{"id":"https://openalex.org/W2017415976","doi":"https://doi.org/10.1111/j.1398-9995.2004.00576.x","title":"Rupatadine 10 mg and ebastine 10 mg in seasonal allergic rhinitis: a comparison study","display_name":"Rupatadine 10 mg and ebastine 10 mg in seasonal allergic rhinitis: a comparison study","publication_year":2004,"publication_date":"2004-06-04","ids":{"openalex":"https://openalex.org/W2017415976","doi":"https://doi.org/10.1111/j.1398-9995.2004.00576.x","mag":"2017415976","pmid":"https://pubmed.ncbi.nlm.nih.gov/15180765"},"language":"en","primary_location":{"id":"doi:10.1111/j.1398-9995.2004.00576.x","doi":"https://doi.org/10.1111/j.1398-9995.2004.00576.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1398-9995.2004.00576.x","pdf_url":null,"source":{"id":"https://openalex.org/S68090385","display_name":"Allergy","issn_l":"0105-4538","issn":["0105-4538","1398-9995"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Allergy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070355355","display_name":"E Mart\u00ed Guada\u00f1o","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E. M. Guada\u00f1o","raw_affiliation_strings":["Hospital Sant Pere Claver, Barcelona, Spain","Hospital Sant Pere Claver"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Sant Pere Claver, Barcelona, Spain","institution_ids":[]},{"raw_affiliation_string":"Hospital Sant Pere Claver","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110248334","display_name":"Joan Serra-Batll\u00e9s","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. Serra\u2010Batlles","raw_affiliation_strings":["Hospital General de Vic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital General de Vic","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008182726","display_name":"Juan Meseguer","orcid":"https://orcid.org/0009-0004-6610-1258","observed_orcids":["https://orcid.org/0009-0004-6610-1258"]},"institutions":[{"id":"https://openalex.org/I4210125017","display_name":"Hospital General Universitari de Castell\u00f3","ror":"https://ror.org/02yp1e416","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210125017"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"J. Meseguer","raw_affiliation_strings":["Hospital General de Castello\u0301","Hospital General de Castell\u00f3"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital General de Castello\u0301","institution_ids":["https://openalex.org/I4210125017"]},{"raw_affiliation_string":"Hospital General de Castell\u00f3","institution_ids":["https://openalex.org/I4210125017"]}]},{"author_position":"middle","author":{"id":null,"display_name":"J. A. Castillo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I10902133","display_name":"Universitat Jaume I","ror":"https://ror.org/02ws1xc11","country_code":"ES","type":"education","lineage":["https://openalex.org/I10902133"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"J. A. Castillo","raw_affiliation_strings":["Cap Jaume I"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cap Jaume I","institution_ids":["https://openalex.org/I10902133"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058020753","display_name":"Montserrat Molina","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. De Molina","raw_affiliation_strings":["Hospital de la Creu Roja de l'Hospitalet"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital de la Creu Roja de l'Hospitalet","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102743528","display_name":"Antonio Valero","orcid":"https://orcid.org/0000-0002-5543-0345","observed_orcids":["https://orcid.org/0000-0002-5543-0345"]},"institutions":[{"id":"https://openalex.org/I4210115097","display_name":"Hospital Cl\u00ednic de Barcelona","ror":"https://ror.org/02a2kzf50","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210115097"]},{"id":"https://openalex.org/I71999127","display_name":"Universitat de Barcelona","ror":"https://ror.org/021018s57","country_code":"ES","type":"education","lineage":["https://openalex.org/I71999127"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"A. Valero","raw_affiliation_strings":["Hospital Cli\u0301nic, Department of Medicine, Universitat de Barcelona, Barcelona, Spain","Hospital Cl\u00ednic, Department of Medicine, Universitat de Barcelona, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Cli\u0301nic, Department of Medicine, Universitat de Barcelona, Barcelona, Spain","institution_ids":["https://openalex.org/I4210115097","https://openalex.org/I71999127"]},{"raw_affiliation_string":"Hospital Cl\u00ednic, Department of Medicine, Universitat de Barcelona, Barcelona, Spain","institution_ids":["https://openalex.org/I4210115097","https://openalex.org/I71999127"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003561217","display_name":"C\u00e9sar Picado","orcid":"https://orcid.org/0000-0001-7400-4993","observed_orcids":["https://orcid.org/0000-0001-7400-4993"]},"institutions":[{"id":"https://openalex.org/I4210115097","display_name":"Hospital Cl\u00ednic de Barcelona","ror":"https://ror.org/02a2kzf50","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210115097"]},{"id":"https://openalex.org/I71999127","display_name":"Universitat de Barcelona","ror":"https://ror.org/021018s57","country_code":"ES","type":"education","lineage":["https://openalex.org/I71999127"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"C. Picado","raw_affiliation_strings":["Hospital Cli\u0301nic, Department of Medicine, Universitat de Barcelona, Barcelona, Spain","Hospital Cl\u00ednic, Department of Medicine, Universitat de Barcelona, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Cli\u0301nic, Department of Medicine, Universitat de Barcelona, Barcelona, Spain","institution_ids":["https://openalex.org/I4210115097","https://openalex.org/I71999127"]},{"raw_affiliation_string":"Hospital Cl\u00ednic, Department of Medicine, Universitat de Barcelona, Barcelona, Spain","institution_ids":["https://openalex.org/I4210115097","https://openalex.org/I71999127"]}]},{"author_position":"last","author":{"id":null,"display_name":"Rupatadine Study Group","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rupatadine Study Group","raw_affiliation_strings":["For a list of the researchers and their centres see acknowledgements","Hospital Sant Pere Claver"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"For a list of the researchers and their centres see acknowledgements","institution_ids":[]},{"raw_affiliation_string":"Hospital Sant Pere Claver","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5003561217"],"corresponding_institution_ids":["https://openalex.org/I4210115097","https://openalex.org/I71999127"],"apc_list":{"value":5300,"currency":"USD","value_usd":5300},"apc_paid":null,"fwci":1.7545,"has_fulltext":false,"cited_by_count":56,"citation_normalized_percentile":{"value":0.80967812,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"59","issue":"7","first_page":"766","last_page":"771"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10877","display_name":"Allergic Rhinitis and Sensitization","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10877","display_name":"Allergic Rhinitis and Sensitization","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rupatadine","display_name":"rupatadine","score":0.996999979019165},{"id":"https://openalex.org/keywords/ebastine","display_name":"ebastine","score":1.0},{"id":"https://openalex.org/keywords/allergic-rhinitis","display_name":"allergic rhinitis","score":0.996999979019165},{"id":"https://openalex.org/keywords/second-generation-antihistamines","display_name":"second-generation antihistamines","score":0.9350000023841858},{"id":"https://openalex.org/keywords/paf-receptor-antagonism","display_name":"PAF receptor antagonism","score":0.6299999952316284},{"id":"https://openalex.org/keywords/nasal-symptom-score","display_name":"nasal symptom score","score":0.5979999899864197},{"id":"https://openalex.org/keywords/drug-efficacy-and-safety","display_name":"drug safety and efficacy","score":0.7020000219345093},{"id":"https://openalex.org/keywords/once-daily-dosing","display_name":"once-daily dosing","score":0.7279999852180481}],"concepts":[{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.7946344017982483},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.756009578704834},{"id":"https://openalex.org/C2779923671","wikidata":"https://www.wikidata.org/wiki/Q199602","display_name":"Itching","level":2,"score":0.7404183745384216},{"id":"https://openalex.org/C2776880894","wikidata":"https://www.wikidata.org/wiki/Q324089","display_name":"Antihistamine","level":2,"score":0.731907844543457},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.49816036224365234},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.4695573151111603},{"id":"https://openalex.org/C2778311950","wikidata":"https://www.wikidata.org/wiki/Q7363","display_name":"Nose","level":2,"score":0.46820810437202454},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.3923214077949524},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.38464125990867615},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.1591792106628418},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000704","descriptor_name":"Analysis of Variance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002090","descriptor_name":"Butyrophenones","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D002090","descriptor_name":"Butyrophenones","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D003533","descriptor_name":"Cyproheptadine","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D003533","descriptor_name":"Cyproheptadine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D003533","descriptor_name":"Cyproheptadine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006255","descriptor_name":"Rhinitis, Allergic, Seasonal","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006634","descriptor_name":"Histamine H1 Antagonists","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D006634","descriptor_name":"Histamine H1 Antagonists","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010880","descriptor_name":"Piperidines","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D010880","descriptor_name":"Piperidines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D012720","descriptor_name":"Severity of Illness Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018926","descriptor_name":"Anti-Allergic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D018926","descriptor_name":"Anti-Allergic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1398-9995.2004.00576.x","doi":"https://doi.org/10.1111/j.1398-9995.2004.00576.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1398-9995.2004.00576.x","pdf_url":null,"source":{"id":"https://openalex.org/S68090385","display_name":"Allergy","issn_l":"0105-4538","issn":["0105-4538","1398-9995"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Allergy","raw_type":"journal-article"},{"id":"pmid:15180765","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15180765","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Allergy","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9907000064849854,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W189697417","https://openalex.org/W1930304642","https://openalex.org/W1972507936","https://openalex.org/W1995016971","https://openalex.org/W2020721209","https://openalex.org/W2022362725","https://openalex.org/W2023346881","https://openalex.org/W2035279025","https://openalex.org/W2062047724","https://openalex.org/W2068662516","https://openalex.org/W2081529443","https://openalex.org/W2086810127","https://openalex.org/W2105243276","https://openalex.org/W2139119447","https://openalex.org/W2169335265","https://openalex.org/W2171937911"],"related_works":["https://openalex.org/W2185530710","https://openalex.org/W2188585965","https://openalex.org/W128209363","https://openalex.org/W2062047724","https://openalex.org/W2899500212","https://openalex.org/W2015204892","https://openalex.org/W1987722361","https://openalex.org/W2029910677","https://openalex.org/W2979790154","https://openalex.org/W2157000817"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,94,126,186],"aim":[2],"of":[3,13,22,42,51,104,106,135,141,154,184,228],"this":[4],"study":[5,160,211],"is":[6,28],"to":[7,222],"establish":[8],"the":[9,20,45,101,133,136,142,147,152,155,197,210,226],"efficacy":[10,96,250],"and":[11,17,57,75,114,117,123,146,171],"safety":[12],"rupatadine":[14,81,170,176,189,238],"vs":[15],"ebastine":[16,84],"placebo":[18,88,172,223],"in":[19,70,165,224],"treatment":[21],"seasonal":[23],"allergic":[24],"rhinitis":[25],"(SAR).":[26],"Rupatadine":[27,214],"a":[29,61,71,231,240,243],"new":[30],"second":[31],"generation":[32],"H(1)-antihistamine":[33],"with":[34,66,236],"once-daily":[35],"dosing":[36],"that":[37],"may":[38],"provide":[39],"better":[40,244],"control":[41],"symptoms":[43,108,119,144,227],"than":[44,193],"currently":[46],"used":[47],"H(1)-receptor":[48],"blockers":[49],"because":[50],"its":[52],"dual":[53],"pharmacological":[54],"profile":[55,245],"(anti-PAF":[56],"anti-H(1)).":[58],"METHODS:":[59],"In":[60,234],"multicentre":[62],"study,":[63],"250":[64],"patients":[65],"SAR":[67,229],"were":[68,167,190,199,207],"included":[69],"double-blind,":[72],"randomized,":[73],"parallel-group":[74],"placebo-controlled":[76],"study.":[77],"Patients":[78],"received":[79],"either":[80],"10":[82,85,215],"mg,":[83],"mg":[86,216],"or":[87],"once":[89,217],"daily":[90,127,218],"for":[91,139,158,175,188,194],"2":[92,182],"weeks.":[93],"main":[95],"outcome":[97],"was":[98,132,151,219],"based":[99],"on":[100],"patient's":[102],"record":[103],"severity":[105],"nasal":[107,110,115],"(sneezing,":[109],"itching,":[111,121],"runny":[112],"nose":[113],"obstruction)":[116],"nonnasal":[118],"(conjunctival":[120],"tearing":[122],"pharyngeal":[124],"itching).":[125],"total":[128],"symptom":[129],"score":[130],"(DTSS)":[131],"mean":[134,148,153],"DSS":[137],"recorded":[138],"each":[140,159],"seven":[143],"assessed,":[145],"DTSS":[149,156],"(mDTSS)":[150],"values":[157],"day.":[161],"RESULTS:":[162],"Significant":[163],"differences":[164,198],"mDTSS":[166],"detected":[168],"between":[169],"(33%":[173],"lower":[174,192],"group;":[177],"P":[178],"=":[179],"0.005)":[180],"after":[181],"weeks":[183],"treatment.":[185],"TSS":[187],"22%":[191],"ebastine,":[195,237],"although":[196],"not":[200],"statistically":[201],"significant.":[202],"No":[203],"serious":[204],"adverse":[205],"events":[206],"reported":[208],"during":[209],"period.":[212,233],"CONCLUSIONS:":[213],"clearly":[220],"superior":[221],"alleviating":[225],"over":[230],"2-week":[232],"comparison":[235],"shows":[239],"trend":[241],"towards":[242],"as":[246],"regard":[247],"several":[248],"secondary":[249],"variables.":[251]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":8}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}