{"id":"https://openalex.org/W2017335080","doi":"https://doi.org/10.1016/j.freeradbiomed.2014.10.390","title":"Endothelial Hemoglobin Alpha by the HBA1 Gene Is Crucial to Release of NO-Derived Metabolites into Tissue and Blood","display_name":"Endothelial Hemoglobin Alpha by the HBA1 Gene Is Crucial to Release of NO-Derived Metabolites into Tissue and Blood","publication_year":2014,"publication_date":"2014-11-01","ids":{"openalex":"https://openalex.org/W2017335080","doi":"https://doi.org/10.1016/j.freeradbiomed.2014.10.390","mag":"2017335080"},"language":"en","primary_location":{"id":"doi:10.1016/j.freeradbiomed.2014.10.390","doi":"https://doi.org/10.1016/j.freeradbiomed.2014.10.390","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.freeradbiomed.2014.10.390","pdf_url":null,"source":{"id":"https://openalex.org/S128018148","display_name":"Free Radical Biology and Medicine","issn_l":"0891-5849","issn":["0891-5849","1873-4596"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Free Radical Biology and Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090264314","display_name":"Joshua Thomas Butcher","orcid":"https://orcid.org/0000-0002-7341-1949","observed_orcids":["https://orcid.org/0000-0002-7341-1949"]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joshua Thomas Butcher","raw_affiliation_strings":["University of Virginia, USA","University of Virginia , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Virginia, USA","institution_ids":["https://openalex.org/I51556381"]},{"raw_affiliation_string":"University of Virginia , USA","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078813192","display_name":"Leon J. DeLalio","orcid":"https://orcid.org/0000-0002-9251-0109","observed_orcids":["https://orcid.org/0000-0002-9251-0109"]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leon J. DeLalio","raw_affiliation_strings":["University of Virginia, USA","University of Virginia , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Virginia, USA","institution_ids":["https://openalex.org/I51556381"]},{"raw_affiliation_string":"University of Virginia , USA","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062327254","display_name":"Lauren A. Biwer","orcid":"https://orcid.org/0000-0003-2788-9025","observed_orcids":["https://orcid.org/0000-0003-2788-9025"]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lauren A. Biwer","raw_affiliation_strings":["University of Virginia, USA","University of Virginia , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Virginia, USA","institution_ids":["https://openalex.org/I51556381"]},{"raw_affiliation_string":"University of Virginia , USA","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067162296","display_name":"Rachel B. Weaver","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rachel B. Weaver","raw_affiliation_strings":["University of Virginia, USA","University of Virginia , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Virginia, USA","institution_ids":["https://openalex.org/I51556381"]},{"raw_affiliation_string":"University of Virginia , USA","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036017969","display_name":"Brant E. Isakson","orcid":"https://orcid.org/0000-0002-7692-6294","observed_orcids":["https://orcid.org/0000-0002-7692-6294"]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brant E. Isakson","raw_affiliation_strings":["University of Virginia, USA","University of Virginia , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Virginia, USA","institution_ids":["https://openalex.org/I51556381"]},{"raw_affiliation_string":"University of Virginia , USA","institution_ids":["https://openalex.org/I51556381"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I51556381"],"apc_list":{"value":4240,"currency":"USD","value_usd":4240},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.10123643,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"76","issue":null,"first_page":"S42","last_page":"S42"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12094","display_name":"Hemoglobin structure and function","score":0.5503000020980835,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12094","display_name":"Hemoglobin structure and function","score":0.5503000020980835,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.3237000107765198,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11848","display_name":"Heme Oxygenase-1 and Carbon Monoxide","score":0.10700000077486038,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nitric-oxide-metabolites","display_name":"nitric oxide metabolites","score":0.859000027179718},{"id":"https://openalex.org/keywords/nitric-oxide-release","display_name":"nitric oxide release","score":0.4860000014305115},{"id":"https://openalex.org/keywords/endothelial-function","display_name":"endothelial function","score":0.5960000157356262},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.3409999907016754}],"concepts":[{"id":"https://openalex.org/C123273963","wikidata":"https://www.wikidata.org/wiki/Q624758","display_name":"Psychopathology","level":2,"score":0.7142939567565918},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.6618028879165649},{"id":"https://openalex.org/C7991579","wikidata":"https://www.wikidata.org/wiki/Q17955","display_name":"Criticism","level":2,"score":0.6009250283241272},{"id":"https://openalex.org/C2778143943","wikidata":"https://www.wikidata.org/wiki/Q523747","display_name":"Expressed emotion","level":2,"score":0.55010586977005},{"id":"https://openalex.org/C138496976","wikidata":"https://www.wikidata.org/wiki/Q175002","display_name":"Developmental psychology","level":1,"score":0.5452020168304443},{"id":"https://openalex.org/C27415008","wikidata":"https://www.wikidata.org/wiki/Q7256382","display_name":"Psychological intervention","level":2,"score":0.46977418661117554},{"id":"https://openalex.org/C168900304","wikidata":"https://www.wikidata.org/wiki/Q171407","display_name":"Valence (chemistry)","level":2,"score":0.44630664587020874},{"id":"https://openalex.org/C2776910235","wikidata":"https://www.wikidata.org/wiki/Q18574","display_name":"Reactivity (psychology)","level":3,"score":0.4428699016571045},{"id":"https://openalex.org/C70410870","wikidata":"https://www.wikidata.org/wiki/Q199906","display_name":"Clinical psychology","level":1,"score":0.3142928183078766},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.18100106716156006},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.16706398129463196},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C124952713","wikidata":"https://www.wikidata.org/wiki/Q8242","display_name":"Literature","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C142362112","wikidata":"https://www.wikidata.org/wiki/Q735","display_name":"Art","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.freeradbiomed.2014.10.390","doi":"https://doi.org/10.1016/j.freeradbiomed.2014.10.390","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.freeradbiomed.2014.10.390","pdf_url":null,"source":{"id":"https://openalex.org/S128018148","display_name":"Free Radical Biology and Medicine","issn_l":"0891-5849","issn":["0891-5849","1873-4596"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Free Radical Biology and Medicine","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8371999859809875,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.8299999833106995,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3037142710","https://openalex.org/W4242379013","https://openalex.org/W2383040752","https://openalex.org/W2128346441","https://openalex.org/W2071017401","https://openalex.org/W2101119071","https://openalex.org/W3122105657","https://openalex.org/W2594716788","https://openalex.org/W2125773506","https://openalex.org/W3163286018"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2025-10-10T00:00:00"}