{"id":"https://openalex.org/W2017242008","doi":"https://doi.org/10.1021/bi047469h","title":"Relocation of Water Molecules between the Schiff Base and the Thr46\u2212Asp96 Region during Light-Driven Unidirectional Proton Transport by Bacteriorhodopsin: An FTIR Study of the N Intermediate","display_name":"Relocation of Water Molecules between the Schiff Base and the Thr46\u2212Asp96 Region during Light-Driven Unidirectional Proton Transport by Bacteriorhodopsin: An FTIR Study of the N Intermediate","publication_year":2005,"publication_date":"2005-03-31","ids":{"openalex":"https://openalex.org/W2017242008","doi":"https://doi.org/10.1021/bi047469h","mag":"2017242008","pmid":"https://pubmed.ncbi.nlm.nih.gov/15835885"},"language":"en","primary_location":{"id":"doi:10.1021/bi047469h","doi":"https://doi.org/10.1021/bi047469h","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi047469h","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111635866","display_name":"Akio Maeda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Akio Maeda","raw_affiliation_strings":["Department of Biochemistry, University of Illinois at Urbana/Champaign, Urbana, Illinois 61801, Department of Biology, University of Washington, Seattle, Washington 98195, and Department of Physiology and Biophysics, University of California, Irvine, California 92697"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Illinois at Urbana/Champaign, Urbana, Illinois 61801, Department of Biology, University of Washington, Seattle, Washington 98195, and Department of Physiology and Biophysics, University of California, Irvine, California 92697","institution_ids":["https://openalex.org/I157725225","https://openalex.org/I201448701","https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008855880","display_name":"Robert B. Gennis","orcid":"https://orcid.org/0000-0002-3805-6945","observed_orcids":["https://orcid.org/0000-0002-3805-6945"]},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert B. Gennis","raw_affiliation_strings":["Department of Biochemistry, University of Illinois at Urbana/Champaign, Urbana, Illinois 61801, Department of Biology, University of Washington, Seattle, Washington 98195, and Department of Physiology and Biophysics, University of California, Irvine, California 92697"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Illinois at Urbana/Champaign, Urbana, Illinois 61801, Department of Biology, University of Washington, Seattle, Washington 98195, and Department of Physiology and Biophysics, University of California, Irvine, California 92697","institution_ids":["https://openalex.org/I157725225","https://openalex.org/I201448701","https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004318630","display_name":"Sergei P. Balashov","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sergei P. Balashov","raw_affiliation_strings":["Department of Biochemistry, University of Illinois at Urbana/Champaign, Urbana, Illinois 61801, Department of Biology, University of Washington, Seattle, Washington 98195, and Department of Physiology and Biophysics, University of California, Irvine, California 92697"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Illinois at Urbana/Champaign, Urbana, Illinois 61801, Department of Biology, University of Washington, Seattle, Washington 98195, and Department of Physiology and Biophysics, University of California, Irvine, California 92697","institution_ids":["https://openalex.org/I157725225","https://openalex.org/I201448701","https://openalex.org/I204250578"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108345253","display_name":"Thomas G. Ebrey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Thomas G. Ebrey","raw_affiliation_strings":["Department of Biochemistry, University of Illinois at Urbana/Champaign, Urbana, Illinois 61801, Department of Biology, University of Washington, Seattle, Washington 98195, and Department of Physiology and Biophysics, University of California, Irvine, California 92697"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Illinois at Urbana/Champaign, Urbana, Illinois 61801, Department of Biology, University of Washington, Seattle, Washington 98195, and Department of Physiology and Biophysics, University of California, Irvine, California 92697","institution_ids":["https://openalex.org/I157725225","https://openalex.org/I201448701","https://openalex.org/I204250578"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5108345253"],"corresponding_institution_ids":["https://openalex.org/I157725225","https://openalex.org/I201448701","https://openalex.org/I204250578"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":0.8283,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.64061096,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"44","issue":"16","first_page":"5960","last_page":"5968"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12236","display_name":"Photoreceptor and optogenetics research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12236","display_name":"Photoreceptor and optogenetics research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11177","display_name":"Spectroscopy and Quantum Chemical Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3107","display_name":"Atomic and Molecular Physics, and Optics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11129","display_name":"Photochemistry and Electron Transfer Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1606","display_name":"Physical and Theoretical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bacteriorhodopsin","display_name":"bacteriorhodopsin","score":1.0},{"id":"https://openalex.org/keywords/n-intermediate","display_name":"N intermediate","score":0.8240000009536743},{"id":"https://openalex.org/keywords/light-driven-proton-transport","display_name":"light-driven proton transport","score":0.7210000157356262},{"id":"https://openalex.org/keywords/water-clusters","display_name":"water clusters","score":0.5899999737739563},{"id":"https://openalex.org/keywords/schiff-base","display_name":"Schiff base","score":0.8640000224113464},{"id":"https://openalex.org/keywords/l-intermediate","display_name":"L intermediate","score":0.6819999814033508},{"id":"https://openalex.org/keywords/proton-transfer","display_name":"proton transfer","score":0.5149999856948853},{"id":"https://openalex.org/keywords/reprotonation","display_name":"reprotonation","score":0.6060000061988831}],"concepts":[{"id":"https://openalex.org/C189542057","wikidata":"https://www.wikidata.org/wiki/Q242310","display_name":"Bacteriorhodopsin","level":3,"score":0.9537051320075989},{"id":"https://openalex.org/C2776428424","wikidata":"https://www.wikidata.org/wiki/Q2602701","display_name":"Schiff base","level":2,"score":0.7805009484291077},{"id":"https://openalex.org/C54516573","wikidata":"https://www.wikidata.org/wiki/Q2294","display_name":"Proton","level":2,"score":0.7121753096580505},{"id":"https://openalex.org/C2992012372","wikidata":"https://www.wikidata.org/wiki/Q412272","display_name":"Proton transport","level":3,"score":0.6185328960418701},{"id":"https://openalex.org/C160892712","wikidata":"https://www.wikidata.org/wiki/Q901559","display_name":"Fourier transform infrared spectroscopy","level":2,"score":0.6128664016723633},{"id":"https://openalex.org/C32909587","wikidata":"https://www.wikidata.org/wiki/Q11369","display_name":"Molecule","level":2,"score":0.5875666737556458},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5806411504745483},{"id":"https://openalex.org/C2779019381","wikidata":"https://www.wikidata.org/wiki/Q3499564","display_name":"Relocation","level":2,"score":0.4778941869735718},{"id":"https://openalex.org/C75473681","wikidata":"https://www.wikidata.org/wiki/Q188651","display_name":"Photochemistry","level":1,"score":0.4509810209274292},{"id":"https://openalex.org/C2776509742","wikidata":"https://www.wikidata.org/wiki/Q764133","display_name":"Halobacteriaceae","level":5,"score":0.44489800930023193},{"id":"https://openalex.org/C42058472","wikidata":"https://www.wikidata.org/wiki/Q810214","display_name":"Base (topology)","level":2,"score":0.4218706786632538},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.24500665068626404},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.1661730706691742},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.12293243408203125},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.10495573282241821},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0969860851764679},{"id":"https://openalex.org/C185544564","wikidata":"https://www.wikidata.org/wiki/Q81197","display_name":"Nuclear physics","level":1,"score":0.08054199814796448},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.07578447461128235},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.06758826971054077},{"id":"https://openalex.org/C2778113554","wikidata":"https://www.wikidata.org/wiki/Q3782756","display_name":"Halobacterium salinarum","level":4,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001436","descriptor_name":"Bacteriorhodopsins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001436","descriptor_name":"Bacteriorhodopsins","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D001436","descriptor_name":"Bacteriorhodopsins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010777","descriptor_name":"Photochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011522","descriptor_name":"Protons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012545","descriptor_name":"Schiff Bases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014867","descriptor_name":"Water","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016297","descriptor_name":"Mutagenesis, Site-Directed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017550","descriptor_name":"Spectroscopy, Fourier Transform Infrared","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019617","descriptor_name":"Halobacterium salinarum","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019617","descriptor_name":"Halobacterium salinarum","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019943","descriptor_name":"Amino Acid Substitution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/bi047469h","doi":"https://doi.org/10.1021/bi047469h","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi047469h","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},{"id":"pmid:15835885","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15835885","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1763103919","display_name":null,"funder_award_id":"HL 16101","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G2332788407","display_name":null,"funder_award_id":"GM52023","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G5831288853","display_name":"MOLECULAR MECHANISMS CONTROLLING BACTERIORHODOPSIN","funder_award_id":"R01GM052023","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320332688","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W90286590","https://openalex.org/W1588117493","https://openalex.org/W1964409003","https://openalex.org/W1971057129","https://openalex.org/W1987571376","https://openalex.org/W2019584134","https://openalex.org/W2021579729","https://openalex.org/W2044158151","https://openalex.org/W2056316643","https://openalex.org/W2076057575","https://openalex.org/W2102793929","https://openalex.org/W2115391980","https://openalex.org/W2115932892","https://openalex.org/W2152668682","https://openalex.org/W2153061750","https://openalex.org/W2156004732"],"related_works":["https://openalex.org/W2082331777","https://openalex.org/W1992984762","https://openalex.org/W2064879007","https://openalex.org/W1983051983","https://openalex.org/W2043617555","https://openalex.org/W2093312134","https://openalex.org/W2156004732","https://openalex.org/W2110343112","https://openalex.org/W1979824330","https://openalex.org/W2018837118"],"abstract_inverted_index":{"A":[0],"key":[1],"event":[2],"in":[3,77,143,164,193,207,236,239],"light-driven":[4],"proton":[5,25,60],"pumping":[6],"by":[7,22,161,245],"bacteriorhodopsin":[8],"is":[9,20,56,158,242],"the":[10,13,23,29,35,41,45,49,53,68,95,99,104,108,111,117,167,178,201,223,233,248],"formation":[11,183],"of":[12,40,48,90,116,136,154,169,173,184,188,205],"L":[14,78,189,214],"intermediate,":[15],"whose":[16],"transition":[17],"to":[18,32,51,87,98,103,152,177,226],"M":[19],"accompanied":[21],"first":[24],"transfer":[26],"step,":[27],"from":[28,44,222],"Schiff":[30,42,96,224,249],"base":[31,43,97,225],"Asp85":[33],"on":[34],"extracellular":[36],"side.":[37],"Subsequent":[38],"reprotonation":[39],"other":[46],"side":[47],"membrane":[50],"form":[52],"N":[54,118,127,137,174,206,216,240],"intermediate":[55,119],"crucial":[57],"for":[58],"unidirectional":[59],"transport.":[61],"Previous":[62],"FTIR":[63],"studies":[64],"have":[65,217],"suggested":[66],"that":[67,212],"intense":[69,202],"water":[70,92,132,171,203,219,234],"O-D":[71,133],"stretching":[72,134],"vibration":[73],"bands":[74],"which":[75,190,199],"appear":[76,138],"at":[79,128],"2589,":[80],"2605,":[81],"and":[82,215],"2621":[83],"cm(-)(1)":[84],"are":[85,191],"due":[86],"a":[88,140,144,149,218],"cluster":[89,220,235],"polarized":[91],"molecules":[93],"connecting":[94],"Thr46-Asp96":[100],"region":[101,147],"closer":[102],"cytoplasmic":[105],"surface.":[106],"In":[107],"present":[109],"study":[110],"difference":[112],"spectrum":[113],"was":[114,197],"obtained":[115],"with":[120,148,247],"its":[121],"photoproduct":[122],"N',":[123,185],"formed":[124],"after":[125],"irradiating":[126],"80":[129],"K.":[130],"The":[131,209,228],"vibrations":[135,172,204],"as":[139],"broad":[141],"feature":[142,157],"similar":[145,150],"frequency":[146],"intensity":[151],"those":[153,187],"L.":[155,165],"This":[156],"also":[159],"affected":[160],"T46V":[162],"like":[163],"However,":[166],"intensities":[168],"these":[170],"nearly":[175],"returned":[176],"initial":[179],"unphotolyzed":[180],"state":[181],"upon":[182],"unlike":[186],"preserved":[192,200],"L'.":[194],"An":[195],"exception":[196],"V49A,":[198],"N'.":[208],"results":[210],"suggest":[211],"both":[213],"extending":[221],"Thr46.":[227],"surrounding":[229],"protein":[230],"moiety":[231],"stabilizes":[232],"L,":[237],"but":[238],"it":[241],"stabilized":[243],"mostly":[244],"interaction":[246],"base.":[250]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}