{"id":"https://openalex.org/W2017355451","doi":"https://doi.org/10.1084/jem.186.3.473","title":"Negative Signaling Pathways of the Killer Cell Inhibitory Receptor and Fc\u03b3RIIb1 Require Distinct Phosphatases","display_name":"Negative Signaling Pathways of the Killer Cell Inhibitory Receptor and Fc\u03b3RIIb1 Require Distinct Phosphatases","publication_year":1997,"publication_date":"1997-08-04","ids":{"openalex":"https://openalex.org/W2017355451","doi":"https://doi.org/10.1084/jem.186.3.473","mag":"2017355451","pmid":"https://pubmed.ncbi.nlm.nih.gov/9236201"},"language":"en","primary_location":{"id":"doi:10.1084/jem.186.3.473","doi":"https://doi.org/10.1084/jem.186.3.473","is_oa":false,"landing_page_url":"https://doi.org/10.1084/jem.186.3.473","pdf_url":null,"source":{"id":"https://openalex.org/S22947807","display_name":"The Journal of Experimental Medicine","issn_l":"0022-1007","issn":["0022-1007","1540-9538"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Experimental Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2199004","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Neetu Gupta","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Neetu Gupta","raw_affiliation_strings":["From the *Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland 20852; \u2021Laboratory of Allergy and Immunology, Department of Pathology, Beth Israel Hospital and Harvard Medical School, Boston, Massachusetts 02215; and the \u00a7Fred Hutchinson Cancer Research Center, Seattle, Washington 98104","From the Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland 20852","the Fred Hutchinson Cancer Research Center, Seattle, Washington 98104"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the *Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland 20852; \u2021Laboratory of Allergy and Immunology, Department of Pathology, Beth Israel Hospital and Harvard Medical School, Boston, Massachusetts 02215; and the \u00a7Fred Hutchinson Cancer Research Center, Seattle, Washington 98104","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I136199984","https://openalex.org/I4210089486","https://openalex.org/I4210134534"]},{"raw_affiliation_string":"From the Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland 20852","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534"]},{"raw_affiliation_string":"the Fred Hutchinson Cancer Research Center, Seattle, Washington 98104","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063879916","display_name":"Andrew M. Scharenberg","orcid":"https://orcid.org/0000-0002-4292-6114","observed_orcids":["https://orcid.org/0000-0002-4292-6114"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew M. Scharenberg","raw_affiliation_strings":["From the *Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland 20852; \u2021Laboratory of Allergy and Immunology, Department of Pathology, Beth Israel Hospital and Harvard Medical School, Boston, Massachusetts 02215; and the \u00a7Fred Hutchinson Cancer Research Center, Seattle, Washington 98104","From the Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland 20852","the Fred Hutchinson Cancer Research Center, Seattle, Washington 98104"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the *Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland 20852; \u2021Laboratory of Allergy and Immunology, Department of Pathology, Beth Israel Hospital and Harvard Medical School, Boston, Massachusetts 02215; and the \u00a7Fred Hutchinson Cancer Research Center, Seattle, Washington 98104","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I136199984","https://openalex.org/I4210089486","https://openalex.org/I4210134534"]},{"raw_affiliation_string":"From the Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland 20852","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534"]},{"raw_affiliation_string":"the Fred Hutchinson Cancer Research Center, Seattle, Washington 98104","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051835176","display_name":"Deborah N. Burshtyn","orcid":"https://orcid.org/0000-0003-4829-3351","observed_orcids":["https://orcid.org/0000-0003-4829-3351"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Deborah N. Burshtyn","raw_affiliation_strings":["From the *Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland 20852; \u2021Laboratory of Allergy and Immunology, Department of Pathology, Beth Israel Hospital and Harvard Medical School, Boston, Massachusetts 02215; and the \u00a7Fred Hutchinson Cancer Research Center, Seattle, Washington 98104","From the Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland 20852","the Fred Hutchinson Cancer Research Center, Seattle, Washington 98104"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the *Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland 20852; \u2021Laboratory of Allergy and Immunology, Department of Pathology, Beth Israel Hospital and Harvard Medical School, Boston, Massachusetts 02215; and the \u00a7Fred Hutchinson Cancer Research Center, Seattle, Washington 98104","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I136199984","https://openalex.org/I4210089486","https://openalex.org/I4210134534"]},{"raw_affiliation_string":"From the Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland 20852","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534"]},{"raw_affiliation_string":"the Fred Hutchinson Cancer Research Center, Seattle, Washington 98104","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045217032","display_name":"Nicolai R. Wagtmann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicolai Wagtmann","raw_affiliation_strings":["From the *Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland 20852; \u2021Laboratory of Allergy and Immunology, Department of Pathology, Beth Israel Hospital and Harvard Medical School, Boston, Massachusetts 02215; and the \u00a7Fred Hutchinson Cancer Research Center, Seattle, Washington 98104","From the Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland 20852","the Fred Hutchinson Cancer Research Center, Seattle, Washington 98104"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the *Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland 20852; \u2021Laboratory of Allergy and Immunology, Department of Pathology, Beth Israel Hospital and Harvard Medical School, Boston, Massachusetts 02215; and the \u00a7Fred Hutchinson Cancer Research Center, Seattle, Washington 98104","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I136199984","https://openalex.org/I4210089486","https://openalex.org/I4210134534"]},{"raw_affiliation_string":"From the Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland 20852","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534"]},{"raw_affiliation_string":"the Fred Hutchinson Cancer Research Center, Seattle, Washington 98104","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059191263","display_name":"Mario N. Lioubin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mario N. Lioubin","raw_affiliation_strings":["From the *Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland 20852; \u2021Laboratory of Allergy and Immunology, Department of Pathology, Beth Israel Hospital and Harvard Medical School, Boston, Massachusetts 02215; and the \u00a7Fred Hutchinson Cancer Research Center, Seattle, Washington 98104","From the Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland 20852","the Fred Hutchinson Cancer Research Center, Seattle, Washington 98104"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the *Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland 20852; \u2021Laboratory of Allergy and Immunology, Department of Pathology, Beth Israel Hospital and Harvard Medical School, Boston, Massachusetts 02215; and the \u00a7Fred Hutchinson Cancer Research Center, Seattle, Washington 98104","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I136199984","https://openalex.org/I4210089486","https://openalex.org/I4210134534"]},{"raw_affiliation_string":"From the Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland 20852","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534"]},{"raw_affiliation_string":"the Fred Hutchinson Cancer Research Center, Seattle, Washington 98104","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032206654","display_name":"Larry R. Rohrschneider","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Larry R. Rohrschneider","raw_affiliation_strings":["From the *Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland 20852; \u2021Laboratory of Allergy and Immunology, Department of Pathology, Beth Israel Hospital and Harvard Medical School, Boston, Massachusetts 02215; and the \u00a7Fred Hutchinson Cancer Research Center, Seattle, Washington 98104","From the Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland 20852","the Fred Hutchinson Cancer Research Center, Seattle, Washington 98104"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the *Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland 20852; \u2021Laboratory of Allergy and Immunology, Department of Pathology, Beth Israel Hospital and Harvard Medical School, Boston, Massachusetts 02215; and the \u00a7Fred Hutchinson Cancer Research Center, Seattle, Washington 98104","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I136199984","https://openalex.org/I4210089486","https://openalex.org/I4210134534"]},{"raw_affiliation_string":"From the Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland 20852","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534"]},{"raw_affiliation_string":"the Fred Hutchinson Cancer Research Center, Seattle, Washington 98104","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109939626","display_name":"Jean-Pierre Kinet","orcid":"https://orcid.org/0000-0003-1475-3364","observed_orcids":["https://orcid.org/0000-0003-1475-3364"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jean-Pierre Kinet","raw_affiliation_strings":["From the *Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland 20852; \u2021Laboratory of Allergy and Immunology, Department of Pathology, Beth Israel Hospital and Harvard Medical School, Boston, Massachusetts 02215; and the \u00a7Fred Hutchinson Cancer Research Center, Seattle, Washington 98104","From the Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland 20852","the Fred Hutchinson Cancer Research Center, Seattle, Washington 98104"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the *Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland 20852; \u2021Laboratory of Allergy and Immunology, Department of Pathology, Beth Israel Hospital and Harvard Medical School, Boston, Massachusetts 02215; and the \u00a7Fred Hutchinson Cancer Research Center, Seattle, Washington 98104","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I136199984","https://openalex.org/I4210089486","https://openalex.org/I4210134534"]},{"raw_affiliation_string":"From the Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland 20852","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534"]},{"raw_affiliation_string":"the Fred Hutchinson Cancer Research Center, Seattle, Washington 98104","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087340494","display_name":"Eric O. Long","orcid":"https://orcid.org/0000-0002-7793-3728","observed_orcids":["https://orcid.org/0000-0002-7793-3728"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric O. Long","raw_affiliation_strings":["From the *Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland 20852; \u2021Laboratory of Allergy and Immunology, Department of Pathology, Beth Israel Hospital and Harvard Medical School, Boston, Massachusetts 02215; and the \u00a7Fred Hutchinson Cancer Research Center, Seattle, Washington 98104","From the Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland 20852","the Fred Hutchinson Cancer Research Center, Seattle, Washington 98104"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the *Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland 20852; \u2021Laboratory of Allergy and Immunology, Department of Pathology, Beth Israel Hospital and Harvard Medical School, Boston, Massachusetts 02215; and the \u00a7Fred Hutchinson Cancer Research Center, Seattle, Washington 98104","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I136199984","https://openalex.org/I4210089486","https://openalex.org/I4210134534"]},{"raw_affiliation_string":"From the Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland 20852","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534"]},{"raw_affiliation_string":"the Fred Hutchinson Cancer Research Center, Seattle, Washington 98104","institution_ids":["https://openalex.org/I4210089486"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":6.3899,"has_fulltext":false,"cited_by_count":91,"citation_normalized_percentile":{"value":0.97044431,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"186","issue":"3","first_page":"473","last_page":"478"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11510","display_name":"Reproductive System and Pregnancy","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/natural-killer-cells","display_name":"natural killer cells","score":0.7860000133514404},{"id":"https://openalex.org/keywords/killer-cell-inhibitory-receptors","display_name":"killer cell inhibitory receptors","score":0.9679999947547913},{"id":"https://openalex.org/keywords/shp-1","display_name":"SHP-1","score":0.9559999704360962},{"id":"https://openalex.org/keywords/ships","display_name":"ships","score":0.996999979019165},{"id":"https://openalex.org/keywords/negative-signaling","display_name":"negative signaling","score":0.7390000224113464},{"id":"https://openalex.org/keywords/protein-tyrosine-phosphatase","display_name":"protein tyrosine phosphatase","score":0.8659999966621399},{"id":"https://openalex.org/keywords/inositol-phosphatase","display_name":"inositol phosphatase","score":0.9340000152587891},{"id":"https://openalex.org/keywords/dominant-negative-mutant","display_name":"dominant-negative mutant","score":0.5730000138282776},{"id":"https://openalex.org/keywords/chimeric-receptors","display_name":"chimeric receptors","score":0.8489999771118164},{"id":"https://openalex.org/keywords/nk-cell-inhibition","display_name":"NK cell inhibition","score":0.5440000295639038},{"id":"https://openalex.org/keywords/b-cell-receptor","display_name":"B cell receptor","score":0.5690000057220459},{"id":"https://openalex.org/keywords/fcepsilonri","display_name":"Fc\u03b5RI","score":0.8119999766349792},{"id":"https://openalex.org/keywords/mast-cells","display_name":"mast cells","score":0.9330000281333923}],"concepts":[{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.6371057629585266},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6353156566619873},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5333055853843689},{"id":"https://openalex.org/C85528070","wikidata":"https://www.wikidata.org/wiki/Q643602","display_name":"Protein tyrosine phosphatase","level":3,"score":0.4760662913322449},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4233211278915405},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.40290457010269165},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.19083574414253235}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003602","descriptor_name":"Cytotoxicity, Immunologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003602","descriptor_name":"Cytotoxicity, Immunologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003602","descriptor_name":"Cytotoxicity, Immunologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007694","descriptor_name":"Killer Cells, Natural","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007694","descriptor_name":"Killer Cells, Natural","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007694","descriptor_name":"Killer Cells, Natural","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007694","descriptor_name":"Killer Cells, Natural","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007694","descriptor_name":"Killer Cells, Natural","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007694","descriptor_name":"Killer Cells, Natural","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010744","descriptor_name":"Phosphoric Monoester Hydrolases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010744","descriptor_name":"Phosphoric Monoester Hydrolases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010744","descriptor_name":"Phosphoric Monoester Hydrolases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010744","descriptor_name":"Phosphoric Monoester Hydrolases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D010744","descriptor_name":"Phosphoric Monoester Hydrolases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D010744","descriptor_name":"Phosphoric Monoester Hydrolases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D010744","descriptor_name":"Phosphoric Monoester Hydrolases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010744","descriptor_name":"Phosphoric Monoester Hydrolases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010744","descriptor_name":"Phosphoric Monoester Hydrolases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011971","descriptor_name":"Receptors, Immunologic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011971","descriptor_name":"Receptors, Immunologic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011971","descriptor_name":"Receptors, Immunologic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011971","descriptor_name":"Receptors, Immunologic","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011971","descriptor_name":"Receptors, Immunologic","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011971","descriptor_name":"Receptors, Immunologic","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D017027","descriptor_name":"Protein Tyrosine Phosphatases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017027","descriptor_name":"Protein Tyrosine Phosphatases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017027","descriptor_name":"Protein Tyrosine Phosphatases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017027","descriptor_name":"Protein Tyrosine Phosphatases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D017027","descriptor_name":"Protein Tyrosine Phosphatases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D017027","descriptor_name":"Protein Tyrosine Phosphatases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D017027","descriptor_name":"Protein Tyrosine Phosphatases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017027","descriptor_name":"Protein Tyrosine Phosphatases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017027","descriptor_name":"Protein Tyrosine Phosphatases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017452","descriptor_name":"Receptors, IgG","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017452","descriptor_name":"Receptors, IgG","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017452","descriptor_name":"Receptors, IgG","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017452","descriptor_name":"Receptors, IgG","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017452","descriptor_name":"Receptors, IgG","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017452","descriptor_name":"Receptors, IgG","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1084/jem.186.3.473","doi":"https://doi.org/10.1084/jem.186.3.473","is_oa":false,"landing_page_url":"https://doi.org/10.1084/jem.186.3.473","pdf_url":null,"source":{"id":"https://openalex.org/S22947807","display_name":"The Journal of Experimental Medicine","issn_l":"0022-1007","issn":["0022-1007","1540-9538"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Experimental Medicine","raw_type":"journal-article"},{"id":"pmid:9236201","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9236201","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of experimental medicine","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2199004","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2199004","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Exp Med","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2199004","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2199004","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Exp Med","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.7246000170707703}],"sustainable_development_goals_aurora":[{"display_name":"Life below water","id":"https://metadata.un.org/sdg/14","score":0.5}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W76522298","https://openalex.org/W1487855049","https://openalex.org/W1513412079","https://openalex.org/W1548757245","https://openalex.org/W1675910238","https://openalex.org/W1861660397","https://openalex.org/W1900810111","https://openalex.org/W1976805459","https://openalex.org/W2000061036","https://openalex.org/W2007133520","https://openalex.org/W2018826402","https://openalex.org/W2030788598","https://openalex.org/W2053142169","https://openalex.org/W2055143049","https://openalex.org/W2058924545","https://openalex.org/W2063290750","https://openalex.org/W2069545269","https://openalex.org/W2073410553","https://openalex.org/W2079923162","https://openalex.org/W2083111576","https://openalex.org/W2083480719","https://openalex.org/W2083618683","https://openalex.org/W2113536356","https://openalex.org/W2119204846","https://openalex.org/W2123158636","https://openalex.org/W2127534803","https://openalex.org/W2133226508","https://openalex.org/W2146953988","https://openalex.org/W2161165126","https://openalex.org/W2165023381","https://openalex.org/W2165449806","https://openalex.org/W4313325051","https://openalex.org/W6603128427"],"related_works":["https://openalex.org/W1974312557","https://openalex.org/W2949966763","https://openalex.org/W1593725015","https://openalex.org/W2000143670","https://openalex.org/W2027995286","https://openalex.org/W2626780842","https://openalex.org/W2018029590","https://openalex.org/W2133580829","https://openalex.org/W1967871974","https://openalex.org/W2377402187"],"abstract_inverted_index":{"Inhibition":[0],"of":[1,15,27,66,83,92,105,121,137,160,165,183,208,241],"natural":[2],"killer":[3,8],"(NK)":[4],"cells":[5,62,79,94,171,243],"by":[6,20,25,115,158,172,189,198,215,244,255],"the":[7,16,36,57,84,103,119,152,173,186,190,212,216,230,248,260],"cell":[9,113],"inhibitory":[10,34,108],"receptor":[11,40,59],"(KIR)":[12],"involves":[13,246],"recruitment":[14,82],"tyrosine":[17,249],"phosphatase":[18,87,250,262],"SHP-1":[19,31,53,122,138,184],"KIR":[21,153,191,245],"and":[22,72,89,118,123,133,139,147],"is":[23],"prevented":[24],"expression":[26,144],"a":[28,204,227],"dominant":[29,134,180,205],"negative":[30,135,181,206,234],"mutant.":[32],"Another":[33],"receptor,":[35],"low":[37],"affinity":[38],"Fc":[39,67,74,161,199,217,231,256],"for":[41,143],"immunoglobulin":[42],"G":[43],"(IgG)":[44],"(Fc":[45],"gamma":[46,68,162,200,218,232,257],"RIIb1),":[47],"has":[48],"been":[49],"shown":[50],"to":[51,81,90,110,125],"bind":[52],"when":[54],"cocross-linked":[55],"with":[56,70,73],"antigen":[58],"on":[60,77,169],"B":[61],"(BCR).":[63],"However,":[64],"coligation":[65],"RIIb1":[69,219,258],"BCR":[71],"epsilon":[75],"RI":[76],"mast":[78,93],"leads":[80],"inositol":[85,261],"5'":[86],"SHIP":[88,124,140,209,225],"inhibition":[91,187,213,240,253],"from":[95],"SHP-1-deficient":[96],"mice.":[97],"In":[98,202],"this":[99],"study,":[100],"we":[101],"evaluated":[102],"ability":[104],"these":[106],"two":[107],"receptors":[109,132],"block":[111],"target":[112,170],"lysis":[114],"NK":[116,149,242],"cells,":[117],"contribution":[120],"inhibition.":[126,178],"Recombinant":[127],"vaccinia":[128],"viruses":[129],"encoding":[130],"chimeric":[131],"mutants":[136],"were":[141],"used":[142],"in":[145,177,229],"mouse":[146],"human":[148],"cells.":[150],"When":[151],"cytoplasmic":[154,192],"tail":[155,193],"was":[156],"replaced":[157],"that":[159,196,224,239],"RIIb1,":[163],"recognition":[164],"HLA":[166],"class":[167],"I":[168],"extracellular":[174],"domain":[175],"resulted":[176],"A":[179],"mutant":[182,207],"reverted":[185,210],"mediated":[188,197,214,254],"but":[194],"not":[195],"RIIb1.":[201],"contrast,":[203],"only":[211],"tail,":[220],"providing":[221],"functional":[222],"evidence":[223],"plays":[226],"role":[228],"RIIb1-mediated":[233],"signal.":[235],"These":[236],"data":[237],"demonstrate":[238],"primarily":[247],"SHP-1,":[251],"whereas":[252],"requires":[259],"SHIP.":[263]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2025-10-10T00:00:00"}
