{"id":"https://openalex.org/W2017228455","doi":"https://doi.org/10.1093/eurheartj/8.suppl_m.31","title":"Comparison of the effects of two doses of bisoprolol on exercise tolerance in exercise-induced stable angina pectoris","display_name":"Comparison of the effects of two doses of bisoprolol on exercise tolerance in exercise-induced stable angina pectoris","publication_year":1987,"publication_date":"1987-12-02","ids":{"openalex":"https://openalex.org/W2017228455","doi":"https://doi.org/10.1093/eurheartj/8.suppl_m.31","mag":"2017228455","pmid":"https://pubmed.ncbi.nlm.nih.gov/2897300"},"language":"en","primary_location":{"id":"doi:10.1093/eurheartj/8.suppl_m.31","doi":"https://doi.org/10.1093/eurheartj/8.suppl_m.31","is_oa":false,"landing_page_url":"https://doi.org/10.1093/eurheartj/8.suppl_m.31","pdf_url":null,"source":{"id":"https://openalex.org/S181568219","display_name":"European Heart Journal","issn_l":"0195-668X","issn":["0195-668X","1522-9645"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Heart Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069246245","display_name":"Ebo D. de Muinck","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E. De Muinck","raw_affiliation_strings":["Akademisch Ziekenhuis, Groningen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Akademisch Ziekenhuis, Groningen, The Netherlands","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085692608","display_name":"G. Wagner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I164928964","display_name":"Merck KGaA, Darmstadt (Germany)","ror":"https://ror.org/04b2dty93","country_code":"DE","type":"company","lineage":["https://openalex.org/I164928964"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"G. Wagner","raw_affiliation_strings":["Clinical Research Division E. Merck, 6100 Darmstadt, F.R.G"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Research Division E. Merck, 6100 Darmstadt, F.R.G","institution_ids":["https://openalex.org/I164928964"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111519786","display_name":"Louis L.M. van de Ven","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210100089","display_name":"Merck B.V. (Netherlands)","ror":"https://ror.org/012chae64","country_code":"NL","type":"company","lineage":["https://openalex.org/I164928964","https://openalex.org/I4210100089"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"L. L. M. V. D. Ven","raw_affiliation_strings":["E. Merck Nederland B.V., 1005AD Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"E. Merck Nederland B.V., 1005AD Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I4210100089"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109044744","display_name":"Kong Ing Lie","orcid":"https://orcid.org/0000-0002-5779-5989","observed_orcids":["https://orcid.org/0000-0002-5779-5989"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K. I. Lie","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5240,"currency":"EUR","value_usd":5922},"apc_paid":null,"fwci":0.724,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.69415852,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":"8","issue":"suppl M","first_page":"31","last_page":"35"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13381","display_name":"Heart rate and cardiovascular health","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13381","display_name":"Heart rate and cardiovascular health","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11209","display_name":"Cardiovascular and exercise physiology","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10372","display_name":"Cardiac Imaging and Diagnostics","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bisoprolol","display_name":"bisoprolol","score":1.0},{"id":"https://openalex.org/keywords/stable-angina","display_name":"stable angina","score":0.8769999742507935},{"id":"https://openalex.org/keywords/exercise-tolerance","display_name":"exercise tolerance","score":0.7490000128746033},{"id":"https://openalex.org/keywords/coronary-artery-disease","display_name":"coronary artery disease","score":0.8550000190734863},{"id":"https://openalex.org/keywords/dose-comparison","display_name":"dose comparison","score":0.7089999914169312},{"id":"https://openalex.org/keywords/duration-of-action","display_name":"duration of action","score":0.871999979019165},{"id":"https://openalex.org/keywords/exercise-capacity","display_name":"exercise capacity","score":0.7630000114440918},{"id":"https://openalex.org/keywords/beta-blockers","display_name":"beta-blockers","score":0.7049999833106995},{"id":"https://openalex.org/keywords/heart-rate","display_name":"heart rate","score":0.656000018119812},{"id":"https://openalex.org/keywords/rate-pressure-product","display_name":"rate-pressure product","score":0.8960000276565552},{"id":"https://openalex.org/keywords/st-segment-depression","display_name":"ST-segment depression","score":0.921999990940094}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.95741868019104},{"id":"https://openalex.org/C2779670145","wikidata":"https://www.wikidata.org/wiki/Q412515","display_name":"Bisoprolol","level":3,"score":0.8714598417282104},{"id":"https://openalex.org/C2778425758","wikidata":"https://www.wikidata.org/wiki/Q180762","display_name":"Angina","level":3,"score":0.6722573041915894},{"id":"https://openalex.org/C162156334","wikidata":"https://www.wikidata.org/wiki/Q473420","display_name":"Dose","level":2,"score":0.624549388885498},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.5811779499053955},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.49336186051368713},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.47839224338531494},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.44938036799430847},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.3390255570411682},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.21282610297203064},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.19491362571716309}],"mesh":[{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000319","descriptor_name":"Adrenergic beta-Antagonists","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000319","descriptor_name":"Adrenergic beta-Antagonists","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000787","descriptor_name":"Angina Pectoris","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D000787","descriptor_name":"Angina Pectoris","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D000787","descriptor_name":"Angina Pectoris","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004562","descriptor_name":"Electrocardiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005080","descriptor_name":"Exercise Test","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006339","descriptor_name":"Heart Rate","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011412","descriptor_name":"Propanolamines","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D011412","descriptor_name":"Propanolamines","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017298","descriptor_name":"Bisoprolol","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/eurheartj/8.suppl_m.31","doi":"https://doi.org/10.1093/eurheartj/8.suppl_m.31","is_oa":false,"landing_page_url":"https://doi.org/10.1093/eurheartj/8.suppl_m.31","pdf_url":null,"source":{"id":"https://openalex.org/S181568219","display_name":"European Heart Journal","issn_l":"0195-668X","issn":["0195-668X","1522-9645"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Heart Journal","raw_type":"journal-article"},{"id":"pmid:2897300","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2897300","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European heart journal","raw_type":"Clinical Trial"},{"id":"pmh:oai:open-archive.highwire.org:ehj:8/suppl_M/31","doi":null,"is_oa":false,"landing_page_url":"http://eurheartj.oxfordjournals.org/cgi/content/short/8/suppl_M/31","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":4,"referenced_works":["https://openalex.org/W2025128453","https://openalex.org/W2025355402","https://openalex.org/W2029136939","https://openalex.org/W2079733554"],"related_works":["https://openalex.org/W2316223588","https://openalex.org/W1986776083","https://openalex.org/W2025128453","https://openalex.org/W2322100443","https://openalex.org/W2226989106","https://openalex.org/W2158929932","https://openalex.org/W1975475382","https://openalex.org/W2050661476","https://openalex.org/W2396374269","https://openalex.org/W1632980919"],"abstract_inverted_index":{"Recently,":[0],"bisoprolol":[1,38,52,88,178,273],"has":[2],"been":[3],"investigated":[4],"regarding":[5],"its":[6],"effects":[7,34,46,185,202,281],"on":[8,226,249],"exercise":[9,104,225,237,297],"tolerance":[10,105],"and":[11,49,53,112,123,146,236,259],"the":[12,31,45,54,138,171],"duration":[13,55,286],"of":[14,33,35,47,56,140,175,287,295],"action":[15,57,288],"in":[16,60],"patients":[17,62],"with":[18,71,177,216,282,302],"coronary":[19],"heart":[20,227,250],"disease":[21],"(CHD)":[22],"following":[23,113],"single":[24],"oral":[25],"administration.":[26,80],"It":[27,269],"appears,":[28],"however,":[29],"that":[30,272],"extent":[32],"5":[36,48,84,179,221,274],"mg":[37,51,87,180,218,275],"is":[39],"not":[40],"fully":[41],"established":[42],"yet.":[43],"Therefore,":[44],"10":[50,86,217,303],"were":[58,82,118,159,189,203],"assessed":[59],"12":[61],"(10":[63],"male,":[64],"2":[65,92],"female;":[66],"mean":[67],"age":[68],"60.2":[69],"years)":[70],"stable":[72],"angina":[73,176],"pectoris":[74],"due":[75],"to":[76,95,151,167,220,234,244,257,267,279],"CHD":[77],"after":[78,126,194,212],"repeated":[79],"Patients":[81],"given":[83],"or":[85,165,232,242,255,265],"once":[89,276],"daily":[90,277],"for":[91,170,197],"weeks":[93],"according":[94],"a":[96,283],"double-blind,":[97],"randomized":[98],"cross-over":[99],"design.":[100],"At":[101],"entry":[102],"one":[103],"test":[106],"(ETT)":[107],"served":[108],"as":[109,207,209],"baseline":[110,152],"measurement":[111],"each":[114],"treatment":[115,215],"period":[116],"ETTs":[117],"performed":[119],"before":[120],"(24-hour":[121],"value)":[122],"3":[124,187,205],"hours":[125,188,196,206,211],"tablet":[127],"intake.":[128],"Exercise":[129],"capacity":[130,238,298],"(in":[131],"W":[132],"X":[133],"min)":[134],"was":[135,270],"calculated":[136],"until":[137],"onset":[139,174],"angina,":[141],"0.1":[142],"mV":[143],"ST-segment":[144],"depression":[145],"at":[147,181,186,223,246],"peak":[148,224,296],"exercise.":[149],"Compared":[150],"all":[153],"workload":[154,172,248],"values":[155],"during":[156,214],"active":[157],"therapy":[158],"significantly":[160,190],"improved":[161],"(P":[162,229,239,252,262],"less":[163,230,240,253,263],"than":[164,192,231,241,254,264],"equal":[166,233,243,256,266],"0.05)":[168,235],"except":[169],"till":[173],"24":[182,195,210,290],"hours.":[183],"The":[184],"stronger":[191,201],"those":[193],"both":[198],"dosages.":[199],"Significantly":[200],"observed":[204],"well":[208],"intake":[213],"compared":[219],"mg:":[222],"rate":[228,251],"0.01),":[245],"identical":[247],"0.01)":[258],"rate-pressure":[260],"product":[261],"0.01).":[268],"found":[271],"leads":[278],"therapeutic":[280],"clearly":[284],"maintained":[285],"over":[289],"hours,":[291],"but":[292],"further":[293],"increase":[294],"may":[299],"be":[300],"achieved":[301],"mg.":[304]},"counts_by_year":[{"year":2021,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
