{"id":"https://openalex.org/W2017247290","doi":"https://doi.org/10.1210/jcem-72-5-1014","title":"Regulation of Insulin-Like Growth Factor-Binding Protein-1 Synthesis and Secretion by Progestin and Relaxin in Long Term Cultures of Human Endometrial Stromal Cells*","display_name":"Regulation of Insulin-Like Growth Factor-Binding Protein-1 Synthesis and Secretion by Progestin and Relaxin in Long Term Cultures of Human Endometrial Stromal Cells*","publication_year":1991,"publication_date":"1991-05-01","ids":{"openalex":"https://openalex.org/W2017247290","doi":"https://doi.org/10.1210/jcem-72-5-1014","mag":"2017247290","pmid":"https://pubmed.ncbi.nlm.nih.gov/1708779"},"language":"en","primary_location":{"id":"doi:10.1210/jcem-72-5-1014","doi":"https://doi.org/10.1210/jcem-72-5-1014","is_oa":false,"landing_page_url":"https://doi.org/10.1210/jcem-72-5-1014","pdf_url":null,"source":{"id":"https://openalex.org/S205775358","display_name":"The Journal of Clinical Endocrinology & Metabolism","issn_l":"0021-972X","issn":["0021-972X","1945-7197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Endocrinology & Metabolism","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108212535","display_name":"Stephen C. Bell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1327163397","display_name":"State University of New York","ror":"https://ror.org/01q1z8k08","country_code":"US","type":"education","lineage":["https://openalex.org/I1327163397"]},{"id":"https://openalex.org/I153648349","display_name":"University of Leicester","ror":"https://ror.org/04h699437","country_code":"GB","type":"education","lineage":["https://openalex.org/I153648349"]},{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["GB","US"],"is_corresponding":false,"raw_author_name":"STEPHEN CHARLES BELL","raw_affiliation_strings":["Department of Obstetrics and Gynecology, University of Leicester, United Kingdom","Departments of Obstetrics and Gynecology (S.C.B., J.A.J., J.A.) and Biochemistry (S.C.B.) University of Leicester Leicester, United Kingdom","the Department of Obstetrics and Gynaecology, State University of New York (H.H.Z., L.T.) Stony Brook, New York 11794"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, University of Leicester, United Kingdom","institution_ids":["https://openalex.org/I153648349"]},{"raw_affiliation_string":"Departments of Obstetrics and Gynecology (S.C.B., J.A.J., J.A.) and Biochemistry (S.C.B.) University of Leicester Leicester, United Kingdom","institution_ids":["https://openalex.org/I153648349"]},{"raw_affiliation_string":"the Department of Obstetrics and Gynaecology, State University of New York (H.H.Z., L.T.) Stony Brook, New York 11794","institution_ids":["https://openalex.org/I1327163397","https://openalex.org/I59553526"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109841636","display_name":"J Jackson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1327163397","display_name":"State University of New York","ror":"https://ror.org/01q1z8k08","country_code":"US","type":"education","lineage":["https://openalex.org/I1327163397"]},{"id":"https://openalex.org/I153648349","display_name":"University of Leicester","ror":"https://ror.org/04h699437","country_code":"GB","type":"education","lineage":["https://openalex.org/I153648349"]},{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["GB","US"],"is_corresponding":false,"raw_author_name":"JULIET ANN JACKSON","raw_affiliation_strings":["Departments of Obstetrics and Gynecology (S.C.B., J.A.J., J.A.) and Biochemistry (S.C.B.) University of Leicester Leicester, United Kingdom; and the Department of Obstetrics and Gynaecology, State University of New York (H.H.Z., L.T.) Stony Brook, New York 11794","Departments of Obstetrics and Gynecology (S.C.B., J.A.J., J.A.) and Biochemistry (S.C.B.) University of Leicester Leicester, United Kingdom","the Department of Obstetrics and Gynaecology, State University of New York (H.H.Z., L.T.) Stony Brook, New York 11794"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Obstetrics and Gynecology (S.C.B., J.A.J., J.A.) and Biochemistry (S.C.B.) University of Leicester Leicester, United Kingdom; and the Department of Obstetrics and Gynaecology, State University of New York (H.H.Z., L.T.) Stony Brook, New York 11794","institution_ids":["https://openalex.org/I1327163397","https://openalex.org/I153648349","https://openalex.org/I59553526"]},{"raw_affiliation_string":"Departments of Obstetrics and Gynecology (S.C.B., J.A.J., J.A.) and Biochemistry (S.C.B.) University of Leicester Leicester, United Kingdom","institution_ids":["https://openalex.org/I153648349"]},{"raw_affiliation_string":"the Department of Obstetrics and Gynaecology, State University of New York (H.H.Z., L.T.) Stony Brook, New York 11794","institution_ids":["https://openalex.org/I1327163397","https://openalex.org/I59553526"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075503674","display_name":"JILLIAN ASHMORE","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1327163397","display_name":"State University of New York","ror":"https://ror.org/01q1z8k08","country_code":"US","type":"education","lineage":["https://openalex.org/I1327163397"]},{"id":"https://openalex.org/I153648349","display_name":"University of Leicester","ror":"https://ror.org/04h699437","country_code":"GB","type":"education","lineage":["https://openalex.org/I153648349"]},{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["GB","US"],"is_corresponding":false,"raw_author_name":"JILLIAN ASHMORE","raw_affiliation_strings":["Departments of Obstetrics and Gynecology (S.C.B., J.A.J., J.A.) and Biochemistry (S.C.B.) University of Leicester Leicester, United Kingdom; and the Department of Obstetrics and Gynaecology, State University of New York (H.H.Z., L.T.) Stony Brook, New York 11794","Departments of Obstetrics and Gynecology (S.C.B., J.A.J., J.A.) and Biochemistry (S.C.B.) University of Leicester Leicester, United Kingdom","the Department of Obstetrics and Gynaecology, State University of New York (H.H.Z., L.T.) Stony Brook, New York 11794"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Obstetrics and Gynecology (S.C.B., J.A.J., J.A.) and Biochemistry (S.C.B.) University of Leicester Leicester, United Kingdom; and the Department of Obstetrics and Gynaecology, State University of New York (H.H.Z., L.T.) Stony Brook, New York 11794","institution_ids":["https://openalex.org/I1327163397","https://openalex.org/I153648349","https://openalex.org/I59553526"]},{"raw_affiliation_string":"Departments of Obstetrics and Gynecology (S.C.B., J.A.J., J.A.) and Biochemistry (S.C.B.) University of Leicester Leicester, United Kingdom","institution_ids":["https://openalex.org/I153648349"]},{"raw_affiliation_string":"the Department of Obstetrics and Gynaecology, State University of New York (H.H.Z., L.T.) Stony Brook, New York 11794","institution_ids":["https://openalex.org/I1327163397","https://openalex.org/I59553526"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109172648","display_name":"Hui Zhu","orcid":"https://orcid.org/0000-0001-5238-5342","observed_orcids":["https://orcid.org/0000-0001-5238-5342"]},"institutions":[{"id":"https://openalex.org/I1327163397","display_name":"State University of New York","ror":"https://ror.org/01q1z8k08","country_code":"US","type":"education","lineage":["https://openalex.org/I1327163397"]},{"id":"https://openalex.org/I153648349","display_name":"University of Leicester","ror":"https://ror.org/04h699437","country_code":"GB","type":"education","lineage":["https://openalex.org/I153648349"]},{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["GB","US"],"is_corresponding":false,"raw_author_name":"HUI HUI ZHU","raw_affiliation_strings":["Departments of Obstetrics and Gynecology (S.C.B., J.A.J., J.A.) and Biochemistry (S.C.B.) University of Leicester Leicester, United Kingdom; and the Department of Obstetrics and Gynaecology, State University of New York (H.H.Z., L.T.) Stony Brook, New York 11794","Departments of Obstetrics and Gynecology (S.C.B., J.A.J., J.A.) and Biochemistry (S.C.B.) University of Leicester Leicester, United Kingdom","the Department of Obstetrics and Gynaecology, State University of New York (H.H.Z., L.T.) Stony Brook, New York 11794"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Obstetrics and Gynecology (S.C.B., J.A.J., J.A.) and Biochemistry (S.C.B.) University of Leicester Leicester, United Kingdom; and the Department of Obstetrics and Gynaecology, State University of New York (H.H.Z., L.T.) Stony Brook, New York 11794","institution_ids":["https://openalex.org/I1327163397","https://openalex.org/I153648349","https://openalex.org/I59553526"]},{"raw_affiliation_string":"Departments of Obstetrics and Gynecology (S.C.B., J.A.J., J.A.) and Biochemistry (S.C.B.) University of Leicester Leicester, United Kingdom","institution_ids":["https://openalex.org/I153648349"]},{"raw_affiliation_string":"the Department of Obstetrics and Gynaecology, State University of New York (H.H.Z., L.T.) Stony Brook, New York 11794","institution_ids":["https://openalex.org/I1327163397","https://openalex.org/I59553526"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110335693","display_name":"Linda Tseng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1327163397","display_name":"State University of New York","ror":"https://ror.org/01q1z8k08","country_code":"US","type":"education","lineage":["https://openalex.org/I1327163397"]},{"id":"https://openalex.org/I153648349","display_name":"University of Leicester","ror":"https://ror.org/04h699437","country_code":"GB","type":"education","lineage":["https://openalex.org/I153648349"]},{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["GB","US"],"is_corresponding":false,"raw_author_name":"LINDA TSENG","raw_affiliation_strings":["Departments of Obstetrics and Gynecology (S.C.B., J.A.J., J.A.) and Biochemistry (S.C.B.) University of Leicester Leicester, United Kingdom; and the Department of Obstetrics and Gynaecology, State University of New York (H.H.Z., L.T.) Stony Brook, New York 11794","Departments of Obstetrics and Gynecology (S.C.B., J.A.J., J.A.) and Biochemistry (S.C.B.) University of Leicester Leicester, United Kingdom","the Department of Obstetrics and Gynaecology, State University of New York (H.H.Z., L.T.) Stony Brook, New York 11794"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Obstetrics and Gynecology (S.C.B., J.A.J., J.A.) and Biochemistry (S.C.B.) University of Leicester Leicester, United Kingdom; and the Department of Obstetrics and Gynaecology, State University of New York (H.H.Z., L.T.) Stony Brook, New York 11794","institution_ids":["https://openalex.org/I1327163397","https://openalex.org/I153648349","https://openalex.org/I59553526"]},{"raw_affiliation_string":"Departments of Obstetrics and Gynecology (S.C.B., J.A.J., J.A.) and Biochemistry (S.C.B.) University of Leicester Leicester, United Kingdom","institution_ids":["https://openalex.org/I153648349"]},{"raw_affiliation_string":"the Department of Obstetrics and Gynaecology, State University of New York (H.H.Z., L.T.) Stony Brook, New York 11794","institution_ids":["https://openalex.org/I1327163397","https://openalex.org/I59553526"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":12.8462,"has_fulltext":false,"cited_by_count":139,"citation_normalized_percentile":{"value":0.98943948,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"72","issue":"5","first_page":"1014","last_page":"1024"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12715","display_name":"Pregnancy-related medical research","score":0.48899999260902405,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12715","display_name":"Pregnancy-related medical research","score":0.48899999260902405,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11510","display_name":"Reproductive System and Pregnancy","score":0.39160001277923584,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.09799999743700027,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/igfbp-1","display_name":"IGFBP-1","score":0.9639999866485596},{"id":"https://openalex.org/keywords/endometrial-stromal-cells","display_name":"endometrial stromal cells","score":0.9190000295639038},{"id":"https://openalex.org/keywords/decidualization","display_name":"decidualization","score":0.8970000147819519},{"id":"https://openalex.org/keywords/medroxyprogesterone-acetate","display_name":"medroxyprogesterone acetate","score":0.9649999737739563},{"id":"https://openalex.org/keywords/progestins","display_name":"progestins","score":0.9179999828338623},{"id":"https://openalex.org/keywords/relaxin","display_name":"relaxin","score":0.9980000257492065},{"id":"https://openalex.org/keywords/decidual-cells","display_name":"decidual cells","score":0.6430000066757202},{"id":"https://openalex.org/keywords/protein-secretion","display_name":"protein secretion","score":0.47699999809265137},{"id":"https://openalex.org/keywords/luteal-phase","display_name":"luteal phase","score":0.7279999852180481},{"id":"https://openalex.org/keywords/pregnancy","display_name":"pregnancy","score":0.38499999046325684},{"id":"https://openalex.org/keywords/cell-differentiation","display_name":"cell differentiation","score":0.3109999895095825},{"id":"https://openalex.org/keywords/cell-adhesion","display_name":"cell adhesion","score":0.30300000309944153}],"concepts":[{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8126767873764038},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8092957139015198},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.7452095150947571},{"id":"https://openalex.org/C2777121736","wikidata":"https://www.wikidata.org/wiki/Q24773888","display_name":"Relaxin","level":3,"score":0.7365325689315796},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5911275148391724},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.534975528717041},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.5062164664268494},{"id":"https://openalex.org/C2779742232","wikidata":"https://www.wikidata.org/wiki/Q839508","display_name":"Endometrium","level":2,"score":0.5017890930175781},{"id":"https://openalex.org/C2780378035","wikidata":"https://www.wikidata.org/wiki/Q17143674","display_name":"Insulin-like growth factor-binding protein","level":5,"score":0.432065486907959},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.42209795117378235},{"id":"https://openalex.org/C2780689927","wikidata":"https://www.wikidata.org/wiki/Q24766801","display_name":"Insulin-like growth factor","level":4,"score":0.3596566319465637},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.2518843412399292},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.23291823267936707},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.12661397457122803},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09518018364906311},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004591","descriptor_name":"Electrophoresis, Polyacrylamide Gel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004717","descriptor_name":"Endometrium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008525","descriptor_name":"Medroxyprogesterone","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D008525","descriptor_name":"Medroxyprogesterone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008715","descriptor_name":"Methionine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011233","descriptor_name":"Precipitin Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011372","descriptor_name":"Progestins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011863","descriptor_name":"Radioimmunoassay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012065","descriptor_name":"Relaxin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013462","descriptor_name":"Sulfur Radioisotopes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015151","descriptor_name":"Immunoblotting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017258","descriptor_name":"Medroxyprogesterone Acetate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018969","descriptor_name":"Insulin-Like Growth Factor Binding Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1210/jcem-72-5-1014","doi":"https://doi.org/10.1210/jcem-72-5-1014","is_oa":false,"landing_page_url":"https://doi.org/10.1210/jcem-72-5-1014","pdf_url":null,"source":{"id":"https://openalex.org/S205775358","display_name":"The Journal of Clinical Endocrinology & Metabolism","issn_l":"0021-972X","issn":["0021-972X","1945-7197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Endocrinology & Metabolism","raw_type":"journal-article"},{"id":"pmid:1708779","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1708779","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical endocrinology and metabolism","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8560000061988831,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G176210559","display_name":null,"funder_award_id":"HD 19247","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G3132225695","display_name":"ENDOMETRIUM GENE REGULATION DURING DECIDUALIZATION","funder_award_id":"5r01hd019247-16","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W221421711","https://openalex.org/W1598230405","https://openalex.org/W1602528313","https://openalex.org/W1966316431","https://openalex.org/W1974776814","https://openalex.org/W1981434344","https://openalex.org/W1992535920","https://openalex.org/W1993463279","https://openalex.org/W1999630773","https://openalex.org/W2007903777","https://openalex.org/W2011598405","https://openalex.org/W2012831570","https://openalex.org/W2018082219","https://openalex.org/W2023698107","https://openalex.org/W2026397471","https://openalex.org/W2030060235","https://openalex.org/W2032558447","https://openalex.org/W2032829459","https://openalex.org/W2033765902","https://openalex.org/W2042154738","https://openalex.org/W2044472384","https://openalex.org/W2047477289","https://openalex.org/W2049749719","https://openalex.org/W2052365448","https://openalex.org/W2063463365","https://openalex.org/W2064957404","https://openalex.org/W2069107191","https://openalex.org/W2069571646","https://openalex.org/W2071168485","https://openalex.org/W2075003870","https://openalex.org/W2077133676","https://openalex.org/W2084310213","https://openalex.org/W2090789426","https://openalex.org/W2092727047","https://openalex.org/W2098011432","https://openalex.org/W2101108802","https://openalex.org/W2136167057","https://openalex.org/W2145733556","https://openalex.org/W2148885338","https://openalex.org/W2214695306","https://openalex.org/W2303020048","https://openalex.org/W2310275009","https://openalex.org/W2417603518","https://openalex.org/W2419419304","https://openalex.org/W2622739063"],"related_works":["https://openalex.org/W1971545747","https://openalex.org/W2137657922","https://openalex.org/W2335938177","https://openalex.org/W1997203242","https://openalex.org/W2031482067","https://openalex.org/W2105701716","https://openalex.org/W7098146526","https://openalex.org/W2303370813","https://openalex.org/W2051047261","https://openalex.org/W1975627123"],"abstract_inverted_index":{"The":[0,156,273],"decidualized":[1,333],"endometrium":[2,59,231,334],"during":[3,232],"the":[4,25,38,43,47,57,65,163,191,233,246,261,266,324,332],"first":[5],"trimester":[6],"of":[7,30,53,80,86,119,131,136,143,165,193,212,242,263,288,304,327,331,335],"pregnancy":[8],"synthesizes":[9],"and":[10,33,167,260],"secretes":[11],"a":[12,197,204,286,301],"32-kDa":[13],"insulin-like":[14],"growth":[15],"factor-binding":[16],"protein":[17,28,247,252,268],"(termed":[18],"hIGFBP-1)":[19],"at":[20],"high":[21,224,226,240,325],"levels.":[22],"IGFBP-1":[23,69,72,137,225,244,264,275,291,328],"is":[24,34],"major":[26,250],"soluble":[27],"product":[29],"this":[31],"tissue":[32],"principally":[35],"localized":[36],"to":[37,63,139,141,159,172,186,200,282,318,322],"differentiated":[39],"endometrial":[40,315],"stromal":[41,54,316],"cell,":[42],"decidual":[44,112,294],"cell.":[45],"In":[46,103,115,237],"present":[48],"study":[49],"long":[50],"term":[51],"culture":[52,271,278],"cells":[55,106,317,319],"from":[56,190,230,277,293],"nonpregnant":[58],"have":[60],"been":[61],"employed":[62],"elucidate":[64],"hormonal":[66],"requirements":[67],"for":[68,123],"production.":[70],"Immunoreactive":[71],"was":[73,255,280],"undetectable":[74],"in":[75,170,207,219,269,308,311,313],"control":[76],"cultures.":[77],"However,":[78],"inclusion":[79,130,164],"medroxyprogesterone":[81],"acetate":[82],"(MPA)":[83],"induced":[84,223],"rates":[85,142,157,177,211,241,326],"0.35":[87],"+/-":[88,95],"0.09":[89],"microgram/0.1":[90],"mg":[91,146,215],"cell":[92,113,147,216],"DNA.day":[93,148],"(mean":[94],"SEM;":[96],"n":[97],"=":[98],"5)":[99],"after":[100,121],"20-30":[101],"days.":[102],"these":[104],"cultures":[105,117,173,183,238],"exhibited":[107],"morphological":[108],"changes":[109],"consistent":[110,299],"with":[111,126,162,195,290,300],"differentiation.":[114],"all":[116],"removal":[118],"MPA":[120,201],"exposure":[122],"10-16":[124],"days,":[125],"or":[127,149,203,310],"without":[128,174],"subsequent":[129],"relaxin":[132],"(RLX),":[133],"increased":[134],"production":[135,227,329],"450-":[138],"4600-fold":[140],"150-710":[144],"micrograms/0.1":[145,214],"26-131":[150],"micrograms/10(6)":[151],"cells.day":[152],"on":[153],"days":[154],"24-26.":[155],"tended":[158],"be":[160,283],"higher":[161],"RLX":[166,187,221],"were":[168,228,298],"sustained":[169],"contrast":[171],"RLX,":[175],"where":[176],"fell":[178],"by":[179,257,285],"day":[180],"30.":[181],"Individual":[182],"responded":[184],"differently":[185],"when":[188],"added":[189],"initiation":[192],"culture,":[194],"either":[196],"response":[198],"similar":[199],"alone":[202,222],"cyclical":[205],"change":[206],"production,":[208,245],"achieving":[209],"maximal":[210],"190-290":[213],"DNA.day.":[217],"Cultures":[218],"which":[220],"obtained":[229],"progesterone-dominated":[234],"luteal":[235],"phase.":[236],"exhibiting":[239],"immunoreactive":[243,274],"represented":[248],"their":[249],"secretory":[251],"product.":[253],"This":[254],"confirmed":[256],"[35S]methionine":[258],"incorporation":[259],"presence":[262],"as":[265],"predominant":[267],"serum-free":[270],"medium.":[272],"isolated":[276],"medium":[279],"found":[281],"identical,":[284],"number":[287],"criteria,":[289],"derived":[292],"tissue.":[295],"These":[296],"results":[297],"primary":[302],"role":[303],"progestin":[305],"exposure,":[306],"whether":[307],"vivo":[309],"vitro,":[312],"converting":[314],"potentially":[320],"able":[321],"exhibit":[323],"typical":[330],"pregnancy.":[336]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}