{"id":"https://openalex.org/W2017257602","doi":"https://doi.org/10.1111/j.1600-051x.1983.tb01272.x","title":"Initial observation that cyclosporin\u2010A induces gingival enlargement in man","display_name":"Initial observation that cyclosporin\u2010A induces gingival enlargement in man","publication_year":1983,"publication_date":"1983-06-01","ids":{"openalex":"https://openalex.org/W2017257602","doi":"https://doi.org/10.1111/j.1600-051x.1983.tb01272.x","mag":"2017257602","pmid":"https://pubmed.ncbi.nlm.nih.gov/6575979"},"language":"en","primary_location":{"id":"doi:10.1111/j.1600-051x.1983.tb01272.x","doi":"https://doi.org/10.1111/j.1600-051x.1983.tb01272.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1600-051x.1983.tb01272.x","pdf_url":null,"source":{"id":"https://openalex.org/S61859066","display_name":"Journal Of Clinical Periodontology","issn_l":"0303-6979","issn":["0303-6979","1600-051X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Periodontology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030843554","display_name":"Edith M. Rateitschak\u2010Pl\u00fcss","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"E. M. Rateitschak\u2010Pl\u00fcss","raw_affiliation_strings":["Department of Cariology and Periodontology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cariology and Periodontology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110426522","display_name":"A Hefti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1850255","display_name":"University of Basel","ror":"https://ror.org/02s6k3f65","country_code":"CH","type":"education","lineage":["https://openalex.org/I1850255"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"A. Hefti","raw_affiliation_strings":["Department of Preventive Dentistry, Dental Institute, University of Basle"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Preventive Dentistry, Dental Institute, University of Basle","institution_ids":["https://openalex.org/I1850255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035413888","display_name":"Randall H. Lortscher","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R. L\u00f6rtscher","raw_affiliation_strings":["Department of Cariology and Periodontology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cariology and Periodontology","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113608383","display_name":"G. Thiel","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G. Thiel","raw_affiliation_strings":["Department of Internal Medicine, University Medical Clinic, Cantonal Hospital, Basle, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, University Medical Clinic, Cantonal Hospital, Basle, Switzerland","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5030843554"],"corresponding_institution_ids":[],"apc_list":{"value":5510,"currency":"USD","value_usd":5510},"apc_paid":null,"fwci":5.4803,"has_fulltext":false,"cited_by_count":263,"citation_normalized_percentile":{"value":0.95766423,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"10","issue":"3","first_page":"237","last_page":"246"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13768","display_name":"Oral and gingival health research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13768","display_name":"Oral and gingival health research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11452","display_name":"Oral Health Pathology and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3500","display_name":"General Dentistry"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cyclosporine","display_name":"cyclosporine","score":0.9679999947547913},{"id":"https://openalex.org/keywords/gingival-overgrowth","display_name":"gingival hyperplasia","score":0.9610000252723694},{"id":"https://openalex.org/keywords/drug-induced-gingival-overgrowth","display_name":"drug-induced gingival hyperplasia","score":0.9070000052452087},{"id":"https://openalex.org/keywords/immunosuppressive-drugs","display_name":"immunosuppressants","score":0.9210000038146973},{"id":"https://openalex.org/keywords/kidney-transplantation","display_name":"kidney transplantation","score":0.7960000038146973},{"id":"https://openalex.org/keywords/adverse-drug-reactions","display_name":"adverse drug reactions","score":0.7400000095367432},{"id":"https://openalex.org/keywords/periodontal-treatment","display_name":"periodontal treatment","score":0.6660000085830688}],"concepts":[{"id":"https://openalex.org/C2780090536","wikidata":"https://www.wikidata.org/wiki/Q2637111","display_name":"Gingival enlargement","level":2,"score":0.955060601234436},{"id":"https://openalex.org/C137627325","wikidata":"https://www.wikidata.org/wiki/Q156318","display_name":"Etiology","level":2,"score":0.7422566413879395},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7347151041030884},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.501619815826416},{"id":"https://openalex.org/C2778330430","wikidata":"https://www.wikidata.org/wiki/Q249619","display_name":"Immunosuppressive drug","level":3,"score":0.458290696144104},{"id":"https://openalex.org/C3020606620","wikidata":"https://www.wikidata.org/wiki/Q179661","display_name":"Treatment modality","level":2,"score":0.4409828782081604},{"id":"https://openalex.org/C2779903281","wikidata":"https://www.wikidata.org/wiki/Q6888026","display_name":"Modalities","level":2,"score":0.435238242149353},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3882589340209961},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.3591955304145813},{"id":"https://openalex.org/C199343813","wikidata":"https://www.wikidata.org/wiki/Q12128","display_name":"Dentistry","level":1,"score":0.2644999027252197},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.2507851719856262},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.18635305762290955},{"id":"https://openalex.org/C36289849","wikidata":"https://www.wikidata.org/wiki/Q34749","display_name":"Social science","level":1,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003524","descriptor_name":"Cyclosporins","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D003524","descriptor_name":"Cyclosporins","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005881","descriptor_name":"Gingiva","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005886","descriptor_name":"Gingival Hypertrophy","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D005886","descriptor_name":"Gingival Hypertrophy","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1600-051x.1983.tb01272.x","doi":"https://doi.org/10.1111/j.1600-051x.1983.tb01272.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1600-051x.1983.tb01272.x","pdf_url":null,"source":{"id":"https://openalex.org/S61859066","display_name":"Journal Of Clinical Periodontology","issn_l":"0303-6979","issn":["0303-6979","1600-051X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Periodontology","raw_type":"journal-article"},{"id":"pmid:6575979","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6575979","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of clinical periodontology","raw_type":"Case Reports"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W110068356","https://openalex.org/W121524232","https://openalex.org/W1505860666","https://openalex.org/W1513402792","https://openalex.org/W1604963391","https://openalex.org/W1968457405","https://openalex.org/W1997411530","https://openalex.org/W2009359814","https://openalex.org/W2011694438","https://openalex.org/W2027513882","https://openalex.org/W2078267612","https://openalex.org/W2080064179","https://openalex.org/W2080605900","https://openalex.org/W2093239124","https://openalex.org/W2105506999","https://openalex.org/W2136574289","https://openalex.org/W2315377404","https://openalex.org/W2413078505"],"related_works":["https://openalex.org/W2413451324","https://openalex.org/W1572132769","https://openalex.org/W2273414415","https://openalex.org/W2413300904","https://openalex.org/W881528916","https://openalex.org/W2801477634","https://openalex.org/W2415080558","https://openalex.org/W2441799941","https://openalex.org/W2046763149","https://openalex.org/W4300553083"],"abstract_inverted_index":{"Abstract":[0],"In":[1],"the":[2,6,10],"Medical":[3],"Clinic":[4],"at":[5],"University":[7],"of":[8,25,43],"Basle,":[9],"immunosuppressive":[11],"drug":[12,27],"cyclosporin\u2010A":[13],"has":[14],"been":[15],"employed":[16],"recently":[17],"for":[18],"kidney":[19],"transplant":[20],"patients.":[21],"A":[22],"side":[23],"effect":[24],"this":[26],"appears":[28],"to":[29],"be":[30],"pronounced":[31],"gingival":[32],"enlargement.":[33],"This":[34],"report":[35],"documents":[36],"3":[37],"such":[38],"cases,":[39],"with":[40],"a":[41],"discussion":[42],"etiology":[44],"and":[45],"possible":[46],"treatment":[47],"modalities":[48]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}