalex.org/W2045927409","https://openalex.org/W2516063125","https://openalex.org/W2155543179","https://openalex.org/W2058131459","https://openalex.org/W2162518180","https://openalex.org/W2019681366","https://openalex.org/W1981585855","https://openalex.org/W1977685772"],"abstract_inverted_index":{"ADVERTISEMENT":[0],"RETURN":[1],"TO":[2],"ISSUEPREVArticleNEXTBiosynthesis":[3],"of":[4,10,57,92,118],"chloramphenicol.":[5],"V.":[6],"Origin":[7],"and":[8,23,67,72,101,145,162,178,180],"degradation":[9],"the":[11,54,85,90,119,130,143,146,151,158,164],"aromatic":[12],"ringWilliam":[13],"P.":[14],"O'Neill,":[15],"Robert":[16],"F.":[17],"Nystrom,":[18],"Kenneth":[19],"L.":[20],"Rinehart,":[21],"Jr.,":[22],"David":[24],"GottliebCite":[25],"this:":[26],"Biochemistry":[27],"1973,":[28],"12,":[29],"23,":[30],"4775\u20134784Publication":[31],"Date":[32],"(Print):November":[33],"1,":[34],"1973Publication":[35],"History":[36],"Published":[37],"online1":[38],"May":[39],"2002Published":[40],"inissue":[41],"1":[42],"November":[43,63],"1973https://pubs.acs.org/doi/10.1021/bi00747a033https://doi.org/10.1021/bi00747a033research-articleACS":[44],"PublicationsRequest":[45],"reuse":[46],"permissionsArticle":[47],"Views129Altmetric-Citations7LEARN":[48],"ABOUT":[49],"THESE":[50],"METRICSArticle":[51],"Views":[52],"are":[53,76,89],"COUNTER-compliant":[55],"sum":[56],"full":[58],"text":[59],"article":[60,124],"downloads":[61],"since":[62],"2008":[64],"(both":[65],"PDF":[66],"HTML)":[68],"across":[69],"all":[70],"institutions":[71],"individuals.":[73],"These":[74],"metrics":[75],"regularly":[77],"updated":[78,102],"to":[79,84],"reflect":[80],"usage":[81],"leading":[82],"up":[83],"last":[86],"few":[87],"days.Citations":[88],"number":[91],"other":[93],"articles":[94],"citing":[95],"this":[96],"article,":[97],"calculated":[98],"by":[99],"Crossref":[100,108],"daily.":[103],"Find":[104,154],"more":[105,155],"information":[106,156],"about":[107,142],"citation":[109],"counts.The":[110],"Altmetric":[111,159],"Attention":[112,160],"Score":[113,161],"is":[114,166],"a":[115,122,135],"quantitative":[116],"measure":[117],"attention":[120],"that":[121],"research":[123],"has":[125],"received":[126],"online.":[127],"Clicking":[128],"on":[129,157],"donut":[131],"icon":[132],"will":[133],"load":[134],"page":[136],"at":[137],"altmetric.com":[138],"with":[139,174],"additional":[140],"details":[141],"score":[144,165],"social":[147],"media":[148],"presence":[149],"for":[150],"given":[152],"article.":[153],"how":[163],"calculated.":[167],"Share":[168,183],"Add":[169],"toView":[170],"InAdd":[171],"Full":[172],"Text":[173],"ReferenceAdd":[175],"Description":[176],"ExportRISCitationCitation":[177],"abstractCitation":[179],"referencesMore":[181],"Options":[182],"onFacebookTwitterWechatLinked":[184],"InRedditEmail":[185],"Other":[186],"access":[187],"optionsGet":[188],"e-Alertsclose":[189],"Get":[190],"e-Alerts":[191]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}