{"id":"https://openalex.org/W2017325634","doi":"https://doi.org/10.1111/j.1365-2893.2009.01156.x","title":"Hepatitis B virus X protein induces hypermethylation of p16INK4Apromoter via DNA methyltransferases in the early stage of HBV-associated hepatocarcinogenesis","display_name":"Hepatitis B virus X protein induces hypermethylation of p16INK4Apromoter via DNA methyltransferases in the early stage of HBV-associated hepatocarcinogenesis","publication_year":2009,"publication_date":"2009-09-03","ids":{"openalex":"https://openalex.org/W2017325634","doi":"https://doi.org/10.1111/j.1365-2893.2009.01156.x","mag":"2017325634","pmid":"https://pubmed.ncbi.nlm.nih.gov/19732323"},"language":"en","primary_location":{"id":"doi:10.1111/j.1365-2893.2009.01156.x","doi":"https://doi.org/10.1111/j.1365-2893.2009.01156.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1365-2893.2009.01156.x","pdf_url":null,"source":{"id":"https://openalex.org/S164225461","display_name":"Journal of Viral Hepatitis","issn_l":"1352-0504","issn":["1352-0504","1365-2893"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Viral Hepatitis","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088412895","display_name":"Yi Zhun Zhu","orcid":"https://orcid.org/0000-0001-7700-8041","observed_orcids":["https://orcid.org/0000-0001-7700-8041","https://orcid.org/0000-0003-0845-0164"]},"institutions":[{"id":"https://openalex.org/I133868755","display_name":"Shanghai Medical College of Fudan University","ror":"https://ror.org/01zntxs11","country_code":"CN","type":"education","lineage":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Y.-Z. Zhu","raw_affiliation_strings":["Department of Pathology, Shanghai Medical College, Fudan University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Shanghai Medical College, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I133868755","https://openalex.org/I24943067"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068436495","display_name":"Rong Zhu","orcid":"https://orcid.org/0000-0001-7553-7249","observed_orcids":["https://orcid.org/0000-0001-7553-7249"]},"institutions":[{"id":"https://openalex.org/I133868755","display_name":"Shanghai Medical College of Fudan University","ror":"https://ror.org/01zntxs11","country_code":"CN","type":"education","lineage":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"R. Zhu","raw_affiliation_strings":["Department of Pathology, Shanghai Medical College, Fudan University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Shanghai Medical College, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I133868755","https://openalex.org/I24943067"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100659621","display_name":"Jia Fan","orcid":"https://orcid.org/0000-0001-5158-629X","observed_orcids":["https://orcid.org/0000-0001-5158-629X"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210127074","display_name":"Zhongshan Hospital","ror":"https://ror.org/032x22645","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127074"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"J. Fan","raw_affiliation_strings":["Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210127074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100778410","display_name":"Qi Pan","orcid":"https://orcid.org/0000-0003-2543-2937","observed_orcids":["https://orcid.org/0000-0003-2543-2937"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210127074","display_name":"Zhongshan Hospital","ror":"https://ror.org/032x22645","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127074"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Q. Pan","raw_affiliation_strings":["Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210127074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100423905","display_name":"Hui Li","orcid":"https://orcid.org/0000-0002-5604-0592","observed_orcids":["https://orcid.org/0000-0002-5604-0592"]},"institutions":[{"id":"https://openalex.org/I133868755","display_name":"Shanghai Medical College of Fudan University","ror":"https://ror.org/01zntxs11","country_code":"CN","type":"education","lineage":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"H. Li","raw_affiliation_strings":["Department of Pathology, Shanghai Medical College, Fudan University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Shanghai Medical College, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I133868755","https://openalex.org/I24943067"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082257500","display_name":"Q. Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I133868755","display_name":"Shanghai Medical College of Fudan University","ror":"https://ror.org/01zntxs11","country_code":"CN","type":"education","lineage":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Q. Chen","raw_affiliation_strings":["Department of Pathology, Shanghai Medical College, Fudan University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Shanghai Medical College, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I133868755","https://openalex.org/I24943067"]}]},{"author_position":"last","author":{"id":null,"display_name":"H.-G. Zhu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I133868755","display_name":"Shanghai Medical College of Fudan University","ror":"https://ror.org/01zntxs11","country_code":"CN","type":"education","lineage":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"H.-G. Zhu","raw_affiliation_strings":["Department of Pathology, Shanghai Medical College, Fudan University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Shanghai Medical College, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I133868755","https://openalex.org/I24943067"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5068436495"],"corresponding_institution_ids":["https://openalex.org/I133868755","https://openalex.org/I24943067"],"apc_list":{"value":4610,"currency":"USD","value_usd":4610},"apc_paid":null,"fwci":1.743,"has_fulltext":false,"cited_by_count":64,"citation_normalized_percentile":{"value":0.83086351,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"17","issue":"2","first_page":"98","last_page":"107"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.8788999915122986,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.8788999915122986,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.08799999952316284,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10146","display_name":"Cervical Cancer and HPV Research","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatitis-b-virus-x-protein","display_name":"hepatitis B virus X protein","score":0.9639999866485596},{"id":"https://openalex.org/keywords/dna-methyltransferases","display_name":"DNA methyltransferases","score":0.9620000123977661},{"id":"https://openalex.org/keywords/dnmt1","display_name":"DNMT1","score":0.9929999709129333},{"id":"https://openalex.org/keywords/dnmt3a","display_name":"DNMT3A","score":1.0},{"id":"https://openalex.org/keywords/mbd2","display_name":"MBD2","score":0.9120000004768372},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.8539999723434448},{"id":"https://openalex.org/keywords/epigenetic-silencing","display_name":"epigenetic silencing","score":0.8519999980926514},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.7480000257492065}],"concepts":[{"id":"https://openalex.org/C67567795","wikidata":"https://www.wikidata.org/wiki/Q5629069","display_name":"HBx","level":4,"score":0.9720741510391235},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.7729228734970093},{"id":"https://openalex.org/C91965660","wikidata":"https://www.wikidata.org/wiki/Q415875","display_name":"Methyltransferase","level":4,"score":0.7169567346572876},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.6959810853004456},{"id":"https://openalex.org/C175211621","wikidata":"https://www.wikidata.org/wiki/Q14907998","display_name":"DNMT1","level":5,"score":0.6169489026069641},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.6007765531539917},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5780593156814575},{"id":"https://openalex.org/C140173407","wikidata":"https://www.wikidata.org/wiki/Q1138358","display_name":"CpG site","level":5,"score":0.5419190526008606},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.5182642936706543},{"id":"https://openalex.org/C2779979206","wikidata":"https://www.wikidata.org/wiki/Q1154602","display_name":"DNA methyltransferase","level":5,"score":0.5166411995887756},{"id":"https://openalex.org/C2780593183","wikidata":"https://www.wikidata.org/wiki/Q6844","display_name":"Hepatitis B virus","level":3,"score":0.46754780411720276},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.45244190096855164},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.2652311325073242},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.26154303550720215},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2312215268611908},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.1706136167049408},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.14093315601348877},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.056582123041152954}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006509","descriptor_name":"Hepatitis B","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D006509","descriptor_name":"Hepatitis B","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015257","descriptor_name":"DNA-Cytosine Methylases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019941","descriptor_name":"Cyclin-Dependent Kinase Inhibitor p16","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D054334","descriptor_name":"Viral Regulatory and Accessory Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1365-2893.2009.01156.x","doi":"https://doi.org/10.1111/j.1365-2893.2009.01156.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1365-2893.2009.01156.x","pdf_url":null,"source":{"id":"https://openalex.org/S164225461","display_name":"Journal of Viral Hepatitis","issn_l":"1352-0504","issn":["1352-0504","1365-2893"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Viral Hepatitis","raw_type":"journal-article"},{"id":"pmid:19732323","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19732323","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of viral hepatitis","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.699999988079071,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":47,"referenced_works":["https://openalex.org/W151439609","https://openalex.org/W1572264474","https://openalex.org/W1964829819","https://openalex.org/W1967064280","https://openalex.org/W1967705712","https://openalex.org/W1967799787","https://openalex.org/W1971281277","https://openalex.org/W1976118924","https://openalex.org/W1982191424","https://openalex.org/W1989368522","https://openalex.org/W1991504495","https://openalex.org/W1993817279","https://openalex.org/W1994465394","https://openalex.org/W2000940387","https://openalex.org/W2015362806","https://openalex.org/W2015702695","https://openalex.org/W2031439729","https://openalex.org/W2040257851","https://openalex.org/W2042515987","https://openalex.org/W2044383056","https://openalex.org/W2048854681","https://openalex.org/W2055985776","https://openalex.org/W2070572466","https://openalex.org/W2071019693","https://openalex.org/W2074137258","https://openalex.org/W2085745662","https://openalex.org/W2087564721","https://openalex.org/W2088731634","https://openalex.org/W2097518733","https://openalex.org/W2103637700","https://openalex.org/W2109242135","https://openalex.org/W2114973741","https://openalex.org/W2125931439","https://openalex.org/W2130516508","https://openalex.org/W2130570765","https://openalex.org/W2135169407","https://openalex.org/W2135231304","https://openalex.org/W2158997389","https://openalex.org/W2159183335","https://openalex.org/W2159954692","https://openalex.org/W2162299386","https://openalex.org/W2164247688","https://openalex.org/W2188418835","https://openalex.org/W2314214777","https://openalex.org/W2415104542","https://openalex.org/W3029059650","https://openalex.org/W6643271983"],"related_works":["https://openalex.org/W2070572466","https://openalex.org/W2069391957","https://openalex.org/W2470067719","https://openalex.org/W2415389123","https://openalex.org/W2419652931","https://openalex.org/W4310957001","https://openalex.org/W4362043115","https://openalex.org/W1546920068","https://openalex.org/W2095981529","https://openalex.org/W1976118924"],"abstract_inverted_index":{"The":[0,59,207],"aim":[1],"of":[2,11,25,46,62,85,100,140,199,210,230,234,242],"the":[3,9,23,63,83,97,127,138,141,149,155,200,211,228,235,239],"present":[4],"study":[5],"was":[6,66,115,135,145,178],"to":[7],"authenticate":[8],"involvement":[10],"DNA":[12],"methyltransferases":[13],"(DNMTs)":[14],"and":[15,36,51,76,88,92,104,120,151,157,163,183,188,221],"methyl-CpG":[16],"binding":[17],"domain":[18],"protein":[19,98,158,165,172,189,205],"2":[20],"(MBD2)":[21],"in":[22,31,227,238],"process":[24,229],"HBx":[26,133,144,177,192,231],"induced":[27],"p16(INK4A)":[28,64,142,201,212,236],"promoter":[29,65,202,213,237,246],"hypermethylation":[30,139,198,233,247],"HBV-related":[32],"hepatocellular":[33],"carcinoma":[34],"(HCC)":[35],"their":[37,52],"corresponding":[38,53,128],"noncancerous":[39,54,129],"liver":[40,55,130],"tissues.":[41],"Eighty-eight":[42],"fresh":[43],"tissue":[44],"specimens":[45],"surgically":[47],"resected":[48],"HBV-associated":[49,243,255],"HCC":[50,175],"tissues":[56],"were":[57,94,109,167],"studied.":[58],"methylation":[60,208],"status":[61,209],"determined":[67,110],"by":[68,111,117],"methylation-specific":[69],"polymerase":[70,78],"chain":[71,79],"reaction":[72,80],"(MSP).":[73],"Reverse":[74],"transcription":[75],"real-time":[77],"(RT-PCR)":[81],"showed":[82],"expression":[84,134,166,193],"DNMTs,":[86],"MBD2":[87],"HBx.":[89],"Western":[90],"blot":[91],"immunohistochemistry":[93],"used":[95],"for":[96,252],"analysis":[99],"HBx,":[101,161],"DNMT1,":[102],"DNMT3A":[103,152,164,184,222],"P16.":[105],"Tissue":[106],"HBV-DNA":[107],"levels":[108],"RT-PCR.":[112],"HBV":[113],"genotype":[114],"examined":[116],"nested":[118],"PCR":[119],"restriction":[121],"fragment":[122],"length":[123],"polymorphism":[124],"(RFLP).":[125],"In":[126,174],"tissues,":[131,176],"higher":[132],"associated":[136],"with":[137,148,170,181,197,217],"promoter.":[143],"positively":[146,179],"correlated":[147,169,180],"DNMT1":[150,162,182,220],"at":[153,185],"both":[154,186],"mRNA":[156,187],"level.":[159],"Furthermore,":[160],"negatively":[168],"p16":[171,204],"expression.":[173,206],"level,":[190],"but":[191],"did":[194,214],"not":[195,215],"correlate":[196,216],"or":[203],"clinicopathological":[218],"characteristics.":[219],"may":[223,248],"play":[224],"important":[225],"roles":[226],"inducing":[232],"early":[240],"stages":[241],"HCC.":[244],"HBx-DNMTs-p16(INK4A)":[245],"constitute":[249],"a":[250],"mechanism":[251],"tumorigenesis":[253],"during":[254],"hepatocarcinogenesis.":[256]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":11},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
