{"id":"https://openalex.org/W2017365574","doi":"https://doi.org/10.1046/j.1365-2141.2002.03720.x","title":"Superior vena cava syndrome and hypercalcaemia in a patient with a primary mediastinal B\u2010cell lymphoma secreting parathyroid hormone\u2010related protein","display_name":"Superior vena cava syndrome and hypercalcaemia in a patient with a primary mediastinal B\u2010cell lymphoma secreting parathyroid hormone\u2010related protein","publication_year":2002,"publication_date":"2002-10-01","ids":{"openalex":"https://openalex.org/W2017365574","doi":"https://doi.org/10.1046/j.1365-2141.2002.03720.x","mag":"2017365574","pmid":"https://pubmed.ncbi.nlm.nih.gov/12358896"},"language":"en","primary_location":{"id":"doi:10.1046/j.1365-2141.2002.03720.x","doi":"https://doi.org/10.1046/j.1365-2141.2002.03720.x","is_oa":false,"landing_page_url":"https://doi.org/10.1046/j.1365-2141.2002.03720.x","pdf_url":null,"source":{"id":"https://openalex.org/S153015021","display_name":"British Journal of Haematology","issn_l":"0007-1048","issn":["0007-1048","1365-2141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Haematology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5105753393","display_name":"Liang\u2010Tsai Hsiao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2803004286","display_name":"Taipei Veterans General Hospital","ror":"https://ror.org/03ymy8z76","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I2803004286"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Liang\u2010Tsai Hsiao","raw_affiliation_strings":["Department of Pathology, Taipei Veterans General Hospital, Taiwan. tjhiou@vghtpe.gov.tw","Division of Medical Oncology, Department of Medicine,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Taipei Veterans General Hospital, Taiwan. tjhiou@vghtpe.gov.tw","institution_ids":["https://openalex.org/I2803004286"]},{"raw_affiliation_string":"Division of Medical Oncology, Department of Medicine,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111647111","display_name":"Tzeon-Jye Chiou","orcid":"https://orcid.org/0000-0002-0495-3859","observed_orcids":["https://orcid.org/0000-0002-0495-3859"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tzeon\u2010Jye Chiou","raw_affiliation_strings":["Division of Medical Oncology, Department of Medicine,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medical Oncology, Department of Medicine,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045003018","display_name":"I\u2010Ting Yu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2803004286","display_name":"Taipei Veterans General Hospital","ror":"https://ror.org/03ymy8z76","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I2803004286"]},{"id":"https://openalex.org/I4387156312","display_name":"National Yang Ming University","ror":"https://ror.org/009h5ks85","country_code":"TW","type":"education","lineage":["https://openalex.org/I148366613","https://openalex.org/I4387156312"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"I\u2010Ting Yu","raw_affiliation_strings":["Department of Pathology, Taipei Veterans General Hospital, and National Yang-Ming University School of Medicine, Taipei, Taiwan. E-mail: tjchiou@vghtpe.gov.tw","Department of Pathology, Taipei Veterans General Hospital and National Yang Ming University School of Medicine, Taipei, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Taipei Veterans General Hospital, and National Yang-Ming University School of Medicine, Taipei, Taiwan. E-mail: tjchiou@vghtpe.gov.tw","institution_ids":["https://openalex.org/I2803004286","https://openalex.org/I4387156312"]},{"raw_affiliation_string":"Department of Pathology, Taipei Veterans General Hospital and National Yang Ming University School of Medicine, Taipei, Taiwan","institution_ids":["https://openalex.org/I2803004286","https://openalex.org/I4387156312"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110122231","display_name":"Po\u2010Min Chen","orcid":"https://orcid.org/0000-0003-1270-2205","observed_orcids":["https://orcid.org/0000-0003-1270-2205"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Po\u2010Min Chen","raw_affiliation_strings":["Division of Medical Oncology, Department of Medicine,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medical Oncology, Department of Medicine,","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5045003018"],"corresponding_institution_ids":["https://openalex.org/I2803004286","https://openalex.org/I4387156312"],"apc_list":{"value":5190,"currency":"USD","value_usd":5190},"apc_paid":null,"fwci":1.7665,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.84821288,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"119","issue":"1","first_page":"1","last_page":"1"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.9312000274658203,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.9312000274658203,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10516","display_name":"Parathyroid Disorders and Treatments","score":0.03909999877214432,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.00430000014603138,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/superior-vena-cava-syndrome","display_name":"superior vena cava syndrome","score":0.9819999933242798},{"id":"https://openalex.org/keywords/hypercalcemia","display_name":"hypercalcemia","score":0.9120000004768372},{"id":"https://openalex.org/keywords/primary-mediastinal-large-b-cell-lymphoma","display_name":"primary mediastinal B-cell lymphoma","score":0.8489999771118164},{"id":"https://openalex.org/keywords/diffuse-large-b-cell-lymphoma","display_name":"diffuse large B-cell lymphoma","score":0.8659999966621399},{"id":"https://openalex.org/keywords/parathyroid-hormone-related-protein","display_name":"parathyroid hormone-related protein","score":0.9879999756813049},{"id":"https://openalex.org/keywords/superior-vena-cava-obstruction","display_name":"superior vena cava obstruction","score":0.871999979019165},{"id":"https://openalex.org/keywords/pamidronate","display_name":"pamidronate","score":0.9010000228881836},{"id":"https://openalex.org/keywords/chemotherapy","display_name":"chemotherapy","score":0.39100000262260437}],"concepts":[{"id":"https://openalex.org/C2779674975","wikidata":"https://www.wikidata.org/wiki/Q1474877","display_name":"Hypercalcaemia","level":3,"score":0.8315069079399109},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8230655193328857},{"id":"https://openalex.org/C2778828131","wikidata":"https://www.wikidata.org/wiki/Q2007821","display_name":"Parathyroid hormone-related protein","level":4,"score":0.6246806383132935},{"id":"https://openalex.org/C2777953354","wikidata":"https://www.wikidata.org/wiki/Q610737","display_name":"Superior vena cava syndrome","level":3,"score":0.5847142338752747},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.5722932815551758},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5194510817527771},{"id":"https://openalex.org/C2779126056","wikidata":"https://www.wikidata.org/wiki/Q337247","display_name":"Mediastinum","level":2,"score":0.49691084027290344},{"id":"https://openalex.org/C2781208988","wikidata":"https://www.wikidata.org/wiki/Q202476","display_name":"Parathyroid hormone","level":3,"score":0.44928857684135437},{"id":"https://openalex.org/C2775934546","wikidata":"https://www.wikidata.org/wiki/Q179991","display_name":"Biopsy","level":2,"score":0.4102345108985901},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.37695255875587463},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.37460166215896606},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.3461587429046631},{"id":"https://openalex.org/C2908767450","wikidata":"https://www.wikidata.org/wiki/Q736995","display_name":"Superior vena cava","level":2,"score":0.3307943344116211},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.1882532835006714}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006934","descriptor_name":"Hypercalcemia","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D008479","descriptor_name":"Mediastinal Neoplasms","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D008479","descriptor_name":"Mediastinal Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013479","descriptor_name":"Superior Vena Cava Syndrome","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D016393","descriptor_name":"Lymphoma, B-Cell","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D016393","descriptor_name":"Lymphoma, B-Cell","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D036361","descriptor_name":"Peptide Hormones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D044162","descriptor_name":"Parathyroid Hormone-Related Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1046/j.1365-2141.2002.03720.x","doi":"https://doi.org/10.1046/j.1365-2141.2002.03720.x","is_oa":false,"landing_page_url":"https://doi.org/10.1046/j.1365-2141.2002.03720.x","pdf_url":null,"source":{"id":"https://openalex.org/S153015021","display_name":"British Journal of Haematology","issn_l":"0007-1048","issn":["0007-1048","1365-2141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Haematology","raw_type":"journal-article"},{"id":"pmid:12358896","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12358896","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British journal of haematology","raw_type":"Case Reports"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2062381413","https://openalex.org/W93709159","https://openalex.org/W4409697522","https://openalex.org/W2120352556","https://openalex.org/W2011830970","https://openalex.org/W2009157353","https://openalex.org/W1983548023","https://openalex.org/W3121635409","https://openalex.org/W1984356758","https://openalex.org/W2525521616"],"abstract_inverted_index":{"A":[0,142],"78-year-old":[1],"woman":[2],"presented":[3],"with":[4,150,175],"shortness":[5],"of":[6,24,93,129,145,147,169,172],"breath":[7],"and":[8,22,64,76,124,160],"numbness":[9],"in":[10,19,177],"her":[11],"left":[12,39],"arm.":[13],"Physical":[14],"examinations":[15],"found":[16],"confluent":[17],"masses":[18],"the":[20,38,42,91,139,173],"neck":[21,40],"features":[23],"superior":[25,161],"vena":[26,162],"cava":[27,163],"obstruction.":[28],"Computerized":[29],"tomography":[30],"showed":[31,48],"a":[32,77],"7-cm":[33],"diameter":[34],"tumour":[35],"extending":[36],"from":[37],"to":[41,137],"upper":[43],"mediastinum":[44],"(top).":[45],"Laboratory":[46],"tests":[47],"elevated":[49],"serum":[50,65,79,134],"calcium":[51],"(3\u00b725":[52],"mmol/l;":[53],"normal":[54,61,72,85,140],"range":[55,62,73,86],"2\u00b723\u20132\u00b757),":[56],"lactate":[57],"dehydrogenase":[58],"(1108":[59],"IU/l;":[60],"100\u2013250)":[63],"parathyroid":[66,80],"hormone-related":[67],"protein":[68],"(PTHrP)":[69],"(27\u00b709":[70],"pmol/l;":[71],"<":[74],"9\u00b72),":[75],"low":[78],"hormone":[81],"(<":[82],"10":[83],"pg/ml;":[84],"10\u201355).":[87],"Incision":[88],"biopsy":[89],"confirmed":[90],"diagnosis":[92],"diffuse":[94],"large":[95],"B-cell":[96,148],"non-Hodgkin's":[97],"lymphoma":[98,149],"(bottom),":[99],"which":[100],"also":[101],"was":[102,115],"focally":[103],"positive":[104],"for":[105],"PTHrP":[106,135],"immunohistochemical":[107],"staining.":[108],"No":[109],"bony":[110],"destruction":[111],"or":[112],"marrow":[113],"involvement":[114],"detected.":[116],"The":[117],"hypercalcaemia":[118,153,159],"initially":[119],"improved":[120],"after":[121],"intravenous":[122],"pamidronate":[123],"resolved":[125],"following":[126],"one":[127],"cycle":[128],"combination":[130],"chemotherapy.":[131],"On":[132],"follow-up,":[133],"returned":[136],"within":[138],"range.":[141],"small":[143],"number":[144],"cases":[146],"PTHrP-mediated":[151],"humoral":[152],"have":[154],"been":[155],"reported.":[156],"However,":[157],"simultaneous":[158],"obstruction":[164],"is":[165],"almost":[166],"always":[167],"indicative":[168],"primary":[170],"carcinoma":[171],"lung":[174],"metastases":[176],"mediastinal":[178],"lymph":[179],"nodes.":[180]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}