{"id":"https://openalex.org/W2017348165","doi":"https://doi.org/10.1016/j.clim.2012.12.011","title":"Immunopathogenesis of osteoarthritis","display_name":"Immunopathogenesis of osteoarthritis","publication_year":2013,"publication_date":"2013-01-06","ids":{"openalex":"https://openalex.org/W2017348165","doi":"https://doi.org/10.1016/j.clim.2012.12.011","mag":"2017348165","pmid":"https://pubmed.ncbi.nlm.nih.gov/23360836","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4015466"},"language":"en","primary_location":{"id":"doi:10.1016/j.clim.2012.12.011","doi":"https://doi.org/10.1016/j.clim.2012.12.011","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.clim.2012.12.011","pdf_url":null,"source":{"id":"https://openalex.org/S37169408","display_name":"Clinical Immunology","issn_l":"1521-6616","issn":["1521-6616","1521-7035"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Immunology","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2017348165"],"child_works_count":0,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/articles/PMC4015466","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5106856692","display_name":"Abdul Haseeb","orcid":"https://orcid.org/0000-0002-2623-1275","observed_orcids":["https://orcid.org/0000-0002-2623-1275"]},"institutions":[{"id":"https://openalex.org/I95240055","display_name":"Northeast Ohio Medical University","ror":"https://ror.org/04q9qf557","country_code":"US","type":"education","lineage":["https://openalex.org/I95240055"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Abdul Haseeb","raw_affiliation_strings":["Department of Anatomy & Neurobiology, Northeast Ohio Medical University, Rootstown, OH 44272, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy & Neurobiology, Northeast Ohio Medical University, Rootstown, OH 44272, USA","institution_ids":["https://openalex.org/I95240055"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057245262","display_name":"Tariq M. Haqqi","orcid":"https://orcid.org/0000-0003-3506-6133","observed_orcids":["https://orcid.org/0000-0003-3506-6133"]},"institutions":[{"id":"https://openalex.org/I95240055","display_name":"Northeast Ohio Medical University","ror":"https://ror.org/04q9qf557","country_code":"US","type":"education","lineage":["https://openalex.org/I95240055"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Tariq M. Haqqi","raw_affiliation_strings":["Department of Anatomy & Neurobiology, Northeast Ohio Medical University, 4209 St. Rt. 44, P.O. Box 95, Rootstown, OH 44272, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy & Neurobiology, Northeast Ohio Medical University, 4209 St. Rt. 44, P.O. Box 95, Rootstown, OH 44272, USA","institution_ids":["https://openalex.org/I95240055"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5057245262"],"corresponding_institution_ids":["https://openalex.org/I95240055"],"apc_list":{"value":4400,"currency":"USD","value_usd":4400},"apc_paid":null,"fwci":4.4059,"has_fulltext":false,"cited_by_count":427,"citation_normalized_percentile":{"value":0.98344066,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"146","issue":"3","first_page":"185","last_page":"196"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/osteoarthritis","display_name":"osteoarthritis","score":0.9879999756813049},{"id":"https://openalex.org/keywords/immunopathogenesis","display_name":"immunopathogenesis","score":0.9629999995231628},{"id":"https://openalex.org/keywords/articular-cartilage-degeneration","display_name":"articular cartilage degeneration","score":0.8140000104904175},{"id":"https://openalex.org/keywords/t-cells","display_name":"T cells","score":0.7900000214576721},{"id":"https://openalex.org/keywords/b-cells","display_name":"B cells","score":0.9990000128746033},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.953000009059906},{"id":"https://openalex.org/keywords/cytokines","display_name":"cytokines","score":0.9340000152587891},{"id":"https://openalex.org/keywords/chemokines","display_name":"chemokines","score":0.9990000128746033},{"id":"https://openalex.org/keywords/complement-system","display_name":"complement system","score":0.9520000219345093},{"id":"https://openalex.org/keywords/matrix-metalloproteinases","display_name":"matrix metalloproteinases","score":1.0},{"id":"https://openalex.org/keywords/prostaglandin-e2","display_name":"prostaglandin E2","score":1.0},{"id":"https://openalex.org/keywords/anti-cytokine-therapy","display_name":"anti-cytokine therapy","score":0.9359999895095825},{"id":"https://openalex.org/keywords/plant-natural-products","display_name":"plant natural products","score":0.9300000071525574},{"id":"https://openalex.org/keywords/drug-development","display_name":"drug development","score":0.5440000295639038}],"concepts":[{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.7942135334014893},{"id":"https://openalex.org/C2780550940","wikidata":"https://www.wikidata.org/wiki/Q502730","display_name":"Cartilage","level":2,"score":0.7595674395561218},{"id":"https://openalex.org/C2776164576","wikidata":"https://www.wikidata.org/wiki/Q62736","display_name":"Osteoarthritis","level":3,"score":0.7502685785293579},{"id":"https://openalex.org/C109523444","wikidata":"https://www.wikidata.org/wiki/Q424216","display_name":"Matrix metalloproteinase","level":2,"score":0.6443166732788086},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.6134534478187561},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6128562688827515},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.592524528503418},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5788620710372925},{"id":"https://openalex.org/C2777575956","wikidata":"https://www.wikidata.org/wiki/Q187255","display_name":"Rheumatoid arthritis","level":2,"score":0.542018711566925},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.47503119707107544},{"id":"https://openalex.org/C2777077863","wikidata":"https://www.wikidata.org/wiki/Q170990","display_name":"Arthritis","level":2,"score":0.4657737910747528},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.20652657747268677},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.08515569567680359},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.08500930666923523},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007113","descriptor_name":"Immunity, Innate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010003","descriptor_name":"Osteoarthritis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056704","descriptor_name":"Adaptive Immunity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.clim.2012.12.011","doi":"https://doi.org/10.1016/j.clim.2012.12.011","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.clim.2012.12.011","pdf_url":null,"source":{"id":"https://openalex.org/S37169408","display_name":"Clinical Immunology","issn_l":"1521-6616","issn":["1521-6616","1521-7035"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Immunology","raw_type":"journal-article"},{"id":"pmid:23360836","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23360836","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical immunology (Orlando, Fla.)","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2993676","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC4015466","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4015466","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4015466/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Clin Immunol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2993676","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC4015466","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1172224398","display_name":"Mechanisms of Chondroprotection by Pomegranate Fruit Extract","funder_award_id":"R01AT003627","funder_id":"https://openalex.org/F4320337593","funder_display_name":"National Center for Complementary and Integrative Health"},{"id":"https://openalex.org/G2331579559","display_name":"Suppression of MMP-13 Expression in Arthritis by Pomegranate","funder_award_id":"R01AT005520","funder_id":"https://openalex.org/F4320337593","funder_display_name":"National Center for Complementary and Integrative Health"},{"id":"https://openalex.org/G2382938015","display_name":"CHONDROPROTECTIVE ACTIVITY OF POMEGRANATE EXTRACT","funder_award_id":"R21AT004026","funder_id":"https://openalex.org/F4320337593","funder_display_name":"National Center for Complementary and Integrative Health"}],"funders":[{"id":"https://openalex.org/F4320337593","display_name":"National Center for Complementary and Integrative Health","ror":"https://ror.org/00190t495"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":179,"referenced_works":["https://openalex.org/W15708667","https://openalex.org/W56207713","https://openalex.org/W175199685","https://openalex.org/W183410626","https://openalex.org/W193282271","https://openalex.org/W1488112431","https://openalex.org/W1607875640","https://openalex.org/W1768099775","https://openalex.org/W1782148244","https://openalex.org/W1848420443","https://openalex.org/W1851925799","https://openalex.org/W1922662285","https://openalex.org/W1929515229","https://openalex.org/W1944061732","https://openalex.org/W1959157182","https://openalex.org/W1963315781","https://openalex.org/W1963657283","https://openalex.org/W1964132223","https://openalex.org/W1967024742","https://openalex.org/W1967357201","https://openalex.org/W1967469609","https://openalex.org/W1969540068","https://openalex.org/W1971066261","https://openalex.org/W1971355172","https://openalex.org/W1971710323","https://openalex.org/W1972861978","https://openalex.org/W1974996960","https://openalex.org/W1975566660","https://openalex.org/W1975777695","https://openalex.org/W1977564820","https://openalex.org/W1979971922","https://openalex.org/W1979972616","https://openalex.org/W1980409139","https://openalex.org/W1981199758","https://openalex.org/W1981799488","https://openalex.org/W1982564040","https://openalex.org/W1983063657","https://openalex.org/W1983345459","https://openalex.org/W1984367241","https://openalex.org/W1987383242","https://openalex.org/W1993922139","https://openalex.org/W1996058009","https://openalex.org/W1996501296","https://openalex.org/W1997957358","https://openalex.org/W1998866269","https://openalex.org/W2001405211","https://openalex.org/W2002398009","https://openalex.org/W2003442374","https://openalex.org/W2004062708","https://openalex.org/W2005091462","https://openalex.org/W2008430756","https://openalex.org/W2008596857","https://openalex.org/W2010802338","https://openalex.org/W2011471302","https://openalex.org/W2011509273","https://openalex.org/W2014458492","https://openalex.org/W2014751598","https://openalex.org/W2014952783","https://openalex.org/W2016268966","https://openalex.org/W2016594353","https://openalex.org/W2017604635","https://openalex.org/W2017720269","https://openalex.org/W2017750008","https://openalex.org/W2017824359","https://openalex.org/W2022640830","https://openalex.org/W2023723670","https://openalex.org/W2024452130","https://openalex.org/W2028255006","https://openalex.org/W2029355740","https://openalex.org/W2029818075","https://openalex.org/W2032010202","https://openalex.org/W2033088300","https://openalex.org/W2035242925","https://openalex.org/W2035696265","https://openalex.org/W2036556119","https://openalex.org/W2037174379","https://openalex.org/W2037755817","https://openalex.org/W2038503730","https://openalex.org/W2038773696","https://openalex.org/W2039799680","https://openalex.org/W2041480611","https://openalex.org/W2041766211","https://openalex.org/W2041865050","https://openalex.org/W2042469661","https://openalex.org/W2044000768","https://openalex.org/W2044953211","https://openalex.org/W2046712927","https://openalex.org/W2047334057","https://openalex.org/W2049907045","https://openalex.org/W2053342448","https://openalex.org/W2055019305","https://openalex.org/W2055316800","https://openalex.org/W2055361189","https://openalex.org/W2056209478","https://openalex.org/W2062013622","https://openalex.org/W2063728474","https://openalex.org/W2063795634","https://openalex.org/W2065990895","https://openalex.org/W2067042828","https://openalex.org/W2067581223","https://openalex.org/W2067870418","https://openalex.org/W2068780189","https://openalex.org/W2071823815","https://openalex.org/W2071862575","https://openalex.org/W2074830311","https://openalex.org/W2075095085","https://openalex.org/W2076653117","https://openalex.org/W2079011919","https://openalex.org/W2079164159","https://openalex.org/W2080242509","https://openalex.org/W2080749521","https://openalex.org/W2080847834","https://openalex.org/W2084612356","https://openalex.org/W2085467998","https://openalex.org/W2085788584","https://openalex.org/W2086276639","https://openalex.org/W2086319788","https://openalex.org/W2088018213","https://openalex.org/W2089293788","https://openalex.org/W2090327351","https://openalex.org/W2097250275","https://openalex.org/W2098049472","https://openalex.org/W2099489843","https://openalex.org/W2101842801","https://openalex.org/W2103691455","https://openalex.org/W2104206929","https://openalex.org/W2106597066","https://openalex.org/W2107103044","https://openalex.org/W2107154754","https://openalex.org/W2116655288","https://openalex.org/W2116948093","https://openalex.org/W2118519694","https://openalex.org/W2119005679","https://openalex.org/W2123884480","https://openalex.org/W2124248657","https://openalex.org/W2124504432","https://openalex.org/W2126397496","https://openalex.org/W2126659405","https://openalex.org/W2127093616","https://openalex.org/W2130574707","https://openalex.org/W2131626977","https://openalex.org/W2132612143","https://openalex.org/W2134451181","https://openalex.org/W2134486617","https://openalex.org/W2135556909","https://openalex.org/W2136570699","https://openalex.org/W2137111577","https://openalex.org/W2137742454","https://openalex.org/W2139676110","https://openalex.org/W2141363952","https://openalex.org/W2142278557","https://openalex.org/W2142925530","https://openalex.org/W2144032514","https://openalex.org/W2144739570","https://openalex.org/W2144828122","https://openalex.org/W2150602579","https://openalex.org/W2151098475","https://openalex.org/W2152217106","https://openalex.org/W2153192975","https://openalex.org/W2154519842","https://openalex.org/W2158344822","https://openalex.org/W2161060506","https://openalex.org/W2171529323","https://openalex.org/W2338326476","https://openalex.org/W2400761325","https://openalex.org/W2409338306","https://openalex.org/W2409562611","https://openalex.org/W2414710470","https://openalex.org/W2417238687","https://openalex.org/W2417725630","https://openalex.org/W2467650495","https://openalex.org/W4241343866","https://openalex.org/W4313341423","https://openalex.org/W4407211842","https://openalex.org/W6638007500","https://openalex.org/W6638855577","https://openalex.org/W6638902552","https://openalex.org/W6712796331","https://openalex.org/W6719793375"],"related_works":["https://openalex.org/W7124293971","https://openalex.org/W4388183569","https://openalex.org/W2971013613","https://openalex.org/W2103713026","https://openalex.org/W1873410371","https://openalex.org/W4367295905","https://openalex.org/W7161771748","https://openalex.org/W2912297647","https://openalex.org/W2257713522"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":19},{"year":2025,"cited_by_count":28},{"year":2024,"cited_by_count":34},{"year":2023,"cited_by_count":41},{"year":2022,"cited_by_count":50},{"year":2021,"cited_by_count":46},{"year":2020,"cited_by_count":35},{"year":2019,"cited_by_count":28},{"year":2018,"cited_by_count":26},{"year":2017,"cited_by_count":32},{"year":2016,"cited_by_count":30},{"year":2015,"cited_by_count":26},{"year":2014,"cited_by_count":19},{"year":2013,"cited_by_count":13}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2016-06-24T00:00:00"}
