{"id":"https://openalex.org/W2017363986","doi":"https://doi.org/10.1111/j.1582-4934.2011.01273.x","title":"The toxicity of tau in Alzheimer disease: turnover, targets and potential therapeutics","display_name":"The toxicity of tau in Alzheimer disease: turnover, targets and potential therapeutics","publication_year":2011,"publication_date":"2011-02-26","ids":{"openalex":"https://openalex.org/W2017363986","doi":"https://doi.org/10.1111/j.1582-4934.2011.01273.x","mag":"2017363986","pmid":"https://pubmed.ncbi.nlm.nih.gov/21348938","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4373356"},"language":"en","primary_location":{"id":"doi:10.1111/j.1582-4934.2011.01273.x","doi":"https://doi.org/10.1111/j.1582-4934.2011.01273.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1582-4934.2011.01273.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1582-4934.2011.01273.x","source":{"id":"https://openalex.org/S76698325","display_name":"Journal of Cellular and Molecular Medicine","issn_l":"1582-1838","issn":["1582-1838","1582-4934"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cellular and Molecular Medicine","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1582-4934.2011.01273.x","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056455022","display_name":"Susanne M. Pritchard","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28792581","display_name":"University of Rochester Medicine","ror":"https://ror.org/00trqv719","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I28792581","https://openalex.org/I5388228"]},{"id":"https://openalex.org/I5388228","display_name":"University of Rochester","ror":"https://ror.org/022kthw22","country_code":"US","type":"education","lineage":["https://openalex.org/I5388228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Susanne M. Pritchard","raw_affiliation_strings":["Department of Anesthesiology and the Interdepartmental Graduate Program in Neuroscience, University of Rochester, Rochester, NY, USA","These authors contributed equally"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology and the Interdepartmental Graduate Program in Neuroscience, University of Rochester, Rochester, NY, USA","institution_ids":["https://openalex.org/I28792581","https://openalex.org/I5388228"]},{"raw_affiliation_string":"These authors contributed equally","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039518106","display_name":"Philip J. Dolan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28792581","display_name":"University of Rochester Medicine","ror":"https://ror.org/00trqv719","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I28792581","https://openalex.org/I5388228"]},{"id":"https://openalex.org/I5388228","display_name":"University of Rochester","ror":"https://ror.org/022kthw22","country_code":"US","type":"education","lineage":["https://openalex.org/I5388228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Philip J. Dolan","raw_affiliation_strings":["Department of Anesthesiology and the Interdepartmental Graduate Program in Neuroscience, University of Rochester, Rochester, NY, USA","These authors contributed equally"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology and the Interdepartmental Graduate Program in Neuroscience, University of Rochester, Rochester, NY, USA","institution_ids":["https://openalex.org/I28792581","https://openalex.org/I5388228"]},{"raw_affiliation_string":"These authors contributed equally","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067495832","display_name":"Alisa Vitkus","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28792581","display_name":"University of Rochester Medicine","ror":"https://ror.org/00trqv719","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I28792581","https://openalex.org/I5388228"]},{"id":"https://openalex.org/I5388228","display_name":"University of Rochester","ror":"https://ror.org/022kthw22","country_code":"US","type":"education","lineage":["https://openalex.org/I5388228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alisa Vitkus","raw_affiliation_strings":["Department of Anesthesiology and the Interdepartmental Graduate Program in Neuroscience, University of Rochester, Rochester, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology and the Interdepartmental Graduate Program in Neuroscience, University of Rochester, Rochester, NY, USA","institution_ids":["https://openalex.org/I28792581","https://openalex.org/I5388228"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025207687","display_name":"Gail V.W. Johnson","orcid":"https://orcid.org/0000-0003-3464-0404","observed_orcids":["https://orcid.org/0000-0003-3464-0404"]},"institutions":[{"id":"https://openalex.org/I28792581","display_name":"University of Rochester Medicine","ror":"https://ror.org/00trqv719","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I28792581","https://openalex.org/I5388228"]},{"id":"https://openalex.org/I5388228","display_name":"University of Rochester","ror":"https://ror.org/022kthw22","country_code":"US","type":"education","lineage":["https://openalex.org/I5388228"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Gail V.W. Johnson","raw_affiliation_strings":["Department of Anesthesiology and the Interdepartmental Graduate Program in Neuroscience, University of Rochester, Rochester, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology and the Interdepartmental Graduate Program in Neuroscience, University of Rochester, Rochester, NY, USA","institution_ids":["https://openalex.org/I28792581","https://openalex.org/I5388228"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5025207687"],"corresponding_institution_ids":["https://openalex.org/I28792581","https://openalex.org/I5388228"],"apc_list":{"value":5210,"currency":"USD","value_usd":5210},"apc_paid":null,"fwci":1.0894,"has_fulltext":true,"cited_by_count":89,"citation_normalized_percentile":{"value":0.71950134,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"15","issue":"8","first_page":"1621","last_page":"1635"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tau-protein","display_name":"tau protein","score":0.9110000133514404},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9810000061988831},{"id":"https://openalex.org/keywords/tau-phosphorylation","display_name":"tau phosphorylation","score":0.722000002861023},{"id":"https://openalex.org/keywords/tau-truncation","display_name":"tau truncation","score":0.9769999980926514},{"id":"https://openalex.org/keywords/neurofibrillary-tangles","display_name":"neurofibrillary tangles","score":0.9940000176429749},{"id":"https://openalex.org/keywords/proteasomal-degradation","display_name":"proteasomal degradation","score":0.7919999957084656},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.9990000128746033},{"id":"https://openalex.org/keywords/tau-aggregation-inhibitors","display_name":"tau aggregation inhibitors","score":0.8209999799728394},{"id":"https://openalex.org/keywords/microtubule-stabilizing-agents","display_name":"microtubule-stabilizing agents","score":0.9449999928474426},{"id":"https://openalex.org/keywords/tau-immunotherapy","display_name":"tau immunotherapy","score":0.9739999771118164},{"id":"https://openalex.org/keywords/autophagy-activators","display_name":"autophagy activators","score":0.925000011920929},{"id":"https://openalex.org/keywords/mitochondria-targeted-therapy","display_name":"mitochondrial-targeted therapy","score":0.828000009059906},{"id":"https://openalex.org/keywords/amyloid-beta-toxicity","display_name":"amyloid-beta toxicity","score":0.7390000224113464}],"concepts":[{"id":"https://openalex.org/C2777739294","wikidata":"https://www.wikidata.org/wiki/Q2397106","display_name":"Tauopathy","level":4,"score":0.7224656343460083},{"id":"https://openalex.org/C2778670691","wikidata":"https://www.wikidata.org/wiki/Q419507","display_name":"Tau protein","level":4,"score":0.6597413420677185},{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.5544881224632263},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5401721000671387},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.5325488448143005},{"id":"https://openalex.org/C207886595","wikidata":"https://www.wikidata.org/wiki/Q1456138","display_name":"Pathological","level":2,"score":0.5207985639572144},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.5204439759254456},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.46875548362731934},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.4546440541744232},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4456091821193695},{"id":"https://openalex.org/C3017833866","wikidata":"https://www.wikidata.org/wiki/Q2397106","display_name":"Tau pathology","level":4,"score":0.43926316499710083},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.3018437623977661},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.2815589904785156},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2804897129535675},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2565801441669464},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1777050793170929},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.09238266944885254},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07334139943122864}],"mesh":[{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008751","descriptor_name":"Methylene Blue","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016874","descriptor_name":"Neurofibrillary Tangles","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016874","descriptor_name":"Neurofibrillary Tangles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016875","descriptor_name":"tau Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D046988","descriptor_name":"Proteasome Endopeptidase Complex","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1111/j.1582-4934.2011.01273.x","doi":"https://doi.org/10.1111/j.1582-4934.2011.01273.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1582-4934.2011.01273.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1582-4934.2011.01273.x","source":{"id":"https://openalex.org/S76698325","display_name":"Journal of Cellular and Molecular Medicine","issn_l":"1582-1838","issn":["1582-1838","1582-4934"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cellular and Molecular Medicine","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3351909","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4373356","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4373356","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4373356","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Cell Mol Med","raw_type":"Text"},{"id":"pmid:21348938","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21348938","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cellular and molecular medicine","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.811.9092","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.811.9092","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/bb/b0/jcmm0015-1621.PMC4373356.pdf","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1111/j.1582-4934.2011.01273.x","doi":"https://doi.org/10.1111/j.1582-4934.2011.01273.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1582-4934.2011.01273.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1582-4934.2011.01273.x","source":{"id":"https://openalex.org/S76698325","display_name":"Journal of Cellular and Molecular Medicine","issn_l":"1582-1838","issn":["1582-1838","1582-4934"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cellular and Molecular Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2316715470","display_name":"Mutant Huntingtin Compromises Mitochondrial Function","funder_award_id":"R01NS041744","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G8274643510","display_name":"Posttranslational processing of tau: function & dysfunction","funder_award_id":"R01NS051279","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320306219","display_name":"Alzheimer's Association","ror":"https://ror.org/0375f4d26"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2017363986.pdf","grobid_xml":"https://content.openalex.org/works/W2017363986.grobid-xml"},"referenced_works_count":184,"referenced_works":["https://openalex.org/W62865870","https://openalex.org/W150987474","https://openalex.org/W1193806329","https://openalex.org/W1481130297","https://openalex.org/W1490798921","https://openalex.org/W1511517753","https://openalex.org/W1515449698","https://openalex.org/W1523693806","https://openalex.org/W1528790659","https://openalex.org/W1532265037","https://openalex.org/W1538925586","https://openalex.org/W1544371346","https://openalex.org/W1549257777","https://openalex.org/W1562146500","https://openalex.org/W1600812038","https://openalex.org/W1611407165","https://openalex.org/W1675881254","https://openalex.org/W1744236062","https://openalex.org/W1889306845","https://openalex.org/W1911014954","https://openalex.org/W1929269608","https://openalex.org/W1944699774","https://openalex.org/W1963791487","https://openalex.org/W1968937229","https://openalex.org/W1969076369","https://openalex.org/W1970272456","https://openalex.org/W1970354788","https://openalex.org/W1971145588","https://openalex.org/W1975040221","https://openalex.org/W1975321314","https://openalex.org/W1976740826","https://openalex.org/W1977267085","https://openalex.org/W1978671913","https://openalex.org/W1980115442","https://openalex.org/W1980768099","https://openalex.org/W1983733701","https://openalex.org/W1985351513","https://openalex.org/W1985871594","https://openalex.org/W1986413832","https://openalex.org/W1986809727","https://openalex.org/W1988044873","https://openalex.org/W1989208474","https://openalex.org/W1989856924","https://openalex.org/W1994539511","https://openalex.org/W1995515835","https://openalex.org/W1995562130","https://openalex.org/W1997198091","https://openalex.org/W1997426613","https://openalex.org/W1997826645","https://openalex.org/W1998735201","https://openalex.org/W2001752726","https://openalex.org/W2002109811","https://openalex.org/W2002984957","https://openalex.org/W2003772355","https://openalex.org/W2004219186","https://openalex.org/W2005809770","https://openalex.org/W2010973678","https://openalex.org/W2011255469","https://openalex.org/W2013581014","https://openalex.org/W2014300038","https://openalex.org/W2014918593","https://openalex.org/W2015097735","https://openalex.org/W2015948653","https://openalex.org/W2017492709","https://openalex.org/W2020585998","https://openalex.org/W2022214576","https://openalex.org/W2022532556","https://openalex.org/W2025714022","https://openalex.org/W2026311918","https://openalex.org/W2026771024","https://openalex.org/W2030567293","https://openalex.org/W2030602441","https://openalex.org/W2030667534","https://openalex.org/W2030997817","https://openalex.org/W2032515864","https://openalex.org/W2032879521","https://openalex.org/W2035216963","https://openalex.org/W2036755018","https://openalex.org/W2038120434","https://openalex.org/W2038523706","https://openalex.org/W2039111245","https://openalex.org/W2039468514","https://openalex.org/W2040411159","https://openalex.org/W2040454459","https://openalex.org/W2042485050","https://openalex.org/W2045153164","https://openalex.org/W2046209489","https://openalex.org/W2046436217","https://openalex.org/W2049599293","https://openalex.org/W2049991946","https://openalex.org/W2050562362","https://openalex.org/W2052236118","https://openalex.org/W2052742260","https://openalex.org/W2054121489","https://openalex.org/W2056666417","https://openalex.org/W2057894590","https://openalex.org/W2058723245","https://openalex.org/W2059005775","https://openalex.org/W2060458492","https://openalex.org/W2064913654","https://openalex.org/W2068780874","https://openalex.org/W2068798911","https://openalex.org/W2070971554","https://openalex.org/W2071276938","https://openalex.org/W2074769970","https://openalex.org/W2075791440","https://openalex.org/W2076032638","https://openalex.org/W2081768153","https://openalex.org/W2082178532","https://openalex.org/W2082429191","https://openalex.org/W2082617925","https://openalex.org/W2083633251","https://openalex.org/W2085170616","https://openalex.org/W2085939493","https://openalex.org/W2086751197","https://openalex.org/W2087246499","https://openalex.org/W2088733194","https://openalex.org/W2088983023","https://openalex.org/W2089141103","https://openalex.org/W2091279967","https://openalex.org/W2091829752","https://openalex.org/W2091935655","https://openalex.org/W2091970266","https://openalex.org/W2092607846","https://openalex.org/W2093537026","https://openalex.org/W2096410114","https://openalex.org/W2096592089","https://openalex.org/W2098077028","https://openalex.org/W2098548022","https://openalex.org/W2099340107","https://openalex.org/W2100026237","https://openalex.org/W2100298346","https://openalex.org/W2103913931","https://openalex.org/W2106200048","https://openalex.org/W2107493006","https://openalex.org/W2111567059","https://openalex.org/W2112136536","https://openalex.org/W2113455273","https://openalex.org/W2114133572","https://openalex.org/W2119983609","https://openalex.org/W2120143950","https://openalex.org/W2120701804","https://openalex.org/W2120947942","https://openalex.org/W2121713269","https://openalex.org/W2124568421","https://openalex.org/W2124955411","https://openalex.org/W2124975942","https://openalex.org/W2125172225","https://openalex.org/W2128101513","https://openalex.org/W2128121742","https://openalex.org/W2128715380","https://openalex.org/W2134138119","https://openalex.org/W2135309154","https://openalex.org/W2135793938","https://openalex.org/W2136709809","https://openalex.org/W2137176838","https://openalex.org/W2137337037","https://openalex.org/W2142964430","https://openalex.org/W2144533748","https://openalex.org/W2145440751","https://openalex.org/W2148473649","https://openalex.org/W2149562999","https://openalex.org/W2149631100","https://openalex.org/W2149960670","https://openalex.org/W2152420555","https://openalex.org/W2153578959","https://openalex.org/W2157535220","https://openalex.org/W2157578198","https://openalex.org/W2160912479","https://openalex.org/W2162847877","https://openalex.org/W2164065816","https://openalex.org/W2164298973","https://openalex.org/W2165049228","https://openalex.org/W2165284149","https://openalex.org/W2167818155","https://openalex.org/W2168079270","https://openalex.org/W2169200799","https://openalex.org/W2171471740","https://openalex.org/W2327443968","https://openalex.org/W2412153316","https://openalex.org/W2461636874","https://openalex.org/W2743254891","https://openalex.org/W3026558616","https://openalex.org/W4230565756"],"related_works":["https://openalex.org/W7096433160","https://openalex.org/W2072880750","https://openalex.org/W1502779454","https://openalex.org/W2613251848","https://openalex.org/W2002223411","https://openalex.org/W3118987270","https://openalex.org/W2071916510","https://openalex.org/W2309818890","https://openalex.org/W2312794169","https://openalex.org/W2112136536"],"abstract_inverted_index":{"\u2022":[0,2,21,30,36,59],"Introduction":[1],"Pathological":[3],"modifications":[4],"of":[5,79,118,131,145,171,177,180,186,190,205,225],"tau":[6,74,101,107,132,139,154,191,206],"-":[7,10,13,41,45,49,52,55],"Tau":[8,11,22,31,42,50],"phosphorylation":[9],"truncation":[12],"NFTs":[14],"are":[15],"not":[16,106],"the":[17,70,76,80,125,187,194],"primary":[18,77],"toxic":[19],"species":[20],"turnover":[23],"and":[24,61,100,137,198],"possible":[25,199,215],"deficits":[26],"in":[27,33,84,112,159,228],"Alzheimer":[28,34,85],"disease":[29,35,86,113],"toxicity":[32],"Potential":[37],"\u2018tau-centric\u2019":[38],"therapeutic":[39,218],"strategies":[40],"aggregation":[43],"inhibitors":[44],"Microtubule":[46],"stabilizing":[47],"agents":[48],"immunotherapy":[51],"Autophagy":[53],"activators":[54],"Mitochondria":[56],"targeted":[57],"therapies":[58],"Summary":[60],"conclusions":[62],"It":[63],"has":[64],"been":[65],"almost":[66],"25":[67],"years":[68],"since":[69],"initial":[71],"discovery":[72],"that":[73,128,138,153],"was":[75,115],"component":[78],"neurofibrillary":[81],"tangles":[82],"(NFTs)":[83],"(AD)":[87],"brain.":[88],"Although":[89],"AD":[90,160],"is":[91,140,149,155],"defined":[92],"by":[93,183,192,201,213],"both":[94],"\u03b2-amyloid":[95],"(A\u03b2)":[96],"pathology":[97,102],"(A\u03b2":[98],"plaques)":[99],"(NFTs),":[103],"whether":[104],"or":[105,196],"played":[108],"a":[109,116,150,156,168,184],"critical":[110],"role":[111,227],"pathogenesis":[114],"subject":[117],"discussion":[119,185],"for":[120,217],"many":[121],"years.":[122],"However,":[123],"given":[124],"increasing":[126],"evidence":[127],"pathological":[129,178,203],"forms":[130,179,204],"can":[133],"compromise":[134],"neuronal":[135],"function":[136],"likely":[141],"an":[142,175],"important":[143],"mediator":[144],"A\u03b2":[146],"toxicity,":[147],"there":[148],"growing":[151],"awareness":[152],"central":[157],"player":[158],"pathogenesis.":[161],"In":[162],"this":[163],"review":[164],"we":[165],"begin":[166],"with":[167],"brief":[169],"history":[170],"tau,":[172,181],"then":[173],"provide":[174],"overview":[176],"followed":[182],"differential":[188],"degradation":[189],"either":[193],"proteasome":[195],"autophagy":[197],"mechanisms":[200],"which":[202],"may":[207],"exert":[208],"their":[209],"toxicity.":[210],"We":[211],"conclude":[212],"discussing":[214],"avenues":[216],"intervention":[219],"based":[220],"on":[221],"these":[222],"emerging":[223],"themes":[224],"tau\u2019s":[226],"AD.":[229]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":15}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
