{"id":"https://openalex.org/W2017314731","doi":"https://doi.org/10.1097/00003086-198910000-00041","title":"The Effects of Two Nonsteroidal Antiinflammatory Drugs on Limb Swelling, Joint Stiffness, and Bone Torsional Strength Following Fracture in a Rabbit Model","display_name":"The Effects of Two Nonsteroidal Antiinflammatory Drugs on Limb Swelling, Joint Stiffness, and Bone Torsional Strength Following Fracture in a Rabbit Model","publication_year":1989,"publication_date":"1989-10-01","ids":{"openalex":"https://openalex.org/W2017314731","doi":"https://doi.org/10.1097/00003086-198910000-00041","mag":"2017314731","pmid":"https://pubmed.ncbi.nlm.nih.gov/2791397"},"language":"en","primary_location":{"id":"doi:10.1097/00003086-198910000-00041","doi":"https://doi.org/10.1097/00003086-198910000-00041","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00003086-198910000-00041","pdf_url":null,"source":{"id":"https://openalex.org/S191421250","display_name":"Clinical Orthopaedics and Related Research","issn_l":"0009-921X","issn":["0009-921X","1528-1132"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Orthopaedics and Related Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009067688","display_name":"Robert C. More","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1322918889","display_name":"United States Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889"]},{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"ROBERT C. MORE","raw_affiliation_strings":["Wadsworth Veterans Administration Medical Center and the Division of Orthopaedic Surgery, UCLA School of Medicine, Los Angeles, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wadsworth Veterans Administration Medical Center and the Division of Orthopaedic Surgery, UCLA School of Medicine, Los Angeles, California","institution_ids":["https://openalex.org/I1322918889","https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113574487","display_name":"Michael H. Kody","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1322918889","display_name":"United States Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889"]},{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"MICHAEL H. KODY","raw_affiliation_strings":["Wadsworth Veterans Administration Medical Center and the Division of Orthopaedic Surgery, UCLA School of Medicine, Los Angeles, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wadsworth Veterans Administration Medical Center and the Division of Orthopaedic Surgery, UCLA School of Medicine, Los Angeles, California","institution_ids":["https://openalex.org/I1322918889","https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113575436","display_name":"J. MICHAEL","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1322918889","display_name":"United States Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889"]},{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. MICHAEL","raw_affiliation_strings":["Wadsworth Veterans Administration Medical Center and the Division of Orthopaedic Surgery, UCLA School of Medicine, Los Angeles, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wadsworth Veterans Administration Medical Center and the Division of Orthopaedic Surgery, UCLA School of Medicine, Los Angeles, California","institution_ids":["https://openalex.org/I1322918889","https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110129376","display_name":"FREDRICK J. DOREY","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1322918889","display_name":"United States Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889"]},{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"FREDRICK J. DOREY","raw_affiliation_strings":["Wadsworth Veterans Administration Medical Center and the Division of Orthopaedic Surgery, UCLA School of Medicine, Los Angeles, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wadsworth Veterans Administration Medical Center and the Division of Orthopaedic Surgery, UCLA School of Medicine, Los Angeles, California","institution_ids":["https://openalex.org/I1322918889","https://openalex.org/I161318765"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080078190","display_name":"Roy A. Meals","orcid":"https://orcid.org/0000-0002-8400-3318","observed_orcids":["https://orcid.org/0000-0002-8400-3318"]},"institutions":[{"id":"https://openalex.org/I1322918889","display_name":"United States Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889"]},{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"ROY A. MEALS","raw_affiliation_strings":["Wadsworth Veterans Administration Medical Center and the Division of Orthopaedic Surgery, UCLA School of Medicine, Los Angeles, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wadsworth Veterans Administration Medical Center and the Division of Orthopaedic Surgery, UCLA School of Medicine, Los Angeles, California","institution_ids":["https://openalex.org/I1322918889","https://openalex.org/I161318765"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.7315,"has_fulltext":false,"cited_by_count":30,"citation_normalized_percentile":{"value":0.7322141,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"247","issue":"247","first_page":"306","last_page":"312"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10658","display_name":"Bone fractures and treatments","score":0.8730000257492065,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10658","display_name":"Bone fractures and treatments","score":0.8730000257492065,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.04149999842047691,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12249","display_name":"Veterinary Orthopedics and Neurology","score":0.026399999856948853,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nonsteroidal-anti-inflammatory-drugs","display_name":"nonsteroidal anti-inflammatory drugs","score":0.9919999837875366},{"id":"https://openalex.org/keywords/piroxicam","display_name":"piroxicam","score":0.972000002861023},{"id":"https://openalex.org/keywords/flunixin","display_name":"flunixin","score":1.0},{"id":"https://openalex.org/keywords/distal-tibia-fractures","display_name":"distal tibial fractures","score":0.9079999923706055},{"id":"https://openalex.org/keywords/limb-swelling","display_name":"limb swelling","score":0.753000020980835},{"id":"https://openalex.org/keywords/joint-stiffness","display_name":"joint stiffness","score":0.9649999737739563},{"id":"https://openalex.org/keywords/ankle-stiffness","display_name":"ankle stiffness","score":0.5450000166893005},{"id":"https://openalex.org/keywords/fracture-immobilization","display_name":"fracture immobilization","score":0.8220000267028809},{"id":"https://openalex.org/keywords/rabbit-model","display_name":"rabbit model","score":0.6470000147819519}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8634162545204163},{"id":"https://openalex.org/C2778484676","wikidata":"https://www.wikidata.org/wiki/Q20707196","display_name":"Nonsteroidal","level":2,"score":0.7562053203582764},{"id":"https://openalex.org/C2779372316","wikidata":"https://www.wikidata.org/wiki/Q569057","display_name":"Stiffness","level":2,"score":0.43304887413978577},{"id":"https://openalex.org/C2989316616","wikidata":"https://www.wikidata.org/wiki/Q6027402","display_name":"Lower limb","level":2,"score":0.43019527196884155},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.25513917207717896},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.23853513598442078},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.10941234230995178},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000894","descriptor_name":"Anti-Inflammatory Agents, Non-Steroidal","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D003002","descriptor_name":"Clonixin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D003002","descriptor_name":"Clonixin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004487","descriptor_name":"Edema","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D004487","descriptor_name":"Edema","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007592","descriptor_name":"Joint Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D007592","descriptor_name":"Joint Diseases","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D009539","descriptor_name":"Nicotinic Acids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010894","descriptor_name":"Piroxicam","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011859","descriptor_name":"Radiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013978","descriptor_name":"Tibial Fractures","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D013978","descriptor_name":"Tibial Fractures","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D013978","descriptor_name":"Tibial Fractures","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/00003086-198910000-00041","doi":"https://doi.org/10.1097/00003086-198910000-00041","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00003086-198910000-00041","pdf_url":null,"source":{"id":"https://openalex.org/S191421250","display_name":"Clinical Orthopaedics and Related Research","issn_l":"0009-921X","issn":["0009-921X","1528-1132"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Orthopaedics and Related Research","raw_type":"journal-article"},{"id":"pmid:2791397","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2791397","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical orthopaedics and related research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8796426451","display_name":"BASIC AND CLINICAL RESEARCH IN JOINT REPLACEMENTS","funder_award_id":"5t32am007207-07","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320313999","display_name":"Hospital for Special Surgery","ror":"https://ror.org/03zjqec80"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4298225570","https://openalex.org/W1977844841","https://openalex.org/W1973364124","https://openalex.org/W2047813251","https://openalex.org/W2031960481","https://openalex.org/W2076048486","https://openalex.org/W2974456699","https://openalex.org/W2267414577","https://openalex.org/W2372372458","https://openalex.org/W2007002110"],"abstract_inverted_index":{"Using":[0],"a":[1],"rabbit":[2],"distal":[3],"tibia":[4,69],"fracture":[5],"model":[6],"treated":[7,36],"by":[8,42,50,59],"immobilization":[9],"for":[10],"three":[11],"weeks,":[12],"the":[13],"effects":[14],"of":[15],"two":[16],"nonsteroidal":[17],"antiinflammatory":[18],"drugs":[19],"on":[20],"postfracture":[21],"limb":[22,48],"swelling,":[23],"joint":[24],"stiffness,":[25],"and":[26,44],"torsional":[27,70],"bone":[28],"strength":[29],"were":[30],"examined.":[31],"Limb":[32],"swelling":[33,49,58],"in":[34],"rabbits":[35],"with":[37],"low-dose":[38],"piroxicam":[39,46,62],"was":[40],"reduced":[41,47,57],"39%,":[43],"high-dose":[45],"86%.":[51],"Flunixin,":[52],"tested":[53],"at":[54],"one":[55],"dose,":[56],"53%.":[60],"Neither":[61],"nor":[63],"flunixin":[64],"affected":[65],"ankle":[66],"stiffness":[67],"or":[68],"strength.":[71]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}