{"id":"https://openalex.org/W2017411547","doi":"https://doi.org/10.1179/136485909x435058","title":"Haematological and clinical-chemistry markers in patients presenting with leptospirosis: a comparison of the findings from uncomplicated cases with those seen in the severe disease","display_name":"Haematological and clinical-chemistry markers in patients presenting with leptospirosis: a comparison of the findings from uncomplicated cases with those seen in the severe disease","publication_year":2009,"publication_date":"2009-05-29","ids":{"openalex":"https://openalex.org/W2017411547","doi":"https://doi.org/10.1179/136485909x435058","mag":"2017411547","pmid":"https://pubmed.ncbi.nlm.nih.gov/19508751"},"language":"en","primary_location":{"id":"doi:10.1179/136485909x435058","doi":"https://doi.org/10.1179/136485909x435058","is_oa":false,"landing_page_url":"https://doi.org/10.1179/136485909x435058","pdf_url":null,"source":{"id":"https://openalex.org/S135866459","display_name":"Annals of Tropical Medicine and Parasitology","issn_l":"0003-4983","issn":["0003-4983","1364-8594"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320442","host_organization_name":"Maney Publishing","host_organization_lineage":["https://openalex.org/P4310320442"],"host_organization_lineage_names":["Maney Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Tropical Medicine & Parasitology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110398237","display_name":"S. B. Craig","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1302211766","display_name":"Queensland Health","ror":"https://ror.org/00c1dt378","country_code":"AU","type":"government","lineage":["https://openalex.org/I1302211766","https://openalex.org/I2801244131"]},{"id":"https://openalex.org/I174025329","display_name":"University of the Sunshine Coast","ror":"https://ror.org/016gb9e15","country_code":"AU","type":"education","lineage":["https://openalex.org/I174025329"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"S. B. Craig","raw_affiliation_strings":["WHO/FAO/OIE Collaborating Centre for Reference and Research on Leptospirosis, Communicable Diseases Unit, Queensland Health Forensic and Scientific Services, P.O. Box 594, Archerfield, Queensland, 4108, Australia. scott_craig@health.qld.gov.au","Faculty of Science, Health and Education, University of the Sunshine Coast, Sippy Downs Drive, Sippy Downs, Queensland, 4556, Australia","WHO/FAO/OIE Collaborating Centre for Reference and Research on Leptospirosis Communicable Diseases Unit, Queensland Health Forensic and Scientific Services, P.O. Box 594, Archerfield, Queensland, 4108, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"WHO/FAO/OIE Collaborating Centre for Reference and Research on Leptospirosis, Communicable Diseases Unit, Queensland Health Forensic and Scientific Services, P.O. Box 594, Archerfield, Queensland, 4108, Australia. scott_craig@health.qld.gov.au","institution_ids":["https://openalex.org/I1302211766"]},{"raw_affiliation_string":"Faculty of Science, Health and Education, University of the Sunshine Coast, Sippy Downs Drive, Sippy Downs, Queensland, 4556, Australia","institution_ids":["https://openalex.org/I174025329"]},{"raw_affiliation_string":"WHO/FAO/OIE Collaborating Centre for Reference and Research on Leptospirosis Communicable Diseases Unit, Queensland Health Forensic and Scientific Services, P.O. Box 594, Archerfield, Queensland, 4108, Australia","institution_ids":["https://openalex.org/I1302211766"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110130572","display_name":"Glenn C. Graham","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1302211766","display_name":"Queensland Health","ror":"https://ror.org/00c1dt378","country_code":"AU","type":"government","lineage":["https://openalex.org/I1302211766","https://openalex.org/I2801244131"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"G. C. Graham","raw_affiliation_strings":["Organic Chemistry Section Chemical Analysis Unit, Queensland Health Forensic and Scientific Services, P.O. Box 594, Archerfield, Queensland, 4108, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Organic Chemistry Section Chemical Analysis Unit, Queensland Health Forensic and Scientific Services, P.O. Box 594, Archerfield, Queensland, 4108, Australia","institution_ids":["https://openalex.org/I1302211766"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109993169","display_name":"Mary\u2010Anne Burns","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1302211766","display_name":"Queensland Health","ror":"https://ror.org/00c1dt378","country_code":"AU","type":"government","lineage":["https://openalex.org/I1302211766","https://openalex.org/I2801244131"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"M.-A. Burns","raw_affiliation_strings":["WHO/FAO/OIE Collaborating Centre for Reference and Research on Leptospirosis Communicable Diseases Unit, Queensland Health Forensic and Scientific Services, P.O. Box 594, Archerfield, Queensland, 4108, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"WHO/FAO/OIE Collaborating Centre for Reference and Research on Leptospirosis Communicable Diseases Unit, Queensland Health Forensic and Scientific Services, P.O. Box 594, Archerfield, Queensland, 4108, Australia","institution_ids":["https://openalex.org/I1302211766"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107412598","display_name":"M. F. Dohnt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1302211766","display_name":"Queensland Health","ror":"https://ror.org/00c1dt378","country_code":"AU","type":"government","lineage":["https://openalex.org/I1302211766","https://openalex.org/I2801244131"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"M. F. Dohnt","raw_affiliation_strings":["WHO/FAO/OIE Collaborating Centre for Reference and Research on Leptospirosis Communicable Diseases Unit, Queensland Health Forensic and Scientific Services, P.O. Box 594, Archerfield, Queensland, 4108, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"WHO/FAO/OIE Collaborating Centre for Reference and Research on Leptospirosis Communicable Diseases Unit, Queensland Health Forensic and Scientific Services, P.O. Box 594, Archerfield, Queensland, 4108, Australia","institution_ids":["https://openalex.org/I1302211766"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110164147","display_name":"Lee D. Smythe","orcid":"https://orcid.org/0009-0009-9689-4806","observed_orcids":["https://orcid.org/0009-0009-9689-4806"]},"institutions":[{"id":"https://openalex.org/I1302211766","display_name":"Queensland Health","ror":"https://ror.org/00c1dt378","country_code":"AU","type":"government","lineage":["https://openalex.org/I1302211766","https://openalex.org/I2801244131"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"L. D. Smythe","raw_affiliation_strings":["WHO/FAO/OIE Collaborating Centre for Reference and Research on Leptospirosis Communicable Diseases Unit, Queensland Health Forensic and Scientific Services, P.O. Box 594, Archerfield, Queensland, 4108, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"WHO/FAO/OIE Collaborating Centre for Reference and Research on Leptospirosis Communicable Diseases Unit, Queensland Health Forensic and Scientific Services, P.O. Box 594, Archerfield, Queensland, 4108, Australia","institution_ids":["https://openalex.org/I1302211766"]}]},{"author_position":"last","author":{"id":null,"display_name":"D. B. McKay","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I174025329","display_name":"University of the Sunshine Coast","ror":"https://ror.org/016gb9e15","country_code":"AU","type":"education","lineage":["https://openalex.org/I174025329"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"D. B. McKay","raw_affiliation_strings":["Faculty of Science Health and Education, University of the Sunshine Coast, Sippy Downs Drive, Sippy Downs, Queensland, 4556, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Science Health and Education, University of the Sunshine Coast, Sippy Downs Drive, Sippy Downs, Queensland, 4556, Australia","institution_ids":["https://openalex.org/I174025329"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.169,"has_fulltext":false,"cited_by_count":34,"citation_normalized_percentile":{"value":0.78196251,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"103","issue":"4","first_page":"333","last_page":"341"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12223","display_name":"Leptospirosis research and findings","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12223","display_name":"Leptospirosis research and findings","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10823","display_name":"Research on Leishmaniasis Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11899","display_name":"Brucella: diagnosis, epidemiology, treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/leptospirosis","display_name":"leptospirosis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/severe-leptospirosis","display_name":"severe leptospirosis","score":0.9879999756813049},{"id":"https://openalex.org/keywords/haematological-markers","display_name":"haematological markers","score":0.8999999761581421},{"id":"https://openalex.org/keywords/disease-severity-assessment","display_name":"disease severity assessment","score":0.7009999752044678},{"id":"https://openalex.org/keywords/hemoglobin","display_name":"hemoglobin","score":0.875},{"id":"https://openalex.org/keywords/hematocrit","display_name":"hematocrit","score":0.7239999771118164},{"id":"https://openalex.org/keywords/white-blood-cell-count","display_name":"white blood cell count","score":0.7429999709129333},{"id":"https://openalex.org/keywords/platelet-count","display_name":"platelet count","score":0.8830000162124634},{"id":"https://openalex.org/keywords/serum-albumin","display_name":"serum albumin","score":0.6940000057220459},{"id":"https://openalex.org/keywords/serum-proteins","display_name":"serum proteins","score":0.7789999842643738},{"id":"https://openalex.org/keywords/creatinine","display_name":"creatinine","score":0.7099999785423279},{"id":"https://openalex.org/keywords/urea","display_name":"urea","score":0.7609999775886536},{"id":"https://openalex.org/keywords/albumin-therapy","display_name":"albumin therapy","score":0.7620000243186951}],"concepts":[{"id":"https://openalex.org/C2778033228","wikidata":"https://www.wikidata.org/wiki/Q155098","display_name":"Leptospirosis","level":2,"score":0.9258842468261719},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.698012113571167},{"id":"https://openalex.org/C2780306776","wikidata":"https://www.wikidata.org/wiki/Q426660","display_name":"Creatinine","level":2,"score":0.6506211757659912},{"id":"https://openalex.org/C2776125364","wikidata":"https://www.wikidata.org/wiki/Q169219","display_name":"Albumin","level":2,"score":0.6126344799995422},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5239277482032776},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.4779203534126282},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4646420478820801},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3557928204536438},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3482207655906677},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3289240300655365},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2950906753540039}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001772","descriptor_name":"Blood Cell Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006400","descriptor_name":"Hematocrit","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006441","descriptor_name":"Hemoglobin A","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007919","descriptor_name":"Leptospira","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D007922","descriptor_name":"Leptospirosis","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D007922","descriptor_name":"Leptospirosis","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010976","descriptor_name":"Platelet Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011793","descriptor_name":"Queensland","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012720","descriptor_name":"Severity of Illness Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1179/136485909x435058","doi":"https://doi.org/10.1179/136485909x435058","is_oa":false,"landing_page_url":"https://doi.org/10.1179/136485909x435058","pdf_url":null,"source":{"id":"https://openalex.org/S135866459","display_name":"Annals of Tropical Medicine and Parasitology","issn_l":"0003-4983","issn":["0003-4983","1364-8594"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320442","host_organization_name":"Maney Publishing","host_organization_lineage":["https://openalex.org/P4310320442"],"host_organization_lineage_names":["Maney Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Tropical Medicine & Parasitology","raw_type":"journal-article"},{"id":"pmid:19508751","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19508751","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of tropical medicine and parasitology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W1528292239","https://openalex.org/W1530786519","https://openalex.org/W1876361883","https://openalex.org/W1902078168","https://openalex.org/W1914946913","https://openalex.org/W1977150432","https://openalex.org/W1979247761","https://openalex.org/W1986282241","https://openalex.org/W1993648008","https://openalex.org/W2005493818","https://openalex.org/W2036833213","https://openalex.org/W2043179128","https://openalex.org/W2069231896","https://openalex.org/W2069375519","https://openalex.org/W2075211044","https://openalex.org/W2079200963","https://openalex.org/W2085914497","https://openalex.org/W2088716190","https://openalex.org/W2102434922","https://openalex.org/W2104934425","https://openalex.org/W2111352111","https://openalex.org/W2112621663","https://openalex.org/W2114332075","https://openalex.org/W2117026738","https://openalex.org/W2126680399","https://openalex.org/W2135517691","https://openalex.org/W2136845531","https://openalex.org/W2151048238","https://openalex.org/W2157801459","https://openalex.org/W2159047625","https://openalex.org/W2168418674","https://openalex.org/W2250170786","https://openalex.org/W2316399484","https://openalex.org/W2407875593","https://openalex.org/W2415522586","https://openalex.org/W2416108452","https://openalex.org/W4211105424","https://openalex.org/W4211128005","https://openalex.org/W4238998962"],"related_works":["https://openalex.org/W4408645244","https://openalex.org/W2148478515","https://openalex.org/W2621403691","https://openalex.org/W2074988147","https://openalex.org/W7098289230","https://openalex.org/W7137245300","https://openalex.org/W4410960173","https://openalex.org/W4245197518","https://openalex.org/W2891245308","https://openalex.org/W2796436869"],"abstract_inverted_index":{"In":[0],"a":[1,32],"retrospective":[2],"study,":[3],"the":[4,8,25,52,66,72,80,115,130,139],"laboratory":[5,48],"findings":[6],"from":[7],"first":[9],"blood":[10],"samples":[11],"taken":[12],"following":[13],"hospital":[14],"presentation":[15],"in":[16,63,88,114,123],"patients":[17,29,73,124,143],"with":[18,24,39,74,79,125,144],"uncomplicated":[19,81],"leptospirosis":[20,76],"have":[21],"been":[22],"compared":[23],"corresponding":[26],"data":[27],"for":[28],"admitted,":[30],"to":[31,45,148],"high-dependency":[33],"medical":[34],"ward":[35],"or":[36],"intensive-care":[37],"unit,":[38],"severe":[40,75],"leptospirosis.":[41,127],"The":[42],"aim":[43],"was":[44],"identify":[46],"those":[47,78],"markers":[49,109],"that":[50],"differentiate":[51],"two":[53],"clinical":[54,140],"groups":[55],"upon":[56],"initial":[57],"presentation.":[58],"Marked":[59],"differences":[60,85],"were":[61,86],"observed,":[62],"some":[64],"of":[65,93,102,120,132,142],"haematological":[67],"and":[68,77,97,99,106,117],"clinical-chemistry":[69],"markers,":[70],"between":[71],"disease.":[82],"Statistically":[83],"significant":[84],"found":[87],"haemoglobin":[89],"concentrations,":[90],"haematocrits,":[91],"counts":[92],"erythrocytes,":[94],"leucocytes,":[95],"neutrophils":[96],"platelets,":[98],"serum":[100],"concentrations":[101],"creatinine,":[103],"urea,":[104],"protein":[105],"albumin.":[107],"These":[108],"may":[110],"therefore":[111],"be":[112,149],"useful":[113],"assessment":[116],"early":[118],"detection":[119],"disease":[121],"severity":[122],"suspected":[126],"Investigations":[128],"into":[129],"use":[131],"albumin":[133],"treatments,":[134],"which":[135],"might":[136],"significantly":[137],"improve":[138],"care":[141],"acute":[145],"leptospirosis,":[146],"appear":[147],"justified.":[150]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":4},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}