{"id":"https://openalex.org/W2017408331","doi":"https://doi.org/10.1186/gm431","title":"Pervasive sequence patents cover the entire human genome","display_name":"Pervasive sequence patents cover the entire human genome","publication_year":2013,"publication_date":"2013-03-25","ids":{"openalex":"https://openalex.org/W2017408331","doi":"https://doi.org/10.1186/gm431","mag":"2017408331","pmid":"https://pubmed.ncbi.nlm.nih.gov/23522065"},"language":"en","primary_location":{"id":"doi:10.1186/gm431","doi":"https://doi.org/10.1186/gm431","is_oa":true,"landing_page_url":"https://doi.org/10.1186/gm431","pdf_url":"https://genomemedicine.biomedcentral.com/counter/pdf/10.1186/gm431","source":{"id":"https://openalex.org/S149201819","display_name":"Genome Medicine","issn_l":"1756-994X","issn":["1756-994X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genome Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://genomemedicine.biomedcentral.com/counter/pdf/10.1186/gm431","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034922709","display_name":"Jeffrey Rosenfeld","orcid":"https://orcid.org/0000-0002-8750-2841","observed_orcids":["https://orcid.org/0000-0002-8750-2841"]},"institutions":[{"id":"https://openalex.org/I1338124936","display_name":"American Museum of Natural History","ror":"https://ror.org/03thb3e06","country_code":"US","type":"archive","lineage":["https://openalex.org/I1338124936"]},{"id":"https://openalex.org/I4405286694","display_name":"University of Medicine and Dentistry of New Jersey","ror":"https://ror.org/02tvvmk84","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142","https://openalex.org/I4405286694"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey A Rosenfeld","raw_affiliation_strings":["IST/Division of High Performance and Research Computing at the University of Medicine & Dentistry of New Jersey, South Orange Avenue, Newark, NJ 07103, USA ; American Museum of Natural History, Sackler Institute for Comparative Genomics, Central Park West at 79th Street, New York, NY 10024, USA","IST/Division of High Performance and Research Computing at the University of Medicine & Dentistry of New Jersey, South Orange Avenue, Newark, NJ, 07103, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IST/Division of High Performance and Research Computing at the University of Medicine & Dentistry of New Jersey, South Orange Avenue, Newark, NJ 07103, USA ; American Museum of Natural History, Sackler Institute for Comparative Genomics, Central Park West at 79th Street, New York, NY 10024, USA","institution_ids":["https://openalex.org/I1338124936","https://openalex.org/I4405286694"]},{"raw_affiliation_string":"IST/Division of High Performance and Research Computing at the University of Medicine & Dentistry of New Jersey, South Orange Avenue, Newark, NJ, 07103, USA","institution_ids":["https://openalex.org/I4405286694"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085435765","display_name":"Christopher E. Mason","orcid":"https://orcid.org/0000-0002-1850-1642","observed_orcids":["https://orcid.org/0000-0002-1850-1642"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Christopher E Mason","raw_affiliation_strings":["Department of Physiology and Biophysics, Weill Medical College, Cornell University, New York, NY 10065, USA ; HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Medical College, Cornell University, New York, NY 10065, USA ; The Information Society Project, Yale Law School, New Haven, CT 06520, USA","Department of Physiology and Biophysics, Weill Medical College, Cornell University, New York, NY, 10065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Biophysics, Weill Medical College, Cornell University, New York, NY 10065, USA ; HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Medical College, Cornell University, New York, NY 10065, USA ; The Information Society Project, Yale Law School, New Haven, CT 06520, USA","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]},{"raw_affiliation_string":"Department of Physiology and Biophysics, Weill Medical College, Cornell University, New York, NY, 10065, USA","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5085435765"],"corresponding_institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4387153466"],"apc_list":{"value":5290,"currency":"USD","value_usd":5290},"apc_paid":{"value":5290,"currency":"USD","value_usd":5290},"fwci":18.0847,"has_fulltext":true,"cited_by_count":37,"citation_normalized_percentile":{"value":0.98982614,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"5","issue":"3","first_page":"27","last_page":"27"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10856","display_name":"Intellectual Property and Patents","score":0.8428000211715698,"subfield":{"id":"https://openalex.org/subfields/1405","display_name":"Management of Technology and Innovation"},"field":{"id":"https://openalex.org/fields/14","display_name":"Business, Management and Accounting"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T10856","display_name":"Intellectual Property and Patents","score":0.8428000211715698,"subfield":{"id":"https://openalex.org/subfields/1405","display_name":"Management of Technology and Innovation"},"field":{"id":"https://openalex.org/fields/14","display_name":"Business, Management and Accounting"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T13842","display_name":"Intellectual Property Law","score":0.10270000249147415,"subfield":{"id":"https://openalex.org/subfields/3308","display_name":"Law"},"field":{"id":"https://openalex.org/fields/33","display_name":"Social Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T13851","display_name":"Law, AI, and Intellectual Property","score":0.008299999870359898,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gene-patents","display_name":"gene patents","score":0.9440000057220459},{"id":"https://openalex.org/keywords/human-genome","display_name":"human genome","score":0.6340000033378601},{"id":"https://openalex.org/keywords/brca1","display_name":"BRCA1","score":0.7590000033378601},{"id":"https://openalex.org/keywords/united-states-supreme-court","display_name":"United States Supreme Court","score":0.7049999833106995},{"id":"https://openalex.org/keywords/intellectual-property","display_name":"intellectual property","score":0.49300000071525574},{"id":"https://openalex.org/keywords/targeted-re-sequencing","display_name":"targeted re-sequencing","score":0.9259999990463257}],"concepts":[{"id":"https://openalex.org/C197077220","wikidata":"https://www.wikidata.org/wiki/Q720988","display_name":"Human genome","level":4,"score":0.7403072714805603},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6055147647857666},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5809327960014343},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.5672630071640015},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.47990453243255615},{"id":"https://openalex.org/C62177273","wikidata":"https://www.wikidata.org/wiki/Q5531556","display_name":"Gene nomenclature","level":4,"score":0.47321218252182007},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.395906925201416},{"id":"https://openalex.org/C514705636","wikidata":"https://www.wikidata.org/wiki/Q863247","display_name":"Nomenclature","level":3,"score":0.08962330222129822},{"id":"https://openalex.org/C58642233","wikidata":"https://www.wikidata.org/wiki/Q8269924","display_name":"Taxonomy (biology)","level":2,"score":0.0},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1186/gm431","doi":"https://doi.org/10.1186/gm431","is_oa":true,"landing_page_url":"https://doi.org/10.1186/gm431","pdf_url":"https://genomemedicine.biomedcentral.com/counter/pdf/10.1186/gm431","source":{"id":"https://openalex.org/S149201819","display_name":"Genome Medicine","issn_l":"1756-994X","issn":["1756-994X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genome Medicine","raw_type":"journal-article"},{"id":"pmid:23522065","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23522065","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genome medicine","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2706394","doi":null,"is_oa":false,"landing_page_url":"http://europepmc.org/articles/PMC3706854","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3706854","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3706854","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Genome Med","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/gm431","doi":"https://doi.org/10.1186/gm431","is_oa":true,"landing_page_url":"https://doi.org/10.1186/gm431","pdf_url":"https://genomemedicine.biomedcentral.com/counter/pdf/10.1186/gm431","source":{"id":"https://openalex.org/S149201819","display_name":"Genome Medicine","issn_l":"1756-994X","issn":["1756-994X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genome Medicine","raw_type":"journal-article"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320337348","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2017408331.pdf","grobid_xml":"https://content.openalex.org/works/W2017408331.grobid-xml"},"referenced_works_count":19,"referenced_works":["https://openalex.org/W127721222","https://openalex.org/W1681219967","https://openalex.org/W1973690102","https://openalex.org/W1978554685","https://openalex.org/W2008420899","https://openalex.org/W2008576283","https://openalex.org/W2017775269","https://openalex.org/W2024071709","https://openalex.org/W2037444377","https://openalex.org/W2079273360","https://openalex.org/W2101735289","https://openalex.org/W2110820132","https://openalex.org/W2114820744","https://openalex.org/W2124985265","https://openalex.org/W2127768708","https://openalex.org/W2132762486","https://openalex.org/W2142678478","https://openalex.org/W2233549744","https://openalex.org/W2772971838"],"related_works":["https://openalex.org/W2987420353","https://openalex.org/W1902770889","https://openalex.org/W1491897707","https://openalex.org/W1969895229","https://openalex.org/W2108497208","https://openalex.org/W1970768498","https://openalex.org/W2151043263","https://openalex.org/W2351145408","https://openalex.org/W783423684","https://openalex.org/W2017408331"],"abstract_inverted_index":{"The":[0,87],"scope":[1],"and":[2,67,122,179,186,201],"eligibility":[3],"of":[4,22,61,133,163],"patents":[5,20,44,125,156,175],"for":[6,12,176,192],"genetic":[7],"sequences":[8,51,76,109,182],"have":[9,38,170],"been":[10,171],"debated":[11],"decades,":[13],"but":[14,58],"a":[15],"critical":[16],"case":[17],"regarding":[18],"gene":[19,89,98],"(Association":[21],"Molecular":[23],"Pathologists":[24],"v.":[25],"Myriad":[26],"Genetics)":[27],"is":[28],"now":[29],"reaching":[30],"the":[31,40,68,96,134,137,164,167],"US":[32,64,155],"Supreme":[33],"Court.":[34],"Recent":[35],"court":[36],"rulings":[37],"supported":[39],"assertion":[41],"that":[42,74,161],"such":[43],"can":[45],"provide":[46],"intellectual":[47],"property":[48],"rights":[49],"on":[50,151],"as":[52,54,94,129,131],"small":[53],"15":[55],"nucleotides":[56],"(15mers),":[57],"an":[59,188],"analysis":[60,146],"all":[62,78,154],"current":[63,174],"patent":[65,149],"claims":[66,119,150],"human":[69,79,138,168],"genome":[70,169],"presented":[71],"here":[72],"shows":[73],"15mer":[75],"from":[77,120,153],"genes":[80,93,135,165],"match":[81],"at":[82,103],"least":[83,104],"one":[84],"other":[85,92,106,123,202],"gene.":[86],"average":[88],"matches":[90],"364":[91],"15mers;":[95],"breast-cancer-associated":[97],"BRCA1":[99],"has":[100],"15mers":[101],"matching":[102],"689":[105],"genes.":[107],"Longer":[108],"(1,000":[110],"bp)":[111],"still":[112],"showed":[113],"extensive":[114],"cross-gene":[115],"matches.":[116],"Furthermore,":[117],"15mer-length":[118],"bovine":[121],"animal":[124],"could":[126],"also":[127],"claim":[128],"much":[130],"84%":[132],"in":[136,166,196],"genome.":[139],"In":[140],"addition,":[141],"when":[142],"we":[143,159],"expanded":[144],"our":[145],"to":[147,157,198],"full-length":[148],"DNA":[152],"date,":[158],"found":[160],"41%":[162],"claimed.":[172],"Thus,":[173],"both":[177],"short":[178],"long":[180],"nucleotide":[181],"are":[183],"extraordinarily":[184],"non-specific":[185],"create":[187],"uncertain,":[189],"problematic":[190],"liability":[191],"genomic":[193],"medicine,":[194],"especially":[195],"regard":[197],"targeted":[199],"re-sequencing":[200],"sequence":[203],"diagnostic":[204],"assays.":[205]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":12},{"year":2013,"cited_by_count":6}],"updated_date":"2026-10-24T09:50:30.924529","created_date":"2025-10-10T00:00:00"}
