{"id":"https://openalex.org/W2017439620","doi":"https://doi.org/10.1097/00001648-200407000-00371","title":"BIOLOGICAL MARKERS OF FETAL LEAD EXPOSURE AT EACH STAGE OF PREGNANCY","display_name":"BIOLOGICAL MARKERS OF FETAL LEAD EXPOSURE AT EACH STAGE OF PREGNANCY","publication_year":2004,"publication_date":"2004-07-01","ids":{"openalex":"https://openalex.org/W2017439620","doi":"https://doi.org/10.1097/00001648-200407000-00371","mag":"2017439620"},"language":"en","primary_location":{"id":"doi:10.1097/00001648-200407000-00371","doi":"https://doi.org/10.1097/00001648-200407000-00371","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00001648-200407000-00371","pdf_url":null,"source":{"id":"https://openalex.org/S15470582","display_name":"Epidemiology","issn_l":"1044-3983","issn":["1044-3983","1531-5487"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Epidemiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053842341","display_name":"H\u00e9ctor Lamadrid\u2010Figueroa","orcid":"https://orcid.org/0000-0001-8775-8399","observed_orcids":["https://orcid.org/0000-0001-8775-8399"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Hector Lamadrid-Figueroa","raw_affiliation_strings":["National Institute of Public Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute of Public Health","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073631691","display_name":"Martha Mar\u00eda T\u00e9llez\u2010Rojo","orcid":"https://orcid.org/0000-0003-3322-3334","observed_orcids":["https://orcid.org/0000-0003-3322-3334"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Martha Maria Tellez-Rojo","raw_affiliation_strings":["National Institute of Public Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute of Public Health","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072669225","display_name":"Leticia Hernandez Cadena","orcid":"https://orcid.org/0000-0003-3807-2758","observed_orcids":["https://orcid.org/0000-0003-3807-2758"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Leticia Hernandez-Cadena","raw_affiliation_strings":["National Institute of Public Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute of Public Health","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007603850","display_name":"Adriana Mercado\u2010Garc\u00eda","orcid":"https://orcid.org/0000-0001-5358-3156","observed_orcids":["https://orcid.org/0000-0001-5358-3156"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Adriana Mercado-Garcia","raw_affiliation_strings":["National Institute of Public Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute of Public Health","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074940124","display_name":"Donald R. Smith","orcid":"https://orcid.org/0000-0002-4919-1042","observed_orcids":["https://orcid.org/0000-0002-4919-1042"]},"institutions":[{"id":"https://openalex.org/I2803209242","display_name":"University of California System","ror":"https://ror.org/00pjdza24","country_code":"US","type":"education","lineage":["https://openalex.org/I2803209242"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Donald Smith","raw_affiliation_strings":["University of California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California","institution_ids":["https://openalex.org/I2803209242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110966854","display_name":"Mauricio Hern\u00e1ndez-\u00c1vila","orcid":"https://orcid.org/0000-0002-0393-7590","observed_orcids":["https://orcid.org/0000-0002-0393-7590"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Mauricio Hernandez-Avila","raw_affiliation_strings":["National Institute of Public Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute of Public Health","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078987114","display_name":"Howard Hu","orcid":"https://orcid.org/0000-0002-3676-2707","observed_orcids":["https://orcid.org/0000-0002-3676-2707"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Howard Hu","raw_affiliation_strings":["National Institute of Public Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute of Public Health","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5007603850","https://openalex.org/A5053842341","https://openalex.org/A5072669225","https://openalex.org/A5073631691","https://openalex.org/A5078987114","https://openalex.org/A5110966854"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2615,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.59383278,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"15","issue":"4","first_page":"S143","last_page":"S143"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10790","display_name":"Heavy Metal Exposure and Toxicity","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10790","display_name":"Heavy Metal Exposure and Toxicity","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10139","display_name":"Heavy metals in environment","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2310","display_name":"Pollution"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10819","display_name":"Mercury impact and mitigation studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fetal-lead-exposure","display_name":"fetal lead exposure","score":0.8679999709129333},{"id":"https://openalex.org/keywords/plasma-lead","display_name":"plasma lead","score":0.6420000195503235},{"id":"https://openalex.org/keywords/whole-blood-lead","display_name":"whole blood lead","score":0.9990000128746033},{"id":"https://openalex.org/keywords/placental-transfer","display_name":"placental transfer","score":0.6359999775886536},{"id":"https://openalex.org/keywords/environmental-lead-exposure","display_name":"environmental lead exposure","score":0.6779999732971191},{"id":"https://openalex.org/keywords/maternal-blood-lead","display_name":"maternal blood lead","score":0.6290000081062317},{"id":"https://openalex.org/keywords/hematocrit","display_name":"hematocrit","score":0.8050000071525574},{"id":"https://openalex.org/keywords/bone-resorption","display_name":"bone resorption","score":0.8169999718666077},{"id":"https://openalex.org/keywords/trimester-differences","display_name":"trimester differences","score":0.47699999809265137}],"concepts":[{"id":"https://openalex.org/C1621761","wikidata":"https://www.wikidata.org/wiki/Q7997549","display_name":"Whole blood","level":2,"score":0.6689493060112},{"id":"https://openalex.org/C2780959883","wikidata":"https://www.wikidata.org/wiki/Q111146","display_name":"Hematocrit","level":2,"score":0.6260676980018616},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.6176491379737854},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.5577126145362854},{"id":"https://openalex.org/C3020026551","wikidata":"https://www.wikidata.org/wiki/Q110315","display_name":"Lead exposure","level":3,"score":0.5385739207267761},{"id":"https://openalex.org/C46973012","wikidata":"https://www.wikidata.org/wiki/Q28627","display_name":"Gestation","level":3,"score":0.5295570492744446},{"id":"https://openalex.org/C2776575606","wikidata":"https://www.wikidata.org/wiki/Q79749","display_name":"Blood plasma","level":2,"score":0.4869000017642975},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.48080316185951233},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.47580772638320923},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4714665710926056},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.37827539443969727},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.36611267924308777},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.33850324153900146},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18799659609794617},{"id":"https://openalex.org/C2779904517","wikidata":"https://www.wikidata.org/wiki/Q5008900","display_name":"CATS","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1097/00001648-200407000-00371","doi":"https://doi.org/10.1097/00001648-200407000-00371","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00001648-200407000-00371","pdf_url":null,"source":{"id":"https://openalex.org/S15470582","display_name":"Epidemiology","issn_l":"1044-3983","issn":["1044-3983","1531-5487"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Epidemiology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7096956827","https://openalex.org/W1977959660","https://openalex.org/W2066695938","https://openalex.org/W7095068194","https://openalex.org/W2102398175","https://openalex.org/W1970631481","https://openalex.org/W2002514019","https://openalex.org/W1985741359","https://openalex.org/W4327518406","https://openalex.org/W2040803869"],"abstract_inverted_index":{"ISEE-348":[0],"Introduction:":[1],"It":[2],"has":[3],"been":[4],"suggested":[5],"that":[6,16,29,221,259],"plasma":[7,45,63,85,101,123,172,177,247,282],"lead":[8,86],"(Pb)":[9],"represents":[10],"the":[11,18,25,34,57,134,137,146,151,158,169,266],"fraction":[12],"of":[13,50,68,96,133,139,168,218,231,244,274],"circulating":[14,39],"Pb":[15,32,46,64,127,173,178,185,193,203,234,239,245,264,275,283,290],"crosses":[17],"placental":[19],"barrier":[20],"with":[21],"consequent":[22],"exposure":[23,276],"to":[24,54,150,215,246],"fetus.":[26],"Evidence":[27],"indicates":[28],"whole":[30,60,125,183,191,288],"blood":[31,61,83,126,184,192,202,263,289],"levels,":[33,174,240],"conventional":[35],"method":[36],"for":[37,166,180,190,201],"measuring":[38],"Pb,":[40],"may":[41,269],"not":[42,200],"adequately":[43],"reflect":[44],"levels.":[47,291],"The":[48,141,161],"objective":[49],"this":[51],"study":[52],"was":[53,143],"longitudinally":[55],"assess":[56],"relationship":[58,121],"between":[59,122],"and":[62,84,93,124,129,153,241,277],"in":[65,73,107,145,157,171],"a":[66,108,112,181,216],"cohort":[67],"environmentally":[69],"exposed":[70],"pregnant":[71,80],"women":[72],"Mexico":[74],"City.":[75],"Methods:":[76],"We":[77,117],"studied":[78],"237":[79],"women.":[81],"Whole":[82],"concentrations":[87],"were":[88,105],"evaluated":[89],"at":[90,237,260,271],"12th,":[91],"24th":[92],"34th":[94],"weeks":[95],"gestation":[97],"by":[98,136],"inductively":[99],"coupled":[100],"mass":[102],"spectrometry.":[103],"Data":[104],"analyzed":[106],"longitudinal":[109],"fashion":[110],"using":[111],"mixed-effects":[113],"regression":[114],"model.":[115],"Results:":[116],"found":[118],"an":[119],"exponential":[120],"levels":[128,179,194,204,265],"sign":[130],"ificant":[131],"modification":[132],"association":[135,142],"stage":[138],"pregnancy.":[140],"stronger":[144],"2nd":[147],"trimester":[148],"relative":[149],"1st,":[152],"it":[154],"further":[155],"increased":[156,176,242,249,280],"3rd":[159],"trimester.":[160],"fitted":[162],"model,":[163],"which":[164],"accounts":[165],"60%":[167],"variability":[170],"predicts":[175],"given":[182],"value":[186],"as":[187,223,227],"pregnancy":[188,224],"advances":[189],"greater":[195,272],"than":[196,206,284],"\u223c110":[197],"\u03bcg/L,":[198],"but":[199],"less":[205],"100":[207],"\u03bcg/L.":[208],"Discussion:":[209],"These":[210],"findings":[211],"could":[212],"be":[213,270],"due":[214],"combination":[217],"physiologic":[219],"changes":[220],"occur":[222],"progresses":[225],"such":[226],"decreasing":[228],"hematocrit,":[229],"saturation":[230],"red":[232],"cell":[233],"binding":[235],"capacity":[236],"higher":[238],"input":[243],"from":[248,279,287],"bone":[250],"resorption":[251],"and/or":[252],"intestinal":[253],"absorption.":[254],"Collectively,":[255],"these":[256],"data":[257],"suggest":[258],"elevated":[261],"maternal":[262,281],"developing":[267],"fetus":[268],"risk":[273],"toxicity":[278],"otherwise":[285],"predicted":[286]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2016-06-24T00:00:00"}