{"id":"https://openalex.org/W2017390384","doi":"https://doi.org/10.1111/j.1600-065x.2009.00782.x","title":"Molecular mechanism and function of CD40/CD40L engagement in the immune system","display_name":"Molecular mechanism and function of CD40/CD40L engagement in the immune system","publication_year":2009,"publication_date":"2009-04-21","ids":{"openalex":"https://openalex.org/W2017390384","doi":"https://doi.org/10.1111/j.1600-065x.2009.00782.x","mag":"2017390384","pmid":"https://pubmed.ncbi.nlm.nih.gov/19426221","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3826168"},"language":"en","primary_location":{"id":"doi:10.1111/j.1600-065x.2009.00782.x","doi":"https://doi.org/10.1111/j.1600-065x.2009.00782.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1600-065x.2009.00782.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1600-065X.2009.00782.x","source":{"id":"https://openalex.org/S133112385","display_name":"Immunological Reviews","issn_l":"0105-2896","issn":["0105-2896","1600-065X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunological Reviews","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2017390384"],"child_works_count":0,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1600-065X.2009.00782.x","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043218129","display_name":"Ra\u00fal Elgueta","orcid":"https://orcid.org/0000-0002-7083-2430","observed_orcids":["https://orcid.org/0000-0002-7083-2430"]},"institutions":[{"id":"https://openalex.org/I107672454","display_name":"Dartmouth College","ror":"https://ror.org/049s0rh22","country_code":"US","type":"education","lineage":["https://openalex.org/I107672454"]},{"id":"https://openalex.org/I4390039367","display_name":"Dartmouth Cancer Center","ror":"https://ror.org/044b05b34","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039367"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Raul Elgueta","raw_affiliation_strings":["Department of Microbiology and Immunology, Dartmouth Medical School and The Norris Cotton Cancer Center, Lebanon, NH 03756, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Dartmouth Medical School and The Norris Cotton Cancer Center, Lebanon, NH 03756, USA","institution_ids":["https://openalex.org/I107672454","https://openalex.org/I4390039367"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067968491","display_name":"Micah J. Benson","orcid":"https://orcid.org/0009-0006-7407-6659","observed_orcids":["https://orcid.org/0009-0006-7407-6659"]},"institutions":[{"id":"https://openalex.org/I107672454","display_name":"Dartmouth College","ror":"https://ror.org/049s0rh22","country_code":"US","type":"education","lineage":["https://openalex.org/I107672454"]},{"id":"https://openalex.org/I4390039367","display_name":"Dartmouth Cancer Center","ror":"https://ror.org/044b05b34","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039367"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Micah J. Benson","raw_affiliation_strings":["Department of Microbiology and Immunology, Dartmouth Medical School and The Norris Cotton Cancer Center, Lebanon, NH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Dartmouth Medical School and The Norris Cotton Cancer Center, Lebanon, NH, USA","institution_ids":["https://openalex.org/I107672454","https://openalex.org/I4390039367"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067364382","display_name":"Victor C. de Vries","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I107672454","display_name":"Dartmouth College","ror":"https://ror.org/049s0rh22","country_code":"US","type":"education","lineage":["https://openalex.org/I107672454"]},{"id":"https://openalex.org/I4390039367","display_name":"Dartmouth Cancer Center","ror":"https://ror.org/044b05b34","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039367"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Victor C. De Vries","raw_affiliation_strings":["Department of Microbiology and Immunology, Dartmouth Medical School and The Norris Cotton Cancer Center, Lebanon, NH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Dartmouth Medical School and The Norris Cotton Cancer Center, Lebanon, NH, USA","institution_ids":["https://openalex.org/I107672454","https://openalex.org/I4390039367"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078113552","display_name":"Anna Wasiuk","orcid":"https://orcid.org/0000-0003-0090-2752","observed_orcids":["https://orcid.org/0000-0003-0090-2752"]},"institutions":[{"id":"https://openalex.org/I107672454","display_name":"Dartmouth College","ror":"https://ror.org/049s0rh22","country_code":"US","type":"education","lineage":["https://openalex.org/I107672454"]},{"id":"https://openalex.org/I4390039367","display_name":"Dartmouth Cancer Center","ror":"https://ror.org/044b05b34","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039367"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anna Wasiuk","raw_affiliation_strings":["Department of Microbiology and Immunology, Dartmouth Medical School and The Norris Cotton Cancer Center, Lebanon, NH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Dartmouth Medical School and The Norris Cotton Cancer Center, Lebanon, NH, USA","institution_ids":["https://openalex.org/I107672454","https://openalex.org/I4390039367"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101752153","display_name":"Yanxia Guo","orcid":"https://orcid.org/0009-0009-7522-4459","observed_orcids":["https://orcid.org/0009-0009-7522-4459"]},"institutions":[{"id":"https://openalex.org/I107672454","display_name":"Dartmouth College","ror":"https://ror.org/049s0rh22","country_code":"US","type":"education","lineage":["https://openalex.org/I107672454"]},{"id":"https://openalex.org/I4390039367","display_name":"Dartmouth Cancer Center","ror":"https://ror.org/044b05b34","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039367"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yanxia Guo","raw_affiliation_strings":["Department of Microbiology and Immunology, Dartmouth Medical School and The Norris Cotton Cancer Center, Lebanon, NH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Dartmouth Medical School and The Norris Cotton Cancer Center, Lebanon, NH, USA","institution_ids":["https://openalex.org/I107672454","https://openalex.org/I4390039367"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050616725","display_name":"Randolph J. Noelle","orcid":"https://orcid.org/0000-0002-2222-2136","observed_orcids":["https://orcid.org/0000-0002-2222-2136"]},"institutions":[{"id":"https://openalex.org/I107672454","display_name":"Dartmouth College","ror":"https://ror.org/049s0rh22","country_code":"US","type":"education","lineage":["https://openalex.org/I107672454"]},{"id":"https://openalex.org/I4390039367","display_name":"Dartmouth Cancer Center","ror":"https://ror.org/044b05b34","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039367"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Randolph J. Noelle","raw_affiliation_strings":["Department of Microbiology and Immunology, Dartmouth Medical School and The Norris Cotton Cancer Center, Lebanon, NH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Dartmouth Medical School and The Norris Cotton Cancer Center, Lebanon, NH, USA","institution_ids":["https://openalex.org/I107672454","https://openalex.org/I4390039367"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5050616725"],"corresponding_institution_ids":["https://openalex.org/I107672454","https://openalex.org/I4390039367"],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":null,"fwci":4.4625,"has_fulltext":true,"cited_by_count":1709,"citation_normalized_percentile":{"value":0.97109471,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"229","issue":"1","first_page":"152","last_page":"172"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.8070999979972839,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.8070999979972839,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.10970000177621841,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.04439999908208847,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cd40","display_name":"CD40","score":0.9919999837875366},{"id":"https://openalex.org/keywords/cd40-ligand","display_name":"CD40 ligand","score":0.9639999866485596},{"id":"https://openalex.org/keywords/costimulatory-molecules","display_name":"costimulatory molecules","score":0.8180000185966492},{"id":"https://openalex.org/keywords/tnf-receptor-superfamily","display_name":"TNF receptor superfamily","score":0.9440000057220459},{"id":"https://openalex.org/keywords/b-cell-activation","display_name":"B cell activation","score":0.6340000033378601},{"id":"https://openalex.org/keywords/humoral-immunity","display_name":"humoral immunity","score":0.8370000123977661},{"id":"https://openalex.org/keywords/cell-mediated-immunity","display_name":"cell-mediated immunity","score":0.9470000267028809},{"id":"https://openalex.org/keywords/adaptive-immune-response","display_name":"adaptive immune response","score":0.6790000200271606},{"id":"https://openalex.org/keywords/downstream-signaling-pathways","display_name":"downstream signaling pathways","score":0.7620000243186951},{"id":"https://openalex.org/keywords/antitumor-immunity","display_name":"antitumor immunity","score":0.9100000262260437},{"id":"https://openalex.org/keywords/professional-antigen-presenting-cells","display_name":"professional antigen-presenting cells","score":0.8429999947547913}],"concepts":[{"id":"https://openalex.org/C39347974","wikidata":"https://www.wikidata.org/wiki/Q21135811","display_name":"CD40","level":4,"score":0.7669137716293335},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7081526517868042},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6981745362281799},{"id":"https://openalex.org/C193419808","wikidata":"https://www.wikidata.org/wiki/Q1645075","display_name":"Acquired immune system","level":3,"score":0.6665637493133545},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5497690439224243},{"id":"https://openalex.org/C3017875465","wikidata":"https://www.wikidata.org/wiki/Q189146","display_name":"Cellular immunity","level":3,"score":0.5418395400047302},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.5207902789115906},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.46569618582725525},{"id":"https://openalex.org/C2776548049","wikidata":"https://www.wikidata.org/wiki/Q1142875","display_name":"Humoral immunity","level":3,"score":0.4522857367992401},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.421561598777771},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.41814321279525757},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.2768728733062744},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10049718618392944},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.06570953130722046}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000938","descriptor_name":"Antigen-Presenting Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000938","descriptor_name":"Antigen-Presenting Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007111","descriptor_name":"Immunity, Cellular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D019013","descriptor_name":"CD40 Antigens","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D019013","descriptor_name":"CD40 Antigens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D023201","descriptor_name":"CD40 Ligand","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D023201","descriptor_name":"CD40 Ligand","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D047988","descriptor_name":"Tumor Necrosis Factor Receptor-Associated Peptides and Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D047988","descriptor_name":"Tumor Necrosis Factor Receptor-Associated Peptides and Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1111/j.1600-065x.2009.00782.x","doi":"https://doi.org/10.1111/j.1600-065x.2009.00782.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1600-065x.2009.00782.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1600-065X.2009.00782.x","source":{"id":"https://openalex.org/S133112385","display_name":"Immunological Reviews","issn_l":"0105-2896","issn":["0105-2896","1600-065X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunological Reviews","raw_type":"journal-article"},{"id":"pmid:19426221","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19426221","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunological reviews","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2814178","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3826168","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3826168","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3826168/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Immunol Rev","raw_type":"Text"},{"id":"pmh:oai:kclpure.kcl.ac.uk:openaire/8907bca3-2e71-4e7e-a3ce-b547e1ef4b39","doi":null,"is_oa":true,"landing_page_url":"https://kclpure.kcl.ac.uk/portal/en/publications/8907bca3-2e71-4e7e-a3ce-b547e1ef4b39","pdf_url":null,"source":{"id":"https://openalex.org/S4306400216","display_name":"Research Portal (King's College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I183935753","host_organization_name":"King's College London","host_organization_lineage":["https://openalex.org/I183935753"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Elgueta, R, Benson, M J, De Vries, V C, Wasiuk, A, Guo, Y & Noelle, R J 2009, 'Molecular mechanism and function of CD40/CD40L engagement in the immune system', Immunological Reviews, vol. 229, no. 1, pp. 152-72. https://doi.org/10.1111/j.1600-065X.2009.00782.x","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1111/j.1600-065x.2009.00782.x","doi":"https://doi.org/10.1111/j.1600-065x.2009.00782.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1600-065x.2009.00782.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1600-065X.2009.00782.x","source":{"id":"https://openalex.org/S133112385","display_name":"Immunological Reviews","issn_l":"0105-2896","issn":["0105-2896","1600-065X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunological Reviews","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1737283734","display_name":"Cognate Activation of B-Lymphocytes","funder_award_id":"R37AI026296","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2017390384.pdf","grobid_xml":"https://content.openalex.org/works/W2017390384.grobid-xml"},"referenced_works_count":233,"referenced_works":["https://openalex.org/W1248870","https://openalex.org/W23912248","https://openalex.org/W95996026","https://openalex.org/W150619360","https://openalex.org/W304288346","https://openalex.org/W899734449","https://openalex.org/W1483682701","https://openalex.org/W1484194160","https://openalex.org/W1493383266","https://openalex.org/W1499230593","https://openalex.org/W1510347472","https://openalex.org/W1514075797","https://openalex.org/W1519180472","https://openalex.org/W1522802573","https://openalex.org/W1532325696","https://openalex.org/W1540593704","https://openalex.org/W1540648309","https://openalex.org/W1544679084","https://openalex.org/W1570258903","https://openalex.org/W1579488001","https://openalex.org/W1586339617","https://openalex.org/W1586572475","https://openalex.org/W1593640213","https://openalex.org/W1594509286","https://openalex.org/W1607301590","https://openalex.org/W1610529667","https://openalex.org/W1612841052","https://openalex.org/W1625203433","https://openalex.org/W1646023877","https://openalex.org/W1661117573","https://openalex.org/W1661544713","https://openalex.org/W1729035541","https://openalex.org/W1806946083","https://openalex.org/W1819850574","https://openalex.org/W1876800744","https://openalex.org/W1918714088","https://openalex.org/W1919103296","https://openalex.org/W1964181260","https://openalex.org/W1966657425","https://openalex.org/W1966791309","https://openalex.org/W1967668018","https://openalex.org/W1969797237","https://openalex.org/W1971487921","https://openalex.org/W1971670799","https://openalex.org/W1972414794","https://openalex.org/W1972952658","https://openalex.org/W1976763120","https://openalex.org/W1978683506","https://openalex.org/W1978790143","https://openalex.org/W1979595147","https://openalex.org/W1982906491","https://openalex.org/W1983192653","https://openalex.org/W1983918344","https://openalex.org/W1984827303","https://openalex.org/W1987968095","https://openalex.org/W1989055057","https://openalex.org/W1989134497","https://openalex.org/W1990089954","https://openalex.org/W1990130913","https://openalex.org/W1990435078","https://openalex.org/W1990456551","https://openalex.org/W1991905557","https://openalex.org/W1992949591","https://openalex.org/W1996510381","https://openalex.org/W1997977761","https://openalex.org/W2000502665","https://openalex.org/W2001039642","https://openalex.org/W2001297846","https://openalex.org/W2002143278","https://openalex.org/W2002965088","https://openalex.org/W2006196051","https://openalex.org/W2008236686","https://openalex.org/W2013464021","https://openalex.org/W2015027328","https://openalex.org/W2015788325","https://openalex.org/W2016354161","https://openalex.org/W2016724468","https://openalex.org/W2017521983","https://openalex.org/W2019291297","https://openalex.org/W2020860790","https://openalex.org/W2022376210","https://openalex.org/W2022405886","https://openalex.org/W2024306318","https://openalex.org/W2026538540","https://openalex.org/W2027277422","https://openalex.org/W2027998343","https://openalex.org/W2029013083","https://openalex.org/W2029601242","https://openalex.org/W2030086024","https://openalex.org/W2030645533","https://openalex.org/W2036217549","https://openalex.org/W2037084317","https://openalex.org/W2037374883","https://openalex.org/W2037920661","https://openalex.org/W2038829679","https://openalex.org/W2039787192","https://openalex.org/W2042872424","https://openalex.org/W2044467049","https://openalex.org/W2044526263","https://openalex.org/W2045208132","https://openalex.org/W2045514446","https://openalex.org/W2050432242","https://openalex.org/W2051708207","https://openalex.org/W2053215305","https://openalex.org/W2053958882","https://openalex.org/W2054139058","https://openalex.org/W2055558953","https://openalex.org/W2055609413","https://openalex.org/W2057049237","https://openalex.org/W2057159816","https://openalex.org/W2058661677","https://openalex.org/W2059769094","https://openalex.org/W2059838421","https://openalex.org/W2060004314","https://openalex.org/W2060382742","https://openalex.org/W2060652048","https://openalex.org/W2061115519","https://openalex.org/W2061300591","https://openalex.org/W2061414876","https://openalex.org/W2061793675","https://openalex.org/W2062755237","https://openalex.org/W2067182963","https://openalex.org/W2068225706","https://openalex.org/W2069080743","https://openalex.org/W2069292681","https://openalex.org/W2069784383","https://openalex.org/W2069800916","https://openalex.org/W2070467251","https://openalex.org/W2071435594","https://openalex.org/W2072162251","https://openalex.org/W2072930832","https://openalex.org/W2072953299","https://openalex.org/W2073281674","https://openalex.org/W2074150439","https://openalex.org/W2077389439","https://openalex.org/W2077773329","https://openalex.org/W2078366306","https://openalex.org/W2079414001","https://openalex.org/W2079633218","https://openalex.org/W2080643918","https://openalex.org/W2082871926","https://openalex.org/W2083718378","https://openalex.org/W2083737924","https://openalex.org/W2084157708","https://openalex.org/W2084407937","https://openalex.org/W2086706430","https://openalex.org/W2087663736","https://openalex.org/W2087757222","https://openalex.org/W2089907953","https://openalex.org/W2090992688","https://openalex.org/W2091085026","https://openalex.org/W2093215633","https://openalex.org/W2093393916","https://openalex.org/W2094308554","https://openalex.org/W2094328965","https://openalex.org/W2094374305","https://openalex.org/W2095903025","https://openalex.org/W2096084302","https://openalex.org/W2096158777","https://openalex.org/W2096370504","https://openalex.org/W2097181734","https://openalex.org/W2097767970","https://openalex.org/W2099503195","https://openalex.org/W2099739487","https://openalex.org/W2100645145","https://openalex.org/W2101492664","https://openalex.org/W2103526187","https://openalex.org/W2104732141","https://openalex.org/W2106138445","https://openalex.org/W2106713876","https://openalex.org/W2107245918","https://openalex.org/W2107631420","https://openalex.org/W2108695164","https://openalex.org/W2111583062","https://openalex.org/W2112853593","https://openalex.org/W2112965657","https://openalex.org/W2114123652","https://openalex.org/W2115291391","https://openalex.org/W2116372484","https://openalex.org/W2116428551","https://openalex.org/W2116683300","https://openalex.org/W2116815941","https://openalex.org/W2118637098","https://openalex.org/W2121500468","https://openalex.org/W2122074499","https://openalex.org/W2126835073","https://openalex.org/W2126845096","https://openalex.org/W2127529545","https://openalex.org/W2129554239","https://openalex.org/W2133197586","https://openalex.org/W2133634704","https://openalex.org/W2133756100","https://openalex.org/W2137524068","https://openalex.org/W2138071207","https://openalex.org/W2138319005","https://openalex.org/W2138384967","https://openalex.org/W2138582495","https://openalex.org/W2145993965","https://openalex.org/W2147022432","https://openalex.org/W2147715156","https://openalex.org/W2149123553","https://openalex.org/W2151962109","https://openalex.org/W2154165492","https://openalex.org/W2154286184","https://openalex.org/W2156588547","https://openalex.org/W2158148166","https://openalex.org/W2159149406","https://openalex.org/W2160927547","https://openalex.org/W2161870927","https://openalex.org/W2165768304","https://openalex.org/W2165925577","https://openalex.org/W2166556012","https://openalex.org/W2166637079","https://openalex.org/W2171093844","https://openalex.org/W2171120503","https://openalex.org/W2171179852","https://openalex.org/W2171429483","https://openalex.org/W2172658766","https://openalex.org/W2204310027","https://openalex.org/W2242060213","https://openalex.org/W2272766747","https://openalex.org/W2396548507","https://openalex.org/W2399136519","https://openalex.org/W2399250917","https://openalex.org/W2408675421","https://openalex.org/W2438869247","https://openalex.org/W2491090413","https://openalex.org/W2536369583","https://openalex.org/W2550696733","https://openalex.org/W2581091011","https://openalex.org/W2583036110","https://openalex.org/W4251633039","https://openalex.org/W4313344593"],"related_works":["https://openalex.org/W2994676200","https://openalex.org/W2051822564","https://openalex.org/W3094495571","https://openalex.org/W1968054754","https://openalex.org/W4251395177","https://openalex.org/W33286521","https://openalex.org/W1995900569","https://openalex.org/W1967173876","https://openalex.org/W1643704430","https://openalex.org/W2383971381"],"abstract_inverted_index":{"SUMMARY:":[0],"During":[1],"the":[2,19,38,62,66,70,78,132,147,169,183],"generation":[3],"of":[4,21,40,54,61,65,77,121,136,171],"a":[5,75,174],"successful":[6],"adaptive":[7,140,189],"immune":[8],"response,":[9],"multiple":[10],"molecular":[11,122],"signals":[12,36],"are":[13],"required.":[14],"A":[15,118],"primary":[16],"signal":[17],"is":[18,69,84,105,126],"binding":[20],"cognate":[22],"antigen":[23,26],"to":[24],"an":[25],"receptor":[27,71,82],"expressed":[28,43,85,107],"by":[29,44,86,128,152],"T":[30,45,109],"and":[31,46,97,111,123,134,138,154,163],"B":[32,47,87],"lymphocytes.":[33],"Multiple":[34],"secondary":[35],"involve":[37],"engagement":[39,130,158],"costimulatory":[41,67],"molecules":[42,68],"lymphocytes":[48],"with":[49],"their":[50],"respective":[51],"ligands.":[52],"Because":[53],"its":[55,101],"essential":[56,184],"role":[57,170,185],"in":[58,176,188],"immunity,":[59],"one":[60],"best":[63],"characterized":[64],"CD40.":[72],"This":[73,180],"receptor,":[74],"member":[76],"tumor":[79],"necrosis":[80],"factor":[81],"family,":[83],"cells,":[88,91],"professional":[89],"antigen-presenting":[90],"as":[92,94,173],"well":[93],"non-immune":[95,113],"cells":[96,110,114],"tumors.":[98],"CD40":[99,129,153,157,172,186],"binds":[100],"ligand":[102],"CD40L,":[103],"which":[104],"transiently":[106],"on":[108],"other":[112],"under":[115],"inflammatory":[116],"conditions.":[117],"wide":[119],"spectrum":[120],"cellular":[124,137,164],"processes":[125],"regulated":[127],"including":[131],"initiation":[133],"progression":[135],"humoral":[139,162],"immunity.":[141,165,179,190],"In":[142],"this":[143],"review,":[144],"we":[145,167],"describe":[146],"downstream":[148],"signaling":[149],"pathways":[150],"initiated":[151],"overview":[155],"how":[156],"or":[159],"antagonism":[160],"modulates":[161],"Lastly,":[166],"discuss":[168],"target":[175],"harnessing":[177],"anti-tumor":[178],"review":[181],"underscores":[182],"plays":[187]},"counts_by_year":[{"year":2026,"cited_by_count":158},{"year":2025,"cited_by_count":164},{"year":2024,"cited_by_count":167},{"year":2023,"cited_by_count":147},{"year":2022,"cited_by_count":136},{"year":2021,"cited_by_count":149},{"year":2020,"cited_by_count":115},{"year":2019,"cited_by_count":93},{"year":2018,"cited_by_count":98},{"year":2017,"cited_by_count":75},{"year":2016,"cited_by_count":67},{"year":2015,"cited_by_count":64},{"year":2014,"cited_by_count":58},{"year":2013,"cited_by_count":48},{"year":2012,"cited_by_count":60}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}