{"id":"https://openalex.org/W2017458992","doi":"https://doi.org/10.1517/14656566.2012.642865","title":"Combination Nucleoside/Nucleotide Reverse Transcriptase Inhibitors for Treatment of HIV Infection","display_name":"Combination Nucleoside/Nucleotide Reverse Transcriptase Inhibitors for Treatment of HIV Infection","publication_year":2011,"publication_date":"2011-12-09","ids":{"openalex":"https://openalex.org/W2017458992","doi":"https://doi.org/10.1517/14656566.2012.642865","mag":"2017458992","pmid":"https://pubmed.ncbi.nlm.nih.gov/22149368"},"language":"en","primary_location":{"id":"doi:10.1517/14656566.2012.642865","doi":"https://doi.org/10.1517/14656566.2012.642865","is_oa":false,"landing_page_url":"https://doi.org/10.1517/14656566.2012.642865","pdf_url":null,"source":{"id":"https://openalex.org/S52020611","display_name":"Expert Opinion on Pharmacotherapy","issn_l":"1465-6566","issn":["1465-6566","1744-7666"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Opinion on Pharmacotherapy","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3397780","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074187192","display_name":"Maxwell Oluwole Akanbi","orcid":"https://orcid.org/0000-0001-6022-2359","observed_orcids":["https://orcid.org/0000-0001-6022-2359"]},"institutions":[{"id":"https://openalex.org/I4210149308","display_name":"Jos University Teaching Hospital","ror":"https://ror.org/042vvex07","country_code":"NG","type":"healthcare","lineage":["https://openalex.org/I4210149308"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"Maxwell O Akanbi","raw_affiliation_strings":["Jos University Teaching Hospital, Department of Internal Medicine, P M B 2076, Jos. Plateau State, 930001, Nigeria","Jos University Teaching Hospital, Department of Internal Medicine,\nP M B 2076, Jos. Plateau State, 930001, Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jos University Teaching Hospital, Department of Internal Medicine, P M B 2076, Jos. Plateau State, 930001, Nigeria","institution_ids":["https://openalex.org/I4210149308"]},{"raw_affiliation_string":"Jos University Teaching Hospital, Department of Internal Medicine,\nP M B 2076, Jos. Plateau State, 930001, Nigeria","institution_ids":["https://openalex.org/I4210149308"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005928906","display_name":"Kimberly K. Scarsi","orcid":"https://orcid.org/0000-0001-9406-693X","observed_orcids":["https://orcid.org/0000-0001-9406-693X"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kimberly Scarsi","raw_affiliation_strings":["Northwestern University Feinberg School of Medicine, Division of Infectious Diseases, Center for Global Health, 645 N. Michigan Ave, Ste 1058, Chicago, IL 60611, USA","Northwestern University Feinberg School of Medicine, Division of Infectious Diseases, Center for Global Health,\n645 N. Michigan Ave, Ste 1058, Chicago, IL 60611, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northwestern University Feinberg School of Medicine, Division of Infectious Diseases, Center for Global Health, 645 N. Michigan Ave, Ste 1058, Chicago, IL 60611, USA","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"Northwestern University Feinberg School of Medicine, Division of Infectious Diseases, Center for Global Health,\n645 N. Michigan Ave, Ste 1058, Chicago, IL 60611, USA","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015872083","display_name":"Babafemi Taiwo","orcid":"https://orcid.org/0000-0003-2661-9103","observed_orcids":["https://orcid.org/0000-0003-2661-9103"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Babafemi Taiwo","raw_affiliation_strings":["Northwestern University, Center for Global Health, Chicago, IL 60611, USA","Northwestern University, Center for Global Health,\nChicago, IL 60611, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northwestern University, Center for Global Health, Chicago, IL 60611, USA","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"Northwestern University, Center for Global Health,\nChicago, IL 60611, USA","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041036157","display_name":"Robert L. Murphy","orcid":"https://orcid.org/0000-0003-3936-2052","observed_orcids":["https://orcid.org/0000-0003-3936-2052","https://orcid.org/0000-0002-9057-5144"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert L Murphy","raw_affiliation_strings":["Northwestern University, Division of infectious Diseases, Chicago, IL 60611, USA +1 312 695 5085; +1 312 695 5088; b-taiwo@northwestern.edu","+1 312 695 5088","Northwestern University, Division of infectious Diseases,\nChicago, IL 60611, USA +1 312 695 5085"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northwestern University, Division of infectious Diseases, Chicago, IL 60611, USA +1 312 695 5085; +1 312 695 5088; b-taiwo@northwestern.edu","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"+1 312 695 5088","institution_ids":[]},{"raw_affiliation_string":"Northwestern University, Division of infectious Diseases,\nChicago, IL 60611, USA +1 312 695 5085","institution_ids":["https://openalex.org/I111979921"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4002,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.6553297,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"13","issue":"1","first_page":"65","last_page":"79"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10082","display_name":"HIV/AIDS Research and Interventions","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-infection","display_name":"HIV infection","score":0.8479999899864197},{"id":"https://openalex.org/keywords/nucleoside-reverse-transcriptase-inhibitors","display_name":"nucleoside reverse transcriptase inhibitors","score":0.9869999885559082},{"id":"https://openalex.org/keywords/nucleotide-reverse-transcriptase-inhibitors","display_name":"nucleotide reverse transcriptase inhibitors","score":0.9990000128746033},{"id":"https://openalex.org/keywords/fixed-dose-combination-antiretroviral-therapy","display_name":"fixed-dose combination antiretroviral therapy","score":0.871999979019165},{"id":"https://openalex.org/keywords/antiretroviral-therapy-regimens","display_name":"antiretroviral therapy regimens","score":0.7950000166893005},{"id":"https://openalex.org/keywords/drug-drug-interactions","display_name":"drug-drug interactions","score":0.8769999742507935},{"id":"https://openalex.org/keywords/antiretroviral-drug-resistance","display_name":"antiretroviral resistance","score":0.8799999952316284},{"id":"https://openalex.org/keywords/hiv-hbv-coinfection","display_name":"HIV/HBV coinfection","score":0.902999997138977},{"id":"https://openalex.org/keywords/hiv-2","display_name":"HIV-2","score":0.9959999918937683},{"id":"https://openalex.org/keywords/pill-burden","display_name":"medication burden","score":0.8569999933242798},{"id":"https://openalex.org/keywords/dosing-frequency","display_name":"dosing frequency","score":0.6370000243186951}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8624040484428406},{"id":"https://openalex.org/C2777351918","wikidata":"https://www.wikidata.org/wiki/Q421559","display_name":"Reverse-transcriptase inhibitor","level":5,"score":0.5599746704101562},{"id":"https://openalex.org/C156719811","wikidata":"https://www.wikidata.org/wiki/Q28774","display_name":"Reverse transcriptase","level":4,"score":0.520551323890686},{"id":"https://openalex.org/C2777288759","wikidata":"https://www.wikidata.org/wiki/Q4164182","display_name":"Dosing","level":2,"score":0.5159774422645569},{"id":"https://openalex.org/C2909970146","wikidata":"https://www.wikidata.org/wiki/Q421559","display_name":"Nucleoside Reverse Transcriptase Inhibitor","level":5,"score":0.47889843583106995},{"id":"https://openalex.org/C2781413609","wikidata":"https://www.wikidata.org/wiki/Q7308373","display_name":"Regimen","level":2,"score":0.46977323293685913},{"id":"https://openalex.org/C2777813720","wikidata":"https://www.wikidata.org/wiki/Q1243018","display_name":"Coinfection","level":3,"score":0.45675545930862427},{"id":"https://openalex.org/C2781432083","wikidata":"https://www.wikidata.org/wiki/Q422645","display_name":"Efavirenz","level":5,"score":0.4481036067008972},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.4234466254711151},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4180355370044708},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3748389780521393},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.33510518074035645},{"id":"https://openalex.org/C2993143319","wikidata":"https://www.wikidata.org/wiki/Q583050","display_name":"Antiretroviral therapy","level":4,"score":0.2903491258621216},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.28638944029808044},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.27396008372306824},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.08806121349334717},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009705","descriptor_name":"Nucleosides","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D009705","descriptor_name":"Nucleosides","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D009705","descriptor_name":"Nucleosides","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D009711","descriptor_name":"Nucleotides","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D009711","descriptor_name":"Nucleotides","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D009711","descriptor_name":"Nucleotides","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D018894","descriptor_name":"Reverse Transcriptase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D018894","descriptor_name":"Reverse Transcriptase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D018894","descriptor_name":"Reverse Transcriptase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D019380","descriptor_name":"Anti-HIV Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D019380","descriptor_name":"Anti-HIV Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D019380","descriptor_name":"Anti-HIV Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1517/14656566.2012.642865","doi":"https://doi.org/10.1517/14656566.2012.642865","is_oa":false,"landing_page_url":"https://doi.org/10.1517/14656566.2012.642865","pdf_url":null,"source":{"id":"https://openalex.org/S52020611","display_name":"Expert Opinion on Pharmacotherapy","issn_l":"1465-6566","issn":["1465-6566","1744-7666"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Opinion on Pharmacotherapy","raw_type":"journal-article"},{"id":"pmid:22149368","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22149368","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert opinion on pharmacotherapy","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2532794","doi":null,"is_oa":false,"landing_page_url":"http://europepmc.org/articles/PMC3397780","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3397780","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3397780","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Expert Opin Pharmacother","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3397780","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3397780","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Expert Opin Pharmacother","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.8500000238418579,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2407837069","display_name":null,"funder_award_id":"D43TW007995","funder_id":"https://openalex.org/F4320337356","funder_display_name":"Fogarty International Center"}],"funders":[{"id":"https://openalex.org/F4320337356","display_name":"Fogarty International Center","ror":"https://ror.org/02xey9a22"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":121,"referenced_works":["https://openalex.org/W32782082","https://openalex.org/W84153590","https://openalex.org/W151722349","https://openalex.org/W202332265","https://openalex.org/W1426208733","https://openalex.org/W1439128072","https://openalex.org/W1550604532","https://openalex.org/W1724881152","https://openalex.org/W1965370152","https://openalex.org/W1968789632","https://openalex.org/W1971987445","https://openalex.org/W1978696458","https://openalex.org/W1978724449","https://openalex.org/W1979035566","https://openalex.org/W1979116787","https://openalex.org/W1980463219","https://openalex.org/W1981280862","https://openalex.org/W1985698850","https://openalex.org/W1986185361","https://openalex.org/W1990951677","https://openalex.org/W1991476347","https://openalex.org/W1996313031","https://openalex.org/W1998204576","https://openalex.org/W2002521249","https://openalex.org/W2003990352","https://openalex.org/W2004813828","https://openalex.org/W2007535230","https://openalex.org/W2010831960","https://openalex.org/W2013129339","https://openalex.org/W2014533894","https://openalex.org/W2015796602","https://openalex.org/W2016257631","https://openalex.org/W2016842950","https://openalex.org/W2017480044","https://openalex.org/W2026323517","https://openalex.org/W2028873388","https://openalex.org/W2029174775","https://openalex.org/W2030384645","https://openalex.org/W2031845569","https://openalex.org/W2032026161","https://openalex.org/W2033101026","https://openalex.org/W2034727191","https://openalex.org/W2041314794","https://openalex.org/W2049287879","https://openalex.org/W2055922999","https://openalex.org/W2056779298","https://openalex.org/W2057392755","https://openalex.org/W2058712798","https://openalex.org/W2061857819","https://openalex.org/W2063546567","https://openalex.org/W2067043659","https://openalex.org/W2067346978","https://openalex.org/W2068616720","https://openalex.org/W2069455040","https://openalex.org/W2071687590","https://openalex.org/W2086785150","https://openalex.org/W2086893453","https://openalex.org/W2088089484","https://openalex.org/W2089493687","https://openalex.org/W2093984759","https://openalex.org/W2095273553","https://openalex.org/W2096070610","https://openalex.org/W2096494132","https://openalex.org/W2098330191","https://openalex.org/W2099736382","https://openalex.org/W2100157044","https://openalex.org/W2101610242","https://openalex.org/W2102136130","https://openalex.org/W2103920597","https://openalex.org/W2107901271","https://openalex.org/W2108978066","https://openalex.org/W2109159474","https://openalex.org/W2109213931","https://openalex.org/W2110937893","https://openalex.org/W2112687747","https://openalex.org/W2113092110","https://openalex.org/W2114281928","https://openalex.org/W2115768301","https://openalex.org/W2117261241","https://openalex.org/W2119433625","https://openalex.org/W2126312216","https://openalex.org/W2127069469","https://openalex.org/W2127518061","https://openalex.org/W2127578660","https://openalex.org/W2128469241","https://openalex.org/W2131730357","https://openalex.org/W2140055542","https://openalex.org/W2141776019","https://openalex.org/W2143161491","https://openalex.org/W2144095981","https://openalex.org/W2144658061","https://openalex.org/W2144920286","https://openalex.org/W2146634980","https://openalex.org/W2148535109","https://openalex.org/W2148750104","https://openalex.org/W2154935934","https://openalex.org/W2155595945","https://openalex.org/W2158715155","https://openalex.org/W2158891667","https://openalex.org/W2161193921","https://openalex.org/W2161654186","https://openalex.org/W2162703468","https://openalex.org/W2162776180","https://openalex.org/W2165548089","https://openalex.org/W2166409471","https://openalex.org/W2168652503","https://openalex.org/W2168665142","https://openalex.org/W2168980838","https://openalex.org/W2171236519","https://openalex.org/W2177271924","https://openalex.org/W2182777591","https://openalex.org/W2183940924","https://openalex.org/W2187081677","https://openalex.org/W2333399282","https://openalex.org/W2334273836","https://openalex.org/W2428830433","https://openalex.org/W2438650709","https://openalex.org/W4238659572","https://openalex.org/W4247605623","https://openalex.org/W4285719527","https://openalex.org/W4300745548"],"related_works":["https://openalex.org/W2021968949","https://openalex.org/W1985622714","https://openalex.org/W2083854818","https://openalex.org/W4240819394","https://openalex.org/W2318685045","https://openalex.org/W2060157537","https://openalex.org/W3129004714","https://openalex.org/W2138414945","https://openalex.org/W2074238145","https://openalex.org/W2042528212"],"abstract_inverted_index":{"INTRODUCTION:":[0],"The":[1,121],"combination":[2,162],"of":[3,118,124,152,175],"two":[4,55],"nucleoside/nucleotide":[5],"reverse":[6,38,44],"transcriptase":[7,39,45],"inhibitors":[8,40],"(N(t)RTIs)":[9],"and":[10,41,50,68,84,104,127,155,178,190],"a":[11,60,92,182],"third":[12],"agent":[13],"from":[14],"another":[15],"antiretroviral":[16,23,81],"class":[17],"is":[18,96,141,181],"currently":[19,35],"recommended":[20],"for":[21,184],"initial":[22],"therapy.":[24,163],"In":[25],"general,":[26],"N(t)RTIs":[27,58,144,171,186],"remain":[28],"relevant":[29],"in":[30,59,98,115,160],"subsequent":[31],"regimens.":[32],"There":[33,180],"are":[34,136],"six":[36],"nucleoside":[37],"one":[42],"nucleotide":[43],"inhibitor":[46],"drug":[47,82],"entities":[48,64],"available,":[49],"several":[51],"formulations":[52],"that":[53,131,143],"include":[54,173],"or":[56],"more":[57],"fixed-dose":[61],"combination.":[62],"These":[63],"have":[65,132],"heterogeneous":[66],"pharmacological":[67,122],"clinical":[69,105,129],"properties.":[70],"Accordingly,":[71],"toxicity,":[72],"pill":[73],"burden,":[74],"dosing":[75],"frequency,":[76],"potential":[77],"drug-drug":[78],"interaction,":[79],"preexisting":[80],"resistance":[83,191],"comorbid":[85],"conditions":[86],"should":[87],"be":[88],"considered":[89],"when":[90],"constructing":[91],"regimen.":[93],"This":[94,109],"approach":[95],"critical":[97],"order":[99],"to":[100,147,170],"optimize":[101],"virologic":[102],"efficacy":[103],"outcomes.":[106],"AREAS":[107],"COVERED:":[108],"article":[110],"reviews":[111],"N(t)RTI":[112],"combinations":[113],"used":[114],"the":[116,128,149],"treatment":[117,134,154,174],"HIV-infected":[119],"adults.":[120],"properties":[123],"each":[125],"N(t)RTI,":[126],"trials":[130],"influenced":[133],"guidelines":[135],"discussed.":[137],"EXPERT":[138],"OPINION:":[139],"It":[140],"likely":[142],"will":[145],"continue":[146],"dominate":[148],"global":[150],"landscape":[151],"HIV":[153],"prevention,":[156],"despite":[157],"emerging":[158],"interest":[159],"N(t)RTI-free":[161],"Clinical":[164],"domains":[165],"where":[166],"only":[167],"few":[168],"alternatives":[169],"exist":[172],"HIV/HBV":[176],"coinfection":[177],"HIV-2.":[179],"need":[183],"novel":[185],"with":[187,194],"enhanced":[188],"safety":[189],"profiles":[192],"compared":[193],"current":[195],"N(t)RTIs.":[196]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-15T10:00:46.086208","created_date":"2025-10-10T00:00:00"}