{"id":"https://openalex.org/W2017387433","doi":"https://doi.org/10.1046/j.1537-2995.1998.38298193096.x","title":"Hemodilution and intravenous perflubron emulsion as an alternative to blood transfusion: effects on tissue oxygenation during profound hemodilution in anesthetized dogs","display_name":"Hemodilution and intravenous perflubron emulsion as an alternative to blood transfusion: effects on tissue oxygenation during profound hemodilution in anesthetized dogs","publication_year":1998,"publication_date":"1998-02-01","ids":{"openalex":"https://openalex.org/W2017387433","doi":"https://doi.org/10.1046/j.1537-2995.1998.38298193096.x","mag":"2017387433","pmid":"https://pubmed.ncbi.nlm.nih.gov/9531945"},"language":"en","primary_location":{"id":"doi:10.1046/j.1537-2995.1998.38298193096.x","doi":"https://doi.org/10.1046/j.1537-2995.1998.38298193096.x","is_oa":false,"landing_page_url":"https://doi.org/10.1046/j.1537-2995.1998.38298193096.x","pdf_url":null,"source":{"id":"https://openalex.org/S186746772","display_name":"Transfusion","issn_l":"0041-1132","issn":["0041-1132","0372-1248","1537-2995","1878-2000"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transfusion","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049650973","display_name":"Oliver P Habler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405258122","display_name":"Institut f\u00fcr Chirurgische Forschung","ror":"https://ror.org/005506478","country_code":"DE","type":"facility","lineage":["https://openalex.org/I3018771216","https://openalex.org/I4405258122","https://openalex.org/I8204097"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"O.P. Habler","raw_affiliation_strings":["Institute for Surgical Research, Ludwig-Maximilians University, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Surgical Research, Ludwig-Maximilians University, Munich, Germany","institution_ids":["https://openalex.org/I4405258122","https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029253656","display_name":"Martin S. Kleen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"M.S. Kleen","raw_affiliation_strings":["Martin S. Kleen, MD, Resident in Anesthesia, Institute of Anesthesiology, and Research Fellow, Institute for Surgical Research, Ludwig-Maximilians-Universita\u0308t","Martin S. Kleen, MD, Resident in Anesthesia, Institute of Anesthesiology, and Research Fellow, Institute for Surgical Research, Ludwig-Maximilians-Universit\u00e4t"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Martin S. Kleen, MD, Resident in Anesthesia, Institute of Anesthesiology, and Research Fellow, Institute for Surgical Research, Ludwig-Maximilians-Universita\u0308t","institution_ids":["https://openalex.org/I8204097"]},{"raw_affiliation_string":"Martin S. Kleen, MD, Resident in Anesthesia, Institute of Anesthesiology, and Research Fellow, Institute for Surgical Research, Ludwig-Maximilians-Universit\u00e4t","institution_ids":["https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111631975","display_name":"J\u00f6rg W. Hutter","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405258122","display_name":"Institut f\u00fcr Chirurgische Forschung","ror":"https://ror.org/005506478","country_code":"DE","type":"facility","lineage":["https://openalex.org/I3018771216","https://openalex.org/I4405258122","https://openalex.org/I8204097"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"J.W. Hutter","raw_affiliation_strings":["Jo\u0308rg W. Hutter, Research Fellow, Institute for Surgical Research, Ludwig-Maximilians-Universita\u0308t","J\u00f6rg W. Hutter, Research Fellow, Institute for Surgical Research, Ludwig-Maximilians-Universit\u00e4t"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jo\u0308rg W. Hutter, Research Fellow, Institute for Surgical Research, Ludwig-Maximilians-Universita\u0308t","institution_ids":["https://openalex.org/I4405258122","https://openalex.org/I8204097"]},{"raw_affiliation_string":"J\u00f6rg W. Hutter, Research Fellow, Institute for Surgical Research, Ludwig-Maximilians-Universit\u00e4t","institution_ids":["https://openalex.org/I4405258122","https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072214497","display_name":"Armin Horst Podtschaske","orcid":"https://orcid.org/0000-0003-4081-3228","observed_orcids":["https://orcid.org/0000-0003-4081-3228"]},"institutions":[{"id":"https://openalex.org/I4405258122","display_name":"Institut f\u00fcr Chirurgische Forschung","ror":"https://ror.org/005506478","country_code":"DE","type":"facility","lineage":["https://openalex.org/I3018771216","https://openalex.org/I4405258122","https://openalex.org/I8204097"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"A.H. Podtschaske","raw_affiliation_strings":["Armin H. Podtschaske, Research Fellow, Institute for Surgical Research, Ludwig-Maximilians-Universita\u0308t","Armin H. Podtschaske, Research Fellow, Institute for Surgical Research, Ludwig-Maximilians-Universit\u00e4t"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Armin H. Podtschaske, Research Fellow, Institute for Surgical Research, Ludwig-Maximilians-Universita\u0308t","institution_ids":["https://openalex.org/I4405258122","https://openalex.org/I8204097"]},{"raw_affiliation_string":"Armin H. Podtschaske, Research Fellow, Institute for Surgical Research, Ludwig-Maximilians-Universit\u00e4t","institution_ids":["https://openalex.org/I4405258122","https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087904836","display_name":"Matthias Tiede","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405258122","display_name":"Institut f\u00fcr Chirurgische Forschung","ror":"https://ror.org/005506478","country_code":"DE","type":"facility","lineage":["https://openalex.org/I3018771216","https://openalex.org/I4405258122","https://openalex.org/I8204097"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"M. Tiede","raw_affiliation_strings":["Mathias Tiede, Research Fellow, Institute for Surgical Research, Ludwig-Maximilians-Universita\u0308t","Mathias Tiede, Research Fellow, Institute for Surgical Research, Ludwig-Maximilians-Universit\u00e4t"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mathias Tiede, Research Fellow, Institute for Surgical Research, Ludwig-Maximilians-Universita\u0308t","institution_ids":["https://openalex.org/I4405258122","https://openalex.org/I8204097"]},{"raw_affiliation_string":"Mathias Tiede, Research Fellow, Institute for Surgical Research, Ludwig-Maximilians-Universit\u00e4t","institution_ids":["https://openalex.org/I4405258122","https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031141271","display_name":"G. Kemming","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"G.I. Kemming","raw_affiliation_strings":["Gregor I. Kemming, MD, Resident in Anesthesia, Institute of Anesthesiology, Ludwig-Maximilians-Universita\u0308t","Gregor I. Kemming, MD, Resident in Anesthesia, Institute of Anesthesiology, Ludwig-Maximilians-Universit\u00e4t"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gregor I. Kemming, MD, Resident in Anesthesia, Institute of Anesthesiology, Ludwig-Maximilians-Universita\u0308t","institution_ids":["https://openalex.org/I8204097"]},{"raw_affiliation_string":"Gregor I. Kemming, MD, Resident in Anesthesia, Institute of Anesthesiology, Ludwig-Maximilians-Universit\u00e4t","institution_ids":["https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032822381","display_name":"M. Welte","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"M.V. Welte","raw_affiliation_strings":["Martin Welte, MD, Assistant Professor in Anesthesia, Institute of Anesthesiology and Institute for Surgical Research, Ludwig-Maximilians-Universita\u0308t","Martin Welte, MD, Assistant Professor in Anesthesia, Institute of Anesthesiology and Institute for Surgical Research, Ludwig-Maximilians-Universit\u00e4t"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Martin Welte, MD, Assistant Professor in Anesthesia, Institute of Anesthesiology and Institute for Surgical Research, Ludwig-Maximilians-Universita\u0308t","institution_ids":["https://openalex.org/I8204097"]},{"raw_affiliation_string":"Martin Welte, MD, Assistant Professor in Anesthesia, Institute of Anesthesiology and Institute for Surgical Research, Ludwig-Maximilians-Universit\u00e4t","institution_ids":["https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009260986","display_name":"Carlos Ot\u00e1vio Corso","orcid":"https://orcid.org/0000-0003-3485-4445","observed_orcids":["https://orcid.org/0000-0003-3485-4445"]},"institutions":[{"id":"https://openalex.org/I4405258122","display_name":"Institut f\u00fcr Chirurgische Forschung","ror":"https://ror.org/005506478","country_code":"DE","type":"facility","lineage":["https://openalex.org/I3018771216","https://openalex.org/I4405258122","https://openalex.org/I8204097"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"C.O. Corso","raw_affiliation_strings":["Carlos O. Corso, MD, Research Fellow, Institute for Surgical Research, Ludwig-Maximilians-Universita\u0308t","Carlos O. Corso, MD, Research Fellow, Institute for Surgical Research, Ludwig-Maximilians-Universit\u00e4t"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Carlos O. Corso, MD, Research Fellow, Institute for Surgical Research, Ludwig-Maximilians-Universita\u0308t","institution_ids":["https://openalex.org/I4405258122","https://openalex.org/I8204097"]},{"raw_affiliation_string":"Carlos O. Corso, MD, Research Fellow, Institute for Surgical Research, Ludwig-Maximilians-Universit\u00e4t","institution_ids":["https://openalex.org/I4405258122","https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015588470","display_name":"Sanjay Batra","orcid":"https://orcid.org/0000-0002-8980-3592","observed_orcids":["https://orcid.org/0000-0002-8980-3592"]},"institutions":[{"id":"https://openalex.org/I4210088999","display_name":"Alliance Pharmaceutical (United States)","ror":"https://ror.org/0060hwx87","country_code":"US","type":"company","lineage":["https://openalex.org/I4210088999"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. Batra","raw_affiliation_strings":["Sanjay Batra, PhD, Senior Research Scientist, Biological Sciences, Alliance Pharmaceutical Corporation, San Diego, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sanjay Batra, PhD, Senior Research Scientist, Biological Sciences, Alliance Pharmaceutical Corporation, San Diego, CA","institution_ids":["https://openalex.org/I4210088999"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006113206","display_name":"Peter E. Keipert","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210088999","display_name":"Alliance Pharmaceutical (United States)","ror":"https://ror.org/0060hwx87","country_code":"US","type":"company","lineage":["https://openalex.org/I4210088999"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P.E. Keipert","raw_affiliation_strings":["Peter E. Keipert, PhD, Program Director, Oxygen Carriers Development, Alliance Pharmaceutical Corp"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Peter E. Keipert, PhD, Program Director, Oxygen Carriers Development, Alliance Pharmaceutical Corp","institution_ids":["https://openalex.org/I4210088999"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034961671","display_name":"N. Simon Faithfull","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210088999","display_name":"Alliance Pharmaceutical (United States)","ror":"https://ror.org/0060hwx87","country_code":"US","type":"company","lineage":["https://openalex.org/I4210088999"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"N.S. Faithfull","raw_affiliation_strings":["Simon N. Faithfull, MD, PhD, Vice President, Medical Research, Alliance Pharmaceutical Corp"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Simon N. Faithfull, MD, PhD, Vice President, Medical Research, Alliance Pharmaceutical Corp","institution_ids":["https://openalex.org/I4210088999"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110028522","display_name":"K. Me\u00dfmer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405258122","display_name":"Institut f\u00fcr Chirurgische Forschung","ror":"https://ror.org/005506478","country_code":"DE","type":"facility","lineage":["https://openalex.org/I3018771216","https://openalex.org/I4405258122","https://openalex.org/I8204097"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"K.F.W. Messmer","raw_affiliation_strings":["Konrad F. W. Messmer, MD, Professor and Chief, Institute for Surgical Research, Ludwig-Maximilians-Universita\u0308t","Konrad F. W. Messmer, MD, Professor and Chief, Institute for Surgical Research, Ludwig-Maximilians-Universit\u00e4t"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Konrad F. W. Messmer, MD, Professor and Chief, Institute for Surgical Research, Ludwig-Maximilians-Universita\u0308t","institution_ids":["https://openalex.org/I4405258122","https://openalex.org/I8204097"]},{"raw_affiliation_string":"Konrad F. W. Messmer, MD, Professor and Chief, Institute for Surgical Research, Ludwig-Maximilians-Universit\u00e4t","institution_ids":["https://openalex.org/I4405258122","https://openalex.org/I8204097"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5049650973"],"corresponding_institution_ids":["https://openalex.org/I4405258122","https://openalex.org/I8204097"],"apc_list":{"value":4100,"currency":"USD","value_usd":4100},"apc_paid":null,"fwci":4.8881,"has_fulltext":false,"cited_by_count":77,"citation_normalized_percentile":{"value":0.95398459,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"38","issue":"2","first_page":"145","last_page":"155"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10693","display_name":"Blood transfusion and management","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10693","display_name":"Blood transfusion and management","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11116","display_name":"Trauma, Hemostasis, Coagulopathy, Resuscitation","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11700","display_name":"Hemodynamic Monitoring and Therapy","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/perflubron","display_name":"perflubron","score":0.8399999737739563},{"id":"https://openalex.org/keywords/perfluorocarbon-emulsions","display_name":"perfluorocarbon emulsions","score":0.9649999737739563},{"id":"https://openalex.org/keywords/hemodilution","display_name":"hemodilution","score":0.8510000109672546},{"id":"https://openalex.org/keywords/autologous-blood-transfusion","display_name":"autologous blood transfusion","score":0.8429999947547913},{"id":"https://openalex.org/keywords/tissue-oxygenation","display_name":"tissue oxygenation","score":0.9399999976158142},{"id":"https://openalex.org/keywords/acute-normovolemic-hemodilution","display_name":"acute normovolemic hemodilution","score":0.9259999990463257},{"id":"https://openalex.org/keywords/surgical-bleeding","display_name":"surgical bleeding","score":0.6510000228881836},{"id":"https://openalex.org/keywords/myocardial-oxygenation","display_name":"myocardial oxygenation","score":0.9449999928474426},{"id":"https://openalex.org/keywords/mixed-venous-oxygenation","display_name":"mixed venous oxygenation","score":0.7070000171661377},{"id":"https://openalex.org/keywords/skeletal-muscle-oxygenation","display_name":"skeletal muscle oxygenation","score":0.8820000290870667}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8110851645469666},{"id":"https://openalex.org/C70289976","wikidata":"https://www.wikidata.org/wiki/Q17143603","display_name":"Oxygenation","level":2,"score":0.7209699153900146},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.7155000567436218},{"id":"https://openalex.org/C2778917026","wikidata":"https://www.wikidata.org/wiki/Q43041","display_name":"Hemoglobin","level":2,"score":0.5488534569740295},{"id":"https://openalex.org/C37557685","wikidata":"https://www.wikidata.org/wiki/Q1896673","display_name":"Blood volume","level":2,"score":0.5454287528991699},{"id":"https://openalex.org/C178853913","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Hemodynamics","level":2,"score":0.49793529510498047},{"id":"https://openalex.org/C43376680","wikidata":"https://www.wikidata.org/wiki/Q6580786","display_name":"Bolus (digestion)","level":2,"score":0.4732773005962372},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.2886171042919159},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.15964338183403015}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001803","descriptor_name":"Blood Transfusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005466","descriptor_name":"Fluorocarbons","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D006438","descriptor_name":"Hemodilution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006842","descriptor_name":"Hydrocarbons, Brominated","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007275","descriptor_name":"Injections, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010101","descriptor_name":"Oxygen Consumption","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012119","descriptor_name":"Respiration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1046/j.1537-2995.1998.38298193096.x","doi":"https://doi.org/10.1046/j.1537-2995.1998.38298193096.x","is_oa":false,"landing_page_url":"https://doi.org/10.1046/j.1537-2995.1998.38298193096.x","pdf_url":null,"source":{"id":"https://openalex.org/S186746772","display_name":"Transfusion","issn_l":"0041-1132","issn":["0041-1132","0372-1248","1537-2995","1878-2000"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transfusion","raw_type":"journal-article"},{"id":"pmid:9531945","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9531945","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transfusion","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W104689148","https://openalex.org/W109843434","https://openalex.org/W124376116","https://openalex.org/W178238348","https://openalex.org/W1929398776","https://openalex.org/W2008628347","https://openalex.org/W2014912234","https://openalex.org/W2022855908","https://openalex.org/W2050129447","https://openalex.org/W2053380484","https://openalex.org/W2066915223","https://openalex.org/W2091210055","https://openalex.org/W2105932108","https://openalex.org/W2269919727","https://openalex.org/W2282326764","https://openalex.org/W2302665586","https://openalex.org/W2334231928","https://openalex.org/W2429894882","https://openalex.org/W2473262130","https://openalex.org/W4242728389"],"related_works":["https://openalex.org/W2102349872","https://openalex.org/W2020929469","https://openalex.org/W1968622293","https://openalex.org/W2005970796","https://openalex.org/W1958499971","https://openalex.org/W2340623166","https://openalex.org/W1991649411","https://openalex.org/W2046618277","https://openalex.org/W2043771884","https://openalex.org/W2054512832"],"abstract_inverted_index":{"BACKGROUND:":[0],"Intravenously":[1],"administered":[2],"perfluorocarbon":[3],"(PFC)":[4],"emulsions":[5],"increase":[6],"oxygen":[7],"solubility":[8],"in":[9,92,210,220,239,295],"plasma.":[10],"PFC":[11,56,119,129,199,222,231,241],"might":[12],"therefore":[13],"temporarily":[14],"replace":[15],"red":[16],"cells":[17],"(RBCs)":[18],"lost":[19],"during":[20,194,299],"intraoperative":[21,80],"hemorrhage.":[22],"In":[23,67,197],"patients":[24],"who":[25],"have":[26],"undergone":[27],"hemodilution,":[28],"the":[29,38,60,198,221,224,230,240],"return":[30],"of":[31,40,88,105,115,126,143,161,184,229,265,276,283],"autologous":[32,43,116,292],"blood":[33,82,195,301],"may":[34,45],"be":[35,46],"delayed":[36],"by":[37,59,113,245],"administration":[39,264],"PFC,":[41],"and":[42,55,134,148,167,171,191,200,205,223,232,252,258,270],"RBCs":[44,178],"saved":[47],"for":[48],"transfusion":[49,114,294],"after":[50],"surgical":[51,306],"bleeding":[52],"is":[53,57],"stopped":[54],"cleared":[58],"reticuloendothelial":[61],"system.":[62],"STUDY":[63],"DESIGN":[64],"AND":[65],"METHODS:":[66],"22":[68],"anesthetized,":[69],"hemodiluted":[70],"dogs":[71],"(hemoglobin":[72],"[Hb]":[73],"7":[74,109,185,277],"g/dL)":[75],"breathing":[76],"100-percent":[77],"O2,":[78],"an":[79],"volume-compensated":[81,300],"loss":[83,302],"was":[84,96,217],"simulated.":[85],"The":[86],"efficacy":[87],"three":[89],"therapeutic":[90],"regimens":[91],"maintaining":[93,296],"tissue":[94,172,192,237,254,297],"oxygenation":[95,169,173,193,216,238,298],"compared:":[97],"1)":[98],"RBC":[99,225,293],"group":[100,120,151],"(n":[101,121,152],"=":[102,122,153],"7):":[103,123,154],"maintenance":[104],"a":[106,127,141,159,182,274],"Hb":[107,142,160,183,275],">":[108],"g":[110,145,163,186,278,285],"per":[111,146,164,187,279,286],"dL":[112,188,280,287],"RBCs;":[117],"2)":[118],"bolus":[124],"application":[125],"second-generation":[128],"emulsion":[130,269],"(60%":[131],"wt/vol":[132],"perflubron)":[133],"further":[135,155,213,271],"acute":[136],"normovolemic":[137],"hemodilution":[138,272],"(ANH)":[139],"to":[140,158,180,212,281,304],"3":[144,162,284],"dL;":[147],"3)":[149],"control":[150,201,233],"ANH":[156],"alone":[157],"dL.":[165],"Systemic":[166],"myocardial":[168],"status":[170],"were":[174,288],"assessed.":[175],"RESULTS:":[176],"Autologous":[177],"transfused":[179],"maintain":[181],"preserved":[189],"hemodynamics":[190],"loss.":[196],"groups,":[202],"heart":[203],"rate":[204],"cardiac":[206],"index":[207],"increased":[208],"significantly":[209,246],"response":[211],"ANH.":[214],"Tissue":[215],"not":[218],"different":[219],"groups.":[226],"Direct":[227],"comparison":[228],"groups":[234],"revealed":[235],"better":[236],"group,":[242],"as":[243,289,291],"reflected":[244],"higher":[247],"mixed":[248],"venous,":[249,251],"coronary":[250],"local":[253],"pO2":[255],"on":[256],"liver":[257],"skeletal":[259],"muscle.":[260],"CONCLUSION:":[261],"Bolus":[262],"intravenous":[263],"60-percent":[266],"(wt/vol)":[267],"perflubron":[268],"from":[273],"one":[282],"effective":[290],"designed":[303],"mimic":[305],"bleeding.":[307]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}