{"id":"https://openalex.org/W2017381063","doi":"https://doi.org/10.1016/s0014-2999(01)01523-0","title":"Possible involvement of tachykinin NK1 and NMDA receptors in histamine-induced hyperalgesia in mice","display_name":"Possible involvement of tachykinin NK1 and NMDA receptors in histamine-induced hyperalgesia in mice","publication_year":2002,"publication_date":"2002-01-01","ids":{"openalex":"https://openalex.org/W2017381063","doi":"https://doi.org/10.1016/s0014-2999(01)01523-0","mag":"2017381063","pmid":"https://pubmed.ncbi.nlm.nih.gov/11755162"},"language":"en","primary_location":{"id":"doi:10.1016/s0014-2999(01)01523-0","doi":"https://doi.org/10.1016/s0014-2999(01)01523-0","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0014-2999(01)01523-0","pdf_url":null,"source":{"id":"https://openalex.org/S187816532","display_name":"European Journal of Pharmacology","issn_l":"0014-2999","issn":["0014-2999","1879-0712"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112082492","display_name":"Shinobu Sakurada","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I85324120","display_name":"Tohoku Medical and Pharmaceutical University","ror":"https://ror.org/0264zxa45","country_code":"JP","type":"education","lineage":["https://openalex.org/I85324120"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Shinobu Sakurada","raw_affiliation_strings":["Department of Physiology and Anatomy, Tohoku Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, Japan. s-sakura@tohoku-u.ac.jp","Department of Physiology and Anatomy, Tohoku Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Anatomy, Tohoku Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, Japan. s-sakura@tohoku-u.ac.jp","institution_ids":["https://openalex.org/I85324120"]},{"raw_affiliation_string":"Department of Physiology and Anatomy, Tohoku Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, Japan","institution_ids":["https://openalex.org/I85324120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001290996","display_name":"Tohru Orito","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I85324120","display_name":"Tohoku Medical and Pharmaceutical University","ror":"https://ror.org/0264zxa45","country_code":"JP","type":"education","lineage":["https://openalex.org/I85324120"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tohru Orito","raw_affiliation_strings":["Department of Physiology and Anatomy, Tohoku Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Anatomy, Tohoku Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, Japan","institution_ids":["https://openalex.org/I85324120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060396150","display_name":"Chikai Sakurada","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802008203","display_name":"Daiichi University of Pharmacy","ror":"https://ror.org/03jvvjr23","country_code":"JP","type":"education","lineage":["https://openalex.org/I2802008203"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Chikai Sakurada","raw_affiliation_strings":["Department of Biochemistry, Daiichi College of Pharmaceutical Sciences, 22-1 Tamagawa-cho, Minami-ku, Fukuoka 815-8511, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Daiichi College of Pharmaceutical Sciences, 22-1 Tamagawa-cho, Minami-ku, Fukuoka 815-8511, Japan","institution_ids":["https://openalex.org/I2802008203"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103189730","display_name":"Takumi Sato","orcid":"https://orcid.org/0000-0001-7699-8768","observed_orcids":["https://orcid.org/0000-0001-7699-8768"]},"institutions":[{"id":"https://openalex.org/I85324120","display_name":"Tohoku Medical and Pharmaceutical University","ror":"https://ror.org/0264zxa45","country_code":"JP","type":"education","lineage":["https://openalex.org/I85324120"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takumi Sato","raw_affiliation_strings":["Department of Physiology and Anatomy, Tohoku Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Anatomy, Tohoku Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, Japan","institution_ids":["https://openalex.org/I85324120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101704771","display_name":"Takafumi Hayashi","orcid":"https://orcid.org/0000-0002-7032-3505","observed_orcids":["https://orcid.org/0000-0002-7032-3505"]},"institutions":[{"id":"https://openalex.org/I85324120","display_name":"Tohoku Medical and Pharmaceutical University","ror":"https://ror.org/0264zxa45","country_code":"JP","type":"education","lineage":["https://openalex.org/I85324120"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takafumi Hayashi","raw_affiliation_strings":["Department of Physiology and Anatomy, Tohoku Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Anatomy, Tohoku Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, Japan","institution_ids":["https://openalex.org/I85324120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086147987","display_name":"Jalal Izadi Mobarakeh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Jalal Izadi Mobarakeh","raw_affiliation_strings":["Department of Pharmacology, Tohoku University School of Medicine, Seiryo-machi 2-1, Aoba-ku, Sendai, 980-8575, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Tohoku University School of Medicine, Seiryo-machi 2-1, Aoba-ku, Sendai, 980-8575, Japan","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035847289","display_name":"Kazuhiko Yanai","orcid":"https://orcid.org/0000-0001-9068-7907","observed_orcids":["https://orcid.org/0000-0001-9068-7907"]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazuhiko Yanai","raw_affiliation_strings":["Department of Pharmacology, Tohoku University School of Medicine, Seiryo-machi 2-1, Aoba-ku, Sendai, 980-8575, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Tohoku University School of Medicine, Seiryo-machi 2-1, Aoba-ku, Sendai, 980-8575, Japan","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111483903","display_name":"Kenji Onodera","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kenji Onodera","raw_affiliation_strings":["Department of Dental Pharmacology, Okayama University Dental School, Okayama, 700-8525, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dental Pharmacology, Okayama University Dental School, Okayama, 700-8525, Japan","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113504097","display_name":"Takehiko Watanabe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takehiko Watanabe","raw_affiliation_strings":["Department of Pharmacology, Tohoku University School of Medicine, Seiryo-machi 2-1, Aoba-ku, Sendai, 980-8575, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Tohoku University School of Medicine, Seiryo-machi 2-1, Aoba-ku, Sendai, 980-8575, Japan","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068482988","display_name":"Tsukasa Sakurada","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802008203","display_name":"Daiichi University of Pharmacy","ror":"https://ror.org/03jvvjr23","country_code":"JP","type":"education","lineage":["https://openalex.org/I2802008203"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tsukasa Sakurada","raw_affiliation_strings":["Department of Biochemistry, Daiichi College of Pharmaceutical Sciences, 22-1 Tamagawa-cho, Minami-ku, Fukuoka 815-8511, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Daiichi College of Pharmaceutical Sciences, 22-1 Tamagawa-cho, Minami-ku, Fukuoka 815-8511, Japan","institution_ids":["https://openalex.org/I2802008203"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5112082492"],"corresponding_institution_ids":["https://openalex.org/I85324120"],"apc_list":{"value":3230,"currency":"USD","value_usd":3230},"apc_paid":null,"fwci":2.0179,"has_fulltext":false,"cited_by_count":28,"citation_normalized_percentile":{"value":0.84772781,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"434","issue":"1-2","first_page":"29","last_page":"34"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tachykinin-nk1-receptor","display_name":"tachykinin NK1 receptor","score":0.9570000171661377},{"id":"https://openalex.org/keywords/nmda-receptor","display_name":"NMDA receptor","score":0.9070000052452087},{"id":"https://openalex.org/keywords/substance-p","display_name":"substance P","score":0.7960000038146973},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.7580000162124634},{"id":"https://openalex.org/keywords/spinal-cord","display_name":"spinal cord","score":0.7940000295639038},{"id":"https://openalex.org/keywords/intrathecal-administration","display_name":"intrathecal administration","score":0.7990000247955322},{"id":"https://openalex.org/keywords/nmda-receptor-antagonist","display_name":"NMDA receptor antagonists","score":0.7839999794960022},{"id":"https://openalex.org/keywords/nitric-oxide-synthase-inhibition","display_name":"nitric oxide synthase inhibition","score":0.6840000152587891},{"id":"https://openalex.org/keywords/nociception","display_name":"nociception","score":0.5830000042915344},{"id":"https://openalex.org/keywords/mice","display_name":"mice","score":0.4909999966621399},{"id":"https://openalex.org/keywords/tail-flick-test","display_name":"tail-flick test","score":0.7680000066757202},{"id":"https://openalex.org/keywords/cp-99-994","display_name":"CP-99,994","score":0.7739999890327454}],"concepts":[{"id":"https://openalex.org/C1122143","wikidata":"https://www.wikidata.org/wiki/Q61233","display_name":"Histamine","level":2,"score":0.7761840224266052},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7138870358467102},{"id":"https://openalex.org/C2776533618","wikidata":"https://www.wikidata.org/wiki/Q411041","display_name":"Substance P","level":4,"score":0.6757853031158447},{"id":"https://openalex.org/C30862142","wikidata":"https://www.wikidata.org/wiki/Q288382","display_name":"Histamine H4 receptor","level":5,"score":0.5527334809303284},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5442779660224915},{"id":"https://openalex.org/C2778122271","wikidata":"https://www.wikidata.org/wiki/Q410943","display_name":"Receptor antagonist","level":4,"score":0.5389848947525024},{"id":"https://openalex.org/C202871150","wikidata":"https://www.wikidata.org/wiki/Q12744608","display_name":"NK1 receptor antagonist","level":5,"score":0.4975118935108185},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.49667030572891235},{"id":"https://openalex.org/C159545944","wikidata":"https://www.wikidata.org/wiki/Q424228","display_name":"Histamine receptor","level":4,"score":0.4935094118118286},{"id":"https://openalex.org/C2777836312","wikidata":"https://www.wikidata.org/wiki/Q4386371","display_name":"Dizocilpine","level":4,"score":0.47788941860198975},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.44638770818710327},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4449971616268158},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.42814886569976807},{"id":"https://openalex.org/C10335311","wikidata":"https://www.wikidata.org/wiki/Q309513","display_name":"Histamine H1 receptor","level":4,"score":0.42604079842567444},{"id":"https://openalex.org/C34400551","wikidata":"https://www.wikidata.org/wiki/Q311568","display_name":"Histamine H2 receptor","level":4,"score":0.3831719160079956},{"id":"https://openalex.org/C118303440","wikidata":"https://www.wikidata.org/wiki/Q419968","display_name":"Neuropeptide","level":3,"score":0.187046080827713},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17872744798660278},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.14695990085601807}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006632","descriptor_name":"Histamine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006633","descriptor_name":"Histamine Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006930","descriptor_name":"Hyperalgesia","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010880","descriptor_name":"Piperidines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016194","descriptor_name":"Receptors, N-Methyl-D-Aspartate","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D018040","descriptor_name":"Receptors, Neurokinin-1","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D018691","descriptor_name":"Excitatory Amino Acid Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0014-2999(01)01523-0","doi":"https://doi.org/10.1016/s0014-2999(01)01523-0","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0014-2999(01)01523-0","pdf_url":null,"source":{"id":"https://openalex.org/S187816532","display_name":"European Journal of Pharmacology","issn_l":"0014-2999","issn":["0014-2999","1879-0712"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Pharmacology","raw_type":"journal-article"},{"id":"pmid:11755162","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11755162","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of pharmacology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W639473593","https://openalex.org/W1761965274","https://openalex.org/W1966564730","https://openalex.org/W1969816505","https://openalex.org/W1972688670","https://openalex.org/W1983984229","https://openalex.org/W1987461819","https://openalex.org/W1988980312","https://openalex.org/W1990809315","https://openalex.org/W1992897355","https://openalex.org/W1994067213","https://openalex.org/W1994667935","https://openalex.org/W2009955868","https://openalex.org/W2029850759","https://openalex.org/W2031603062","https://openalex.org/W2034102455","https://openalex.org/W2041930903","https://openalex.org/W2046182002","https://openalex.org/W2058159881","https://openalex.org/W2070068440","https://openalex.org/W2075212681","https://openalex.org/W2076141541","https://openalex.org/W2087756960","https://openalex.org/W2090135185","https://openalex.org/W2091486123","https://openalex.org/W2094038408","https://openalex.org/W2114808045","https://openalex.org/W2128020612","https://openalex.org/W2142698011","https://openalex.org/W2154496696","https://openalex.org/W2272838397","https://openalex.org/W2311312317","https://openalex.org/W2401188729","https://openalex.org/W2414917160","https://openalex.org/W6694345731"],"related_works":["https://openalex.org/W2010066133","https://openalex.org/W2086766732","https://openalex.org/W2054700696","https://openalex.org/W1989516082","https://openalex.org/W2084299721","https://openalex.org/W2003672379","https://openalex.org/W1982329180","https://openalex.org/W2082298377","https://openalex.org/W2316344853","https://openalex.org/W2132549675"],"abstract_inverted_index":null,"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}