{"id":"https://openalex.org/W2017295967","doi":"https://doi.org/10.4161/cc.3.4.773","title":"Polycomb Group Proteins in Cell Cycle Progression and Cancer","display_name":"Polycomb Group Proteins in Cell Cycle Progression and Cancer","publication_year":2004,"publication_date":"2004-04-02","ids":{"openalex":"https://openalex.org/W2017295967","doi":"https://doi.org/10.4161/cc.3.4.773","mag":"2017295967","pmid":"https://pubmed.ncbi.nlm.nih.gov/14752272"},"language":"en","primary_location":{"id":"doi:10.4161/cc.3.4.773","doi":"https://doi.org/10.4161/cc.3.4.773","is_oa":true,"landing_page_url":"https://doi.org/10.4161/cc.3.4.773","pdf_url":"https://www.tandfonline.com/doi/pdf/10.4161/cc.3.4.773?needAccess=true","source":{"id":"https://openalex.org/S86011449","display_name":"Cell Cycle","issn_l":"1551-4005","issn":["1551-4005","1538-4101"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","medline","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Cycle","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.tandfonline.com/doi/pdf/10.4161/cc.3.4.773?needAccess=true","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056723765","display_name":"Diego Pasini","orcid":"https://orcid.org/0000-0002-9879-6486","observed_orcids":["https://orcid.org/0000-0002-9879-6486"]},"institutions":[{"id":"https://openalex.org/I6141010","display_name":"European Institute of Oncology","ror":"https://ror.org/02vr0ne26","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I6141010"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Diego Pasini","raw_affiliation_strings":["\u2020Department of Experimental Oncology, European Institute of Oncology, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u2020Department of Experimental Oncology, European Institute of Oncology, Milan, Italy","institution_ids":["https://openalex.org/I6141010"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007899825","display_name":"Adrian P. Bracken","orcid":"https://orcid.org/0000-0002-1547-9443","observed_orcids":["https://orcid.org/0000-0002-1547-9443"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]},{"id":"https://openalex.org/I6141010","display_name":"European Institute of Oncology","ror":"https://ror.org/02vr0ne26","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I6141010"]}],"countries":["DK","IT"],"is_corresponding":false,"raw_author_name":"Adrian P. Bracken","raw_affiliation_strings":["Department of Experimental Oncology ; European Institute of Oncology ; Milan , Italy","Helin Group, BRIC Research Groups, BRIC, K\u00f8benhavns Universitet"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Oncology ; European Institute of Oncology ; Milan , Italy","institution_ids":["https://openalex.org/I6141010"]},{"raw_affiliation_string":"Helin Group, BRIC Research Groups, BRIC, K\u00f8benhavns Universitet","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011822969","display_name":"Kristian Helin","orcid":"https://orcid.org/0000-0003-1975-6097","observed_orcids":["https://orcid.org/0000-0003-1975-6097"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]},{"id":"https://openalex.org/I6141010","display_name":"European Institute of Oncology","ror":"https://ror.org/02vr0ne26","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I6141010"]}],"countries":["DK","IT"],"is_corresponding":false,"raw_author_name":"Kristian Helin","raw_affiliation_strings":["Department of Experimental Oncology ; European Institute of Oncology ; Milan , Italy","Department of Experimental Oncology ; European Institute of Oncology ; Via Ripamonti 434 ; 20141 Milan Italy;","BRIC Administration, BRIC, Faculty of Health and Medical Sciences, K\u00f8benhavns Universitet"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Oncology ; European Institute of Oncology ; Milan , Italy","institution_ids":["https://openalex.org/I6141010"]},{"raw_affiliation_string":"Department of Experimental Oncology ; European Institute of Oncology ; Via Ripamonti 434 ; 20141 Milan Italy;","institution_ids":["https://openalex.org/I6141010"]},{"raw_affiliation_string":"BRIC Administration, BRIC, Faculty of Health and Medical Sciences, K\u00f8benhavns Universitet","institution_ids":["https://openalex.org/I124055696"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.502,"has_fulltext":true,"cited_by_count":97,"citation_normalized_percentile":{"value":0.89561134,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"3","issue":"4","first_page":"394","last_page":"398"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.010900000110268593,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/polycomb-group-proteins","display_name":"Polycomb group proteins","score":0.9559999704360962},{"id":"https://openalex.org/keywords/polycomb-repressive-complex-2","display_name":"polycomb repressive complex 2","score":0.9940000176429749},{"id":"https://openalex.org/keywords/cell-cycle-progression","display_name":"cell cycle progression","score":0.8040000200271606},{"id":"https://openalex.org/keywords/cancer","display_name":"cancer","score":0.8059999942779541},{"id":"https://openalex.org/keywords/epigenetic-dysregulation","display_name":"epigenetic dysregulation","score":0.9139999747276306},{"id":"https://openalex.org/keywords/chromatin-remodeling","display_name":"chromatin remodeling","score":0.9480000138282776},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.9179999828338623},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.871999979019165},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.9470000267028809}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8838030099868774},{"id":"https://openalex.org/C2776915012","wikidata":"https://www.wikidata.org/wiki/Q17125871","display_name":"PRC2","level":5,"score":0.8710801601409912},{"id":"https://openalex.org/C2777116130","wikidata":"https://www.wikidata.org/wiki/Q4082046","display_name":"Polycomb-group proteins","level":5,"score":0.8663915395736694},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.7210742831230164},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.7156209945678711},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.7139443159103394},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.52964186668396},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.49736288189888},{"id":"https://openalex.org/C167227067","wikidata":"https://www.wikidata.org/wiki/Q5113739","display_name":"Chromatin remodeling","level":4,"score":0.49163657426834106},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.46493643522262573},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4542343020439148},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.449826180934906},{"id":"https://openalex.org/C179463898","wikidata":"https://www.wikidata.org/wiki/Q10273301","display_name":"Epigenesis","level":5,"score":0.4454256594181061},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4409196376800537},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.44073817133903503},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.438997745513916},{"id":"https://openalex.org/C50171091","wikidata":"https://www.wikidata.org/wiki/Q17917770","display_name":"EZH2","level":4,"score":0.3199664354324341},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.2605542540550232},{"id":"https://openalex.org/C158448853","wikidata":"https://www.wikidata.org/wiki/Q425218","display_name":"Repressor","level":4,"score":0.14672809839248657}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002843","descriptor_name":"Chromatin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004330","descriptor_name":"Drosophila","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011233","descriptor_name":"Precipitin Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020868","descriptor_name":"Gene Silencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D063146","descriptor_name":"Polycomb-Group Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D063151","descriptor_name":"Polycomb Repressive Complex 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.4161/cc.3.4.773","doi":"https://doi.org/10.4161/cc.3.4.773","is_oa":true,"landing_page_url":"https://doi.org/10.4161/cc.3.4.773","pdf_url":"https://www.tandfonline.com/doi/pdf/10.4161/cc.3.4.773?needAccess=true","source":{"id":"https://openalex.org/S86011449","display_name":"Cell Cycle","issn_l":"1551-4005","issn":["1551-4005","1538-4101"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","medline","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Cycle","raw_type":"journal-article"},{"id":"pmid:14752272","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14752272","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell cycle (Georgetown, Tex.)","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.4161/cc.3.4.773","doi":"https://doi.org/10.4161/cc.3.4.773","is_oa":true,"landing_page_url":"https://doi.org/10.4161/cc.3.4.773","pdf_url":"https://www.tandfonline.com/doi/pdf/10.4161/cc.3.4.773?needAccess=true","source":{"id":"https://openalex.org/S86011449","display_name":"Cell Cycle","issn_l":"1551-4005","issn":["1551-4005","1538-4101"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","medline","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Cycle","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.6240000128746033,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320323054","display_name":"Associazione Italiana per la Ricerca sul Cancro","ror":"https://ror.org/02g2x7380"},{"id":"https://openalex.org/F4320324143","display_name":"Fondazione Italiana per la Ricerca sul Cancro","ror":"https://ror.org/02g2x7380"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2017295967.pdf","grobid_xml":"https://content.openalex.org/works/W2017295967.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4389981876","https://openalex.org/W2739602575","https://openalex.org/W2502703983","https://openalex.org/W4296407078","https://openalex.org/W2531569648","https://openalex.org/W2004380823","https://openalex.org/W3082798317","https://openalex.org/W2988405541","https://openalex.org/W3111709235","https://openalex.org/W4389636631"],"abstract_inverted_index":{"Epigenetic":[0],"deregulation":[1],"of":[2,14,45],"gene":[3,51],"expression":[4,52],"is":[5],"emerging":[6],"as":[7],"key":[8],"mechanism":[9],"in":[10,32,49],"tumorigenesis.":[11],"Deregulated":[12],"activity":[13],"the":[15,43,46],"chromatin":[16],"remodeling":[17],"Polycomb":[18],"Repressive":[19],"Complex":[20],"2":[21],"(PRC2)":[22],"has":[23],"recently":[24],"been":[25],"shown":[26],"to":[27],"be":[28],"a":[29],"frequent":[30],"event":[31],"human":[33],"tumors.":[34],"Here":[35],"we":[36],"discuss":[37],"these":[38],"findings":[39],"and":[40,57],"speculate":[41],"on":[42],"role":[44],"PRC2":[47],"complex":[48],"controlling":[50],"during":[53],"normal":[54],"cellular":[55],"proliferation":[56],"cancer":[58],"development.":[59]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}