{"id":"https://openalex.org/W2017343452","doi":"https://doi.org/10.1016/j.febslet.2013.11.007","title":"Protein engineering to target complement evasion in cancer","display_name":"Protein engineering to target complement evasion in cancer","publication_year":2013,"publication_date":"2013-11-14","ids":{"openalex":"https://openalex.org/W2017343452","doi":"https://doi.org/10.1016/j.febslet.2013.11.007","mag":"2017343452","pmid":"https://pubmed.ncbi.nlm.nih.gov/24239543","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3894055"},"language":"en","primary_location":{"id":"doi:10.1016/j.febslet.2013.11.007","doi":"https://doi.org/10.1016/j.febslet.2013.11.007","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.febslet.2013.11.007","pdf_url":null,"source":{"id":"https://openalex.org/S104830714","display_name":"FEBS Letters","issn_l":"0014-5793","issn":["0014-5793","1873-3468"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS Letters","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3894055","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072667047","display_name":"Darrick Carter","orcid":"https://orcid.org/0000-0001-5901-3402","observed_orcids":["https://orcid.org/0000-0001-5901-3402"]},"institutions":[{"id":"https://openalex.org/I4210105994","display_name":"Compliment Corporation (United States)","ror":"https://ror.org/01gy41z17","country_code":"US","type":"company","lineage":["https://openalex.org/I4210105994"]},{"id":"https://openalex.org/I4210158131","display_name":"PAI Life Sciences (United States)","ror":"https://ror.org/00tbsgb37","country_code":"US","type":"company","lineage":["https://openalex.org/I4210158131"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Darrick Carter","raw_affiliation_strings":["PAI Life Sciences Inc., Seattle, WA, United States; Compliment Corp., Seattle, WA, United States. Electronic address: darrick.carter@pailifesciences.com","Compliment Corp., Seattle, WA, United States","PAI Life Sciences Inc., Seattle, WA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PAI Life Sciences Inc., Seattle, WA, United States; Compliment Corp., Seattle, WA, United States. Electronic address: darrick.carter@pailifesciences.com","institution_ids":["https://openalex.org/I4210105994","https://openalex.org/I4210158131"]},{"raw_affiliation_string":"Compliment Corp., Seattle, WA, United States","institution_ids":["https://openalex.org/I4210105994"]},{"raw_affiliation_string":"PAI Life Sciences Inc., Seattle, WA, United States","institution_ids":["https://openalex.org/I4210158131"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029285661","display_name":"Andr\u00e9 Lieber","orcid":"https://orcid.org/0000-0001-6742-6266","observed_orcids":["https://orcid.org/0000-0001-6742-6266"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andr\u00e9 Lieber","raw_affiliation_strings":["Department of Medicine, University of Washington, Seattle, WA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Washington, Seattle, WA, United States","institution_ids":["https://openalex.org/I201448701"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5072667047"],"corresponding_institution_ids":["https://openalex.org/I4210105994","https://openalex.org/I4210158131"],"apc_list":{"value":3980,"currency":"USD","value_usd":3980},"apc_paid":null,"fwci":0.2038,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.17857143,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"588","issue":"2","first_page":"334","last_page":"340"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/complement-system","display_name":"complement system","score":0.781000018119812},{"id":"https://openalex.org/keywords/complement-evasion","display_name":"complement evasion","score":0.8769999742507935},{"id":"https://openalex.org/keywords/tumor-immune-evasion","display_name":"tumor immune evasion","score":0.8939999938011169},{"id":"https://openalex.org/keywords/protein-engineering","display_name":"protein engineering","score":0.8080000281333923},{"id":"https://openalex.org/keywords/antibody-engineering","display_name":"antibody engineering","score":0.7639999985694885},{"id":"https://openalex.org/keywords/complement-fixation","display_name":"complement fixation","score":0.9110000133514404},{"id":"https://openalex.org/keywords/membrane-attack-complex","display_name":"membrane attack complex","score":0.9549999833106995},{"id":"https://openalex.org/keywords/opsonization","display_name":"opsonization","score":0.6930000185966492},{"id":"https://openalex.org/keywords/complement-resistance","display_name":"complement resistance","score":0.4180000126361847}],"concepts":[{"id":"https://openalex.org/C112313634","wikidata":"https://www.wikidata.org/wiki/Q7886648","display_name":"Complement (music)","level":5,"score":0.6032675504684448},{"id":"https://openalex.org/C2781251061","wikidata":"https://www.wikidata.org/wiki/Q5416089","display_name":"Evasion (ethics)","level":3,"score":0.5921523571014404},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.44269508123397827},{"id":"https://openalex.org/C147816474","wikidata":"https://www.wikidata.org/wiki/Q169525","display_name":"Protein engineering","level":3,"score":0.44218504428863525},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.35660529136657715},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.34031325578689575},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.265948623418808},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.25409966707229614},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.10510408878326416},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07126742601394653},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.0},{"id":"https://openalex.org/C188082640","wikidata":"https://www.wikidata.org/wiki/Q1780899","display_name":"Complementation","level":4,"score":0.0},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003165","descriptor_name":"Complement System Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015202","descriptor_name":"Protein Engineering","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019139","descriptor_name":"Tumor Escape","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057170","descriptor_name":"Translational Research, Biomedical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058990","descriptor_name":"Molecular Targeted Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.febslet.2013.11.007","doi":"https://doi.org/10.1016/j.febslet.2013.11.007","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.febslet.2013.11.007","pdf_url":null,"source":{"id":"https://openalex.org/S104830714","display_name":"FEBS Letters","issn_l":"0014-5793","issn":["0014-5793","1873-3468"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS Letters","raw_type":"journal-article"},{"id":"pmid:24239543","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24239543","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS letters","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:3265704","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3894055","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3894055","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3894055","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"FEBS Lett","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:3265704","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3894055","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.699999988079071,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3533434708","display_name":"Reducing Complement Inhibition to Treat Leukemia and Lymphoma","funder_award_id":"R44CA162582","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4363373668","display_name":"Evaluation of vectors based on group B adenoviruses","funder_award_id":"R01HL078836","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5879276888","display_name":"ONCOLYTIC ADENOVIRUSES FOR CERVICAL CANCER GENE THERAPY","funder_award_id":"R01CA080192","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":90,"referenced_works":["https://openalex.org/W16479714","https://openalex.org/W60759546","https://openalex.org/W1516695624","https://openalex.org/W1520434148","https://openalex.org/W1550517269","https://openalex.org/W1563987451","https://openalex.org/W1589026573","https://openalex.org/W1592208285","https://openalex.org/W1594450556","https://openalex.org/W1598814826","https://openalex.org/W1760063727","https://openalex.org/W1812697829","https://openalex.org/W1898469614","https://openalex.org/W1937064569","https://openalex.org/W1978306901","https://openalex.org/W1980219722","https://openalex.org/W1981755236","https://openalex.org/W1984342356","https://openalex.org/W1985505595","https://openalex.org/W1986592145","https://openalex.org/W1990559365","https://openalex.org/W1992868764","https://openalex.org/W1994476982","https://openalex.org/W1999357965","https://openalex.org/W2005044790","https://openalex.org/W2006089798","https://openalex.org/W2006210104","https://openalex.org/W2008908847","https://openalex.org/W2010378809","https://openalex.org/W2010690729","https://openalex.org/W2011498518","https://openalex.org/W2012804478","https://openalex.org/W2015642465","https://openalex.org/W2015977494","https://openalex.org/W2016661084","https://openalex.org/W2016865478","https://openalex.org/W2021004292","https://openalex.org/W2021202438","https://openalex.org/W2034837473","https://openalex.org/W2037163794","https://openalex.org/W2038369384","https://openalex.org/W2044722821","https://openalex.org/W2048215714","https://openalex.org/W2050349950","https://openalex.org/W2050486788","https://openalex.org/W2059435741","https://openalex.org/W2062697989","https://openalex.org/W2065316818","https://openalex.org/W2065908828","https://openalex.org/W2066485964","https://openalex.org/W2069524809","https://openalex.org/W2073591257","https://openalex.org/W2076953008","https://openalex.org/W2080421046","https://openalex.org/W2081162417","https://openalex.org/W2084462937","https://openalex.org/W2087327320","https://openalex.org/W2089036873","https://openalex.org/W2092518756","https://openalex.org/W2094030754","https://openalex.org/W2095444125","https://openalex.org/W2096252424","https://openalex.org/W2096376610","https://openalex.org/W2104199760","https://openalex.org/W2105158060","https://openalex.org/W2110243495","https://openalex.org/W2115351802","https://openalex.org/W2120377442","https://openalex.org/W2120844308","https://openalex.org/W2122417682","https://openalex.org/W2122725450","https://openalex.org/W2130867811","https://openalex.org/W2134119060","https://openalex.org/W2136165024","https://openalex.org/W2136648677","https://openalex.org/W2139256276","https://openalex.org/W2142355921","https://openalex.org/W2147085530","https://openalex.org/W2152966387","https://openalex.org/W2153255423","https://openalex.org/W2162409851","https://openalex.org/W2165016134","https://openalex.org/W2165211727","https://openalex.org/W2168648203","https://openalex.org/W2169697055","https://openalex.org/W2177719047","https://openalex.org/W2270317063","https://openalex.org/W2316655979","https://openalex.org/W3022944672","https://openalex.org/W4238278421"],"related_works":["https://openalex.org/W2122417682","https://openalex.org/W2186786976","https://openalex.org/W4405933795","https://openalex.org/W2416658983","https://openalex.org/W4414887600","https://openalex.org/W3030033315","https://openalex.org/W2568898424","https://openalex.org/W2294306447","https://openalex.org/W4411206902","https://openalex.org/W3095746971"],"abstract_inverted_index":{"The":[0],"complement":[1,23,48,71,85,92,113,118,135,140,154],"system":[2],"is":[3],"composed":[4],"of":[5,22,26,30,36,53,90,131,152],"soluble":[6],"factors":[7,50,73,94],"in":[8,70,95,125],"plasma":[9],"that":[10,138,148],"enhance":[11,134],"or":[12,115],"\"complement\"":[13],"immune-mediated":[14],"killing":[15,35],"through":[16,39],"innate":[17],"and":[18,33,87],"adaptive":[19],"mechanisms.":[20],"Activation":[21],"causes":[24],"recruitment":[25],"immune":[27,59,97],"cells;":[28,32],"opsonization":[29],"coated":[31],"direct":[34],"affected":[37],"cells":[38,46],"a":[40],"membrane":[41],"attack":[42],"complex":[43],"(MAC).":[44],"Tumor":[45],"up-regulate":[47],"inhibitory":[49,72,93,141],"-":[51],"one":[52],"several":[54],"strategies":[55],"to":[56,111,116,121,133],"evade":[57],"the":[58,65,83,88,153],"system.":[60,155],"In":[61],"many":[62],"cases":[63],"as":[64,99,101,143,145],"tumor":[66],"progresses,":[67],"dramatic":[68],"increases":[69],"are":[74,108],"found":[75],"on":[76,82,102],"these":[77],"cells.":[78],"This":[79],"review":[80],"focuses":[81],"classic":[84],"pathway":[86],"role":[89],"major":[91],"cancer":[96],"evasion":[98],"well":[100,144],"how":[103],"current":[104],"protein":[105],"engineering":[106,130],"efforts":[107],"being":[109],"employed":[110],"increase":[112],"fixing":[114],"reverse":[117],"resistance":[119],"leading":[120],"better":[122],"therapeutic":[123],"outcomes":[124],"oncology.":[126],"Strategies":[127],"discussed":[128],"include":[129],"antibodies":[132,137],"fixation,":[136],"neutralize":[139],"proteins":[142],"engineered":[146],"constructs":[147],"specifically":[149],"target":[150],"inhibition":[151]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
