{"id":"https://openalex.org/W2017239646","doi":"https://doi.org/10.1002/jnr.21548","title":"Amyloid \u03b2\u2010peptide activates nuclear factor\u2010\u03baB through an N\u2010methyl\u2010D\u2010aspartate signaling pathway in cultured cerebellar cells","display_name":"Amyloid \u03b2\u2010peptide activates nuclear factor\u2010\u03baB through an N\u2010methyl\u2010D\u2010aspartate signaling pathway in cultured cerebellar cells","publication_year":2007,"publication_date":"2007-10-29","ids":{"openalex":"https://openalex.org/W2017239646","doi":"https://doi.org/10.1002/jnr.21548","mag":"2017239646","pmid":"https://pubmed.ncbi.nlm.nih.gov/17969100"},"language":"en","primary_location":{"id":"doi:10.1002/jnr.21548","doi":"https://doi.org/10.1002/jnr.21548","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jnr.21548","pdf_url":null,"source":{"id":"https://openalex.org/S76417895","display_name":"Journal of Neuroscience Research","issn_l":"0360-4012","issn":["0360-4012","1097-4547"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neuroscience Research","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2017239646"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078750239","display_name":"Elisa Mitiko Kawamoto","orcid":"https://orcid.org/0000-0001-8637-414X","observed_orcids":["https://orcid.org/0000-0001-8637-414X"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"E. M. Kawamoto","raw_affiliation_strings":["Department of Pharmacology, Institute of Biomedical Sciences, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Institute of Biomedical Sciences, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112585353","display_name":"Luc\u00edlia Brochado Lepsch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"L. B. Lepsch","raw_affiliation_strings":["Department of Pharmacology, Institute of Biomedical Sciences, University of Sa\u0303o Paulo, Sa\u0303o Paulo, Brazil","Department of Pharmacology, Institute of Biomedical Sciences University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Institute of Biomedical Sciences, University of Sa\u0303o Paulo, Sa\u0303o Paulo, Brazil","institution_ids":["https://openalex.org/I17974374"]},{"raw_affiliation_string":"Department of Pharmacology, Institute of Biomedical Sciences University of S\u00e3o Paulo  S\u00e3o Paulo Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047382456","display_name":"Maria Fernanda Cury\u2010Boaventura","orcid":"https://orcid.org/0000-0002-1596-0624","observed_orcids":["https://orcid.org/0000-0002-1596-0624","https://orcid.org/0000-0002-7523-4616"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"M. F. C. Boaventura","raw_affiliation_strings":["Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sa\u0303o Paulo, Sa\u0303o Paulo, Brazil","Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of S\u00e3o Paulo, Sao Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sa\u0303o Paulo, Sa\u0303o Paulo, Brazil","institution_ids":["https://openalex.org/I17974374"]},{"raw_affiliation_string":"Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of S\u00e3o Paulo, Sao Paulo, Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013277728","display_name":"Carolina Demarchi Munhoz","orcid":"https://orcid.org/0000-0002-8656-5234","observed_orcids":["https://orcid.org/0000-0002-8656-5234"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"C. D. Munhoz","raw_affiliation_strings":["Department of Pharmacology, Institute of Biomedical Sciences, University of Sa\u0303o Paulo, Sa\u0303o Paulo, Brazil","Department of Pharmacology, Institute of Biomedical Sciences University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Institute of Biomedical Sciences, University of Sa\u0303o Paulo, Sa\u0303o Paulo, Brazil","institution_ids":["https://openalex.org/I17974374"]},{"raw_affiliation_string":"Department of Pharmacology, Institute of Biomedical Sciences University of S\u00e3o Paulo  S\u00e3o Paulo Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086768280","display_name":"Larissa S\u00e1 Lima","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"L. S. Lima","raw_affiliation_strings":["Department of Pharmacology, Institute of Biomedical Sciences, University of Sa\u0303o Paulo, Sa\u0303o Paulo, Brazil","Department of Pharmacology, Institute of Biomedical Sciences University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Institute of Biomedical Sciences, University of Sa\u0303o Paulo, Sa\u0303o Paulo, Brazil","institution_ids":["https://openalex.org/I17974374"]},{"raw_affiliation_string":"Department of Pharmacology, Institute of Biomedical Sciences University of S\u00e3o Paulo  S\u00e3o Paulo Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040264217","display_name":"Lidia Yshii","orcid":"https://orcid.org/0000-0002-1988-6855","observed_orcids":["https://orcid.org/0000-0002-1988-6855"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"L. M. Yshii","raw_affiliation_strings":["Department of Pharmacology, Institute of Biomedical Sciences, University of Sa\u0303o Paulo, Sa\u0303o Paulo, Brazil","Department of Pharmacology, Institute of Biomedical Sciences University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Institute of Biomedical Sciences, University of Sa\u0303o Paulo, Sa\u0303o Paulo, Brazil","institution_ids":["https://openalex.org/I17974374"]},{"raw_affiliation_string":"Department of Pharmacology, Institute of Biomedical Sciences University of S\u00e3o Paulo  S\u00e3o Paulo Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084030910","display_name":"Maria Christina W. Avellar","orcid":"https://orcid.org/0000-0003-4392-7554","observed_orcids":["https://orcid.org/0000-0003-4392-7554"]},"institutions":[{"id":"https://openalex.org/I88273585","display_name":"Universidade Federal de S\u00e3o Paulo","ror":"https://ror.org/02k5swt12","country_code":"BR","type":"education","lineage":["https://openalex.org/I88273585"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"M. C. W. Avellar","raw_affiliation_strings":["Department of Pharmacology, Section of Experimental Endocrinology, Federal University of Sa\u0303o Paulo, Sa\u0303o Paulo, Brazil","Department of Pharmacology, Section of Experimental Endocrinology, Federal University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Section of Experimental Endocrinology, Federal University of Sa\u0303o Paulo, Sa\u0303o Paulo, Brazil","institution_ids":["https://openalex.org/I88273585"]},{"raw_affiliation_string":"Department of Pharmacology, Section of Experimental Endocrinology, Federal University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I88273585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004080311","display_name":"Rui Curi","orcid":"https://orcid.org/0000-0001-5095-9154","observed_orcids":["https://orcid.org/0000-0001-5095-9154"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"R. Curi","raw_affiliation_strings":["Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sa\u0303o Paulo, Sa\u0303o Paulo, Brazil","Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of S\u00e3o Paulo, Sao Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sa\u0303o Paulo, Sa\u0303o Paulo, Brazil","institution_ids":["https://openalex.org/I17974374"]},{"raw_affiliation_string":"Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of S\u00e3o Paulo, Sao Paulo, Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083040475","display_name":"Mark P. Mattson","orcid":"https://orcid.org/0000-0002-9816-4155","observed_orcids":["https://orcid.org/0000-0002-9816-4155","https://orcid.org/0009-0000-5542-5565"]},"institutions":[{"id":"https://openalex.org/I4210136897","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. P. Mattson","raw_affiliation_strings":["Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, Maryland","institution_ids":["https://openalex.org/I4210136897"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022566712","display_name":"Crist\u00f3foro Scavone","orcid":"https://orcid.org/0000-0002-1206-0882","observed_orcids":["https://orcid.org/0000-0002-1206-0882"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"C. Scavone","raw_affiliation_strings":["Department of Pharmacology, Institute of Biomedical Sciences, University of Sa\u0303o Paulo, Sa\u0303o Paulo, Brazil","Department of Pharmacology, Institute of Biomedical Sciences University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Institute of Biomedical Sciences, University of Sa\u0303o Paulo, Sa\u0303o Paulo, Brazil","institution_ids":["https://openalex.org/I17974374"]},{"raw_affiliation_string":"Department of Pharmacology, Institute of Biomedical Sciences University of S\u00e3o Paulo  S\u00e3o Paulo Brazil","institution_ids":["https://openalex.org/I17974374"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5022566712"],"corresponding_institution_ids":["https://openalex.org/I17974374"],"apc_list":{"value":4840,"currency":"USD","value_usd":4840},"apc_paid":null,"fwci":0.3369,"has_fulltext":false,"cited_by_count":44,"citation_normalized_percentile":{"value":0.47390101,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"86","issue":"4","first_page":"845","last_page":"860"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9570000171661377,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9570000171661377,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.028300000354647636,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.006300000008195639,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/amyloid-beta","display_name":"amyloid-beta","score":0.9070000052452087},{"id":"https://openalex.org/keywords/nf-kappab-activation","display_name":"NF-\u03baB activation","score":0.9340000152587891},{"id":"https://openalex.org/keywords/nmda-receptor","display_name":"NMDA receptor","score":0.8790000081062317},{"id":"https://openalex.org/keywords/cerebellar-cells","display_name":"cerebellar cells","score":0.7850000262260437},{"id":"https://openalex.org/keywords/src-family-kinases","display_name":"Src family kinases","score":0.7149999737739563},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.8059999942779541},{"id":"https://openalex.org/keywords/pi3k-signaling","display_name":"PI3K signaling","score":0.9139999747276306},{"id":"https://openalex.org/keywords/farnesyltransferase-inhibitors","display_name":"farnesyltransferase inhibitors","score":0.7570000290870667},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.718999981880188},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.8379999995231628},{"id":"https://openalex.org/keywords/brain-derived-neurotrophic-factor","display_name":"brain-derived neurotrophic factor","score":0.7570000290870667},{"id":"https://openalex.org/keywords/inducible-nitric-oxide-synthase","display_name":"inducible nitric oxide synthase","score":0.9269999861717224},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.8949999809265137},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.9279999732971191},{"id":"https://openalex.org/keywords/ikappab","display_name":"I\u03baB","score":0.7559999823570251}],"concepts":[{"id":"https://openalex.org/C2776912716","wikidata":"https://www.wikidata.org/wiki/Q4042503","display_name":"LY294002","level":4,"score":0.644338071346283},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.48963385820388794},{"id":"https://openalex.org/C67018056","wikidata":"https://www.wikidata.org/wiki/Q414896","display_name":"NMDA receptor","level":3,"score":0.46035075187683105},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.4370136260986328},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.42715635895729065},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.42196768522262573},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.41853004693984985},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.412952721118927},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.39348334074020386},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.33607184886932373},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2539752125740051},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2537190318107605}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002531","descriptor_name":"Cerebellum","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002531","descriptor_name":"Cerebellum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005455","descriptor_name":"Fluorescent Antibody Technique","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015151","descriptor_name":"Immunoblotting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016202","descriptor_name":"N-Methylaspartate","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016202","descriptor_name":"N-Methylaspartate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016291","descriptor_name":"Dizocilpine Maleate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018691","descriptor_name":"Excitatory Amino Acid Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019869","descriptor_name":"Phosphatidylinositol 3-Kinases","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019869","descriptor_name":"Phosphatidylinositol 3-Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020928","descriptor_name":"Mitogen-Activated Protein Kinases","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D020928","descriptor_name":"Mitogen-Activated Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D024202","descriptor_name":"Electrophoretic Mobility Shift Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1002/jnr.21548","doi":"https://doi.org/10.1002/jnr.21548","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jnr.21548","pdf_url":null,"source":{"id":"https://openalex.org/S76417895","display_name":"Journal of Neuroscience Research","issn_l":"0360-4012","issn":["0360-4012","1097-4547"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neuroscience Research","raw_type":"journal-article"},{"id":"pmid:17969100","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17969100","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neuroscience research","raw_type":"Journal Article"},{"id":"pmh:oai:www.producao.usp.br:BDPI/27963","doi":null,"is_oa":false,"landing_page_url":"http://producao.usp.br/handle/BDPI/27963","pdf_url":null,"source":{"id":"https://openalex.org/S4306401373","display_name":"Scientific Electronic Library Online (S\u00e3o Paulo Research Foundation, Latin American and Caribbean Center on Health Sciences Information, Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2982035970","host_organization_name":"Costa Rican Department of Social Security","host_organization_lineage":["https://openalex.org/I2982035970"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"article"},{"id":"pmh:oai:repositorio.unifesp.br:11600/30482","doi":null,"is_oa":false,"landing_page_url":"http://repositorio.unifesp.br/handle/11600/30482","pdf_url":null,"source":{"id":"https://openalex.org/S4377196380","display_name":"UNIFESP Institutional Repository (Universidade Federal de S\u00e3o Paulo)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I88273585","host_organization_name":"Universidade Federal de S\u00e3o Paulo","host_organization_lineage":["https://openalex.org/I88273585"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Artigo"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":63,"referenced_works":["https://openalex.org/W38748857","https://openalex.org/W340359662","https://openalex.org/W1542152284","https://openalex.org/W1542202136","https://openalex.org/W1606126476","https://openalex.org/W1694093395","https://openalex.org/W1743329534","https://openalex.org/W1776526278","https://openalex.org/W1956108500","https://openalex.org/W1964780858","https://openalex.org/W1964891910","https://openalex.org/W1967939624","https://openalex.org/W1968786165","https://openalex.org/W1969125125","https://openalex.org/W1976382352","https://openalex.org/W1981513372","https://openalex.org/W1984485912","https://openalex.org/W1989008849","https://openalex.org/W1990264946","https://openalex.org/W1995431361","https://openalex.org/W1997018685","https://openalex.org/W1998033989","https://openalex.org/W1998760380","https://openalex.org/W1999300192","https://openalex.org/W2000706612","https://openalex.org/W2005355701","https://openalex.org/W2009924028","https://openalex.org/W2016293448","https://openalex.org/W2020567039","https://openalex.org/W2020931266","https://openalex.org/W2033775249","https://openalex.org/W2034790142","https://openalex.org/W2037791406","https://openalex.org/W2037863613","https://openalex.org/W2043884992","https://openalex.org/W2045121112","https://openalex.org/W2046571199","https://openalex.org/W2050675499","https://openalex.org/W2051314670","https://openalex.org/W2053116497","https://openalex.org/W2054526986","https://openalex.org/W2059379142","https://openalex.org/W2065535274","https://openalex.org/W2070881916","https://openalex.org/W2077464099","https://openalex.org/W2082963940","https://openalex.org/W2085278496","https://openalex.org/W2087255758","https://openalex.org/W2087350601","https://openalex.org/W2093414824","https://openalex.org/W2099451408","https://openalex.org/W2106877484","https://openalex.org/W2127027544","https://openalex.org/W2140660632","https://openalex.org/W2144232114","https://openalex.org/W2146702633","https://openalex.org/W2148999943","https://openalex.org/W2153897409","https://openalex.org/W2164296549","https://openalex.org/W2170593168","https://openalex.org/W2326352899","https://openalex.org/W2388163742","https://openalex.org/W4322703208"],"related_works":["https://openalex.org/W3146104960","https://openalex.org/W161705813","https://openalex.org/W2338614551","https://openalex.org/W1494476710","https://openalex.org/W1537390295","https://openalex.org/W1977951553","https://openalex.org/W1483432124","https://openalex.org/W1968786165","https://openalex.org/W2130139295","https://openalex.org/W2131565097"],"abstract_inverted_index":{"Amyloid":[0],"beta-peptide":[1],"(A":[2],"beta)":[3],"likely":[4],"causes":[5],"functional":[6],"alterations":[7],"in":[8,28,42,75,80,235],"neurons":[9,43],"well":[10],"prior":[11],"to":[12,24,36,58,247],"their":[13],"death.":[14],"Nuclear":[15],"factor-kappaB":[16],"(NF-kappaB),":[17],"a":[18,149],"transcription":[19],"factor":[20],"that":[21,221],"is":[22,49],"known":[23],"play":[25],"important":[26],"roles":[27],"cell":[29],"survival":[30],"and":[31,44,112,129,151,162,174,184,209,232],"apoptosis,":[32],"has":[33,54],"been":[34,56],"shown":[35,57,213],"be":[37],"modulated":[38],"by":[39,172,176,214,226],"A":[40,52,76,93,111,140,146,186,222,248],"beta":[41,53,141,147,187,211,223],"glia,":[45],"but":[46],"the":[47,67,144,192],"mechanism":[48],"unknown.":[50],"Because":[51],"also":[55],"enhance":[59],"activation":[60,79,153,169],"of":[61,69,92,143,154,194],"N-methyl-D-aspartate":[62],"(NMDA)":[63],"receptors,":[64],"we":[65],"investigated":[66],"role":[68],"NMDA":[70],"receptor-mediated":[71],"intracellular":[72],"signaling":[73],"pathways":[74,234],"beta-induced":[77],"NF-kappaB":[78,155,164,225],"primary":[81],"cultured":[82,236],"rat":[83],"cerebellar":[84,237],"cells.":[85,145,238],"Cells":[86],"were":[87,135,166],"treated":[88],"with":[89],"different":[90,100],"concentrations":[91],"beta1-40":[94],"(1":[95,156],"or":[96,104],"2":[97],"microM)":[98],"for":[99],"periods":[101],"(6,":[102],"12,":[103],"24":[105],"hr).":[106],"MK-801":[107,173],"(NMDA":[108],"antagonist),":[109],"manumycin":[110,177],"FTase":[113,179],"inhibitor":[114,180],"1":[115,189],"(farnesyltransferase":[116],"inhibitors),":[117],"PP1":[118],"(Src-family":[119],"tyrosine":[120],"kinase":[121,126],"inhibitor),":[122],"PD98059":[123],"[mitogen-activated":[124],"protein":[125,196,229],"(MAPK)":[127],"inhibitor],":[128],"LY294002":[130],"[phosphatidylinositol":[131],"3-kinase":[132],"(PI3-k)":[133],"inhibitor]":[134],"added":[136],"20":[137],"min":[138],"before":[139],"treatment":[142],"induced":[148],"time-":[150],"concentration-dependent":[152],"microM,":[157],"12":[158],"hr);":[159],"both":[160],"p50/p65":[161],"p50/p50":[163],"dimers":[165],"involved.":[167],"This":[168,239],"was":[170],"abolished":[171],"attenuated":[175],"A,":[178],"1,":[181],"PP1,":[182],"PD98059,":[183],"LY294002.":[185],"at":[188],"microM":[190],"increased":[191],"expression":[193],"inhibitory":[195],"I":[197],"kappaB,":[198],"brain-derived":[199],"neurotrophic":[200],"factor,":[201],"inducible":[202],"nitric":[203],"oxide":[204],"synthase,":[205],"tumor":[206],"necrosis":[207],"factor-alpha,":[208],"interleukin-1":[210],"as":[212],"RT-PCR":[215],"assays.":[216],"Collectively,":[217],"these":[218],"findings":[219],"suggest":[220],"activates":[224],"an":[227,243],"NMDA-Src-Ras-like":[228],"through":[230],"MAPK":[231],"PI3-k":[233],"pathway":[240],"may":[241],"mediate":[242],"adaptive,":[244],"neuroprotective":[245],"response":[246],"beta.":[249]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":4},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}