{"id":"https://openalex.org/W2017412997","doi":"https://doi.org/10.1002/mrd.1080310207","title":"Cortical granule complements in human oocytes undergoing partial zona dissection","display_name":"Cortical granule complements in human oocytes undergoing partial zona dissection","publication_year":1992,"publication_date":"1992-02-01","ids":{"openalex":"https://openalex.org/W2017412997","doi":"https://doi.org/10.1002/mrd.1080310207","mag":"2017412997","pmid":"https://pubmed.ncbi.nlm.nih.gov/1599681"},"language":"en","primary_location":{"id":"doi:10.1002/mrd.1080310207","doi":"https://doi.org/10.1002/mrd.1080310207","is_oa":false,"landing_page_url":"https://doi.org/10.1002/mrd.1080310207","pdf_url":null,"source":{"id":"https://openalex.org/S125242520","display_name":"Molecular Reproduction and Development","issn_l":"1040-452X","issn":["1040-452X","1098-2795"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Reproduction and Development","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025241721","display_name":"Susan E. Lanzendorf","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I156802259","display_name":"Eastern Virginia Medical School","ror":"https://ror.org/056hr4255","country_code":"US","type":"education","lineage":["https://openalex.org/I156802259"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Susan E. Lanzendorf","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Eastern Virginia Medical School, Norfolk"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Eastern Virginia Medical School, Norfolk","institution_ids":["https://openalex.org/I156802259"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023970446","display_name":"Ralph R. Kazer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ralph R. Kazer","raw_affiliation_strings":["Departments of Obstetrics and Gynecology, Section of Reproductive Endocrinology and Infertility, Prentice Women's Hospital, Northwestern University Medical School, Chicago, Illinois"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Obstetrics and Gynecology, Section of Reproductive Endocrinology and Infertility, Prentice Women's Hospital, Northwestern University Medical School, Chicago, Illinois","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111634724","display_name":"Phillip E. Patton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Phillip E. Patton","raw_affiliation_strings":["Departments of Obstetrics and Gynecology, Oregon Health Sciences University, Portland, Oregon"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Obstetrics and Gynecology, Oregon Health Sciences University, Portland, Oregon","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069135894","display_name":"Don P. Wolf","orcid":"https://orcid.org/0000-0001-6900-2045","observed_orcids":["https://orcid.org/0000-0001-6900-2045"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Don P. Wolf","raw_affiliation_strings":["Oregon Health and Science University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oregon Health and Science University","institution_ids":["https://openalex.org/I165690674"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4260,"currency":"USD","value_usd":4260},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.12516746,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"31","issue":"2","first_page":"131","last_page":"134"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11505","display_name":"Reproductive biology and impacts on aquatic species","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cortical-granules","display_name":"cortical granules","score":0.9459999799728394},{"id":"https://openalex.org/keywords/human-oocytes","display_name":"human oocytes","score":0.890999972820282},{"id":"https://openalex.org/keywords/sucrose-treatment","display_name":"sucrose treatment","score":0.718999981880188},{"id":"https://openalex.org/keywords/oocyte-activation","display_name":"oocyte activation","score":0.9319999814033508},{"id":"https://openalex.org/keywords/zona-pellucida","display_name":"zona pellucida","score":0.800000011920929},{"id":"https://openalex.org/keywords/oocyte-aging","display_name":"oocyte aging","score":0.6809999942779541},{"id":"https://openalex.org/keywords/oocyte-culture","display_name":"oocyte culture","score":0.5879999995231628}],"concepts":[{"id":"https://openalex.org/C2779771984","wikidata":"https://www.wikidata.org/wiki/Q16965740","display_name":"Cortical granule","level":4,"score":0.8745805025100708},{"id":"https://openalex.org/C2776690073","wikidata":"https://www.wikidata.org/wiki/Q3246226","display_name":"Oocyte","level":3,"score":0.8041160106658936},{"id":"https://openalex.org/C2776010925","wikidata":"https://www.wikidata.org/wiki/Q219841","display_name":"Zona pellucida","level":4,"score":0.7293599843978882},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7265224456787109},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.6387758255004883},{"id":"https://openalex.org/C2775862295","wikidata":"https://www.wikidata.org/wiki/Q2660911","display_name":"Dissection (medical)","level":2,"score":0.5853238105773926},{"id":"https://openalex.org/C2778597767","wikidata":"https://www.wikidata.org/wiki/Q4027534","display_name":"Sucrose","level":2,"score":0.5426763296127319},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.4493204355239868},{"id":"https://openalex.org/C49760210","wikidata":"https://www.wikidata.org/wiki/Q5596727","display_name":"Granule (geology)","level":2,"score":0.41096729040145874},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.39727097749710083},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2030201554298401},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.09115469455718994},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07989665865898132},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003594","descriptor_name":"Cytoplasmic Granules","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003594","descriptor_name":"Cytoplasmic Granules","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008854","descriptor_name":"Microscopy, Electron","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009865","descriptor_name":"Oocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009865","descriptor_name":"Oocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009865","descriptor_name":"Oocytes","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D010812","descriptor_name":"Physical Stimulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013395","descriptor_name":"Sucrose","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015044","descriptor_name":"Zona Pellucida","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015044","descriptor_name":"Zona Pellucida","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1002/mrd.1080310207","doi":"https://doi.org/10.1002/mrd.1080310207","is_oa":false,"landing_page_url":"https://doi.org/10.1002/mrd.1080310207","pdf_url":null,"source":{"id":"https://openalex.org/S125242520","display_name":"Molecular Reproduction and Development","issn_l":"1040-452X","issn":["1040-452X","1098-2795"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Reproduction and Development","raw_type":"journal-article"},{"id":"pmid:1599681","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1599681","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular reproduction and development","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G834483484","display_name":null,"funder_award_id":"RR-00163.","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"}],"funders":[{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W119711379","https://openalex.org/W1965345243","https://openalex.org/W1965449402","https://openalex.org/W2003572894","https://openalex.org/W2041072713","https://openalex.org/W2074041491","https://openalex.org/W2079304724","https://openalex.org/W2089826191","https://openalex.org/W2108901477","https://openalex.org/W2124327021","https://openalex.org/W2266298601","https://openalex.org/W2398410354","https://openalex.org/W2413399791","https://openalex.org/W3117416719","https://openalex.org/W4229954146"],"related_works":["https://openalex.org/W2041072713","https://openalex.org/W2018128371","https://openalex.org/W2023380256","https://openalex.org/W2080258138","https://openalex.org/W2151032185","https://openalex.org/W2010342859","https://openalex.org/W2507288339","https://openalex.org/W2129496582","https://openalex.org/W2378996540","https://openalex.org/W2046520856"],"abstract_inverted_index":{"This":[0],"study":[1],"was":[2,83],"performed":[3],"to":[4,26],"evaluate":[5],"the":[6,15,48,78],"effects":[7],"of":[8,39,47,51,80,102],"mechanical":[9],"stimulation":[10],"and":[11,20,28,36,99],"sucrose":[12,27,66,68,100],"treatment":[13,69],"on":[14],"oocyte":[16,113],"activation":[17],"process.":[18],"Fresh":[19],"aged":[21],"human":[22,106],"oocytes":[23,61,63,86,107],"were":[24,30],"exposed":[25],"zonae":[29],"dissected":[31],"with":[32,65],"microneedles":[33],"before":[34],"fixation":[35],"quantitative":[37],"analysis":[38],"cortical":[40,52,81],"granules":[41],"by":[42,71],"transmission":[43],"electron":[44],"microscopy.":[45],"Examination":[46],"mean":[49],"number":[50,79],"granules/analyzed":[53],"segment":[54],"revealed":[55],"no":[56],"significant":[57,75],"differences":[58],"between":[59],"control":[60],"or":[62,67],"treated":[64],"followed":[70],"zona":[72,97],"dissection.":[73],"A":[74],"decline":[76],"in":[77,111],"granules/segment":[82],"observed":[84],"for":[85],"undergoing":[87],"prolonged":[88],"culture":[89],"after":[90],"dissection":[91,98],"(P":[92],"less":[93],"than":[94],"0.05).":[95],"Thus,":[96],"exposure":[101],"freshly":[103],"aspirated":[104],"mature":[105],"do":[108],"not":[109],"result":[110],"classical":[112],"activation.":[114]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}