{"id":"https://openalex.org/W2017288284","doi":"https://doi.org/10.1007/bf00195914","title":"Disposition kinetics of buspirone in patients with renal or hepatic impairment after administration of single and multiple doses","display_name":"Disposition kinetics of buspirone in patients with renal or hepatic impairment after administration of single and multiple doses","publication_year":1994,"publication_date":"1994-02-01","ids":{"openalex":"https://openalex.org/W2017288284","doi":"https://doi.org/10.1007/bf00195914","mag":"2017288284","pmid":"https://pubmed.ncbi.nlm.nih.gov/7911763"},"language":"en","primary_location":{"id":"doi:10.1007/bf00195914","doi":"https://doi.org/10.1007/bf00195914","is_oa":false,"landing_page_url":"https://doi.org/10.1007/bf00195914","pdf_url":null,"source":{"id":"https://openalex.org/S31780008","display_name":"European Journal of Clinical Pharmacology","issn_l":"0031-6970","issn":["0031-6970","1432-1041"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Clinical Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108807818","display_name":"Rashmi H. Barbhaiya","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210091812","display_name":"Bristol-Myers Squibb (United States)","ror":"https://ror.org/00gtmwv55","country_code":"US","type":"company","lineage":["https://openalex.org/I4210091812"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R.H. Barbhaiya","raw_affiliation_strings":["Department of Metabolism and Pharmacokinetics, Bristol-Myers Squibb Pharmaceutical Research Institute, Syracuse, New York 13221-4755"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Metabolism and Pharmacokinetics, Bristol-Myers Squibb Pharmaceutical Research Institute, Syracuse, New York 13221-4755","institution_ids":["https://openalex.org/I4210091812"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111886966","display_name":"Umesh Shukla","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210091812","display_name":"Bristol-Myers Squibb (United States)","ror":"https://ror.org/00gtmwv55","country_code":"US","type":"company","lineage":["https://openalex.org/I4210091812"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"U.A. Shukla","raw_affiliation_strings":["Department of Metabolism and Pharmacokinetics, Bristol-Myers Squibb Pharmaceutical Research Institute, Syracuse, New York, USA","Department of Metabolism and Pharmacokinetics, Bristol-Myers Squibb Pharmaceutical Research Institute, Syracuse, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Metabolism and Pharmacokinetics, Bristol-Myers Squibb Pharmaceutical Research Institute, Syracuse, New York, USA","institution_ids":["https://openalex.org/I4210091812"]},{"raw_affiliation_string":"Department of Metabolism and Pharmacokinetics, Bristol-Myers Squibb Pharmaceutical Research Institute, Syracuse, USA","institution_ids":["https://openalex.org/I4210091812"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113572249","display_name":"M Pfeffer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210091812","display_name":"Bristol-Myers Squibb (United States)","ror":"https://ror.org/00gtmwv55","country_code":"US","type":"company","lineage":["https://openalex.org/I4210091812"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Pfeffer","raw_affiliation_strings":["Department of Metabolism and Pharmacokinetics, Bristol-Myers Squibb Pharmaceutical Research Institute, Syracuse, New York, USA","Department of Metabolism and Pharmacokinetics, Bristol-Myers Squibb Pharmaceutical Research Institute, Syracuse, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Metabolism and Pharmacokinetics, Bristol-Myers Squibb Pharmaceutical Research Institute, Syracuse, New York, USA","institution_ids":["https://openalex.org/I4210091812"]},{"raw_affiliation_string":"Department of Metabolism and Pharmacokinetics, Bristol-Myers Squibb Pharmaceutical Research Institute, Syracuse, USA","institution_ids":["https://openalex.org/I4210091812"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111691203","display_name":"Kelly Pittman","orcid":"https://orcid.org/0009-0008-4074-0915","observed_orcids":["https://orcid.org/0009-0008-4074-0915"]},"institutions":[{"id":"https://openalex.org/I4210091812","display_name":"Bristol-Myers Squibb (United States)","ror":"https://ror.org/00gtmwv55","country_code":"US","type":"company","lineage":["https://openalex.org/I4210091812"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K.A. Pittman","raw_affiliation_strings":["Department of Metabolism and Pharmacokinetics, Bristol-Myers Squibb Pharmaceutical Research Institute, Syracuse, New York, USA","Department of Metabolism and Pharmacokinetics, Bristol-Myers Squibb Pharmaceutical Research Institute, Syracuse, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Metabolism and Pharmacokinetics, Bristol-Myers Squibb Pharmaceutical Research Institute, Syracuse, New York, USA","institution_ids":["https://openalex.org/I4210091812"]},{"raw_affiliation_string":"Department of Metabolism and Pharmacokinetics, Bristol-Myers Squibb Pharmaceutical Research Institute, Syracuse, USA","institution_ids":["https://openalex.org/I4210091812"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016433435","display_name":"Rajesh C. Shrotriya","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210091812","display_name":"Bristol-Myers Squibb (United States)","ror":"https://ror.org/00gtmwv55","country_code":"US","type":"company","lineage":["https://openalex.org/I4210091812"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. Shrotriya","raw_affiliation_strings":["CNS Clinical Research Department, Bristol-Myers Squibb Pharmaceutical Research Instituteristol-Myers Squibb Pharmaceutical Research Institute, Wallingford, Connecticut, USA","CNS Clinical Research Department, Bristol-Myers Squibb Pharmaceutical Research Instituteristol-Myers Squibb Pharmaceutical Research Institute, Wallingford, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CNS Clinical Research Department, Bristol-Myers Squibb Pharmaceutical Research Instituteristol-Myers Squibb Pharmaceutical Research Institute, Wallingford, Connecticut, USA","institution_ids":["https://openalex.org/I4210091812"]},{"raw_affiliation_string":"CNS Clinical Research Department, Bristol-Myers Squibb Pharmaceutical Research Instituteristol-Myers Squibb Pharmaceutical Research Institute, Wallingford, USA","institution_ids":["https://openalex.org/I4210091812"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091587687","display_name":"C. Laroudie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210098725","display_name":"Bristol-Myers Squibb (France)","ror":"https://ror.org/013b57229","country_code":"FR","type":"company","lineage":["https://openalex.org/I4210091812","https://openalex.org/I4210098725"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"C. Laroudie","raw_affiliation_strings":["Bristol-Myers Squibb France, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bristol-Myers Squibb France, Paris, France","institution_ids":["https://openalex.org/I4210098725"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007632135","display_name":"Richard E. Gammans","orcid":"https://orcid.org/0009-0009-3632-1934","observed_orcids":["https://orcid.org/0009-0009-3632-1934"]},"institutions":[{"id":"https://openalex.org/I4210091812","display_name":"Bristol-Myers Squibb (United States)","ror":"https://ror.org/00gtmwv55","country_code":"US","type":"company","lineage":["https://openalex.org/I4210091812"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R.E. Gammans","raw_affiliation_strings":["CNS Clinical Research Department, Bristol-Myers Squibb Pharmaceutical Research Instituteristol-Myers Squibb Pharmaceutical Research Institute, Wallingford, Connecticut, USA","CNS Clinical Research Department, Bristol-Myers Squibb Pharmaceutical Research Instituteristol-Myers Squibb Pharmaceutical Research Institute, Wallingford, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CNS Clinical Research Department, Bristol-Myers Squibb Pharmaceutical Research Instituteristol-Myers Squibb Pharmaceutical Research Institute, Wallingford, Connecticut, USA","institution_ids":["https://openalex.org/I4210091812"]},{"raw_affiliation_string":"CNS Clinical Research Department, Bristol-Myers Squibb Pharmaceutical Research Instituteristol-Myers Squibb Pharmaceutical Research Institute, Wallingford, USA","institution_ids":["https://openalex.org/I4210091812"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3090,"currency":"USD","value_usd":3090},"apc_paid":null,"fwci":0.7601,"has_fulltext":false,"cited_by_count":35,"citation_normalized_percentile":{"value":0.63457815,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"46","issue":"1","first_page":"41","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9692000150680542,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9692000150680542,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.007600000128149986,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12547","display_name":"Pharmaceutical studies and practices","score":0.005900000222027302,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/buspirone","display_name":"buspirone","score":0.9990000128746033},{"id":"https://openalex.org/keywords/renal-dysfunction","display_name":"renal dysfunction","score":0.6600000262260437},{"id":"https://openalex.org/keywords/liver-dysfunction","display_name":"liver dysfunction","score":0.9990000128746033},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.8360000252723694},{"id":"https://openalex.org/keywords/disposition-kinetics","display_name":"disposition kinetics","score":0.6869999766349792},{"id":"https://openalex.org/keywords/steady-state-pharmacokinetics","display_name":"steady-state pharmacokinetics","score":0.7770000100135803},{"id":"https://openalex.org/keywords/single-dose-pharmacokinetics","display_name":"single-dose pharmacokinetics","score":0.6470000147819519},{"id":"https://openalex.org/keywords/dose-adjustment","display_name":"dose adjustment","score":0.39500001072883606},{"id":"https://openalex.org/keywords/serum-albumin","display_name":"serum albumin","score":0.8090000152587891},{"id":"https://openalex.org/keywords/bromsulphalein-clearance","display_name":"bromsulphalein clearance","score":0.9229999780654907},{"id":"https://openalex.org/keywords/adverse-drug-experiences","display_name":"adverse drug experiences","score":0.7059999704360962},{"id":"https://openalex.org/keywords/antipsychotic-safety","display_name":"antipsychotic safety","score":0.5289999842643738},{"id":"https://openalex.org/keywords/liver-drug-metabolism","display_name":"liver drug metabolism","score":0.31299999356269836}],"concepts":[{"id":"https://openalex.org/C2777287423","wikidata":"https://www.wikidata.org/wiki/Q412194","display_name":"Buspirone","level":4,"score":0.9273265600204468},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.7237262725830078},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6995535492897034},{"id":"https://openalex.org/C2778335254","wikidata":"https://www.wikidata.org/wiki/Q5137314","display_name":"Cmin","level":4,"score":0.6652075052261353},{"id":"https://openalex.org/C22979827","wikidata":"https://www.wikidata.org/wiki/Q5137311","display_name":"Cmax","level":3,"score":0.6387794017791748},{"id":"https://openalex.org/C2777056448","wikidata":"https://www.wikidata.org/wiki/Q285166","display_name":"Oral administration","level":2,"score":0.4696749150753021},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.43345633149147034},{"id":"https://openalex.org/C76318530","wikidata":"https://www.wikidata.org/wiki/Q16833590","display_name":"Area under the curve","level":2,"score":0.4301370680332184},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.3762732446193695},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3707476258277893},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.06438121199607849},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002065","descriptor_name":"Buspirone","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D002065","descriptor_name":"Buspirone","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D002065","descriptor_name":"Buspirone","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D002065","descriptor_name":"Buspirone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D002065","descriptor_name":"Buspirone","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007674","descriptor_name":"Kidney Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008107","descriptor_name":"Liver Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014151","descriptor_name":"Anti-Anxiety Agents","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/bf00195914","doi":"https://doi.org/10.1007/bf00195914","is_oa":false,"landing_page_url":"https://doi.org/10.1007/bf00195914","pdf_url":null,"source":{"id":"https://openalex.org/S31780008","display_name":"European Journal of Clinical Pharmacology","issn_l":"0031-6970","issn":["0031-6970","1432-1041"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Clinical Pharmacology","raw_type":"journal-article"},{"id":"pmid:7911763","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7911763","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of clinical pharmacology","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320309532","display_name":"Syracuse University","ror":"https://ror.org/025r5qe02"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W152443942","https://openalex.org/W192226528","https://openalex.org/W1487775648","https://openalex.org/W1812428887","https://openalex.org/W1973755332","https://openalex.org/W1973814642","https://openalex.org/W1976480727","https://openalex.org/W1983439863","https://openalex.org/W1983641507","https://openalex.org/W1994420004","https://openalex.org/W2000699362","https://openalex.org/W2004250621","https://openalex.org/W2018804536","https://openalex.org/W2023437376","https://openalex.org/W2029885817","https://openalex.org/W2043479875","https://openalex.org/W2050891806","https://openalex.org/W2054194336","https://openalex.org/W2055919083","https://openalex.org/W2063980879","https://openalex.org/W2081942338","https://openalex.org/W2083712574","https://openalex.org/W2086028272","https://openalex.org/W2107184859","https://openalex.org/W2111382968","https://openalex.org/W2116870650","https://openalex.org/W2183438053","https://openalex.org/W2336663813","https://openalex.org/W2401648160","https://openalex.org/W2409947791","https://openalex.org/W2427128263","https://openalex.org/W2428713294","https://openalex.org/W4300682046"],"related_works":["https://openalex.org/W2081942338","https://openalex.org/W2069704104","https://openalex.org/W2086028272","https://openalex.org/W2043575872","https://openalex.org/W2068188436","https://openalex.org/W2059520316","https://openalex.org/W2070635635","https://openalex.org/W2022695747","https://openalex.org/W2007708086","https://openalex.org/W1968377472"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
