{"id":"https://openalex.org/W2017322511","doi":"https://doi.org/10.1074/jbc.m306340200","title":"Vitamin D Inhibits G1 to S Progression in LNCaP Prostate Cancer Cells through p27Kip1 Stabilization and Cdk2 Mislocalization to the Cytoplasm","display_name":"Vitamin D Inhibits G1 to S Progression in LNCaP Prostate Cancer Cells through p27Kip1 Stabilization and Cdk2 Mislocalization to the Cytoplasm","publication_year":2003,"publication_date":"2003-11-01","ids":{"openalex":"https://openalex.org/W2017322511","doi":"https://doi.org/10.1074/jbc.m306340200","mag":"2017322511","pmid":"https://pubmed.ncbi.nlm.nih.gov/12954644"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m306340200","doi":"https://doi.org/10.1074/jbc.m306340200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m306340200","pdf_url":"http://www.jbc.org/article/S0021925820759727/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.jbc.org/article/S0021925820759727/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035724058","display_name":"Eddy Shih-Hsin Yang","orcid":"https://orcid.org/0000-0002-6450-2638","observed_orcids":["https://orcid.org/0000-0002-6450-2638"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eddy S. Yang","raw_affiliation_strings":["Department of Molecular and Cellular Pharmacology, University of Miami School of Medicine, Miami, FL 33136, USA","Department of Molecular and Cellular Pharmacology, University of Miami School of Medicine, Miami, Florida 33136"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Cellular Pharmacology, University of Miami School of Medicine, Miami, FL 33136, USA","institution_ids":["https://openalex.org/I145608581"]},{"raw_affiliation_string":"Department of Molecular and Cellular Pharmacology, University of Miami School of Medicine, Miami, Florida 33136","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088558562","display_name":"Kerry L. Burnstein","orcid":"https://orcid.org/0000-0002-7351-0963","observed_orcids":["https://orcid.org/0000-0002-7351-0963"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Kerry L. Burnstein","raw_affiliation_strings":["Department of Molecular and Cellular Pharmacology, University of Miami School of Medicine, Miami, Florida 33136"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Cellular Pharmacology, University of Miami School of Medicine, Miami, Florida 33136","institution_ids":["https://openalex.org/I145608581"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5088558562"],"corresponding_institution_ids":["https://openalex.org/I145608581"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":5.3922,"has_fulltext":true,"cited_by_count":149,"citation_normalized_percentile":{"value":0.95940133,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"278","issue":"47","first_page":"46862","last_page":"46868"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10277","display_name":"Vitamin D Research Studies","score":0.7064999938011169,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10277","display_name":"Vitamin D Research Studies","score":0.7064999938011169,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.13050000369548798,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.1039000004529953,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vitamin-d3","display_name":"vitamin D3","score":0.9110000133514404},{"id":"https://openalex.org/keywords/1-25-dihydroxyvitamin-d3","display_name":"1,25-dihydroxyvitamin D3","score":0.9629999995231628},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.9139999747276306},{"id":"https://openalex.org/keywords/lncap-cells","display_name":"LNCaP cells","score":0.9679999947547913},{"id":"https://openalex.org/keywords/p27","display_name":"p27","score":0.9319999814033508},{"id":"https://openalex.org/keywords/cdk2","display_name":"CDK2","score":0.7889999747276306},{"id":"https://openalex.org/keywords/g1-s-transition","display_name":"G1/S transition","score":0.6859999895095825},{"id":"https://openalex.org/keywords/protein-stabilization","display_name":"protein stabilization","score":0.7369999885559082},{"id":"https://openalex.org/keywords/skp2","display_name":"Skp2","score":0.9549999833106995},{"id":"https://openalex.org/keywords/cdk-activating-kinase","display_name":"CDK-activating kinase","score":0.7670000195503235},{"id":"https://openalex.org/keywords/cdc25a","display_name":"CDC25A","score":0.859000027179718},{"id":"https://openalex.org/keywords/subcellular-localization","display_name":"subcellular localization","score":0.7089999914169312},{"id":"https://openalex.org/keywords/antiproliferative-activity","display_name":"antiproliferative activity","score":0.7979999780654907},{"id":"https://openalex.org/keywords/retinoblastoma-protein","display_name":"retinoblastoma protein","score":0.8159999847412109},{"id":"https://openalex.org/keywords/cyclin-dependent-kinase-inhibitors","display_name":"cyclin-dependent kinase inhibitors","score":0.640999972820282}],"concepts":[{"id":"https://openalex.org/C2779723316","wikidata":"https://www.wikidata.org/wiki/Q6459234","display_name":"LNCaP","level":4,"score":0.8815901279449463},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.758419394493103},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.6492023468017578},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.5169881582260132},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4626055657863617},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.380393385887146},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3524126708507538},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3438956141471863},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.33784347772598267},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.33774620294570923},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.32323116064071655},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.32076185941696167}],"mesh":[{"descriptor_ui":"D002117","descriptor_name":"Calcitriol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003593","descriptor_name":"Cytoplasm","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006207","descriptor_name":"Half-Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D016193","descriptor_name":"G1 Phase","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D016193","descriptor_name":"G1 Phase","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016196","descriptor_name":"S Phase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D021381","descriptor_name":"Protein Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025521","descriptor_name":"Tumor Suppressor Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D025521","descriptor_name":"Tumor Suppressor Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D025521","descriptor_name":"Tumor Suppressor Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D042846","descriptor_name":"CDC2-CDC28 Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D042846","descriptor_name":"CDC2-CDC28 Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D044786","descriptor_name":"S-Phase Kinase-Associated Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050760","descriptor_name":"Cyclin-Dependent Kinase Inhibitor p27","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051357","descriptor_name":"Cyclin-Dependent Kinase 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1074/jbc.m306340200","doi":"https://doi.org/10.1074/jbc.m306340200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m306340200","pdf_url":"http://www.jbc.org/article/S0021925820759727/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:12954644","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12954644","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m306340200","doi":"https://doi.org/10.1074/jbc.m306340200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m306340200","pdf_url":"http://www.jbc.org/article/S0021925820759727/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9789000153541565,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1518233537","display_name":null,"funder_award_id":"F30 ES05910-02","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G3169806923","display_name":"ENVIRONMENTAL ANTI-ANDROGENS AND AR AUTOREGULATION","funder_award_id":"F30ES005910","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G3296321990","display_name":null,"funder_award_id":"DK 45478","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G5673350919","display_name":"HORMONAL REGULATION OF ANDROGEN RECEPTOR EXPRESSION","funder_award_id":"R01DK045478","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2017322511.pdf","grobid_xml":"https://content.openalex.org/works/W2017322511.grobid-xml"},"referenced_works_count":59,"referenced_works":["https://openalex.org/W633735835","https://openalex.org/W1487662609","https://openalex.org/W1605741702","https://openalex.org/W1914602388","https://openalex.org/W1965049479","https://openalex.org/W1972422162","https://openalex.org/W1978052913","https://openalex.org/W1980123375","https://openalex.org/W1986527803","https://openalex.org/W1990613292","https://openalex.org/W1994282776","https://openalex.org/W1998625763","https://openalex.org/W2005744028","https://openalex.org/W2013850508","https://openalex.org/W2027451946","https://openalex.org/W2031646117","https://openalex.org/W2039169535","https://openalex.org/W2041149796","https://openalex.org/W2043092024","https://openalex.org/W2044312503","https://openalex.org/W2045870793","https://openalex.org/W2063955417","https://openalex.org/W2065760788","https://openalex.org/W2067223570","https://openalex.org/W2071429904","https://openalex.org/W2073996456","https://openalex.org/W2079494240","https://openalex.org/W2088749263","https://openalex.org/W2089448004","https://openalex.org/W2091403769","https://openalex.org/W2099438166","https://openalex.org/W2099990598","https://openalex.org/W2101305429","https://openalex.org/W2102323032","https://openalex.org/W2112221714","https://openalex.org/W2115704169","https://openalex.org/W2118040139","https://openalex.org/W2119634498","https://openalex.org/W2120293274","https://openalex.org/W2124814278","https://openalex.org/W2129129118","https://openalex.org/W2129391217","https://openalex.org/W2132568558","https://openalex.org/W2133528029","https://openalex.org/W2147868370","https://openalex.org/W2151559596","https://openalex.org/W2152398347","https://openalex.org/W2157191335","https://openalex.org/W2158253569","https://openalex.org/W2162741492","https://openalex.org/W2163663331","https://openalex.org/W2163931326","https://openalex.org/W2165235512","https://openalex.org/W2166525118","https://openalex.org/W2167263709","https://openalex.org/W2167846026","https://openalex.org/W2399867671","https://openalex.org/W4301651270","https://openalex.org/W7140267905"],"related_works":["https://openalex.org/W2011528548","https://openalex.org/W4237622006","https://openalex.org/W1972422162","https://openalex.org/W2013310853","https://openalex.org/W2079716869","https://openalex.org/W2326551004","https://openalex.org/W2327477759","https://openalex.org/W3202204371","https://openalex.org/W2129391217","https://openalex.org/W1915790967"],"abstract_inverted_index":{"1,25-(OH)2":[0],"vitamin":[1],"D3":[2],"(1,25-(OH)2D3)":[3],"exerts":[4],"antiproliferative":[5,260],"effects":[6,261],"via":[7,198],"cell":[8,29],"cycle":[9],"regulation":[10,82],"in":[11,24,36,57,154,179,185],"a":[12,84],"variety":[13],"of":[14,43,50,55,83,87,93,114,123,138,152,160,167,218,240,248,262],"tumor":[15],"cells,":[16],"including":[17],"prostate.":[18],"We":[19],"have":[20],"previously":[21],"shown":[22],"that":[23,116,253],"the":[25,64,81,88,109,149,186,259],"human":[26],"prostate":[27],"cancer":[28],"line":[30],"LN-CaP,":[31],"1,25-(OH)2D3":[32,67,71,101,133,157,174,204,221],"mediates":[33],"an":[34,127],"increase":[35],"cyclin-dependent":[37,44],"kinase":[38,45,190],"inhibitor":[39],"p27Kip1":[40],"levels,":[41],"inhibition":[42,166],"2":[46],"(Cdk2)":[47],"activity,":[48],"hypophosphorylation":[49],"retinoblastoma":[51],"protein,":[52],"and":[53,111,194,200,214,235,237],"accumulation":[54],"cells":[56],"G1.":[58],"In":[59,172],"this":[60],"study,":[61],"we":[62,147],"investigated":[63],"mechanism":[65],"whereby":[66],"increases":[68],"p27":[69,76,89,94,115,118,125,129,139,143,153,170,243],"levels.":[70],"had":[72],"no":[73],"effect":[74],"on":[75,80],"mRNA":[77],"levels":[78,159,178,208],"or":[79],"3.5-kb":[85],"fragment":[86],"promoter.":[90],"The":[91],"rate":[92],"protein":[95,119,130,177],"synthesis":[96],"was":[97],"not":[98],"affected":[99],"by":[100,104,108,188,195,211,220],"as":[102,209],"measured":[103],"luciferase":[105],"activity":[106],"driven":[107],"5'-":[110],"3'-untranslated":[112],"regions":[113],"regulate":[117],"synthesis.":[120],"Pulse-chase":[121],"analysis":[122],"35S-labeled":[124],"revealed":[126],"increased":[128],"half-life":[131],"with":[132,165],"treatment.":[134],"Because":[135],"Cdk2-mediated":[136],"phosphorylation":[137,150,193],"at":[140],"Thr187":[141,161,168],"targets":[142],"for":[144,232],"Skp2-mediated":[145],"degradation,":[146],"examined":[148],"status":[151],"1,25-(OH)2D3-treated":[155],"cells.":[156,181],"decreased":[158,205],"phosphorylated":[162],"p27,":[163],"consistent":[164],"phosphorylation-dependent":[169],"degradation.":[171],"addition,":[173],"reduced":[175,228],"Skp2":[176],"LNCaP":[180],"Cdk2":[182,207,219,230,254],"is":[183,256],"activated":[184],"nucleus":[187],"Cdk-activating":[189],"through":[191,245],"Thr160":[192],"cdc25A":[196],"phosphatase":[197],"Thr14":[199],"Tyr15":[201],"dephosphorylation.":[202],"Interestingly,":[203],"nuclear":[206,229],"assessed":[210],"subcellular":[212],"fractionation":[213],"confocal":[215],"microscopy.":[216],"Inhibition":[217],"may":[222],"thus":[223],"involve":[224],"two":[225],"mechanisms:":[226],"1)":[227],"available":[231],"cyclin":[233,241],"binding":[234],"activation":[236],"2)":[238],"impairment":[239],"E-Cdk2-dependent":[242],"degradation":[244],"cytoplasmic":[246],"mislocalization":[247,255],"Cdk2.":[249],"These":[250],"data":[251],"suggest":[252],"central":[257],"to":[258],"1,25-(OH)2D3.":[263]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":12}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}