{"id":"https://openalex.org/W2017262220","doi":"https://doi.org/10.1677/joe.0.1190233","title":"Effects of 31 kDa bovine inhibin on FSH and LH in rat pituitary cells in vitro : antagonism of gonadotrophin-releasing hormone agonists","display_name":"Effects of 31 kDa bovine inhibin on FSH and LH in rat pituitary cells in vitro : antagonism of gonadotrophin-releasing hormone agonists","publication_year":1988,"publication_date":"1988-11-01","ids":{"openalex":"https://openalex.org/W2017262220","doi":"https://doi.org/10.1677/joe.0.1190233","mag":"2017262220","pmid":"https://pubmed.ncbi.nlm.nih.gov/3143796"},"language":"en","primary_location":{"id":"doi:10.1677/joe.0.1190233","doi":"https://doi.org/10.1677/joe.0.1190233","is_oa":false,"landing_page_url":"https://doi.org/10.1677/joe.0.1190233","pdf_url":null,"source":{"id":"https://openalex.org/S34842069","display_name":"Journal of Endocrinology","issn_l":"0022-0795","issn":["0022-0795","1479-6805"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319937","host_organization_name":"Bioscientifica","host_organization_lineage":["https://openalex.org/P4310319937"],"host_organization_lineage_names":["Bioscientifica"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Endocrinology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088213224","display_name":"Paul G. Farnworth","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P. G. Farnworth","raw_affiliation_strings":["Medical Research Centre, Prince Henry's Hospital, Melbourne, Victoria, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Research Centre, Prince Henry's Hospital, Melbourne, Victoria, Australia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110133059","display_name":"Duncan M. Robertson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D. M. Robertson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079073181","display_name":"D. M. DE KRETSER","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D. M. de Kretser","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5028122459","display_name":"Henry Burger","orcid":"https://orcid.org/0000-0002-5333-6144","observed_orcids":["https://orcid.org/0000-0002-5333-6144"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H. G. Burger","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":5.5993,"has_fulltext":false,"cited_by_count":60,"citation_normalized_percentile":{"value":0.9679647,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":"119","issue":"2","first_page":"233","last_page":"241"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/inhibin","display_name":"inhibin","score":0.9470000267028809},{"id":"https://openalex.org/keywords/follicle-stimulating-hormone","display_name":"follicle-stimulating hormone","score":0.5839999914169312},{"id":"https://openalex.org/keywords/luteinizing-hormone","display_name":"luteinizing hormone","score":0.8399999737739563},{"id":"https://openalex.org/keywords/gonadotropin-releasing-hormone","display_name":"gonadotropin-releasing hormone","score":0.8730000257492065},{"id":"https://openalex.org/keywords/buserelin","display_name":"buserelin","score":0.9319999814033508},{"id":"https://openalex.org/keywords/gonadotrophs","display_name":"gonadotrophs","score":0.8679999709129333},{"id":"https://openalex.org/keywords/gonadotropin-secretion","display_name":"gonadotropin secretion","score":0.8600000143051147},{"id":"https://openalex.org/keywords/rat-pituitary-cells","display_name":"rat pituitary cells","score":0.7599999904632568},{"id":"https://openalex.org/keywords/gonadotropin-regulation","display_name":"gonadotropin regulation","score":0.550000011920929}],"concepts":[{"id":"https://openalex.org/C2777383412","wikidata":"https://www.wikidata.org/wiki/Q4770891","display_name":"Antagonism","level":3,"score":0.8850545287132263},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8367233872413635},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8251501321792603},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.6512365937232971},{"id":"https://openalex.org/C197012351","wikidata":"https://www.wikidata.org/wiki/Q3099316","display_name":"Gonadotropic cell","level":4,"score":0.49568188190460205},{"id":"https://openalex.org/C3018374343","wikidata":"https://www.wikidata.org/wiki/Q794835","display_name":"Pituitary hormones","level":3,"score":0.48138049244880676},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.46690231561660767},{"id":"https://openalex.org/C2777658017","wikidata":"https://www.wikidata.org/wiki/Q156871","display_name":"Pituitary gland","level":3,"score":0.45191627740859985},{"id":"https://openalex.org/C2778894405","wikidata":"https://www.wikidata.org/wiki/Q318896","display_name":"Gonadotropin-releasing hormone","level":4,"score":0.42167508602142334},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.39397165179252625},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3799455463886261},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.30552250146865845},{"id":"https://openalex.org/C2778575703","wikidata":"https://www.wikidata.org/wiki/Q50265477","display_name":"Luteinizing hormone","level":3,"score":0.2905580401420593},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.18982025980949402},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.044914036989212036}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003864","descriptor_name":"Depression, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005640","descriptor_name":"Follicle Stimulating Hormone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007265","descriptor_name":"Inhibins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007986","descriptor_name":"Luteinizing Hormone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010903","descriptor_name":"Pituitary Gland, Anterior","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010906","descriptor_name":"Pituitary Hormone-Releasing Hormones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1677/joe.0.1190233","doi":"https://doi.org/10.1677/joe.0.1190233","is_oa":false,"landing_page_url":"https://doi.org/10.1677/joe.0.1190233","pdf_url":null,"source":{"id":"https://openalex.org/S34842069","display_name":"Journal of Endocrinology","issn_l":"0022-0795","issn":["0022-0795","1479-6805"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319937","host_organization_name":"Bioscientifica","host_organization_lineage":["https://openalex.org/P4310319937"],"host_organization_lineage_names":["Bioscientifica"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Endocrinology","raw_type":"journal-article"},{"id":"pmid:3143796","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3143796","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of endocrinology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.6240000128746033,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2078311023","https://openalex.org/W2047030030","https://openalex.org/W2120711977","https://openalex.org/W2047849539","https://openalex.org/W2127480347","https://openalex.org/W2074186925","https://openalex.org/W2149412924","https://openalex.org/W1970287328","https://openalex.org/W1969168491","https://openalex.org/W2047950077"],"abstract_inverted_index":{"ABSTRACT":[0],"The":[1,253],"effects":[2,146,203],"of":[3,11,31,41,46,64,105,115,128,142,167,179,196,209,223,248,263,281,289,300,305,316,324,335,350],"31":[4],"kDa":[5],"bovine":[6,258],"inhibin":[7,47,74,111,143,164,211,224,233,259,306,336],"on":[8],"the":[9,61,72,102,106,113,129,148,176,210,226,246,251,261,278,287,322,347],"release":[10,77,90,134,155,161,236,262,315],"FSH":[12,76,107,116,154,181,265,317,325],"and":[13,52,67,157,169,182,198,266,284,318],"LH":[14,89,118,160,183,267,319],"stimulated":[15,68,268,314],"by":[16,93,120,191,207,221,237,243,269,276,285,297],"gonadotrophin-releasing":[17],"hormone":[18,131],"(GnRH)":[19],"or":[20,117,220,272,331],"its":[21,341],"agonist":[22,122],"analogue":[23],"buserelin":[24,238,273],"have":[25],"been":[26],"studied":[27],"using":[28],"5-day-old":[29],"cultures":[30,42],"pituitary":[32],"cells":[33],"prepared":[34],"from":[35,110,214],"adult":[36],"male":[37],"Sprague\u2013Dawley":[38],"rats.":[39],"Exposure":[40],"to":[43,217,340,345],"increasing":[44],"concentrations":[45,75,141,304],"for":[48,101,133,153,159,309,321],"3":[49,215],"days":[50,216],"before":[51],"during":[53,225],"a":[54,126,230],"4-h":[55],"stimulation":[56,227],"with":[57,163,193],"GnRH":[58,149,186,271,282,301],"resulted":[59],"in":[60,135,188,274,338],"progressive":[62],"suppression":[63],"both":[65,180,264],"basal":[66],"gonadotrophin":[69,235,292],"release.":[70],"At":[71],"highest":[73],"was":[78,91,123,250],"abolished":[79],"(inhibin":[80],"median":[81,150],"inhibitory":[82],"concentration":[83,152],"(IC50)":[84],"=":[85,96],"0\u00b715":[86],"U/ml)":[87],"whereas":[88],"suppressed":[92,175],"75%":[94],"(IC50":[95],"0\u00b793":[97],"U/ml).":[98],"To":[99],"correct":[100],"reduced":[103],"size":[104],"pool":[108],"resulting":[109],"pretreatment,":[112,232],"amount":[114],"released":[119,187,296],"an":[121,298],"expressed":[124],"as":[125],"proportion":[127,178,288],"total":[130,290],"available":[132,291],"each":[136],"case.":[137],"Following":[138],"this":[139],"adjustment,":[140],"producing":[144],"maximal":[145],"increased":[147],"effective":[151],"4\u00b71-fold":[156],"that":[158,184,242,256,293],"2\u00b72-fold,":[162],"IC50":[165,194],"values":[166,195],"0\u00b745":[168],"0\u00b732":[170],"U/ml":[171,200],"respectively.":[172,201],"Inhibin":[173],"also":[174],"maximum":[177],"excess":[185,299],"4":[189],"h":[190],"36%,":[192],"0\u00b753":[197],"0\u00b776":[199],"These":[202],"were":[204],"not":[205],"changed":[206],"reduction":[208],"pretreatment":[212],"period":[213],"1":[218],"day":[219],"exclusion":[222],"period.":[228],"After":[229],"3-day":[231],"inhibited":[234],"less":[239],"effectively":[240],"than":[241,320],"GnRH,":[244],"but":[245],"pattern":[247],"antagonism":[249],"same.":[252],"results":[254],"show":[255],"purified":[257],"antagonizes":[260],"either":[270],"vitro":[275],"reducing":[277],"apparent":[279],"potency":[280],"agonists":[283],"decreasing":[286],"can":[294],"be":[295],"agonist.":[302],"Higher":[303],"are":[307],"required":[308],"these":[310],"common":[311],"actions":[312],"against":[313],"inhibition":[323],"tonic":[326],"synthesis/basal":[327],"release,":[328],"indicating":[329],"one":[330],"more":[332],"secondary":[333],"sites":[334],"action":[337,344],"addition":[339],"primary":[342],"selective":[343],"suppress":[346],"constitutive":[348],"synthesis":[349],"FSH.":[351],"J.":[352],"Endocr.":[353],"(1988)":[354],"119,":[355],"233\u2013241":[356]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}