{"id":"https://openalex.org/W2017263600","doi":"https://doi.org/10.1111/j.1755-148x.2011.00940.x","title":"On the edge","display_name":"On the edge","publication_year":2011,"publication_date":"2011-12-16","ids":{"openalex":"https://openalex.org/W2017263600","doi":"https://doi.org/10.1111/j.1755-148x.2011.00940.x","mag":"2017263600","pmid":"https://pubmed.ncbi.nlm.nih.gov/22176508"},"language":"en","primary_location":{"id":"doi:10.1111/j.1755-148x.2011.00940.x","doi":"https://doi.org/10.1111/j.1755-148x.2011.00940.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1755-148x.2011.00940.x","pdf_url":null,"source":{"id":"https://openalex.org/S179442820","display_name":"Pigment Cell & Melanoma Research","issn_l":"1755-1471","issn":["1755-1471","1755-148X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pigment Cell & Melanoma Research","raw_type":"journal-article"},"volume":null,"type":"editorial","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016667595","display_name":"Heinz Arnheiter","orcid":"https://orcid.org/0000-0003-2537-1134","observed_orcids":["https://orcid.org/0000-0003-2537-1134"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Heinz Arnheiter","raw_affiliation_strings":["Executive Editor, Pigment Cell & Melanoma Research"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Executive Editor, Pigment Cell & Melanoma Research","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5016667595"],"corresponding_institution_ids":[],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"25","issue":"1","first_page":"1","last_page":"1"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11144","display_name":"melanin and skin pigmentation","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11144","display_name":"melanin and skin pigmentation","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11167","display_name":"Hair Growth and Disorders","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vitiligo","display_name":"vitiligo","score":0.9919999837875366},{"id":"https://openalex.org/keywords/depigmentation","display_name":"depigmentation","score":0.5680000185966492},{"id":"https://openalex.org/keywords/melanocyte-autoimmunity","display_name":"melanocyte autoimmunity","score":0.6790000200271606},{"id":"https://openalex.org/keywords/koebner-phenomenon","display_name":"Koebner phenomenon","score":0.6830000281333923},{"id":"https://openalex.org/keywords/mx-protein","display_name":"Mx protein","score":0.5550000071525574},{"id":"https://openalex.org/keywords/interferon","display_name":"interferon","score":0.8399999737739563},{"id":"https://openalex.org/keywords/virus-resistance","display_name":"virus resistance","score":0.5669999718666077},{"id":"https://openalex.org/keywords/nlrp1","display_name":"NLRP1","score":0.7680000066757202},{"id":"https://openalex.org/keywords/dendritic-cells","display_name":"dendritic cells","score":0.8019999861717224},{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":0.6700000166893005},{"id":"https://openalex.org/keywords/non-segmental-vitiligo","display_name":"non-segmental vitiligo","score":0.7929999828338623},{"id":"https://openalex.org/keywords/progressive-vitiligo","display_name":"progressive vitiligo","score":0.6949999928474426}],"concepts":[{"id":"https://openalex.org/C2779980618","wikidata":"https://www.wikidata.org/wiki/Q180152","display_name":"Vitiligo","level":2,"score":0.6987006068229675},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.521858811378479},{"id":"https://openalex.org/C2781156865","wikidata":"https://www.wikidata.org/wiki/Q827023","display_name":"Lesion","level":2,"score":0.503297746181488},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4796793460845947},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.4643915295600891},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.43684399127960205},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.43655237555503845},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2217256724834442},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2141418755054474},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.17282909154891968},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.16846272349357605}],"mesh":[{"descriptor_ui":"D003869","descriptor_name":"Dermabrasion","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007166","descriptor_name":"Immunosuppressive Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D007166","descriptor_name":"Immunosuppressive Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014820","descriptor_name":"Vitiligo","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D014820","descriptor_name":"Vitiligo","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D014820","descriptor_name":"Vitiligo","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D014820","descriptor_name":"Vitiligo","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D017679","descriptor_name":"Cryotherapy","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D028022","descriptor_name":"Low-Level Light Therapy","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1755-148x.2011.00940.x","doi":"https://doi.org/10.1111/j.1755-148x.2011.00940.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1755-148x.2011.00940.x","pdf_url":null,"source":{"id":"https://openalex.org/S179442820","display_name":"Pigment Cell & Melanoma Research","issn_l":"1755-1471","issn":["1755-1471","1755-148X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pigment Cell & Melanoma Research","raw_type":"journal-article"},{"id":"pmid:22176508","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22176508","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pigment cell & melanoma research","raw_type":"Editorial"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4235111213","https://openalex.org/W4211181613","https://openalex.org/W1971069223","https://openalex.org/W7217707177","https://openalex.org/W2395909199","https://openalex.org/W2271704404","https://openalex.org/W2089957375","https://openalex.org/W2511547129","https://openalex.org/W4366186092","https://openalex.org/W4404535098"],"abstract_inverted_index":{"When":[0],"looking":[1],"at":[2,158,170,176,440],"the":[3,16,37,88,91,105,129,147,150,154,188,200,238,252,257,263,339,356,363,424,427,446,454,478,522,542,576,582,591],"sharp":[4],"boundaries":[5],"of":[6,15,39,46,72,90,149,156,202,240,256,262,293,323,342,365,404,442,458,487,521,546],"a":[7,43,70,121,135,171,196,228,260,283,288,302,320,326,343,389,510,515],"depigmented":[8],"lesion":[9],"in":[10,32,42,57,76,84,146,165,199,212,215,220,231,282,319,384,400,431,453,495,509,527,536,549],"vitiligo,":[11,222],"I":[12,28,573],"am":[13],"reminded":[14],"\u2018edge":[17],"problem\u2019":[18],"that":[19,128,140,195,235,286,318,409,429,539],"has":[20],"fascinated":[21],"me":[22],"since":[23],"my":[24,30],"early":[25],"graduate":[26],"work.":[27],"started":[29],"career":[31],"virus/host":[33],"interactions":[34],"by":[35,69,133,143,512],"studying":[36],"histopathology":[38],"an":[40,54,205,249,375],"infection":[41],"mouse":[44,284],"model":[45,285],"viral":[47,50],"resistance.":[48],"While":[49],"spread":[51,155],"quickly":[52],"engulfed":[53],"entire":[55],"organ":[56],"control":[58],"susceptible":[59],"mice,":[60,551],"it":[61],"remained":[62],"limited":[63],"to":[64,94,114,187,419,468,589,595],"small":[65],"infected":[66],"foci":[67,92,151],"demarcated":[68],"wall":[71],"healthy,":[73],"uninfected":[74],"cells":[75,113,130,234,297,548],"genetically":[77],"resistant":[78,132],"mice.":[79],"The":[80,117,485],"phenomenon":[81],"was":[82,141],"seen":[83,439],"many":[85,531],"different":[86],"organs,":[87],"location":[89],"appeared":[93],"be":[95,387],"seemingly":[96,299],"random,":[97],"and":[98,152,225,245,254,279,298,348,371,380,398,407,433,462,476,499,519,544,553,555,561,570,585],"no":[99,193],"particular":[100],"anatomical":[101],"barriers":[102],"could":[103,386,472],"explain":[104],"block.":[106],"What,":[107],"then,":[108],"caused":[109],"these":[110],"healthy":[111,168],"neighboring":[112],"resist":[115],"infection?":[116],"explanation":[118],"came":[119],"only":[120],"few":[122],"years":[123],"later":[124],"when":[125],"we":[126,358],"found":[127,273],"became":[131],"expressing":[134],"specific":[136],"antiviral":[137],"protein,":[138],"Mx,":[139],"induced":[142],"interferon":[144],"originating":[145],"center":[148],"outpacing":[153],"virus":[157],"their":[159],"periphery.":[160],"Might":[161],"something":[162],"similar":[163],"occur":[164],"vitiligo?":[166],"Are":[167],"melanocytes":[169],"lesion\u2019s":[172],"edge":[173],"somehow":[174],"protected,":[175],"least":[177],"temporarily,":[178],"or":[179],"have":[180,270],"they":[181,471,483],"simply":[182],"not":[183,360,372,587],"yet":[184],"been":[185,272],"exposed":[186],"destructive":[189],"mechanisms?":[190],"There":[191,529],"is":[192,204,305,313,329,369,422,506],"doubt":[194],"major":[197],"component":[198,261],"pathogenesis":[201],"vitiligo":[203,405,432,490,517],"autoimmune":[206,309],"reaction":[207,346],"against":[208],"melanocytes,":[209],"as":[210,301,316],"addressed":[211],"several":[213],"papers":[214,533,593],"this":[216,410,451,497,505,537],"issue.":[217],"For":[218],"instance,":[219],"progressive":[221,308],"Ben":[223],"Ahmed":[224],"collaborators":[226,280,381,463],"describe":[227],"functional":[229],"defect":[230],"regulatory":[232],"T":[233],"normally":[236],"limit":[237],"activation":[239],"autoreactive":[241],"cytotoxic":[242],"T-cells.":[243],"D\u2019Osualdo":[244],"Reed":[246],"give":[247],"us":[248],"update":[250],"on":[251,450,564],"regulation":[253],"effects":[255],"NLRP1":[258],"gene,":[259],"innate":[264],"immune":[265,345],"system,":[266],"whose":[267],"hereditary":[268],"variants":[269],"previously":[271],"associated":[274],"with":[275,541],"non-segmental":[276],"vitiligo.":[277],"Mosenson":[278],"show":[281],"HSP-70i,":[287],"heat":[289],"shock":[290],"protein":[291],"capable":[292],"activating":[294],"antigen-presenting":[295],"dendritic":[296],"serving":[300],"\u2018danger":[303],"signal\u2019,":[304],"indispensable":[306],"for":[307,334,355],"depigmentation.":[310,413],"This":[311],"observation":[312],"particularly":[314],"important":[315],"finding":[317],"disease":[321],"process":[322],"high":[324],"complexity":[325],"single":[327],"molecule":[328],"critical":[330],"immediately":[331],"suggests":[332],"avenues":[333],"therapeutic":[335],"interventions.":[336],"But":[337],"whatever":[338,349],"ultimate":[340],"triggers":[341],"faulty":[344],"are":[347,417,437,530,557],"underlying":[350],"genetic":[351],"variant":[352],"may":[353,492],"predispose":[354],"disease,":[357],"do":[359,586],"get":[361],"around":[362],"question":[364],"why":[366],"melanocyte":[367],"destruction":[368],"focal":[370],"global.":[373],"In":[374],"interesting":[376],"paper,":[377],"van":[378],"Geel":[379,461],"locally":[382],"applied,":[383],"what":[385,421],"considered":[388],"heroic":[390],"\u2018human":[391],"model\u2019,":[392],"three":[393],"distinct":[394],"stressors":[395,416],"(cold,":[396],"light,":[397],"abrasion)":[399],"still":[401],"pigmented":[402],"skin":[403,435,502],"patients":[406],"confirmed":[408],"induces":[411],"local":[412,415],"Such":[414],"thought":[418],"underly":[420],"called":[423],"\u2018Koebner":[425],"phenomenon\u2019,":[426],"fact":[428],"lesions":[430,491],"other":[434,571],"diseases":[436],"often":[438],"sites":[441],"trauma":[443],"(see":[444],"also":[445,558],"\u2018European":[447],"position":[448],"paper\u2019":[449],"topic":[452,466],"June":[455],"2011":[456],"issue":[457,538],"PCMR).":[459],"Van":[460],"then":[464],"used":[465],"immunomodulators":[467],"test":[469],"whether":[470],"alter":[473],"T-cell":[474],"infiltrates":[475],"inhibit":[477],"Koebner":[479],"phenomenon.":[480],"And":[481],"indeed,":[482],"can.":[484],"approach":[486],"experimentally":[488],"inducing":[489],"help":[493],"further":[494],"elucidating":[496],"intriguing":[498,565],"emotionally":[500],"devastating":[501],"disorder.":[503],"All":[504],"thoughtfully":[507],"discussed":[508],"perspective":[511],"Alain":[513],"Taieb,":[514],"distinguished":[516],"specialist":[518],"organizer":[520],"successful":[523],"recent":[524],"IPCC":[525],"meeting":[526],"Bordeaux.":[528],"additional":[532],"worth":[534],"mentioning":[535],"deal":[540],"development":[543],"function":[545],"pigment":[547],"newts,":[550],"horses":[552],"humans,":[554],"there":[556],"two":[559],"News":[560],"Views":[562],"articles":[563],"novel":[566],"findings":[567],"concerning":[568],"melanoma":[569],"cancers.":[572],"hope":[574],"you,":[575],"reader,":[577],"will":[578],"enjoy":[579],"going":[580],"through":[581],"printed":[583],"pages,":[584],"hesitate":[588],"cite":[590],"PCMR":[592],"relevant":[594],"your":[596],"studies.":[597]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}