{"id":"https://openalex.org/W2017347722","doi":"https://doi.org/10.1016/j.gdata.2014.06.005","title":"Transcriptome profiling of LGR5 positive colorectal cancer cells","display_name":"Transcriptome profiling of LGR5 positive colorectal cancer cells","publication_year":2014,"publication_date":"2014-06-16","ids":{"openalex":"https://openalex.org/W2017347722","doi":"https://doi.org/10.1016/j.gdata.2014.06.005","mag":"2017347722","pmid":"https://pubmed.ncbi.nlm.nih.gov/26484096","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4535966"},"language":"en","primary_location":{"id":"doi:10.1016/j.gdata.2014.06.005","doi":"https://doi.org/10.1016/j.gdata.2014.06.005","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.gdata.2014.06.005","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2213596014000385/pdf","source":{"id":"https://openalex.org/S2764425287","display_name":"Genomics Data","issn_l":"2213-5960","issn":["2213-5960"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","poland-70"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genomics Data","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.sciencedirect.com/science/article/pii/S2213596014000385/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043549277","display_name":"Daniela D. Hirsch","orcid":"https://orcid.org/0000-0001-8883-922X","observed_orcids":["https://orcid.org/0000-0001-8883-922X"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]},{"id":"https://openalex.org/I60668342","display_name":"University of Regensburg","ror":"https://ror.org/01eezs655","country_code":"DE","type":"education","lineage":["https://openalex.org/I60668342"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Daniela Hirsch","raw_affiliation_strings":["Section of Cancer Genomics, Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA ; Institute of Pathology, University of Regensburg, Germany","Institute of Pathology, University of Regensburg, Germany","Section of Cancer Genomics, Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Cancer Genomics, Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA ; Institute of Pathology, University of Regensburg, Germany","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717","https://openalex.org/I60668342"]},{"raw_affiliation_string":"Institute of Pathology, University of Regensburg, Germany","institution_ids":["https://openalex.org/I60668342"]},{"raw_affiliation_string":"Section of Cancer Genomics, Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100755018","display_name":"Yue Hu","orcid":"https://orcid.org/0000-0001-8685-5322","observed_orcids":["https://orcid.org/0000-0001-8685-5322"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yue Hu","raw_affiliation_strings":["Section of Cancer Genomics, Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Cancer Genomics, Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031392514","display_name":"Thomas Ried","orcid":"https://orcid.org/0000-0002-0767-6009","observed_orcids":["https://orcid.org/0000-0002-0767-6009"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Thomas Ried","raw_affiliation_strings":["Section of Cancer Genomics, Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Cancer Genomics, Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111419263","display_name":"Roland Moll","orcid":"https://orcid.org/0000-0002-1791-922X","observed_orcids":["https://orcid.org/0000-0002-1791-922X"]},"institutions":[{"id":"https://openalex.org/I161103922","display_name":"Philipps University of Marburg","ror":"https://ror.org/01rdrb571","country_code":"DE","type":"education","lineage":["https://openalex.org/I161103922"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Roland Moll","raw_affiliation_strings":["Institute of Pathology, University of Marburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathology, University of Marburg, Germany","institution_ids":["https://openalex.org/I161103922"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001177562","display_name":"Timo Gaiser","orcid":"https://orcid.org/0000-0002-6022-073X","observed_orcids":["https://orcid.org/0000-0002-6022-073X"]},"institutions":[{"id":"https://openalex.org/I4210156450","display_name":"University Medical Centre Mannheim","ror":"https://ror.org/05sxbyd35","country_code":"DE","type":"funder","lineage":["https://openalex.org/I4210156450"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Timo Gaiser","raw_affiliation_strings":["Institute of Pathology, University Medical Center Mannheim, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathology, University Medical Center Mannheim, Germany","institution_ids":["https://openalex.org/I4210156450"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5001177562","https://openalex.org/A5031392514"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717","https://openalex.org/I4210156450"],"apc_list":{"value":500,"currency":"USD","value_usd":500},"apc_paid":{"value":500,"currency":"USD","value_usd":500},"fwci":0.8052,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.73066483,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"2","issue":null,"first_page":"212","last_page":"215"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lgr5","display_name":"Lgr5","score":0.7559999823570251},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.9769999980926514},{"id":"https://openalex.org/keywords/cancer-stem-cells","display_name":"cancer stem cells","score":0.9959999918937683},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.7680000066757202},{"id":"https://openalex.org/keywords/notch-signaling","display_name":"Notch signaling","score":0.8880000114440918},{"id":"https://openalex.org/keywords/wnt-signaling","display_name":"Wnt signaling","score":0.9990000128746033},{"id":"https://openalex.org/keywords/sw480-cells","display_name":"SW480 cells","score":0.875},{"id":"https://openalex.org/keywords/intestinal-stem-cells","display_name":"intestinal stem cells","score":0.6449999809265137}],"concepts":[{"id":"https://openalex.org/C10116572","wikidata":"https://www.wikidata.org/wiki/Q18033097","display_name":"LGR5","level":4,"score":0.9588757157325745},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7005996108055115},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.6725213527679443},{"id":"https://openalex.org/C55427017","wikidata":"https://www.wikidata.org/wiki/Q1638475","display_name":"Cancer stem cell","level":3,"score":0.652976930141449},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5366612672805786},{"id":"https://openalex.org/C136302470","wikidata":"https://www.wikidata.org/wiki/Q7607299","display_name":"Stem cell marker","level":3,"score":0.518817126750946},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.5137749314308167},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4882991313934326},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.44646409153938293},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.44099533557891846},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.41550856828689575},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3617473840713501},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.30567264556884766},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.21849605441093445},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.20727097988128662},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.18025809526443481},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.13923150300979614},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.1016/j.gdata.2014.06.005","doi":"https://doi.org/10.1016/j.gdata.2014.06.005","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.gdata.2014.06.005","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2213596014000385/pdf","source":{"id":"https://openalex.org/S2764425287","display_name":"Genomics Data","issn_l":"2213-5960","issn":["2213-5960"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","poland-70"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genomics Data","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3582077","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4535966","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4535966","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4535966","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genom Data","raw_type":"Text"},{"id":"pmid:26484096","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26484096","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genomics data","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:ccdef0e678374b3fbb15841ec2c7bba5","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/ccdef0e678374b3fbb15841ec2c7bba5","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Genomics Data, Vol 2, Iss C, Pp 212-215 (2014)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.gdata.2014.06.005","doi":"https://doi.org/10.1016/j.gdata.2014.06.005","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.gdata.2014.06.005","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2213596014000385/pdf","source":{"id":"https://openalex.org/S2764425287","display_name":"Genomics Data","issn_l":"2213-5960","issn":["2213-5960"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","poland-70"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genomics Data","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8999999761581421,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.7300000190734863,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320875","display_name":"Deutscher Akademischer Austauschdienst","ror":"https://ror.org/039djdh30"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334760","display_name":"German Academic Exchange Service New Delhi","ror":"https://ror.org/039djdh30"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F8394932145","display_name":"Intramural Research Program","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2017347722.pdf","grobid_xml":"https://content.openalex.org/works/W2017347722.grobid-xml"},"referenced_works_count":4,"referenced_works":["https://openalex.org/W1976631815","https://openalex.org/W1982603620","https://openalex.org/W2103548193","https://openalex.org/W2171759387"],"related_works":["https://openalex.org/W2171759387","https://openalex.org/W2330567607","https://openalex.org/W2008176496","https://openalex.org/W2810760803","https://openalex.org/W1977169442","https://openalex.org/W2091996588","https://openalex.org/W2549082964","https://openalex.org/W7100494355","https://openalex.org/W4407232586","https://openalex.org/W1989258758"],"abstract_inverted_index":{"The":[0,28,150,228],"concept":[1],"of":[2,23,30,35,46,76,105,110,121,144,157,166,182,208,232],"cancer":[3,26],"stem":[4,79,184,200],"cells":[5,95,159,178,195],"(CSCs)":[6],"claims":[7],"that":[8,127,160],"colorectal":[9,14],"carcinomas":[10],"(CRCs),":[11],"like":[12],"normal":[13,199],"epithelium,":[15],"are":[16],"organized":[17],"hierarchically":[18],"and":[19,44,146,168,187,196,230,237,246],"contain":[20],"a":[21,39,106,119,205],"subpopulation":[22,109],"qualitatively":[24],"distinct":[25,108],"cells.":[27,113,201],"expression":[29,91,116,173,212,235],"distinctive":[31],"surface":[32],"markers":[33],"or":[34,163],"certain":[36],"enzymes":[37],"is":[38],"prerequisite":[40],"for":[41],"the":[42,47,73,77,103],"isolation":[43],"characterization":[45],"CSC":[48],"population.":[49],"With":[50],"respect":[51],"to":[52,102,219],"CRCs,":[53],"putative":[54],"CSCs":[55],"can":[56],"be":[57,129],"identified":[58],"by":[59,131,244],"leucine-rich-repeat-containing":[60],"G-protein-coupled":[61,68],"receptor":[62,69],"5":[63],"(Lgr5,":[64],"also":[65],"known":[66],"as":[67],"49,":[70],"Gpr49).":[71],"However,":[72],"precise":[74],"function":[75],"intestinal":[78],"cell":[80],"marker":[81],"Lgr5":[82,167,175,192,197],"in":[83,92,139,248,250],"CRCs":[84],"remains":[85],"largely":[86],"unknown.":[87],"We":[88],"silenced":[89],"LGR5":[90,125],"SW480":[93,111],"CRC":[94,112],"via":[96,142],"lentiviral":[97],"shRNA":[98],"constructs.":[99],"This":[100],"led":[101],"depletion":[104],"morphologically":[107],"Microarray":[114],"gene":[115,172,211,234],"profiling":[117],"revealed":[118],"down-regulation":[120],"NOTCH":[122],"signaling":[123,190],"upon":[124],"silencing":[126],"could":[128],"confirmed":[130],"immunohistochemistry.":[132],"Furthermore,":[133],"we":[134,203],"induced":[135,151],"inflammation-driven":[136],"colon":[137],"tumors":[138,152],"Lgr5-EGFP-IRES-Cre-ERT2":[140],"mice":[141],"administration":[143],"azoxymethane":[145],"dextrane":[147],"sodium":[148],"sulfate.":[149],"were":[153,169],"flow-sorted":[154],"into":[155],"fractions":[156],"epithelial":[158],"expressed":[161],"high":[162,176,198],"low":[164,193],"levels":[165,181],"characterized":[170],"using":[171],"profiling.":[174],"tumor":[177,194],"showed":[179],"higher":[180,188],"several":[183],"cell-associated":[185],"genes":[186],"Wnt":[189],"than":[191],"Here":[202],"provide":[204],"thorough":[206],"description":[207],"our":[209,233],"two":[210],"datasets":[213],"including":[214],"quality":[215],"control":[216],"checks":[217],"uploaded":[218],"Gene":[220],"Expression":[221],"Omnibus":[222],"database":[223],"(data":[224],"accession":[225],"number:":[226],"GSE46200).":[227],"analysis":[229],"interpretation":[231],"data":[236],"related":[238],"results":[239],"have":[240],"been":[241],"published":[242],"recently":[243],"Hirsch":[245],"colleagues":[247],"Carcinogenesis":[249],"2014.":[251]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":5}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2016-06-24T00:00:00"}