{"id":"https://openalex.org/W2017241048","doi":"https://doi.org/10.1289/ehp.98106s61307","title":"Role of tissue repair in toxicologic interactions among hepatotoxic organics.","display_name":"Role of tissue repair in toxicologic interactions among hepatotoxic organics.","publication_year":1998,"publication_date":"1998-12-01","ids":{"openalex":"https://openalex.org/W2017241048","doi":"https://doi.org/10.1289/ehp.98106s61307","mag":"2017241048","pmid":"https://pubmed.ncbi.nlm.nih.gov/9860886","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1533468"},"language":"en","primary_location":{"id":"doi:10.1289/ehp.98106s61307","doi":"https://doi.org/10.1289/ehp.98106s61307","is_oa":true,"landing_page_url":"https://doi.org/10.1289/ehp.98106s61307","pdf_url":"https://ehp.niehs.nih.gov/doi/epdf/10.1289/ehp.98106s61307","source":{"id":"https://openalex.org/S10446503","display_name":"Environmental Health Perspectives","issn_l":"0091-6765","issn":["0091-6765","1552-9924"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319799","host_organization_name":"National Institute of Environmental Health Sciences","host_organization_lineage":["https://openalex.org/P4310319799","https://openalex.org/P4310316754"],"host_organization_lineage_names":["National Institute of Environmental Health Sciences","National Institutes of Health"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environmental Health Perspectives","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://ehp.niehs.nih.gov/doi/epdf/10.1289/ehp.98106s61307","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113578076","display_name":"M.G. Soni","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I71730758","display_name":"University of Louisiana at Monroe","ror":"https://ror.org/02qeh3c90","country_code":"US","type":"education","lineage":["https://openalex.org/I2799628689","https://openalex.org/I71730758"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M G Soni","raw_affiliation_strings":["Division of Toxicology, College of Pharmacy and Health Sciences, Northeast Louisiana University, Monroe 71209-0470, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Toxicology, College of Pharmacy and Health Sciences, Northeast Louisiana University, Monroe 71209-0470, USA","institution_ids":["https://openalex.org/I71730758"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008224944","display_name":"Harihara M. Mehendale","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I71730758","display_name":"University of Louisiana at Monroe","ror":"https://ror.org/02qeh3c90","country_code":"US","type":"education","lineage":["https://openalex.org/I2799628689","https://openalex.org/I71730758"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H M Mehendale","raw_affiliation_strings":["Division of Toxicology, College of Pharmacy and Health Sciences, Northeast Louisiana University, Monroe 71209-0470, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Toxicology, College of Pharmacy and Health Sciences, Northeast Louisiana University, Monroe 71209-0470, USA","institution_ids":["https://openalex.org/I71730758"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I71730758"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":{"value":4500,"currency":"USD","value_usd":4500},"fwci":0.2563,"has_fulltext":true,"cited_by_count":48,"citation_normalized_percentile":{"value":0.21111111,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"106","issue":"suppl 6","first_page":"1307","last_page":"1317"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.010599999688565731,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10447","display_name":"Environmental Toxicology and Ecotoxicology","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tissue-repair","display_name":"tissue repair","score":0.9200000166893005},{"id":"https://openalex.org/keywords/hepatotoxicity","display_name":"hepatotoxicity","score":0.8740000128746033},{"id":"https://openalex.org/keywords/chemical-mixtures","display_name":"chemical mixtures","score":0.9589999914169312},{"id":"https://openalex.org/keywords/chlordecone","display_name":"chlordecone","score":0.7799999713897705},{"id":"https://openalex.org/keywords/carbon-tetrachloride","display_name":"carbon tetrachloride","score":1.0},{"id":"https://openalex.org/keywords/phenobarbital","display_name":"phenobarbital","score":0.9980000257492065},{"id":"https://openalex.org/keywords/dose-response-relationship","display_name":"dose-response relationship","score":0.7760000228881836},{"id":"https://openalex.org/keywords/risk-assessment","display_name":"risk assessment","score":0.6200000047683716},{"id":"https://openalex.org/keywords/liver-injury","display_name":"liver injury","score":0.699999988079071}],"concepts":[{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.8418617248535156},{"id":"https://openalex.org/C2777359374","wikidata":"https://www.wikidata.org/wiki/Q225045","display_name":"Carbon tetrachloride","level":2,"score":0.6961405277252197},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5042356252670288},{"id":"https://openalex.org/C2776637226","wikidata":"https://www.wikidata.org/wiki/Q6658207","display_name":"Liver injury","level":2,"score":0.48464304208755493},{"id":"https://openalex.org/C33070731","wikidata":"https://www.wikidata.org/wiki/Q7218","display_name":"Toxicology","level":1,"score":0.4705790877342224},{"id":"https://openalex.org/C102124568","wikidata":"https://www.wikidata.org/wiki/Q5009626","display_name":"CCL4","level":3,"score":0.41336846351623535},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.39943939447402954},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3688003420829773},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30566009879112244},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.11756563186645508},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004347","descriptor_name":"Drug Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008115","descriptor_name":"Liver Regeneration","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015262","descriptor_name":"Xenobiotics","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D056486","descriptor_name":"Chemical and Drug Induced Liver Injury","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1289/ehp.98106s61307","doi":"https://doi.org/10.1289/ehp.98106s61307","is_oa":true,"landing_page_url":"https://doi.org/10.1289/ehp.98106s61307","pdf_url":"https://ehp.niehs.nih.gov/doi/epdf/10.1289/ehp.98106s61307","source":{"id":"https://openalex.org/S10446503","display_name":"Environmental Health Perspectives","issn_l":"0091-6765","issn":["0091-6765","1552-9924"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319799","host_organization_name":"National Institute of Environmental Health Sciences","host_organization_lineage":["https://openalex.org/P4310319799","https://openalex.org/P4310316754"],"host_organization_lineage_names":["National Institute of Environmental Health Sciences","National Institutes of Health"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environmental Health Perspectives","raw_type":"journal-article"},{"id":"pmid:9860886","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9860886","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environmental health perspectives","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.277.725","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.277.725","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/cc/cf/Environ_Health_Perspect_1998_Dec_106(Suppl_6)_1307-1317.tar.gz","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1289/ehp.98106s61307","doi":"https://doi.org/10.1289/ehp.98106s61307","is_oa":true,"landing_page_url":"https://doi.org/10.1289/ehp.98106s61307","pdf_url":"https://ehp.niehs.nih.gov/doi/epdf/10.1289/ehp.98106s61307","source":{"id":"https://openalex.org/S10446503","display_name":"Environmental Health Perspectives","issn_l":"0091-6765","issn":["0091-6765","1552-9924"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319799","host_organization_name":"National Institute of Environmental Health Sciences","host_organization_lineage":["https://openalex.org/P4310319799","https://openalex.org/P4310316754"],"host_organization_lineage_names":["National Institute of Environmental Health Sciences","National Institutes of Health"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environmental Health Perspectives","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7052800679","display_name":"DIETARY RESTRICTION AND TOXICANT-INDUCED LIVER DISEASE","funder_award_id":"R03ES008604","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320309392","display_name":"Louisiana Board of Regents","ror":"https://ror.org/00jv89z46"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"},{"id":"https://openalex.org/F4320337419","display_name":"Agency for Toxic Substances and Disease Registry","ror":"https://ror.org/0045x2741"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2017241048.pdf","grobid_xml":"https://content.openalex.org/works/W2017241048.grobid-xml"},"referenced_works_count":80,"referenced_works":["https://openalex.org/W124345539","https://openalex.org/W1524754033","https://openalex.org/W1554913031","https://openalex.org/W1567011157","https://openalex.org/W1584740983","https://openalex.org/W1902442984","https://openalex.org/W1967367116","https://openalex.org/W1971093574","https://openalex.org/W1971792553","https://openalex.org/W1972753157","https://openalex.org/W1974535438","https://openalex.org/W1975232966","https://openalex.org/W1980058440","https://openalex.org/W1982558668","https://openalex.org/W1986359711","https://openalex.org/W1988036317","https://openalex.org/W1988575972","https://openalex.org/W1991856931","https://openalex.org/W1992127113","https://openalex.org/W1995403429","https://openalex.org/W1997779222","https://openalex.org/W2001774066","https://openalex.org/W2002719814","https://openalex.org/W2006340300","https://openalex.org/W2007595692","https://openalex.org/W2014780926","https://openalex.org/W2017590944","https://openalex.org/W2018639193","https://openalex.org/W2021912494","https://openalex.org/W2024259509","https://openalex.org/W2025665586","https://openalex.org/W2026227050","https://openalex.org/W2029916770","https://openalex.org/W2030540456","https://openalex.org/W2030564610","https://openalex.org/W2037031415","https://openalex.org/W2038537487","https://openalex.org/W2041469915","https://openalex.org/W2042520936","https://openalex.org/W2049751501","https://openalex.org/W2050441727","https://openalex.org/W2055532771","https://openalex.org/W2056223943","https://openalex.org/W2056636760","https://openalex.org/W2060161661","https://openalex.org/W2064534406","https://openalex.org/W2064841381","https://openalex.org/W2065744684","https://openalex.org/W2067939516","https://openalex.org/W2070771892","https://openalex.org/W2071848149","https://openalex.org/W2079598619","https://openalex.org/W2086077686","https://openalex.org/W2090121271","https://openalex.org/W2090665957","https://openalex.org/W2091223805","https://openalex.org/W2091790310","https://openalex.org/W2097092416","https://openalex.org/W2102831033","https://openalex.org/W2106423632","https://openalex.org/W2111176042","https://openalex.org/W2112237035","https://openalex.org/W2117217908","https://openalex.org/W2123963186","https://openalex.org/W2128847976","https://openalex.org/W2131699163","https://openalex.org/W2161991931","https://openalex.org/W2172591290","https://openalex.org/W2340324006","https://openalex.org/W2395200037","https://openalex.org/W2405050077","https://openalex.org/W2416865480","https://openalex.org/W2426364373","https://openalex.org/W2474035293","https://openalex.org/W2563298834","https://openalex.org/W4211173486","https://openalex.org/W4285719527","https://openalex.org/W4290426610","https://openalex.org/W6704077688","https://openalex.org/W6807366397"],"related_works":["https://openalex.org/W1983990916","https://openalex.org/W2020535234","https://openalex.org/W2029457070","https://openalex.org/W2113685352","https://openalex.org/W2024259509","https://openalex.org/W2026227050","https://openalex.org/W2048703287","https://openalex.org/W2093303105","https://openalex.org/W2036225859","https://openalex.org/W2042295344"],"abstract_inverted_index":{"It":[0],"is":[1,49,120,174,193,251,265],"widely":[2],"recognized":[3],"that":[4,74,234,262,273],"exposure":[5,57],"to":[6,58,114,162,209,245,269],"combinations":[7],"or":[8,35],"mixtures":[9,30,60],"of":[10,43,50,54,63,77,102,123,132,140,148,152,167,183,230,257,275,286],"chemicals":[11,21],"may":[12,31,281],"result":[13],"in":[14,95,176,186,238,278,283],"highly":[15,46,124],"exaggerated":[16,47],"toxicity":[17,48,287],"even":[18,115],"though":[19],"individual":[20],"might":[22],"not":[23],"be":[24],"toxic":[25,191,270],"at":[26,90],"low":[27],"doses.":[28],"Chemical":[29],"also":[32],"cause":[33],"additive":[34,38],"less":[36],"than":[37],"toxicity.":[39,168],"From":[40],"the":[41,64,91,137,149,180,189],"perspective":[42],"public":[44],"health,":[45],"significant":[51],"concern.":[52],"Assessment":[53],"risk":[55,279],"from":[56,69],"chemical":[59],"requires":[61],"knowledge":[62],"underlying":[65],"mechanisms.":[66],"Previous":[67],"studies":[68,232],"this":[70,170,204,211,276],"laboratory":[71],"have":[72,223],"shown":[73],"nontoxic":[75],"doses":[76],"chlordecone":[78],"(10":[79],"ppm,":[80],"15":[81],"days)":[82],"and":[83,99,111,198,217,272],"carbon":[84],"tetrachloride":[85],"(CCl4)":[86],"(100":[87],"microliters/kg)":[88],"interact":[89],"biologic":[92],"interface,":[93],"resulting":[94],"potentiated":[96],"liver":[97,153],"injury":[98,154,173,216,243,271],"67-fold":[100],"amplification":[101],"CCl4":[103,112],"lethality.":[104],"In":[105,169,206],"contrast,":[106],"although":[107],"interaction":[108],"between":[109],"phenobarbital":[110],"leads":[113],"higher":[116],"injury,":[117],"animal":[118],"survival":[119],"unaffected":[121],"because":[122],"stimulated":[125,141],"compensatory":[126],"tissue":[127,142,172,200,218,235,263],"repair.":[128],"A":[129],"wide":[130],"variety":[131],"additional":[133],"experimental":[134],"evidence":[135],"confirms":[136],"central":[138],"role":[139],"repair":[143,201,219,236,264],"as":[144,220],"a":[145,164,239,246,266],"decisive":[146],"determinant":[147],"final":[150],"outcome":[151,192],"inflicted":[155,175],"by":[156,179,195],"hepatotoxicants.":[157,228],"These":[158,259],"findings":[159,260],"led":[160],"us":[161],"propose":[163],"two-stage":[165],"model":[166,227],"model,":[171,212],"stage":[177,187],"one":[178],"well-described":[181],"mechanisms":[182],"toxicity,":[184],"whereas":[185],"two":[188],"ultimate":[190],"determined":[194],"whether":[196],"timely":[197],"sufficient":[199],"response":[202,268,277],"accompanies":[203],"injury.":[205,258],"an":[207,254],"attempt":[208],"validate":[210],"dose-response":[213],"relationships":[214],"for":[215,226],"opposing":[221],"responses":[222],"been":[224],"developed":[225],"Results":[229],"these":[231],"suggest":[233],"increases":[237],"dose-dependent":[240],"manner,":[241],"restraining":[242],"up":[244],"threshold":[247],"dose,":[248],"whereupon":[249],"it":[250],"inhibited,":[252],"allowing":[253],"unrestrained":[255],"progression":[256],"indicate":[261],"quantifiable":[267],"inclusion":[274],"assessment":[280],"help":[282],"fine-tuning":[284],"prediction":[285],"outcomes.":[288]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
