{"id":"https://openalex.org/W2017278194","doi":"https://doi.org/10.1590/s1516-44462007000500006","title":"Intera\u00e7\u00f5es imunocerebrais e implica\u00e7\u00f5es nos transtornos psiqui\u00e1tricos","display_name":"Intera\u00e7\u00f5es imunocerebrais e implica\u00e7\u00f5es nos transtornos psiqui\u00e1tricos","publication_year":2007,"publication_date":"2007-05-01","ids":{"openalex":"https://openalex.org/W2017278194","doi":"https://doi.org/10.1590/s1516-44462007000500006","mag":"2017278194","pmid":"https://pubmed.ncbi.nlm.nih.gov/17546344"},"language":"pt","primary_location":{"id":"doi:10.1590/s1516-44462007000500006","doi":"https://doi.org/10.1590/s1516-44462007000500006","is_oa":true,"landing_page_url":"https://doi.org/10.1590/s1516-44462007000500006","pdf_url":"https://www.scielo.br/j/rbp/a/wBFPVGrwmDHVF4yGC8Dbf9M/?lang=pt&format=pdf","source":{"id":"https://openalex.org/S71457257","display_name":"Brazilian Journal of Psychiatry","issn_l":"1516-4446","issn":["1516-4446","1809-452X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-1","scielo","vabb-shw"],"host_organization":"https://openalex.org/P4310312528","host_organization_name":"Associa\u00e7\u00e3o Brasileira de Psiquiatria","host_organization_lineage":["https://openalex.org/P4310312528"],"host_organization_lineage_names":["Associa\u00e7\u00e3o Brasileira de Psiquiatria"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Revista Brasileira de Psiquiatria","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.scielo.br/j/rbp/a/wBFPVGrwmDHVF4yGC8Dbf9M/?lang=pt&format=pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103339982","display_name":"Andrea Hovarth Marques","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210158500","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210158500"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrea H Marques","raw_affiliation_strings":["National Institute of Mental Health, USA","Section on Neuroendocrine Immunology, National Institute of Mental Health, Integrative Neural Immune Program, Bethesda-Rockville, Maryland 20852, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute of Mental Health, USA","institution_ids":["https://openalex.org/I4210158500"]},{"raw_affiliation_string":"Section on Neuroendocrine Immunology, National Institute of Mental Health, Integrative Neural Immune Program, Bethesda-Rockville, Maryland 20852, USA","institution_ids":["https://openalex.org/I4210158500"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032335007","display_name":"Giovanni Cizza","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Giovanni Cizza","raw_affiliation_strings":["NIH, EUA","NIH, Bethesda, EUA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NIH, EUA","institution_ids":["https://openalex.org/I1299303238"]},{"raw_affiliation_string":"NIH, Bethesda, EUA","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111764619","display_name":"Esther M. Sternberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210158500","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210158500"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Esther Sternberg","raw_affiliation_strings":["National Institute of Mental Health, USA","National Institute of Mental Health, Bethesda, USA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute of Mental Health, USA","institution_ids":["https://openalex.org/I4210158500"]},{"raw_affiliation_string":"National Institute of Mental Health, Bethesda, USA;","institution_ids":["https://openalex.org/I4210158500"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6614,"has_fulltext":true,"cited_by_count":46,"citation_normalized_percentile":{"value":0.6372549,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"29","issue":"suppl 1","first_page":"s27","last_page":"s32"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11337","display_name":"Tryptophan and brain disorders","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2803","display_name":"Biological Psychiatry"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11337","display_name":"Tryptophan and brain disorders","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2803","display_name":"Biological Psychiatry"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cytokines","display_name":"cytokines","score":0.9049999713897705},{"id":"https://openalex.org/keywords/major-depressive-disorder","display_name":"major depressive disorder","score":0.9120000004768372},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.8799999952316284},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.6629999876022339},{"id":"https://openalex.org/keywords/sickness-behavior","display_name":"sickness behavior","score":0.8970000147819519},{"id":"https://openalex.org/keywords/immunotherapy","display_name":"immunotherapy","score":0.5410000085830688},{"id":"https://openalex.org/keywords/antidepressant-treatment","display_name":"antidepressant treatment","score":0.824999988079071},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.6869999766349792},{"id":"https://openalex.org/keywords/mental-disorders","display_name":"mental illness","score":0.640999972820282}],"concepts":[{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.5983176827430725}],"mesh":[{"descriptor_ui":"D000928","descriptor_name":"Antidepressive Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D003863","descriptor_name":"Depression","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D003863","descriptor_name":"Depression","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D003865","descriptor_name":"Major Depressive Disorder","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D003866","descriptor_name":"Depressive Disorder","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D003866","descriptor_name":"Depressive Disorder","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D003866","descriptor_name":"Depressive Disorder","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007107","descriptor_name":"Immune System","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D007107","descriptor_name":"Immune System","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D013315","descriptor_name":"Stress, Psychological","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D015213","descriptor_name":"Neuroimmunomodulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1590/s1516-44462007000500006","doi":"https://doi.org/10.1590/s1516-44462007000500006","is_oa":true,"landing_page_url":"https://doi.org/10.1590/s1516-44462007000500006","pdf_url":"https://www.scielo.br/j/rbp/a/wBFPVGrwmDHVF4yGC8Dbf9M/?lang=pt&format=pdf","source":{"id":"https://openalex.org/S71457257","display_name":"Brazilian Journal of Psychiatry","issn_l":"1516-4446","issn":["1516-4446","1809-452X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-1","scielo","vabb-shw"],"host_organization":"https://openalex.org/P4310312528","host_organization_name":"Associa\u00e7\u00e3o Brasileira de Psiquiatria","host_organization_lineage":["https://openalex.org/P4310312528"],"host_organization_lineage_names":["Associa\u00e7\u00e3o Brasileira de Psiquiatria"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Revista Brasileira de Psiquiatria","raw_type":"journal-article"},{"id":"pmid:17546344","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17546344","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)","raw_type":"English Abstract"},{"id":"pmh:oai:scielo:S1516-44462007000500006","doi":null,"is_oa":true,"landing_page_url":"http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462007000500006","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brazilian Journal of Psychiatry v.29 suppl.1 2007","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:americanae.aecid.es:2753988","doi":null,"is_oa":true,"landing_page_url":"http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462007000500006","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Brazilian Journal of Psychiatry v.29 suppl.1 2007","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:aa14bb147aaa402181b314979b2db163","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/aa14bb147aaa402181b314979b2db163","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Brazilian Journal of Psychiatry, Vol 29, Pp s27-s32 (2007)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1590/s1516-44462007000500006","doi":"https://doi.org/10.1590/s1516-44462007000500006","is_oa":true,"landing_page_url":"https://doi.org/10.1590/s1516-44462007000500006","pdf_url":"https://www.scielo.br/j/rbp/a/wBFPVGrwmDHVF4yGC8Dbf9M/?lang=pt&format=pdf","source":{"id":"https://openalex.org/S71457257","display_name":"Brazilian Journal of Psychiatry","issn_l":"1516-4446","issn":["1516-4446","1809-452X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-1","scielo","vabb-shw"],"host_organization":"https://openalex.org/P4310312528","host_organization_name":"Associa\u00e7\u00e3o Brasileira de Psiquiatria","host_organization_lineage":["https://openalex.org/P4310312528"],"host_organization_lineage_names":["Associa\u00e7\u00e3o Brasileira de Psiquiatria"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Revista Brasileira de Psiquiatria","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2017278194.pdf","grobid_xml":"https://content.openalex.org/works/W2017278194.grobid-xml"},"referenced_works_count":56,"referenced_works":["https://openalex.org/W9739726","https://openalex.org/W1527396061","https://openalex.org/W1963543965","https://openalex.org/W1966523374","https://openalex.org/W1967514749","https://openalex.org/W1968248096","https://openalex.org/W1975726962","https://openalex.org/W1981466881","https://openalex.org/W1981907384","https://openalex.org/W1985094790","https://openalex.org/W1992997185","https://openalex.org/W1993856151","https://openalex.org/W1995525413","https://openalex.org/W1996339192","https://openalex.org/W1997115145","https://openalex.org/W1998405496","https://openalex.org/W1999182152","https://openalex.org/W2002118724","https://openalex.org/W2002267508","https://openalex.org/W2005469249","https://openalex.org/W2007121025","https://openalex.org/W2019324493","https://openalex.org/W2019687946","https://openalex.org/W2022669082","https://openalex.org/W2024951540","https://openalex.org/W2030842202","https://openalex.org/W2033962950","https://openalex.org/W2039399819","https://openalex.org/W2040435093","https://openalex.org/W2046106353","https://openalex.org/W2050442674","https://openalex.org/W2054485811","https://openalex.org/W2054492621","https://openalex.org/W2061011364","https://openalex.org/W2063139961","https://openalex.org/W2064679409","https://openalex.org/W2070718998","https://openalex.org/W2073442404","https://openalex.org/W2080824544","https://openalex.org/W2091975706","https://openalex.org/W2093362918","https://openalex.org/W2095043596","https://openalex.org/W2095473686","https://openalex.org/W2097740790","https://openalex.org/W2105368071","https://openalex.org/W2109668208","https://openalex.org/W2110969697","https://openalex.org/W2122192348","https://openalex.org/W2122246785","https://openalex.org/W2157072257","https://openalex.org/W2171400996","https://openalex.org/W2183286372","https://openalex.org/W2323228237","https://openalex.org/W2330924798","https://openalex.org/W2498862691","https://openalex.org/W2907844645"],"related_works":["https://openalex.org/W2088751222","https://openalex.org/W2014522137","https://openalex.org/W2035981398","https://openalex.org/W1968217035","https://openalex.org/W2125984173","https://openalex.org/W7161015810","https://openalex.org/W2560555595","https://openalex.org/W2111826433","https://openalex.org/W2057670077","https://openalex.org/W2002267508"],"abstract_inverted_index":{"OBJECTIVE:":[0],"This":[1],"review":[2],"will":[3,22],"focus":[4],"on":[5,60,81],"the":[6,11,25,47,85,135,175],"role":[7,133],"of":[8,28,74,87,119,137,140,159,177,184,200],"cytokines":[9,78,94],"in":[10,31,64,134,161],"central":[12],"nervous":[13],"system":[14],"and":[15,50,52,55,100,197],"its":[16],"implications":[17],"to":[18,93,105,156],"depressive":[19,35,53,98,106,165,195],"disorder.":[20,36],"We":[21,38,57],"then":[23],"discuss":[24],"main":[26],"findings":[27],"cytokine":[29,62,160],"measurements":[30,63,183],"patients":[32,65,113,162],"with":[33,66,114,163,174],"major":[34,164,194],"METHOD:":[37],"searched":[39],"Pubmed":[40],"for":[41],"studies":[42,153],"published":[43],"from":[44],"1999-2007,":[45],"using":[46,69],"keywords":[48],"depression":[49,67,115],"cytokine;":[51],"disorder":[54,196],"cytokine.":[56],"have":[58,79,125],"focused":[59],"pro-inflammatory":[61,120,178],"syndrome":[68],"DSM-criteria.":[70],"RESULTS:":[71],"Several":[72],"lines":[73],"evidence":[75],"suggest":[76],"that":[77,95,102],"effects":[80],"depression,":[82,141],"such":[83],"as":[84],"induction":[86],"sickness":[88],"behavior;":[89],"clinical":[90],"conditions":[91],"related":[92],"also":[96],"overlap":[97],"symptoms;":[99],"immunotherapy":[101],"can":[103],"lead":[104],"symptoms":[107],"attenuated":[108],"by":[109],"antidepressant":[110],"treatment.":[111],"Finally,":[112],"exhibit":[116],"increased":[117],"levels":[118],"cytokines,":[121],"although":[122,142],"conflicting":[123],"results":[124],"been":[126,148],"described.":[127],"CONCLUSION:":[128],"Cytokines":[129],"may":[130],"play":[131],"a":[132,143,198],"pathophysiology":[136],"some":[138],"cases":[139],"causal":[144],"link":[145],"has":[146],"not":[147],"established":[149],"yet.":[150],"Further":[151],"longitudinal":[152],"are":[154],"needed":[155],"determine":[157],"patterns":[158],"disorder,":[166],"taking":[167],"into":[168,191],"account":[169],"confounding":[170],"factors":[171],"closely":[172],"associated":[173],"activation":[176],"cytokines.":[179],"In":[180],"addition,":[181],"simultaneous":[182],"multiple":[185],"biomarkers":[186],"could":[187],"provide":[188],"critical":[189],"insights":[190],"mechanisms":[192],"underlying":[193],"variety":[199],"common":[201],"cytokine-related":[202],"diseases.":[203]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}