{"id":"https://openalex.org/W2017391367","doi":"https://doi.org/10.1359/jbmr.1999.14.3.415","title":"Auditory Ossicle Abnormalities and Hearing Loss in the Toothless (Osteopetrotic) Mutation in the Rat and Their Improvement After Treatment with Colony-Stimulating Factor-1","display_name":"Auditory Ossicle Abnormalities and Hearing Loss in the Toothless (Osteopetrotic) Mutation in the Rat and Their Improvement After Treatment with Colony-Stimulating Factor-1","publication_year":1999,"publication_date":"1999-03-01","ids":{"openalex":"https://openalex.org/W2017391367","doi":"https://doi.org/10.1359/jbmr.1999.14.3.415","mag":"2017391367","pmid":"https://pubmed.ncbi.nlm.nih.gov/10027906"},"language":"en","primary_location":{"id":"doi:10.1359/jbmr.1999.14.3.415","doi":"https://doi.org/10.1359/jbmr.1999.14.3.415","is_oa":false,"landing_page_url":"https://doi.org/10.1359/jbmr.1999.14.3.415","pdf_url":null,"source":{"id":"https://openalex.org/S128199769","display_name":"Journal of Bone and Mineral Research","issn_l":"0884-0431","issn":["0884-0431","1523-4681"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bone and Mineral Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044559633","display_name":"S. H. Aharinejad","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129774422","display_name":"University of Vienna","ror":"https://ror.org/03prydq77","country_code":"AT","type":"education","lineage":["https://openalex.org/I129774422"]},{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]}],"countries":["AT","US"],"is_corresponding":false,"raw_author_name":"S. Aharinejad","raw_affiliation_strings":["Department of Anatomy, University of Vienna, Vienna, Austria","Department of Cell Biology, University of Massachusetts Medical Center, Worcester, Massachusetts, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, University of Vienna, Vienna, Austria","institution_ids":["https://openalex.org/I129774422"]},{"raw_affiliation_string":"Department of Cell Biology, University of Massachusetts Medical Center, Worcester, Massachusetts, U.S.A","institution_ids":["https://openalex.org/I166722992"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064325495","display_name":"Karl Gro\u00dfschmidt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129774422","display_name":"University of Vienna","ror":"https://ror.org/03prydq77","country_code":"AT","type":"education","lineage":["https://openalex.org/I129774422"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"K. Grossschmidt","raw_affiliation_strings":["Department of Histology and Embryology, University of Vienna, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Histology and Embryology, University of Vienna, Vienna, Austria","institution_ids":["https://openalex.org/I129774422"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059265523","display_name":"Peter Franz","orcid":"https://orcid.org/0000-0001-9770-743X","observed_orcids":["https://orcid.org/0000-0001-9770-743X"]},"institutions":[{"id":"https://openalex.org/I129774422","display_name":"University of Vienna","ror":"https://ror.org/03prydq77","country_code":"AT","type":"education","lineage":["https://openalex.org/I129774422"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"P. Franz","raw_affiliation_strings":["Department of ENT, University of Vienna, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of ENT, University of Vienna, Vienna, Austria","institution_ids":["https://openalex.org/I129774422"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078151200","display_name":"Johannes Streicher","orcid":"https://orcid.org/0000-0002-4114-2246","observed_orcids":["https://orcid.org/0000-0002-4114-2246"]},"institutions":[{"id":"https://openalex.org/I129774422","display_name":"University of Vienna","ror":"https://ror.org/03prydq77","country_code":"AT","type":"education","lineage":["https://openalex.org/I129774422"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"J. Streicher","raw_affiliation_strings":["Department of Anatomy, University of Vienna, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, University of Vienna, Vienna, Austria","institution_ids":["https://openalex.org/I129774422"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069739600","display_name":"F Nourani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129774422","display_name":"University of Vienna","ror":"https://ror.org/03prydq77","country_code":"AT","type":"education","lineage":["https://openalex.org/I129774422"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"F. Nourani","raw_affiliation_strings":["Department of Anatomy, University of Vienna, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, University of Vienna, Vienna, Austria","institution_ids":["https://openalex.org/I129774422"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010426559","display_name":"Carole A. MacKay","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. A. Mackay","raw_affiliation_strings":["Department of Cell Biology, University of Massachusetts Medical Center, Worcester, Massachusetts, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, University of Massachusetts Medical Center, Worcester, Massachusetts, U.S.A","institution_ids":["https://openalex.org/I166722992"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035492813","display_name":"W. Firbas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129774422","display_name":"University of Vienna","ror":"https://ror.org/03prydq77","country_code":"AT","type":"education","lineage":["https://openalex.org/I129774422"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"W. Firbas","raw_affiliation_strings":["Department of Anatomy, University of Vienna, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, University of Vienna, Vienna, Austria","institution_ids":["https://openalex.org/I129774422"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049172626","display_name":"Hanns Plenk Jr","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129774422","display_name":"University of Vienna","ror":"https://ror.org/03prydq77","country_code":"AT","type":"education","lineage":["https://openalex.org/I129774422"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"H. Plenk","raw_affiliation_strings":["Department of Histology and Embryology, University of Vienna, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Histology and Embryology, University of Vienna, Vienna, Austria","institution_ids":["https://openalex.org/I129774422"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111124844","display_name":"S. C. Marks","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. C. Marks","raw_affiliation_strings":["Department of Cell Biology, University of Massachusetts Medical Center, Worcester, Massachusetts, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, University of Massachusetts Medical Center, Worcester, Massachusetts, U.S.A","institution_ids":["https://openalex.org/I166722992"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3780,"currency":"USD","value_usd":3780},"apc_paid":null,"fwci":0.1916,"has_fulltext":false,"cited_by_count":19,"citation_normalized_percentile":{"value":0.37955956,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"14","issue":"3","first_page":"415","last_page":"423"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.9726999998092651,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.9726999998092651,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10334","display_name":"Hearing, Cochlea, Tinnitus, Genetics","score":0.013899999670684338,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10861","display_name":"Ear Surgery and Otitis Media","score":0.00860000029206276,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/osteopetrosis","display_name":"osteopetrosis","score":0.9729999899864197},{"id":"https://openalex.org/keywords/hearing-loss","display_name":"hearing loss","score":0.7770000100135803},{"id":"https://openalex.org/keywords/stapes","display_name":"stapes","score":0.6549999713897705},{"id":"https://openalex.org/keywords/ossicular-chain","display_name":"ossicular chain","score":0.8410000205039978},{"id":"https://openalex.org/keywords/colony-stimulating-factor-1","display_name":"colony-stimulating factor 1","score":0.8880000114440918},{"id":"https://openalex.org/keywords/bone-resorption","display_name":"bone resorption","score":0.8090000152587891},{"id":"https://openalex.org/keywords/osteoclasts","display_name":"osteoclasts","score":0.7269999980926514},{"id":"https://openalex.org/keywords/porosity","display_name":"porosity","score":0.5320000052452087},{"id":"https://openalex.org/keywords/rat-model","display_name":"rat model","score":0.5540000200271606}],"concepts":[{"id":"https://openalex.org/C2777038747","wikidata":"https://www.wikidata.org/wiki/Q17151027","display_name":"Ossicle","level":3,"score":0.6564724445343018},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6329464316368103},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.5190123319625854},{"id":"https://openalex.org/C2780493683","wikidata":"https://www.wikidata.org/wiki/Q16035842","display_name":"Hearing loss","level":2,"score":0.46788305044174194},{"id":"https://openalex.org/C2781078528","wikidata":"https://www.wikidata.org/wiki/Q1755568","display_name":"Osteopetrosis","level":2,"score":0.459311306476593},{"id":"https://openalex.org/C548259974","wikidata":"https://www.wikidata.org/wiki/Q569965","display_name":"Audiology","level":1,"score":0.4068465828895569},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2765601873397827},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.21492913365364075},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19234225153923035},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12728706002235413},{"id":"https://openalex.org/C2777846895","wikidata":"https://www.wikidata.org/wiki/Q501553","display_name":"Middle ear","level":2,"score":0.04124006628990173},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004429","descriptor_name":"Ear Ossicles","qualifier_ui":"Q000002","qualifier_name":"abnormalities","is_major_topic":true},{"descriptor_ui":"D004429","descriptor_name":"Ear Ossicles","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008854","descriptor_name":"Microscopy, Electron","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008855","descriptor_name":"Microscopy, Electron, Scanning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010022","descriptor_name":"Osteopetrosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D010022","descriptor_name":"Osteopetrosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010022","descriptor_name":"Osteopetrosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011922","descriptor_name":"Rats, Mutant Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016173","descriptor_name":"Macrophage Colony-Stimulating Factor","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D034381","descriptor_name":"Hearing Loss","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D034381","descriptor_name":"Hearing Loss","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D034381","descriptor_name":"Hearing Loss","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1359/jbmr.1999.14.3.415","doi":"https://doi.org/10.1359/jbmr.1999.14.3.415","is_oa":false,"landing_page_url":"https://doi.org/10.1359/jbmr.1999.14.3.415","pdf_url":null,"source":{"id":"https://openalex.org/S128199769","display_name":"Journal of Bone and Mineral Research","issn_l":"0884-0431","issn":["0884-0431","1523-4681"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bone and Mineral Research","raw_type":"journal-article"},{"id":"pmid:10027906","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10027906","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4160942277","display_name":null,"funder_award_id":"DE 07444","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"}],"funders":[{"id":"https://openalex.org/F4320337365","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W16190564","https://openalex.org/W42648995","https://openalex.org/W45935283","https://openalex.org/W606505770","https://openalex.org/W1270370721","https://openalex.org/W1572703898","https://openalex.org/W1589056806","https://openalex.org/W1968312684","https://openalex.org/W1977632246","https://openalex.org/W1990239616","https://openalex.org/W1990358197","https://openalex.org/W2017754197","https://openalex.org/W2021221779","https://openalex.org/W2029802208","https://openalex.org/W2038561015","https://openalex.org/W2054306258","https://openalex.org/W2063206236","https://openalex.org/W2065862466","https://openalex.org/W2068860569","https://openalex.org/W2073614902","https://openalex.org/W2086577073","https://openalex.org/W2087309758","https://openalex.org/W2089162450","https://openalex.org/W2093534596","https://openalex.org/W2096743793","https://openalex.org/W2117838105","https://openalex.org/W2118592639","https://openalex.org/W2120416617","https://openalex.org/W2148006057","https://openalex.org/W2150277199","https://openalex.org/W2311972351","https://openalex.org/W2321969143","https://openalex.org/W2326927087","https://openalex.org/W2409531453","https://openalex.org/W2416342879","https://openalex.org/W2422291003","https://openalex.org/W2467367838","https://openalex.org/W2477690429","https://openalex.org/W2483502410","https://openalex.org/W4300853188"],"related_works":["https://openalex.org/W2074181885","https://openalex.org/W2043386300","https://openalex.org/W3127770303","https://openalex.org/W2096743793","https://openalex.org/W2161124086","https://openalex.org/W1996489532","https://openalex.org/W2102446305","https://openalex.org/W2317218937","https://openalex.org/W2030444789","https://openalex.org/W2118592639"],"abstract_inverted_index":{"Osteopetrosis":[0],"describes":[1],"a":[2,16,30,81,110],"group":[3],"of":[4,8,19,24,32,50,122,133,138,174,189,224],"skeletal":[5,20],"metabolic":[6],"diseases":[7],"heterogeneous":[9],"etiology":[10],"and":[11,48,67,72,92,119,125,159,162,180,195,213,233],"varied":[12],"severity":[13],"that":[14,235],"produces":[15],"generalized":[17],"accumulation":[18],"mass,":[21],"the":[22,36,64,77,96,123,130,134,151,165,171,186,202,221,236],"result":[23],"reduced":[25,107],"bone":[26,74,90,203],"resorption.":[27],"Inherited":[28],"in":[29,76,95,116,129,150,164,228,239],"variety":[31],"species":[33],"including":[34],"humans,":[35],"most":[37],"severe":[38],"forms":[39],"are":[40,45,56],"lethal.":[41],"Among":[42],"common":[43],"features":[44],"progressive":[46],"blindness":[47],"deafness":[49],"controversial":[51],"etiologies":[52],"for":[53],"which":[54],"there":[55],"no":[57],"universally":[58],"effective":[59],"treatments.":[60],"We":[61],"have":[62],"studied":[63],"auditory":[65,68,108,226],"responsiveness":[66],"ossicle":[69],"quantitative":[70],"histomorphology":[71],"temporal":[73,135,166],"vasculature":[75],"toothless":[78],"(tl)":[79],"rat,":[80],"lethal":[82],"osteopetrotic":[83,184,230],"mutation":[84,232],"with":[85,100,140,248],"few":[86],"osteoclasts,":[87],"very":[88],"low":[89],"turnover,":[91],"limited":[93],"angiogenesis":[94,163],"axial":[97,152],"skeleton.":[98],"Compared":[99],"normal":[101,169],"littermates,":[102],"3-week-old":[103],"mutants":[104,139],"showed":[105],"significantly":[106,154,244],"responsiveness,":[109],"hearing":[111,237],"loss":[112,238],"due":[113],"to":[114,146,206,211,216],"abnormalities":[115],"both":[117],"form":[118,158],"tissue":[120,160],"composition":[121],"stapes,":[124],"little":[126],"capillary":[127],"sprouting":[128],"vascular":[131],"bed":[132],"bone.":[136,167],"Treatment":[137],"colony-stimulating":[141],"factor":[142],"1":[143],"(CSF-1),":[144],"known":[145],"greatly":[147],"reduce":[148],"sclerosis":[149],"skeleton,":[153],"improved":[155,245],"hearing,":[156],"stapedial":[157],"composition,":[161],"In":[168,183],"rats,":[170,185],"stapes":[172,187],"consisted":[173,188],"89.3%":[175],"bone,":[176,191],"9.1%":[177],"mineralized":[178,193],"cartilage,":[179,194],"0.8%":[181],"porosity.":[182],"48.3%":[190],"35.9%":[192],"15.9%":[196],"porosity,":[197],"while":[198],"after":[199],"CSF-1":[200],"treatment,":[201],"content":[204],"increased":[205,215],"55.2%,":[207],"cartilage":[208],"was":[209],"decreased":[210],"21.7%,":[212],"porosity":[214],"23.0%,":[217],"respectively.":[218],"This":[219],"is":[220],"first":[222],"demonstration":[223],"an":[225,229],"abnormality":[227],"animal":[231],"shows":[234],"tl":[240],"rats":[241],"can":[242],"be":[243],"following":[246],"treatment":[247],"CSF-1.":[249]},"counts_by_year":[{"year":2021,"cited_by_count":4},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}