{"id":"https://openalex.org/W2017304883","doi":"https://doi.org/10.2337/db12-0428","title":"Pioglitazone Acutely Reduces Energy Metabolism and Insulin Secretion in Rats","display_name":"Pioglitazone Acutely Reduces Energy Metabolism and Insulin Secretion in Rats","publication_year":2013,"publication_date":"2013-02-02","ids":{"openalex":"https://openalex.org/W2017304883","doi":"https://doi.org/10.2337/db12-0428","mag":"2017304883","pmid":"https://pubmed.ncbi.nlm.nih.gov/23378607","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3661607"},"language":"en","primary_location":{"id":"doi:10.2337/db12-0428","doi":"https://doi.org/10.2337/db12-0428","is_oa":true,"landing_page_url":"https://doi.org/10.2337/db12-0428","pdf_url":null,"source":{"id":"https://openalex.org/S129060628","display_name":"Diabetes","issn_l":"0012-1797","issn":["0012-1797","1939-327X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.2337/db12-0428","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087846740","display_name":"Julien Lamontagne","orcid":"https://orcid.org/0000-0002-3973-3047","observed_orcids":["https://orcid.org/0000-0002-3973-3047"]},"institutions":[{"id":"https://openalex.org/I4210142730","display_name":"Centre Hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al","ror":"https://ror.org/0410a8y51","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4210142730","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I70931966","display_name":"Universit\u00e9 de Montr\u00e9al","ror":"https://ror.org/0161xgx34","country_code":"CA","type":"education","lineage":["https://openalex.org/I70931966"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Julien Lamontagne","raw_affiliation_strings":["Department of Biochemistry, Universit\u00e9 de Montr\u00e9al, Montreal, Quebec, Canada","Molecular Nutrition Unit and Montreal Diabetes Research Center at the Centre de Recherche du Centre Hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al (CRCHUM), Universit\u00e9 de Montr\u00e9al, Montreal, Quebec, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Universit\u00e9 de Montr\u00e9al, Montreal, Quebec, Canada","institution_ids":["https://openalex.org/I70931966"]},{"raw_affiliation_string":"Molecular Nutrition Unit and Montreal Diabetes Research Center at the Centre de Recherche du Centre Hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al (CRCHUM), Universit\u00e9 de Montr\u00e9al, Montreal, Quebec, Canada","institution_ids":["https://openalex.org/I4210142730","https://openalex.org/I70931966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081834941","display_name":"\u00c9lise Jalbert-Arsenault","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210142730","display_name":"Centre Hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al","ror":"https://ror.org/0410a8y51","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4210142730","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I70931966","display_name":"Universit\u00e9 de Montr\u00e9al","ror":"https://ror.org/0161xgx34","country_code":"CA","type":"education","lineage":["https://openalex.org/I70931966"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"\u00c9lise Jalbert-Arsenault","raw_affiliation_strings":["Department of Nutrition, Universit\u00e9 de Montr\u00e9al, Montreal, Quebec, Canada","Molecular Nutrition Unit and Montreal Diabetes Research Center at the Centre de Recherche du Centre Hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al (CRCHUM), Universit\u00e9 de Montr\u00e9al, Montreal, Quebec, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutrition, Universit\u00e9 de Montr\u00e9al, Montreal, Quebec, Canada","institution_ids":["https://openalex.org/I70931966"]},{"raw_affiliation_string":"Molecular Nutrition Unit and Montreal Diabetes Research Center at the Centre de Recherche du Centre Hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al (CRCHUM), Universit\u00e9 de Montr\u00e9al, Montreal, Quebec, Canada","institution_ids":["https://openalex.org/I4210142730","https://openalex.org/I70931966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084509581","display_name":"\u00c9milie P\u00e9pin","orcid":"https://orcid.org/0000-0003-4028-5939","observed_orcids":["https://orcid.org/0000-0003-4028-5939"]},"institutions":[{"id":"https://openalex.org/I4210142730","display_name":"Centre Hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al","ror":"https://ror.org/0410a8y51","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4210142730","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I70931966","display_name":"Universit\u00e9 de Montr\u00e9al","ror":"https://ror.org/0161xgx34","country_code":"CA","type":"education","lineage":["https://openalex.org/I70931966"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"\u00c9milie Pepin","raw_affiliation_strings":["Molecular Nutrition Unit and Montreal Diabetes Research Center at the Centre de Recherche du Centre Hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al (CRCHUM), Universit\u00e9 de Montr\u00e9al, Montreal, Quebec, Canada","Program of Molecular Biology, Universit\u00e9 de Montr\u00e9al, Montreal, Quebec, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Nutrition Unit and Montreal Diabetes Research Center at the Centre de Recherche du Centre Hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al (CRCHUM), Universit\u00e9 de Montr\u00e9al, Montreal, Quebec, Canada","institution_ids":["https://openalex.org/I4210142730","https://openalex.org/I70931966"]},{"raw_affiliation_string":"Program of Molecular Biology, Universit\u00e9 de Montr\u00e9al, Montreal, Quebec, Canada","institution_ids":["https://openalex.org/I70931966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111876175","display_name":"Marie\u2010Line Peyot","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210142730","display_name":"Centre Hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al","ror":"https://ror.org/0410a8y51","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4210142730","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I70931966","display_name":"Universit\u00e9 de Montr\u00e9al","ror":"https://ror.org/0161xgx34","country_code":"CA","type":"education","lineage":["https://openalex.org/I70931966"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Marie-Line Peyot","raw_affiliation_strings":["Molecular Nutrition Unit and Montreal Diabetes Research Center at the Centre de Recherche du Centre Hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al (CRCHUM), Universit\u00e9 de Montr\u00e9al, Montreal, Quebec, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Nutrition Unit and Montreal Diabetes Research Center at the Centre de Recherche du Centre Hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al (CRCHUM), Universit\u00e9 de Montr\u00e9al, Montreal, Quebec, Canada","institution_ids":["https://openalex.org/I4210142730","https://openalex.org/I70931966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055882378","display_name":"Neil B. Ruderman","orcid":"https://orcid.org/0000-0002-6589-6587","observed_orcids":["https://orcid.org/0000-0002-6589-6587"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I1286490081","display_name":"Boston Medical Center","ror":"https://ror.org/010b9wj87","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1286490081"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Neil B. Ruderman","raw_affiliation_strings":["Departments of Medicine and Physiology and Biophysics, Boston University School of Medicine and Diabetes Unit, Section of Endocrinology, Boston University School of Medicine and Boston Medical Center, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine and Physiology and Biophysics, Boston University School of Medicine and Diabetes Unit, Section of Endocrinology, Boston University School of Medicine and Boston Medical Center, Boston, Massachusetts","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I1286490081"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051590202","display_name":"Christopher James Nolan","orcid":"https://orcid.org/0000-0002-6964-3819","observed_orcids":["https://orcid.org/0000-0002-6964-3819"]},"institutions":[{"id":"https://openalex.org/I118347636","display_name":"Australian National University","ror":"https://ror.org/019wvm592","country_code":"AU","type":"education","lineage":["https://openalex.org/I118347636"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Christopher J. Nolan","raw_affiliation_strings":["The Australian National University Medical School, Canberra, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Australian National University Medical School, Canberra, Australia","institution_ids":["https://openalex.org/I118347636"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103362692","display_name":"Erik C. Joly","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210142730","display_name":"Centre Hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al","ror":"https://ror.org/0410a8y51","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4210142730","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I70931966","display_name":"Universit\u00e9 de Montr\u00e9al","ror":"https://ror.org/0161xgx34","country_code":"CA","type":"education","lineage":["https://openalex.org/I70931966"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Erik Joly","raw_affiliation_strings":["Molecular Nutrition Unit and Montreal Diabetes Research Center at the Centre de Recherche du Centre Hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al (CRCHUM), Universit\u00e9 de Montr\u00e9al, Montreal, Quebec, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Nutrition Unit and Montreal Diabetes Research Center at the Centre de Recherche du Centre Hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al (CRCHUM), Universit\u00e9 de Montr\u00e9al, Montreal, Quebec, Canada","institution_ids":["https://openalex.org/I4210142730","https://openalex.org/I70931966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102977871","display_name":"S.R. Murthy Madiraju","orcid":"https://orcid.org/0000-0002-2613-2074","observed_orcids":["https://orcid.org/0000-0002-2613-2074"]},"institutions":[{"id":"https://openalex.org/I4210142730","display_name":"Centre Hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al","ror":"https://ror.org/0410a8y51","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4210142730","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I70931966","display_name":"Universit\u00e9 de Montr\u00e9al","ror":"https://ror.org/0161xgx34","country_code":"CA","type":"education","lineage":["https://openalex.org/I70931966"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"S.R. Murthy Madiraju","raw_affiliation_strings":["Molecular Nutrition Unit and Montreal Diabetes Research Center at the Centre de Recherche du Centre Hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al (CRCHUM), Universit\u00e9 de Montr\u00e9al, Montreal, Quebec, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Nutrition Unit and Montreal Diabetes Research Center at the Centre de Recherche du Centre Hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al (CRCHUM), Universit\u00e9 de Montr\u00e9al, Montreal, Quebec, Canada","institution_ids":["https://openalex.org/I4210142730","https://openalex.org/I70931966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084955564","display_name":"Vincent Poitout","orcid":"https://orcid.org/0000-0002-6555-5053","observed_orcids":["https://orcid.org/0000-0002-6555-5053"]},"institutions":[{"id":"https://openalex.org/I70931966","display_name":"Universit\u00e9 de Montr\u00e9al","ror":"https://ror.org/0161xgx34","country_code":"CA","type":"education","lineage":["https://openalex.org/I70931966"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Vincent Poitout","raw_affiliation_strings":["Montreal Diabetes Research Center at the CRCHUM and Departments of Medicine, Biochemistry and Nutrition, Universit\u00e9 de Montr\u00e9al, Montreal, Quebec, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Montreal Diabetes Research Center at the CRCHUM and Departments of Medicine, Biochemistry and Nutrition, Universit\u00e9 de Montr\u00e9al, Montreal, Quebec, Canada","institution_ids":["https://openalex.org/I70931966"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043172423","display_name":"Marc Prentki","orcid":"https://orcid.org/0000-0002-0499-3324","observed_orcids":["https://orcid.org/0000-0002-0499-3324"]},"institutions":[{"id":"https://openalex.org/I4210142730","display_name":"Centre Hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al","ror":"https://ror.org/0410a8y51","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4210142730","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I70931966","display_name":"Universit\u00e9 de Montr\u00e9al","ror":"https://ror.org/0161xgx34","country_code":"CA","type":"education","lineage":["https://openalex.org/I70931966"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Marc Prentki","raw_affiliation_strings":["Department of Biochemistry, Universit\u00e9 de Montr\u00e9al, Montreal, Quebec, Canada","Department of Nutrition, Universit\u00e9 de Montr\u00e9al, Montreal, Quebec, Canada","Molecular Nutrition Unit and Montreal Diabetes Research Center at the Centre de Recherche du Centre Hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al (CRCHUM), Universit\u00e9 de Montr\u00e9al, Montreal, Quebec, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Universit\u00e9 de Montr\u00e9al, Montreal, Quebec, Canada","institution_ids":["https://openalex.org/I70931966"]},{"raw_affiliation_string":"Department of Nutrition, Universit\u00e9 de Montr\u00e9al, Montreal, Quebec, Canada","institution_ids":["https://openalex.org/I70931966"]},{"raw_affiliation_string":"Molecular Nutrition Unit and Montreal Diabetes Research Center at the Centre de Recherche du Centre Hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al (CRCHUM), Universit\u00e9 de Montr\u00e9al, Montreal, Quebec, Canada","institution_ids":["https://openalex.org/I4210142730","https://openalex.org/I70931966"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5043172423"],"corresponding_institution_ids":["https://openalex.org/I4210142730","https://openalex.org/I70931966"],"apc_list":null,"apc_paid":null,"fwci":3.0554,"has_fulltext":true,"cited_by_count":38,"citation_normalized_percentile":{"value":0.91467992,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"62","issue":"6","first_page":"2122","last_page":"2129"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.88919997215271,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.88919997215271,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.09880000352859497,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":0.004000000189989805,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pioglitazone","display_name":"pioglitazone","score":1.0},{"id":"https://openalex.org/keywords/insulin-secretion","display_name":"insulin secretion","score":0.949999988079071},{"id":"https://openalex.org/keywords/energy-expenditure","display_name":"energy expenditure","score":0.6779999732971191},{"id":"https://openalex.org/keywords/glucose-stimulated-insulin-secretion","display_name":"glucose-stimulated insulin secretion","score":0.8970000147819519},{"id":"https://openalex.org/keywords/insulin-sensitivity","display_name":"insulin sensitivity","score":0.6809999942779541},{"id":"https://openalex.org/keywords/beta-cell-function","display_name":"beta-cell function","score":0.7310000061988831},{"id":"https://openalex.org/keywords/insulin-clearance","display_name":"insulin clearance","score":0.6930000185966492},{"id":"https://openalex.org/keywords/glucose-homeostasis","display_name":"glucose homeostasis","score":0.7459999918937683},{"id":"https://openalex.org/keywords/zucker-diabetic-fatty-rats","display_name":"Zucker diabetic fatty rats","score":0.7310000061988831},{"id":"https://openalex.org/keywords/insulin-sensitizing-drugs","display_name":"insulin-sensitizing drugs","score":0.7929999828338623},{"id":"https://openalex.org/keywords/oxygen-consumption","display_name":"oxygen consumption","score":0.6330000162124634}],"concepts":[{"id":"https://openalex.org/C2778384471","wikidata":"https://www.wikidata.org/wiki/Q417765","display_name":"Pioglitazone","level":4,"score":0.9907476902008057},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8782743811607361},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8631848096847534},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.6937822103500366},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5501037240028381},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.4810376465320587},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.46693557500839233},{"id":"https://openalex.org/C3018667095","wikidata":"https://www.wikidata.org/wiki/Q3455903","display_name":"Glucose homeostasis","level":4,"score":0.4474666714668274},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.3821946084499359}],"mesh":[{"descriptor_ui":"D000077205","descriptor_name":"Pioglitazone","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000078790","descriptor_name":"Insulin Secretion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002153","descriptor_name":"Calorimetry, Indirect","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004734","descriptor_name":"Energy Metabolism","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010101","descriptor_name":"Oxygen Consumption","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045162","descriptor_name":"Thiazolidinediones","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.2337/db12-0428","doi":"https://doi.org/10.2337/db12-0428","is_oa":true,"landing_page_url":"https://doi.org/10.2337/db12-0428","pdf_url":null,"source":{"id":"https://openalex.org/S129060628","display_name":"Diabetes","issn_l":"0012-1797","issn":["0012-1797","1939-327X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3661607","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3661607/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3661607/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"Text"},{"id":"pmh:oai:europepmc.org:3012898","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3661607","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:23378607","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23378607","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.872.4005","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.872.4005","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://diabetes.diabetesjournals.org/content/62/6/2122.full.pdf","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.872.4090","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.872.4090","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://diabetes.diabetesjournals.org/content/early/2013/01/30/db12-0428.full.pdf","raw_type":"text"},{"id":"pmh:oai:openresearch-repository.anu.edu.au:1885/74445","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/1885/74445","pdf_url":null,"source":{"id":"https://openalex.org/S4306402539","display_name":"ANU Open Research (Australian National University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I118347636","host_organization_name":"Australian National University","host_organization_lineage":["https://openalex.org/I118347636"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Diabetes","raw_type":"Journal article"},{"id":"mag:2182487021","doi":null,"is_oa":false,"landing_page_url":"https://diabetes.diabetesjournals.org/content/early/2013/01/30/db12-0428.full.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"doi:10.2337/db12-0428","doi":"https://doi.org/10.2337/db12-0428","is_oa":true,"landing_page_url":"https://doi.org/10.2337/db12-0428","pdf_url":null,"source":{"id":"https://openalex.org/S129060628","display_name":"Diabetes","issn_l":"0012-1797","issn":["0012-1797","1939-327X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2879209435","display_name":"The AMPK/SIRT1  Partnershipand Its Biological Relevance","funder_award_id":"R01DK019514","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320306089","display_name":"American Diabetes Association","ror":"https://ror.org/04f6cgz95"},{"id":"https://openalex.org/F4320310920","display_name":"Diab\u00e8te Qu\u00e9bec","ror":"https://ror.org/01dysnd41"},{"id":"https://openalex.org/F4320320994","display_name":"Canada Research Chairs","ror":"https://ror.org/0517h6h17"},{"id":"https://openalex.org/F4320323175","display_name":"Universit\u00e9 de Montr\u00e9al","ror":"https://ror.org/0161xgx34"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334506","display_name":"Canadian Institutes of Health Research","ror":"https://ror.org/01gavpb45"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2017304883.pdf","grobid_xml":"https://content.openalex.org/works/W2017304883.grobid-xml"},"referenced_works_count":39,"referenced_works":["https://openalex.org/W1598254642","https://openalex.org/W1897237112","https://openalex.org/W1968368398","https://openalex.org/W1984661600","https://openalex.org/W1987652896","https://openalex.org/W2012312748","https://openalex.org/W2018821993","https://openalex.org/W2022131162","https://openalex.org/W2025578932","https://openalex.org/W2031283052","https://openalex.org/W2035704352","https://openalex.org/W2040265224","https://openalex.org/W2042871909","https://openalex.org/W2046378557","https://openalex.org/W2047234364","https://openalex.org/W2054777152","https://openalex.org/W2080001569","https://openalex.org/W2082990075","https://openalex.org/W2084388189","https://openalex.org/W2092340120","https://openalex.org/W2097282105","https://openalex.org/W2107333702","https://openalex.org/W2108210081","https://openalex.org/W2111497885","https://openalex.org/W2115414014","https://openalex.org/W2119343648","https://openalex.org/W2125508726","https://openalex.org/W2150619590","https://openalex.org/W2153134360","https://openalex.org/W2154412797","https://openalex.org/W2154507552","https://openalex.org/W2156472431","https://openalex.org/W2166949410","https://openalex.org/W2168853799","https://openalex.org/W2169465693","https://openalex.org/W2169826533","https://openalex.org/W2323706303","https://openalex.org/W2403578638","https://openalex.org/W2805716230"],"related_works":["https://openalex.org/W2182487021","https://openalex.org/W2166949410","https://openalex.org/W2330725586","https://openalex.org/W2414413288","https://openalex.org/W2093762151","https://openalex.org/W8919293","https://openalex.org/W2050896160","https://openalex.org/W2359014402","https://openalex.org/W6981382764","https://openalex.org/W2022200982"],"abstract_inverted_index":{"Our":[0],"objective":[1],"was":[2,73,86,106],"to":[3,190,193],"determine":[4],"if":[5],"the":[6,103,162,168,172,185],"insulin-sensitizing":[7,169],"drug":[8],"pioglitazone":[9,63,82,110,143,152,178],"acutely":[10,153],"reduces":[11,160],"insulin":[12,24,68,134],"secretion":[13,69,135],"and":[14,32,36,42,47,78,137,147,159,196],"causes":[15],"metabolic":[16,156,181],"deceleration":[17,182],"in":[18,23,44,75,89,93,98,121,144],"vivo":[19,67],"independently":[20],"of":[21,62,167,171],"change":[22],"sensitivity.":[25],"We":[26],"assessed":[27,101],"glucose":[28],"homeostasis":[29],"by":[30,39,102,109,142],"hyperinsulinemic-euglycemic":[31,104],"hyperglycemic":[33],"clamp":[34,105],"studies":[35],"energy":[37,119],"expenditure":[38,120],"indirect":[40],"calorimetry":[41],"biotelemetry":[43],"male":[45],"Wistar":[46,77,90,99,122],"obese":[48],"hyperinsulinemic":[49],"Zucker":[50],"diabetic":[51],"fatty":[52],"(ZDF)":[53],"rats":[54,80,100,123],"45":[55],"min":[56],"after":[57,81],"a":[58],"single":[59],"oral":[60],"dose":[61],"(30":[64],"mg/kg).":[65],"In":[66,150],"during":[70],"clamped":[71],"hyperglycemia":[72],"reduced":[74,118,141],"both":[76],"ZDF":[79,94],"administration.":[83],"Insulin":[84,96],"clearance":[85],"slightly":[87],"increased":[88],"but":[91],"not":[92],"rats.":[95],"sensitivity":[97],"minimally":[107],"affected":[108],"at":[111],"this":[112],"early":[113],"time":[114],"point.":[115],"Pioglitazone":[116],"also":[117],"without":[124],"altering":[125],"respiratory":[126],"exchange":[127],"ratio":[128],"or":[129],"core":[130],"body":[131],"temperature.":[132],"Glucose-induced":[133],"(GIIS)":[136],"oxygen":[138],"consumption":[139],"were":[140],"isolated":[145],"islets":[146],"INS832/13":[148],"cells.":[149],"conclusion,":[151],"induces":[154],"whole-body":[155],"slowing":[157],"down":[158],"GIIS,":[161],"latter":[163],"being":[164],"largely":[165],"independent":[166],"action":[170],"drug.":[173],"The":[174],"results":[175],"suggest":[176],"that":[177,187],"has":[179],"direct":[180],"effects":[183],"on":[184],"\u03b2-cell":[186],"may":[188],"contribute":[189],"its":[191],"capacity":[192],"lower":[194],"insulinemia":[195],"antidiabetic":[197],"action.":[198]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2016-06-24T00:00:00"}