{"id":"https://openalex.org/W2017443151","doi":"https://doi.org/10.1111/j.1365-2036.2004.01863.x","title":"An enema formulation of alicaforsen, an antisense inhibitor of intercellular adhesion molecule\u20101, in the treatment of chronic, unremitting pouchitis","display_name":"An enema formulation of alicaforsen, an antisense inhibitor of intercellular adhesion molecule\u20101, in the treatment of chronic, unremitting pouchitis","publication_year":2004,"publication_date":"2004-01-20","ids":{"openalex":"https://openalex.org/W2017443151","doi":"https://doi.org/10.1111/j.1365-2036.2004.01863.x","mag":"2017443151","pmid":"https://pubmed.ncbi.nlm.nih.gov/14984374"},"language":"en","primary_location":{"id":"doi:10.1111/j.1365-2036.2004.01863.x","doi":"https://doi.org/10.1111/j.1365-2036.2004.01863.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1365-2036.2004.01863.x","pdf_url":null,"source":{"id":"https://openalex.org/S158079644","display_name":"Alimentary Pharmacology & Therapeutics","issn_l":"0269-2813","issn":["0269-2813","1365-2036"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alimentary Pharmacology &amp; Therapeutics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052471571","display_name":"Philip B. Miner","orcid":"https://orcid.org/0000-0003-0920-6104","observed_orcids":["https://orcid.org/0000-0003-0920-6104"]},"institutions":[{"id":"https://openalex.org/I4210141448","display_name":"Oklahoma Foundation for Digestive Research","ror":"https://ror.org/034c0gr54","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210141448"]},{"id":"https://openalex.org/I49332381","display_name":"University of Oklahoma Health Sciences Center","ror":"https://ror.org/0457zbj98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I49332381"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"P. Miner","raw_affiliation_strings":["Oklahoma Foundation for Digestive Research, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA. jennifer-mackey@ouhsc.edu","Oklahoma Foundation for Digestive Research, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oklahoma Foundation for Digestive Research, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA. jennifer-mackey@ouhsc.edu","institution_ids":["https://openalex.org/I4210141448","https://openalex.org/I49332381"]},{"raw_affiliation_string":"Oklahoma Foundation for Digestive Research, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA,","institution_ids":["https://openalex.org/I4210141448","https://openalex.org/I49332381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111818669","display_name":"Mark K. Wedel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800035258","display_name":"Ionis Pharmaceuticals (United States)","ror":"https://ror.org/00t8bew53","country_code":"US","type":"company","lineage":["https://openalex.org/I2800035258"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Wedel","raw_affiliation_strings":["Isis Pharmaceuticals, Inc., Carlsbad, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Isis Pharmaceuticals, Inc., Carlsbad, CA, USA","institution_ids":["https://openalex.org/I2800035258"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041520040","display_name":"Barbara L. Bane","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I49332381","display_name":"University of Oklahoma Health Sciences Center","ror":"https://ror.org/0457zbj98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I49332381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B. Bane","raw_affiliation_strings":["Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA","institution_ids":["https://openalex.org/I49332381"]}]},{"author_position":"last","author":{"id":null,"display_name":"J. Bradley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800035258","display_name":"Ionis Pharmaceuticals (United States)","ror":"https://ror.org/00t8bew53","country_code":"US","type":"company","lineage":["https://openalex.org/I2800035258"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Bradley","raw_affiliation_strings":["Isis Pharmaceuticals, Inc., Carlsbad, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Isis Pharmaceuticals, Inc., Carlsbad, CA, USA","institution_ids":["https://openalex.org/I2800035258"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5052471571"],"corresponding_institution_ids":["https://openalex.org/I4210141448","https://openalex.org/I49332381"],"apc_list":{"value":5250,"currency":"USD","value_usd":5250},"apc_paid":null,"fwci":8.1702,"has_fulltext":false,"cited_by_count":131,"citation_normalized_percentile":{"value":0.97849387,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"19","issue":"3","first_page":"281","last_page":"286"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11194","display_name":"Ocular Diseases and Beh\u00e7et\u2019s Syndrome","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13569","display_name":"Microscopic Colitis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-pouchitis","display_name":"chronic pouchitis","score":0.8029999732971191},{"id":"https://openalex.org/keywords/enema","display_name":"enema","score":0.6439999938011169},{"id":"https://openalex.org/keywords/antisense-oligonucleotides","display_name":"antisense oligonucleotides","score":0.8029999732971191},{"id":"https://openalex.org/keywords/icam-1","display_name":"ICAM-1","score":0.9750000238418579},{"id":"https://openalex.org/keywords/ileal-pouch-anal-anastomosis","display_name":"ileal pouch-anal anastomosis","score":0.9670000076293945},{"id":"https://openalex.org/keywords/ulcerative-colitis","display_name":"ulcerative colitis","score":0.9079999923706055},{"id":"https://openalex.org/keywords/pouchitis-disease-activity-index","display_name":"Pouchitis Disease Activity Index","score":0.9319999814033508},{"id":"https://openalex.org/keywords/mucosal-healing","display_name":"mucosal healing","score":0.734000027179718},{"id":"https://openalex.org/keywords/topical-drug-delivery","display_name":"topical drug delivery","score":0.7710000276565552},{"id":"https://openalex.org/keywords/pouchoscopy","display_name":"pouchoscopy","score":0.6679999828338623},{"id":"https://openalex.org/keywords/mucosal-histology","display_name":"mucosal histology","score":0.7139999866485596}],"concepts":[{"id":"https://openalex.org/C2779454807","wikidata":"https://www.wikidata.org/wiki/Q3392956","display_name":"Pouchitis","level":4,"score":0.9756618738174438},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9101764559745789},{"id":"https://openalex.org/C2780479503","wikidata":"https://www.wikidata.org/wiki/Q1477","display_name":"Ulcerative colitis","level":3,"score":0.7164329290390015},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.656700849533081},{"id":"https://openalex.org/C2776530707","wikidata":"https://www.wikidata.org/wiki/Q194517","display_name":"Enema","level":2,"score":0.6545292735099792},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5550379157066345},{"id":"https://openalex.org/C2780101441","wikidata":"https://www.wikidata.org/wiki/Q949930","display_name":"Pouch","level":2,"score":0.4607276916503906},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.44684168696403503},{"id":"https://openalex.org/C2778260677","wikidata":"https://www.wikidata.org/wiki/Q917447","display_name":"Inflammatory bowel disease","level":3,"score":0.4241422414779663},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.41777247190475464},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.12797868251800537}],"mesh":[{"descriptor_ui":"D000285","descriptor_name":"Administration, Rectal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000714","descriptor_name":"Anastomosis, Surgical","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D003093","descriptor_name":"Colitis, Ulcerative","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D004733","descriptor_name":"Enema","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005765","descriptor_name":"Gastrointestinal Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013873","descriptor_name":"Thionucleotides","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018799","descriptor_name":"Intercellular Adhesion Molecule-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019449","descriptor_name":"Pouchitis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D019449","descriptor_name":"Pouchitis","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D020319","descriptor_name":"Oligodeoxyribonucleotides, Antisense","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D054735","descriptor_name":"Phosphorothioate Oligonucleotides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1365-2036.2004.01863.x","doi":"https://doi.org/10.1111/j.1365-2036.2004.01863.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1365-2036.2004.01863.x","pdf_url":null,"source":{"id":"https://openalex.org/S158079644","display_name":"Alimentary Pharmacology & Therapeutics","issn_l":"0269-2813","issn":["0269-2813","1365-2036"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alimentary Pharmacology &amp; Therapeutics","raw_type":"journal-article"},{"id":"pmid:14984374","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14984374","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alimentary pharmacology & therapeutics","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":8,"referenced_works":["https://openalex.org/W1998231725","https://openalex.org/W2028767896","https://openalex.org/W2028875662","https://openalex.org/W2058440611","https://openalex.org/W2060291044","https://openalex.org/W2063512218","https://openalex.org/W2086813209","https://openalex.org/W2115778673"],"related_works":["https://openalex.org/W2136988683","https://openalex.org/W6911057837","https://openalex.org/W3208625944","https://openalex.org/W2755202796","https://openalex.org/W3145438949","https://openalex.org/W2045839932","https://openalex.org/W2066551697","https://openalex.org/W2774837576","https://openalex.org/W4231374748","https://openalex.org/W2093119133"],"abstract_inverted_index":{"BACKGROUND:":[0],"Pouchitis":[1,158],"is":[2,18,93,363,405],"the":[3,72,152,157,169,179,206,220,277,293,303,319,376,389,392,395],"major":[4],"long-term":[5],"complication":[6],"of":[7,16,28,59,66,156,191,276,285,292,306,318,341,394],"ileal":[8],"pouch-anal":[9],"anastomosis":[10],"for":[11,45,116],"ulcerative":[12],"colitis.":[13],"The":[14,148,245,344],"incidence":[15],"pouchitis":[17,29,106],"as":[19,21,326],"high":[20],"50%":[22],"several":[23],"years":[24],"after":[25],"surgery.":[26],"Two-thirds":[27],"patients":[30,82,102,279,295,321],"suffer":[31,38],"recurrence.":[32],"Of":[33],"those":[34],"who":[35],"recur,":[36],"one-quarter":[37],"from":[39,154,208,223,252,309,336],"chronic,":[40,84,104],"unremitting":[41,85,105],"pouchitis.":[42],"Current":[43],"treatments":[44],"this":[46,91,399],"disorder":[47,88],"are":[48],"disappointing.":[49],"AIM:":[50],"To":[51],"determine":[52],"whether":[53],"a":[54,87,195,281,298,333,401],"topically":[55],"administered":[56],"enema":[57,114,358],"formulation":[58],"ISIS":[60],"2302":[61],"(alicaforsen),":[62],"an":[63,97,369],"antisense":[64,113],"inhibitor":[65],"intercellular":[67,360],"adhesion":[68,361],"molecule-1,":[69],"can":[70],"improve":[71,375,388],"clinical":[73,249,379],"symptoms,":[74],"endoscopic":[75,382],"mucosal":[76,79,282,383],"appearance":[77,283],"and":[78,121,127,132,142,146,184,230,240,259,270,350,365,381],"histology":[80,304],"in":[81,89,205,219,248,302,324,338,398],"with":[83,103,109,135,332],"pouchitis,":[86],"which":[90],"molecule":[92],"over-expressed.":[94],"METHODS:":[95],"In":[96,368,391],"open-label,":[98],"uncontrolled":[99],"study,":[100],"12":[101,278,294,320],"were":[107,123,234,263,323,347,354],"treated":[108],"240":[110],"mg":[111],"alicaforsen":[112,193,345],"nightly":[115,192],"6":[117,131,145,189,213,232,261],"weeks.":[118],"Clinical":[119],"evaluation":[120],"endoscopy":[122,221],"performed":[124],"at":[125,128,140,143,163,171,289],"baseline":[126,141,155,209,224,253,310,337],"weeks":[129,144,190],"3,":[130],"10.":[133,147,173],"Pouchoscopy":[134],"biopsy":[136],"was":[137,151,175,215],"carried":[138],"out":[139],"primary":[149],"end-point":[150],"reduction":[153,204],"Disease":[159],"Activity":[160],"Index":[161],"(PDAI)":[162],"week":[164,172,212,227,231,256,260,312,315],"6.":[165,313],"Secondary":[166],"end-points":[167],"included":[168],"PDAI":[170,207,308,329,339,377],"Safety":[174],"evaluated":[176],"by":[177,328],"analysing":[178],"adverse":[180],"events,":[181],"vital":[182],"signs":[183],"laboratory":[185],"parameters.":[186],"RESULTS:":[187],"After":[188],"enema,":[194],"statistically":[196,235,265],"significant":[197,236,266,300],"(n":[198],"=":[199,202,238,242,268,272],"12,":[200],"P":[201,241,271],"0.001)":[203],"(11.42)":[210],"to":[211,226,255,311,359,374],"(6.83)":[214],"observed.":[216],"Mean":[217],"reductions":[218,247],"sub-score":[222,251],"(5.25)":[225],"3":[228,257],"(3.08)":[229],"(2.58)":[233],"(P":[237,267],"0.0039":[239],"0.0005,":[243],"respectively).":[244,274],"mean":[246,334],"symptom":[250],"(3.75)":[254],"(2.33)":[258],"(2.25)":[262],"also":[264,387],"0.0156":[269],"0.0117,":[273],"Ten":[275],"achieved":[280],"score":[284,340],"0":[286],"or":[287],"1":[288],"endoscopy.":[290],"Five":[291],"(42%)":[296],"had":[297],"non-statistically":[299],"decrease":[301,335],"component":[305],"their":[307],"By":[314],"6,":[316],"seven":[317],"(58%)":[322],"remission,":[325],"defined":[327],"<":[330],"7,":[331],"six":[342],"points.":[343],"enemas":[346],"well":[348,366],"tolerated":[349],"no":[351],"serious":[352],"side-effects":[353],"noted.":[355],"CONCLUSIONS:":[356],"Antisense":[357],"molecule-1":[362],"safe":[364],"tolerated.":[367],"open-label":[370],"trial,":[371,400],"it":[372],"appeared":[373],"score,":[378],"symptoms":[380],"appearance.":[384],"It":[385],"may":[386],"histology.":[390],"light":[393],"responses":[396],"observed":[397],"randomized,":[402],"placebo-controlled":[403],"trial":[404],"warranted.":[406]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}