{"id":"https://openalex.org/W2017324952","doi":"https://doi.org/10.1158/1535-7163.targ-13-b34","title":"Abstract B34: Development of a urine microvesicle/exosome RNA biomarker panel to identify prostate cancer.","display_name":"Abstract B34: Development of a urine microvesicle/exosome RNA biomarker panel to identify prostate cancer.","publication_year":2013,"publication_date":"2013-11-01","ids":{"openalex":"https://openalex.org/W2017324952","doi":"https://doi.org/10.1158/1535-7163.targ-13-b34","mag":"2017324952"},"language":"en","primary_location":{"id":"doi:10.1158/1535-7163.targ-13-b34","doi":"https://doi.org/10.1158/1535-7163.targ-13-b34","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1535-7163.targ-13-b34","pdf_url":null,"source":{"id":"https://openalex.org/S48437117","display_name":"Molecular Cancer Therapeutics","issn_l":"1535-7163","issn":["1535-7163","1538-8514"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cancer Therapeutics","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000622048","display_name":"Johan Skog","orcid":"https://orcid.org/0000-0002-0926-1691","observed_orcids":["https://orcid.org/0000-0002-0926-1691"]},"institutions":[{"id":"https://openalex.org/I4210086810","display_name":"Exosome Diagnostics (United States)","ror":"https://ror.org/0032wbe47","country_code":"US","type":"company","lineage":["https://openalex.org/I4210086810"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Johan Skog","raw_affiliation_strings":["1Exosome Diagnostics, Inc., New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Exosome Diagnostics, Inc., New York, NY","institution_ids":["https://openalex.org/I4210086810"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074550205","display_name":"Mikkel Noerholm","orcid":"https://orcid.org/0000-0002-8288-3067","observed_orcids":["https://orcid.org/0000-0002-8288-3067"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mikkel Noerholm","raw_affiliation_strings":["2Exosome Diagnostics, GmbH, Martinsried, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Exosome Diagnostics, GmbH, Martinsried, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025003663","display_name":"Stefan Bentink","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stefan Bentink","raw_affiliation_strings":["2Exosome Diagnostics, GmbH, Martinsried, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Exosome Diagnostics, GmbH, Martinsried, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044855268","display_name":"Charlotte Romain","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210086810","display_name":"Exosome Diagnostics (United States)","ror":"https://ror.org/0032wbe47","country_code":"US","type":"company","lineage":["https://openalex.org/I4210086810"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charlotte Romain","raw_affiliation_strings":["3Exosome Diagnostics, Inc., St Paul, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Exosome Diagnostics, Inc., St Paul, MN","institution_ids":["https://openalex.org/I4210086810"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072588760","display_name":"Jillian Fishbeck","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210086810","display_name":"Exosome Diagnostics (United States)","ror":"https://ror.org/0032wbe47","country_code":"US","type":"company","lineage":["https://openalex.org/I4210086810"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jillian Fishbeck","raw_affiliation_strings":["3Exosome Diagnostics, Inc., St Paul, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Exosome Diagnostics, Inc., St Paul, MN","institution_ids":["https://openalex.org/I4210086810"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ian Sinclair","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210086810","display_name":"Exosome Diagnostics (United States)","ror":"https://ror.org/0032wbe47","country_code":"US","type":"company","lineage":["https://openalex.org/I4210086810"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ian Sinclair","raw_affiliation_strings":["3Exosome Diagnostics, Inc., St Paul, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Exosome Diagnostics, Inc., St Paul, MN","institution_ids":["https://openalex.org/I4210086810"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017951380","display_name":"Anna Scott","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210086810","display_name":"Exosome Diagnostics (United States)","ror":"https://ror.org/0032wbe47","country_code":"US","type":"company","lineage":["https://openalex.org/I4210086810"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anna Scott","raw_affiliation_strings":["3Exosome Diagnostics, Inc., St Paul, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Exosome Diagnostics, Inc., St Paul, MN","institution_ids":["https://openalex.org/I4210086810"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112575125","display_name":"Romy Mueller","orcid":"https://orcid.org/0000-0002-3887-8914","observed_orcids":["https://orcid.org/0000-0002-3887-8914"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Romy Mueller","raw_affiliation_strings":["2Exosome Diagnostics, GmbH, Martinsried, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Exosome Diagnostics, GmbH, Martinsried, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076936444","display_name":"Tina Koestler","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tina Koestler","raw_affiliation_strings":["2Exosome Diagnostics, GmbH, Martinsried, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Exosome Diagnostics, GmbH, Martinsried, Germany","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089807067","display_name":"Susan K. Belzer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210086810","display_name":"Exosome Diagnostics (United States)","ror":"https://ror.org/0032wbe47","country_code":"US","type":"company","lineage":["https://openalex.org/I4210086810"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Susan Belzer","raw_affiliation_strings":["3Exosome Diagnostics, Inc., St Paul, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Exosome Diagnostics, Inc., St Paul, MN","institution_ids":["https://openalex.org/I4210086810"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"12","issue":"11_Supplement","first_page":"B34","last_page":"B34"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.9721999764442444,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.9721999764442444,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":0.01489999983459711,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.9419999718666077},{"id":"https://openalex.org/keywords/urinary-exosomes","display_name":"urinary exosomes","score":0.8450000286102295},{"id":"https://openalex.org/keywords/microvesicles","display_name":"microvesicles","score":0.7630000114440918},{"id":"https://openalex.org/keywords/gene-expression-signatures","display_name":"gene expression signatures","score":0.734000027179718},{"id":"https://openalex.org/keywords/prostate-needle-biopsy","display_name":"prostate needle biopsy","score":0.703000009059906},{"id":"https://openalex.org/keywords/pca3","display_name":"PCA3","score":0.7440000176429749},{"id":"https://openalex.org/keywords/erg","display_name":"ERG","score":0.9909999966621399},{"id":"https://openalex.org/keywords/klk3","display_name":"KLK3","score":0.9990000128746033},{"id":"https://openalex.org/keywords/biopsy-decision","display_name":"biopsy decision","score":0.40299999713897705},{"id":"https://openalex.org/keywords/liquid-biopsy","display_name":"liquid biopsy","score":0.5789999961853027},{"id":"https://openalex.org/keywords/digital-rectal-examination","display_name":"digital rectal examination","score":0.5809999704360962},{"id":"https://openalex.org/keywords/prostate-cancer-screening","display_name":"prostate cancer screening","score":0.4189999997615814},{"id":"https://openalex.org/keywords/false-negative-biopsy","display_name":"false-negative biopsy","score":0.4860000014305115},{"id":"https://openalex.org/keywords/random-urine-sample","display_name":"random urine sample","score":0.4690000116825104},{"id":"https://openalex.org/keywords/histopathology","display_name":"histopathology","score":0.46299999952316284}],"concepts":[{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.7568694949150085},{"id":"https://openalex.org/C2909763251","wikidata":"https://www.wikidata.org/wiki/Q6840469","display_name":"Microvesicle","level":5,"score":0.7385271191596985},{"id":"https://openalex.org/C2781261824","wikidata":"https://www.wikidata.org/wiki/Q903634","display_name":"Exosome","level":5,"score":0.7318878173828125},{"id":"https://openalex.org/C2779529041","wikidata":"https://www.wikidata.org/wiki/Q22349364","display_name":"Liquid biopsy","level":3,"score":0.6807219386100769},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6185117959976196},{"id":"https://openalex.org/C87874733","wikidata":"https://www.wikidata.org/wiki/Q18039844","display_name":"PCA3","level":4,"score":0.5967487096786499},{"id":"https://openalex.org/C2780026642","wikidata":"https://www.wikidata.org/wiki/Q40924","display_name":"Urine","level":2,"score":0.5515100359916687},{"id":"https://openalex.org/C112190416","wikidata":"https://www.wikidata.org/wiki/Q2124450","display_name":"RNA extraction","level":4,"score":0.5131927132606506},{"id":"https://openalex.org/C2775934546","wikidata":"https://www.wikidata.org/wiki/Q179991","display_name":"Biopsy","level":2,"score":0.506393313407898},{"id":"https://openalex.org/C2781217009","wikidata":"https://www.wikidata.org/wiki/Q4086927","display_name":"Prostate biopsy","level":4,"score":0.4943368434906006},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.47484615445137024},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.46773561835289},{"id":"https://openalex.org/C20518536","wikidata":"https://www.wikidata.org/wiki/Q6840469","display_name":"Microvesicles","level":4,"score":0.430738627910614},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.42994797229766846},{"id":"https://openalex.org/C2781406297","wikidata":"https://www.wikidata.org/wiki/Q409450","display_name":"Prostate-specific antigen","level":4,"score":0.42143744230270386},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4093487858772278},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.37726572155952454},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3572089970111847},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.35530489683151245},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2724717855453491},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.25917673110961914},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06744521856307983}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1535-7163.targ-13-b34","doi":"https://doi.org/10.1158/1535-7163.targ-13-b34","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1535-7163.targ-13-b34","pdf_url":null,"source":{"id":"https://openalex.org/S48437117","display_name":"Molecular Cancer Therapeutics","issn_l":"1535-7163","issn":["1535-7163","1538-8514"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cancer Therapeutics","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9789000153541565,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3031034914","https://openalex.org/W2810072280","https://openalex.org/W6926395163","https://openalex.org/W2407497981","https://openalex.org/W2267059343","https://openalex.org/W2888486324","https://openalex.org/W2589455027","https://openalex.org/W4306896913","https://openalex.org/W4226075636","https://openalex.org/W2033536115"],"abstract_inverted_index":{"Abstract":[0],"Introduction:":[1],"Prostate":[2,294],"cancer":[3,91,217,295],"is":[4,20,29,62,96,313],"diagnosed":[5],"utilizing":[6],"anywhere":[7,240],"from":[8,71,103,134,198,241,305],"10-12":[9],"transrectal":[10],"prostate":[11,90,216,392],"needle":[12,94],"biopsy":[13,19,52,95,350],"specimens":[14],"(PNB).":[15],"The":[16,160,173,310],"decision":[17,351],"to":[18,31,44,84,121,188,191,212,225,243,248,390],"driven":[21],"in":[22,35,64,215,347],"part":[23],"by":[24],"the":[25,86,153,348,398],"PSA":[26],"test,":[27],"which":[28],"known":[30],"have":[32,49],"marginal":[33],"accuracy":[34],"appropriate":[36],"patient":[37],"selection.":[38],"As":[39],"a":[40,50,72,93,128,138,203,249,261,270,281,306,327,335,339,384],"result,":[41],"between":[42],"40":[43],"60%":[45],"of":[46,88,101,109,175,227,232,275,288,383,397],"patients":[47],"will":[48],"benign":[51],"with":[53,80,179,223,260,285],"approximately":[54],"20%":[55],"having":[56,89],"false":[57],"negative":[58],"results.":[59,229],"Exosomal":[60],"RNA":[61,102,157,162,312,387],"stable":[63,314],"urine":[65,74,104,308,331,385],"and":[66,106,166,183,220,234,278,315,320,341,404],"can":[67,302,316,345],"be":[68,213,303,317],"easily":[69],"extracted":[70],"random":[73,125,307],"sample.":[75,309],"A":[76,116,230],"novel":[77],"molecular":[78],"assay":[79],"an":[81,110,286],"improved":[82],"ability":[83],"predict":[85],"likelihood":[87],"on":[92],"being":[97],"developed":[98],"through":[99],"isolation":[100],"exosomes":[105,298],"subsequent":[107],"identification":[108],"accurate":[111],"prognostic":[112],"gene":[113,208,236,245,251,258,272],"signature.":[114],"Methods:":[115],"multicenter":[117],"study":[118],"was":[119,163],"designed":[120],"collect":[122],"first":[123],"catch":[124],"urine,":[126],"without":[127,326],"prior":[129,328],"digital":[130],"rectal":[131],"exam":[132],"(DRE)":[133],"men":[135,200],"presenting":[136],"for":[137,169,202,322,338],"PNB.":[139],"Urine":[140,155,196],"samples":[141,197],"were":[142,186,205,218,252,267],"processed":[143],"at":[144],"Exosome":[145],"Diagnostic's":[146],"clinical":[147,181],"laboratory":[148],"under":[149],"quality":[150],"control":[151],"using":[152],"EXO70":[154],"Microvesicle":[156],"Isolation":[158],"Kit.":[159],"exosomal":[161,311],"reverse":[164],"transcribed":[165],"qPCR":[167],"assays":[168,177],"specific":[170],"genes":[171],"performed.":[172],"results":[174],"those":[176],"along":[178],"collected":[180],"data":[182],"PNB":[184,204,228],"histopathology":[185],"subjected":[187],"statistical":[189],"analysis":[190],"derive":[192],"ROC":[193,262],"curves.":[194],"Results:":[195],"258":[199],"scheduled":[201],"tested.":[206],"Triaged":[207],"lists":[209],"previously":[210],"shown":[211],"important":[214],"compiled":[219],"univariately":[221],"assessed":[222],"respect":[224],"discrimination":[226],"series":[231],"single":[233],"multiple":[235],"expression":[237],"profiles":[238],"representing":[239],"1":[242],"3":[244,271],"signatures":[246,259],"relative":[247],"reference":[250],"identified.":[253],"Multivariate":[254],"models":[255],"including":[256],"several":[257],"AUC":[263,287],"performance":[264,284],">":[265],"0.7":[266],"found.":[268],"Interestingly,":[269],"signature":[273],"composed":[274],"PCA3,":[276],"ERG":[277],"KLK3":[279],"provided":[280],"very":[282],"good":[283],"0.76":[289],"(N":[290],"=":[291],"122).":[292],"Conclusions:":[293],"cells":[296],"release":[297],"/":[299],"microvesicles":[300],"that":[301,344],"isolated":[304,319],"efficiently":[318],"used":[321],"tumor":[323],"profiling":[324],"even":[325],"DRE.":[329],"This":[330],"exosome":[332],"platform":[333],"presents":[334],"robust":[336],"model":[337],"quick":[340],"simple":[342],"test":[343],"assist":[346],"initial":[349],"process.":[352],"Citation":[353,360],"Information:":[354],"Mol":[355,415],"Cancer":[356,405,416],"Ther":[357,417],"2013;12(11":[358,418],"Suppl):B34.":[359],"Format:":[361],"Johan":[362],"Skog,":[363],"Mikkel":[364],"Noerholm,":[365],"Stefan":[366],"Bentink,":[367],"Charlotte":[368],"Romain,":[369],"Jillian":[370],"Fishbeck,":[371],"Ian":[372],"Sinclair,":[373],"Anna":[374],"Scott,":[375],"Romy":[376],"Mueller,":[377],"Tina":[378],"Koestler,":[379],"Susan":[380],"Belzer.":[381],"Development":[382],"microvesicle/exosome":[386],"biomarker":[388],"panel":[389],"identify":[391],"cancer.":[393],"[abstract].":[394],"In:":[395],"Proceedings":[396],"AACR-NCI-EORTC":[399],"International":[400],"Conference:":[401],"Molecular":[402],"Targets":[403],"Therapeutics;":[406],"2013":[407],"Oct":[408],"19-23;":[409],"Boston,":[410],"MA.":[411],"Philadelphia":[412],"(PA):":[413],"AACR;":[414],"Suppl):Abstract":[419],"nr":[420],"B34.":[421]},"counts_by_year":[{"year":2017,"cited_by_count":1}],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2016-06-24T00:00:00"}
